A heterogeneously structured composite based on poly(lactic-co-glycolic acid) microspheres and poly(vinyl alcohol) hydrogel nanoparticles for long- term protein drug delivery

Pharmaceutical Research

Volumn 16, Issue 9, 1999, Pages 1430-1435

  Wang, Nuo ^a,b   Wu, Xue Shen ^c   Li, Jia Kui ^d  

^a LONG ISLAND UNIVERSITY   (United States)

^b Mutual Pharmaceutical Company Inc   (United States)

^c SYNTHON BV   (Netherlands)

^d Pharmaceutical and Analytical R and D   (United States)

Author keywords

Microsphere; Nanoparticle; Poly(lactic co glycolic acid); Poly(vinyl alcohol); Protein drug delivery

Indexed keywords

DRUG; MICROSPHERE; NANOPARTICLE; POLYGLACTIN; POLYVINYL ALCOHOL;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; PARTICLE SIZE; PRIORITY JOURNAL;

BIOCOMPATIBLE MATERIALS; CHROMATOGRAPHY; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HYDROGEL; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; POLYVINYL ALCOHOL; SERUM ALBUMIN, BOVINE;

EID: 0032834111     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018911411381     Document Type: Article

References (22)

1. X. S. Wu. Preparation, characterization, and drug delivery applications of microspheres based on biodegradable lactic/glycolic acid polymers. In D. L. Wise, D. J. Trantolo, D. E. Altobeli, M. J. Yaszemski, J. D. Gresser, and E. R. Schwartz (eds.), Encyclopedic Handbook of Biomaterials and Bioengineering, Part A: Materials, Vol. II., Dekker, New York, 1995, pp. 1151-1152.
2. R. Jalil and J. R. Nixon. Biodegradable poly(lactic acid) and poly (lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J. Microencapsulation 7:297-325 (1990).
3. S. Cohen, T. Yoshioka, M. Lucarelli, L. H. Hwang, and R. Langer. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8:713-720 (1991).
4. Y. Ogawa, M. Yamamoto, H. Okada, T. Yashiki, and T. A. Shimamoto. New technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid. Chem. Pharm. Bull. 36:1095-1103 (1988).
5. H. Okada and Y. Ogawa. Prolonged release microcapsule. U.S. patent 5,476,663 (1995).
6. H. Okada, Y. Inoue, and Y. Ogawa. Prolonged release microcapsules. U.S. patent 5,480,656 (1996).
7. W. Lu and T. G. Park. Protein release from poly(lactic-co-glycolic acid) microspheres: Protein stability problems. PDA J. Pharm. Sci. Tech. 49:13-19 (1995).
8. T. Uchida, A. Yagi, Y. Oda, Y. Dakada, and S. Goto. Instability of bovine insulin in poly(lactide-co-glycolide) (PLGA) microspheres. Chem. Pharm. Bull. 44:235-236 (1996).
9. K. J. Zhu, X. Lin, and S. Yang. Preparation and properties of D, L-lactide and ethylene oxide copolymer: A modifying biodegradable polymeric material. J. Polym. Sci.: Part C: Polymer Letters. 24:331-337 (1986).
10. D. Cohn, H. Younes, and G. Marom. Amorphous and crystalline morphologies in glycolic acid and lactic acid polymers. Polymer. 28:18-22 (1987).
11. H. M. Dollinger and S. P. Sawan. Bicontinuous controlled-release matrices composed of poly(d,l-lactic acid) blended with ethylenevinyl acetate copolymer. Polym. Prepr. 31:211-212 (1990).
12. T. Kissel, Z. Brich, S. Bantle, I. Lancranjan, F. Nimmerfall, and P. Vit. Parenteral depot-systems on the basis of biodegradable polyesters. J. Contr. Rel. 16:27-42 (1991).
13. T. G. Park, S. Cohen, and R. Langer. Poly(L-lactic acid)/Pluronic Blends: Characterization of phase separation behavior, degradation, and morphology and use as protein-release matrices. Macromol. 25:116-122 (1992).
14. C. G. Pitt, Y. Cha, S. S. Shah, and K. J. Zhu. Blends of PVA and PGLA: control of the permeability and degradability of hydrogels by blending. J. Contr. Rel. 19:189-200 (1992).
15. J. K. Li, N. Wang, and X. S. Wu. A novel biodegradable system based on gelatin nanoparticles and poly(lactic-co-glycolic acid) microspheres for protein and peptide drag delivery. J. Pharm. Sci. 86:891-895 (1997).
16. N. Wang and X. S. Wu. A novel approach to stabilization of protein drugs in poly(lactic-co-glycolic acid) microspheres using agarose hydrogel. Int. J. Pharm. 166:1-14 (1998).
17. J. K. Li, N. Wang, and X. S. Wu. Poly(vinyl alcohol) nanoparticles prepared by freezing-thawing process for protein drug delivery. J. Contr. Rel. 56:117-126 (1998).
18. M. C. Julienne, M. J. Alonso, J. L. Gómez Amoza, and J. P. Benoit. Preparation of poly(D,L-lactide/glycolide) nanoparticles of controlled particle size distribution: application of experimental designs. Drug Dev. Ind. Pharm. 18:1063-1077 (1992).
19. T. Uchida, S. Goto, and T. P. Foster. Particle size studies for subcutaneous delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation. J. Pharm. Pharmacol. 47:556-560 (1994).
20. G. A. Brazeau, M. Sciame, S. A. Al-Suwayeh, and E. Fattal. Evaluation of PLGA microspheres size effect on myotoxicity using the isolated rodent skeletal muscle model. Pharm. Dev. Tech. 1:279-283 (1996).
21. L. M. Sanders, J. S. Kent, G. I. Mcrae, B. H. Vickery, T. R. Tice, and D. H. Lewis. Controlled release of leutinizing hormone releasing hormone analogue from poly (d,l-lactide-co-glycolide) microspheres. J. Pharm. Sci. 73:1294-1297 (1984).
22. C. N. Pace. Conformational stability of globular proteins. Trends in Biochem. Sci. 15:14-17 (1990).