Effect of protein molecular weight on release from micron-sized PLGA microspheres

Journal of Controlled Release

Volumn 76, Issue 3, 2001, Pages 297-311

  Sandor, Maryellen ^a   Enscore, David ^b   Weston, Paula ^a   Mathiowitz, Edith ^a  

^a BROWN UNIVERSITY   (United States)

^b Spherics Inc   (United States)

Author keywords

Erosion mechanism; Microsphere; PLGA degradation; Pore size; Protein molecular weight

Indexed keywords

ALCOHOL DEHYDROGENASE; BOVINE SERUM ALBUMIN; CARBONATE DEHYDRATASE; LYSOZYME; MICROSPHERE; POLYGLACTIN; POLYMER; PROTEIN; THYROGLOBULIN;

ARTICLE; DRUG DIFFUSION; ENCAPSULATION; MOLECULAR SIZE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DEGRADATION; SUSTAINED DRUG RELEASE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; POROSITY; PROTEINS;

EID: 0035914229     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00446-1     Document Type: Article

References (29)

1. Efficacy of subconjunctival cyclosporin-containing microspheres on keratoplasty rejection in the rabbit
2. Preparation and characterization of poly(lactic-co-glycolic acid) microspheres for targeted delivery of a novel anticancer agent, taxol
3. Transmitter-loaded polymeric microspheres induce regrowth of dopaminergic nerve terminals in striata of rats with 6-OH-DA induced parkinsonism
4. Controlled release of beta-estradiol from PLAGA microparticles: The effect of organic phase solvent on encapsulation and release
5. Diclofenac sodium incorporated PLGA (50:50) microspheres: Formulation considerations and in vitro/in vivo evaluation
6. Sustained release of heparin from polymeric particles for inhibition of human vascular smooth muscle cell proliferation
7. Delivery of MUC1 mucin peptide by poly(DL-lactic-co-glycolic acid) microspheres includes type 1 T helper immune responses
8. Nanosphere based oral insulin delivery
9. Pulmonary delivery if insulin with nebulized DL-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect
10. In vitro effects of brain derived neurotrophic factor released from microspheres
11. Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system
12. Sustained release of nerve growth factor from biodegradable polymer microspheres
13. Oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation: Particle size study
14. Controlled release of thyrotropin releasing hormone from microspheres: Evaluation of release profiles and pharmacokinetics after subcutaneous administration
15. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres
16. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues
17. Biologically erodible microspheres as potential oral drug delivery systems
18. Biodegradable polymers for the sustained release of peptides
19. Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy
20. Prolonged controlled-release of nafarelin, a luteinizing hormone-releasing hormone analogue, from biodegradable polymeric implants: Influence of composition and molecular weight of polymer
21. Poly(glycolic acid-co-DL-lactic acid): Diffusion or degradation controlled drug delivery?
22. NGF release from poly(DL-lactide-co-glycolide) microspheres. Effect of some formulation parameters on encapsulated NGF stability
23. Influence of shaking and surfactants on the release of bsa from plga microspheres
24. The evaluation of lyophilized polymer matrices for administering recombinant human bone morphogenetic protein-2