Factors affecting the in vitro release of recombinant human interferon- γ (rhIFN-γ) from PLGA microspheres

Journal of Pharmaceutical Sciences

Volumn 86, Issue 8, 1997, Pages 908-914

  Yang, Janet ^a   Cleland, Jeffrey L ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSPHERE; POLYGLACTIN; RECOMBINANT GAMMA INTERFERON;

ARTICLE; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; MICROENCAPSULATION;

EID: 0030861258     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js960480l     Document Type: Article

References (17)

1. Kahari, V. M.; Heino, J.; Vuorio, T.; Vuorio, E. Interferon-alpha and interferon-gamma reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture. Biochim. Biophys. Acta 1988, 968, 45-50.
2. Gillery, P.; Serpier, H.; Polette, M.; Bellon, G.; Cavel, C.; Wegrowski, Y.; Birembaut, P.; Kalis, B.; Cariou, R.; Maquart, F. X. Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts. Eur. J. Cell Biol. 1992, 57, 244-253.
3. Fujioka, K.; Takada, Y.; Sato, S.; Miyata, T. Novel delivery system for proteins using collagen as a carrier material: the minipellet. J. Controlled Release 1995, 33, 307-315.
4. Fujioka, K.; Takada, Y.; Sato, S.; Miyate, T. Long-acting delivery system of interferon: IFN minipellet. J. Controlled Release 1995, 33, 317-323.
5. Yu, H.; Grainger, D. W. Modified release of hydrophilic, hydrophobic and peptide agents from ionized amphiphilic gel networks. J. Controlled Release 1995, 34, 117-127.
6. Cleland, J. L.; Jones, A. J. S. Stable formulations of recombinant human growth hormone and interferon-γ for microencapsulation in biodegradable microspheres. Pharm. Res. 1996, 13, 1462-1473.
7. Rinderknecht, E.; O'Connor, B. H.; Rodriquez, H. Natural human interferon-γ: Complete amino acid sequence and determination of sites of glycosylation. J. Biol. Chem. 1984, 6790-6797.
8. Cleland, J. L. Design and production of single immunization vaccines using polylactide polyglycolide microsphere systems. In: Vaccine Design: The Subunit Approach; Powell, M. F.; Newman, M., Eds.; Plenum: New York, 1995; pp 439-472.
9. Cleland, J. L.; Lim, A.; Barrón, L.; Duenas, E. T.; Powell, M. F. Development of a single-shot subunit vaccine for HIV-1: Part 4. optimizing microencapsulation and pulsatile release of MN rgp120 from biodegradable microspheres. J. Controlled Release in press.
10. Cleland, J. L.; Mac, A.; Boyd, B.; Yang, J.; Duenas, E. T.; Yeung, D.; Brooks, D.; Hsu, C.; Chu, H.; Mukku, V.; Jones, A. J. S. The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) PLGA microspheres, Pharm. Res. 1997, 14, 420-425.
11. Johnson, O. L.; Jaworowicz, W.; Cleland, J. L.; Bailey, L.; Charnis, M.; Duenas, E.; Wu, C.; Shepard, D.; Magil, S.; Last, T.; Jones, A. J. S.; Putney, S. D. Characterization and encapsulation of human growth hormone into biodegradable microspheres. Pharm. Res. 1997, 14, 734-739.
12. Hsu, Y. R.; Arakawa, T. Structural studies on acid unfolding and refolding of recombinant human interferon-γ. Biochemistry 1985, 24, 7959-7963.
13. Mulkerrin, M. G.; Wetzel, R. pH dependence of the reversible and irreversible thermal denaturation of γ-interferon. Biochemistry 1989, 28, 6556-6561.
14. Lam, X. M.; Patapoff, T. W.; Nguyen, T. H. Interaction between benzyl alcohol and recombinant human interferon-γ. Pharm. Res., in press.
15. Cleland, J. L.; Duenas, E. T.; Daugherty, A. L.; Marian, M.; Yang, J.; Wilson, M.; Celniker, A. C.; Shahzamani, A.; Quarmby, V.; Chu, H.; Mukku, V.; Mac, A.; Roussakis, M.; Gillette, N.; Boyd, B.; Yeung, D.; Brooks, D.; Maa, Y.-F.; Hsu, C.; Jones, A. J. S. Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect, J. Controlled Release, in press.
16. Lam, X. M.; Costantino, H. R.; Overcashier, D. E.; Nguyen, T. H.; Hsu, C. C. Replacing succinate with glycolate buffer improves the stability of lyophilized interferon-γ. Int. J. Pharm. 1996, 142, 85-95.
17. Park, T. G. Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials 1995, 16, 1123-1130.