Preparation and in vitro/in vivo evaluation of insulin-loaded poly(acryloyl-hydroxyethyl starch)-PLGA composite microspheres

Pharmaceutical Research

Volumn 20, Issue 3, 2003, Pages 452-459

  Jiang, Ge ^a   Qiu, Wei ^a   DeLuca, Patrick P ^a  

^a University of Kentucky   (United States)

Author keywords

Controlled release; Hydroxyethyl starch; Insulin; Microsphere; PLGA

Indexed keywords

INSULIN DERIVATIVE; MICROSPHERE; POLY(ACRYLOYLHYDROXYETHYLSTARCH); POLYGLACTIN; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; ENCAPSULATION; EVAPORATION; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEL; HYPERGLYCEMIA; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PARTICLE SIZE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN STABILITY; RAT; SOLVENT EXTRACTION; ULTRASOUND;

ACRYLIC RESINS; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; ELECTROPHORESIS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; LACTIC ACID; MALE; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; STARCH;

EID: 0037335355     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022668507748     Document Type: Article

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