Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres

Journal of Controlled Release

Volumn 96, Issue 3, 2004, Pages 437-448

  Blanco Príeto, María J ^a,b   Campanero, Miguel A ^c   Besseghir, Kamel ^d   Heimgatner, F ^d   Gander, Bruno ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF NAVARRA   (Spain)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

^d DEBIOPHARM SA   (Switzerland)

Author keywords

Controlled release; IVIV correlation; PLGA microspheres; Polymer blend; Vapreotide

Indexed keywords

CONTROLLED DRUG DELIVERY; ENCAPSULATION; ENDOCRINOLOGY; LIVING SYSTEMS STUDIES; NEUROLOGY; PLASMA SPRAYING; TISSUE CULTURE; TUMORS;

MICORSPHERES; PEPTIDES; SUSTAINED PLASMA; VAPREOTIDE;

POLYMER BLENDS;

MICROSPHERE; POLYGLACTIN; POLYLACTIDE; POLYMER; RESOMER; SOMATOSTATIN DERIVATIVE; VAPREOTIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIODEGRADABILITY; COACERVATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG METABOLISM; IN VITRO STUDY; IN VIVO STUDY; INJECTION; MALE; MICROENCAPSULATION; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SPRAY DRYING; TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BIOCOMPATIBLE MATERIALS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EXCIPIENTS; LACTIC ACID; MALE; MICROSPHERES; PARTICLE SIZE; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS; SOMATOSTATIN;

EID: 2142768756     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.02.015     Document Type: Article

References (31)

1. Walsh G. Biopharmaceutical benchmarks. Nat. Biotechnol. 18:2000;831-833
2. Johnson O.L., Tracy M.A. Peptides and proteins drug delivery. Mathiowitz E. Encyclopedia of Controlled Drug Delivery. vol. 2:1999;823-826 Wiley, New York
3. Heya T., Mikura Y., Nagai A., Miura Y., Futo T., Tomida Y., Shimizu H., Toguchi H. Controlled release of thyrotropin releasing hormone from microspheres: evaluation of release profiles and pharmacokinetics after subcutaneous administration. J. Pharm. Sci. 83:1994;798-801
4. Lancrajan I., Bruns C., Jaquet P., Jevell J., Kendall-Taylor P., Lamberts S.W.J., Marbach P., Ørskov H., Pagani G., Sheppard M., Simionsecu L. Sandostatin LAR: pharmacokinetics, pharmacodynamics, efficacy, and tolerability in acromegalic patients. Metabolism. 44:1995;18-26
5. Cleland J.L., Duenas E., Daugherty A., Marian M., Yang J., Wilson M., Celniker A.C., Shahzamani A., Quarmby V., Chu H., Mukku V., Mac A., Roussakis M., Gillette N., Boyd B., Yeung D., Brooks D., Maa Y.-F., Hsu C., Jones A.J.S. Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect. J. Control. Release. 49:1997;193-205
6. Tracy M.A., Ward K.L., Firouzabadian L., Wang Y., Dong N., Qian R., Zhang Y. Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials. 20:1999;1057-1062
7. Yang L., Alexandris P. Physicochemical aspects of drug delivery and release from polymer-based colloids. Curr. Opin. Colloid Interface Sci. 5:2000;132-143
8. Gander B., Merkle H.P., Ngûyen V.P., Nam-Trâm Hô A new thermodynamic model to predict protein encapsulation efficiency in poly(lactide) microspheres. J. Phys. Chem. 99:1995;16144-16148
9. Youxin L., Volland C., Kissel T. In vitro degradation and bovine serum albumin release of ABA triblock copolymers consisting of poly(L(+) lactic acid), or poly(L(+) lactic-co-glycolic acid) A-blocks attached to central polyoxyethylene B-block. J. Control. Release. 32:1994;121-128
10. Breitenbach A., Li Y.X., Kissel T. Branched biodegradable polyesters for parenteral drug delivery systems. J. Control. Release. 64:2000;167-178
11. Yamakawa I., Tsushima Y., Machida R., Watanabe S. In vitro and in vivo release of poly(DL-lactic acid) microspheres containing neurotensin analogue prepared by novel oil-in-water solvent evaporation method. J. Pharm. Sci. 81:1992;808-811
12. Rojas J., Pinto-Alphandary H., Leo E., Pequect S., Couvreur P., Gulik A., Fattal E. A polysorbate-based non-ionic surfactant can modulate loading and release of β-lactoglobulin entrapped in multiphase poly(DL-lactide-co- glycolide) microspheres. Pharm. Res. 16:1999;255-260
13. Lacasse F.-X., Hildgen P., Pérodin J., Escher E., Philipps N.C., McMullen J.N. Improved activity of a new angiotensin receptor antagonist by an injectable spray-dried polymer microsphere formulation. Pharm. Res. 14:1997;887-891
14. Ravivarapu H.B., Burton K., DeLuca P.P. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur. J. Pharm. Biopharm. 50:2000;263-270
15. Ogawa Y., Okada H., Yamamoto M., Shimamoto T. In vivo release of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers. Chem. Pharm. Bull. 36:1988;2576-2581
16. Heya T., Okada H., Ogawa Y., Toguchi H. In vitro and in vivo evaluation of thyrotropin releasing hormone release from copoly(DL-lactic/glycolic acid) microspheres. J. Pharm. Sci. 83:1994;636-640
17. Lam X.M., Duenas E.T., Daugherty A.L., Levin N., Cleland J.L. Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. J. Control. Release. 67:2000;281-292
18. Iwata M., Nakamura Y., McGinity J.W. In vitro and in vivo release properties of brilliant blue and tumor necrosis factor-alpha (TNF-alpha) from poly(D, L-lactic-co-glycolic acid) multiphase microspheres. J. Microencapsulation. 16:1999;777-792
19. Schally A.V. Oncological applications of somatostatin analogue. Cancer Res. 48:1988;6977-6985
20. Girard P.M., Goldschmidt E., Vittecoq D., Massip P., Gastiaburu J., Mehoyas M.C., Coulaud J.P., Schally A.V. Vapreotide, a somatostatin analogue, in cryptosporidiosis and other AIDS related diseases. AIDS. 6:1992;715-718
21. Blanco-Príeto M.J., Besseghir K., Orsolini P., Heimgartner F., Deuschel C., Merkle H.P., Gander B. Importance of the test medium for the release kinetics of a somatostatin analogue from PLGA microspheres. Int. J. Pharm. 184:1999;243-250
22. Thomasin C., Merkle H.P., Gander B.A. Physico-chemical parameters governing protein microencapsulation into biodegradable polyesters by coacervation. Int. J. Pharm. 147:1997;173-186
23. Blanco-Príeto M.J., Besseghir K., Zerbe O., Andris D., Orsolini P., Heimgartner F., Merkle H.P., Gander B. In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres. J. Control. Release. 67:2000;19-28
24. Thomasin C., Johansen P., Alder R., Bemsel R., Hottinger G., Altorfer H., Wright A.D., Wehrli E., Merkle H.P., Gander B. A contribution to overcoming the problem of residual solvents in biodegradable microspheres prepared by coacervation. Eur. J. Pharm. Biopharm. 42:1996;16-24
25. Manson-Garcia M., Vaccarella M., Horvath J., Redding T.W., Groot K., Orsolini P., Schally A. Radio-immunoassay for octapeptide analogs of somatostatin: measurement of serum levels after administration of long-acting microcapsule formulations. Proc. Natl. Acad. Sci. U. S. A. 85:1988;5688-5692
26. Venkata Ramana S., Uppor M. Regulatory perspectives on in vitro (dissolution)/in vivo (bioavailability) correlations. J. Control. Release. 72:2001;127-132
27. Pak S.J., Duong H., Wood B.A., Vook N., van Hamont J.E. The effect of endgroup on the in vitro release behaviour of capsaicin spheres obtained via solvent extraction process. Proc. Int. Symp. Control. Release Bioact. Mater. 24:1997;637-638
28. Freitas S., Walz A., Merkle H.P., Gander B. Solvent extraction employing a static micromixer: a simple, robust and versatile technology for the microencapsulation of proteins. J. Microencapsulation. 20:2003;67-85
29. Aisina R.B., Diomina N.B., Ovchinnikova T.N., Varfolomeyev S.D. Microencapsulation of somatropic growth hormone. STP Pharma Sci. 4:1994;437-441
30. Ch. Yan, J.H. Resau, J. Hewetson, M. West, W.L. Rill, M. Kende, Characterisation and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique, J. Control. Release 32 (1994) 437-441.4 (1994) 437-441.
31. Thomasin C., Corradin G., Men Y., Merkle H.P., Gander B. Tetanus toxoid and synthetic malaria antigen containing poly(lactide)/poly(lactide-co- glycolide) microspheres: importance of polymer degradation and antigen release for immune response. J. Control. Release. 41:1996;131-145