Effect of the covalent modification with poly(ethylene glycol) on α-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic) microspheres

Journal of Pharmaceutical Sciences

Volumn 94, Issue 2, 2005, Pages 327-340

  Castellanos, Ingrid J ^a   Al Azzam, Wasfi ^a   Criebenow, Kai ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Capillary electrophoresis; Encapsulation; FTIR; Microspheres; Pegylation; Poly(lactic glycolic) acid (PLGA, PLA); Protein aggregation; Protein delivery; Stability

Indexed keywords

CHYMOTRYPSIN A; MACROGOL; MICROSPHERE; POLYGLACTIN; PROTEIN;

ARTICLE; CAPILLARY ELECTROPHORESIS; COVALENT BOND; DRUG FORMULATION; ENCAPSULATION; ENZYME KINETICS; FREEZE DRYING; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; THERMOSTABILITY;

EID: 14344255109     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20243     Document Type: Article

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