A potential approach for decreasing the burst effect of protein from PLGA microspheres

Journal of Pharmaceutical Sciences

Volumn 92, Issue 8, 2003, Pages 1582-1591

  Fu, Karen ^a   Harrell, Roy ^b   Zinski, Kim ^b   Um, Christina ^c   Jaklenec, Ana ^c   Frazier, Jan ^b   Lotan, Noah ^d   Burke, Paul ^b   Klibanov, Alexander M ^a   Langer, Robert ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b AMGEN INC   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Burst effect; PLGA microspheres; Proteins; R met HuGdNF; Spontaneous emulsification

Indexed keywords

MICROSPHERE; POLYGLACTIN; RECOMBINANT METHIONYL HUMAN GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; NONHUMAN; PARTICLE SIZE; PROTEIN ANALYSIS; RAT;

EID: 10744231648     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10414     Document Type: Article

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