Co-lyophilization of bovine serum albumin (BSA) with poly(ethylene glycol) improves efficiency of BSA encapsulation and stability in polyester microspheres by a solid-in-oil-in-oil technique

Biotechnology Letters

Volumn 24, Issue 16, 2002, Pages 1367-1374

  Al Azzam, Wasfi ^a   Pastrana, Emil A ^a   Griebenow, Kai ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Drug delivery; Protein aggregation; Protein stability; Sustained release

Indexed keywords

BOVINE SERUM ALBUMIN; DICHLOROMETHANE; EXCIPIENT; MACROGOL; MACROGOL 8000; MICROSPHERE; OIL; POLYESTER; POLYGLACTIN;

ARTICLE; DRUG DELIVERY SYSTEM; EMULSION; ENCAPSULATION; FREEZE DRYING; PARTICLE SIZE; PROTEIN AGGREGATION; PROTEIN STABILITY; SOLUBILITY; SUSPENSION; SUSTAINED DRUG RELEASE;

BOVINAE;

EID: 0036670249     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019881505734     Document Type: Article

References (18)

1. Bovine serum albumin loaded microspheres: The influence of polymer purity on particle characteristics
2. Structure-guided encapsulation of bovine serum albumin in poly(DL-lactic-co-glycolic)acid
3. Non-aqueous encapsulation of excipient-stabilized spray freeze-dried BSA into poly(lactide-co-glycolide) microspheres results in release of native protein
4. Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique
5. Prevention of structural perturbations and aggregation upon encapsulation of bovine serum albumin into poly(lactide-co-glycolide) microspheres using the solid-in-oil-in-water technique
6. Encapsulation-induced aggregation and loss in activity of γ-chymotrypsin and their prevention
7. The effect of excipients on the structure and stability of lyophilized recombinant human growth hormone (rhGH)
8. Protein spray-freeze drying. Effect of atomization conditions on particle size and stability
9. Heterogeneity of serum albumin samples with respect to solid-state aggregation via thiol-disulfide interchange - Implications for sustained release from polymers
10. FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres
11. On protein denaturation in aqueous-organic but not in pure organic solvents
12. Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process
13. Protein encapsulation into biodegradable microspheres by a novel s/o/w emulsion method using poly(ethylene glycol) as a protein micronization adjuvant
14. Formation and isolation of sphaerical fine protein microparticles through lyophilization of protein-poly (ethylene glycol) aqueous mixture
15. Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers
16. Preservation of lysozyme structure and function upon encapsulation and release from poly (lactic-co-glycollc) acid microspheres prepared by the water-in-oil-in-water method
17. New strategies for the microencapsulation of tetanus vaccine
18. Protein instability in poly(lactic-co-glycolic acid) microparticles