Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres

Journal of Controlled Release

Volumn 69, Issue 2, 2000, Pages 283-295

  Rosa, G De ^a   Iommelli, R ^a   La Rotonda, M I ^a   Miro, A ^a   Quaglia, F ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Insulin; Microspheres; Poly(lactic co glycolic)acid; Surfactants

Indexed keywords

BOVINE INSULIN; INSULIN; MICROSPHERE; NONIONIC SURFACTANT; POLOXAMER; POLYGLACTIN; POLYSORBATE 20; POLYSORBATE 80; RG 504; SOLVENT; SORBITAN MONOOLEATE 80; SORBITAN OLEATE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; EMULSION; ENCAPSULATION; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN STABILITY; SUSTAINED DRUG RELEASE;

DRUG CARRIERS; DRUG STABILITY; HYPOGLYCEMIC AGENTS; INSULIN; LACTIC ACID; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; SOLVENTS; SURFACE-ACTIVE AGENTS;

EID: 0034602127     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00315-1     Document Type: Article

References (28)

1. The pharmaceutics and delivery of therapeutic polypeptides and proteins
2. Toward understanding insulin fibrillation
3. Evidence for a common intermediate in insulin deamidation and covalent dimer formation: Effects of pH and aniline trapping in dilute acidic solutions
4. Stability of bovine insulin
5. Influence of temperature and shaking on stability of insulin preparation: Degradation kinetics
6. Physical stress testing of insulin suspensions and solutions
7. Mechanism of insulin aggregation and stabilization in agitated aqueous solutions
8. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces
9. Chemical stability of insulin in a delivery system environment
10. The use of an implantable insulin pump in the treatment of type II diabetes
11. Physical stability of insulin formulations
12. A remotely programmable insulin delivery system
13. Implantation of insulin infusion devices
14. Stabilisation of dissolved proteins against denaturation at hydrophobic interfaces
15. Aggregation of insulin, containing surfactant, in contact with different materials
16. A novel system based on a poloxamer/PLGA blend as a tetanus toxoid delivery vehicle
17. Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres
18. Lactic Acid Oligomer Microspheres Containing Hydrophylic Drugs
19. Accelerated degradation of poly(epsilon-caprolactone) by organic amines
20. Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions
21. Instability of bovine insulin in poly(lactide-co-glycolide) (PLGA) microspheres
22. Preparation and characterization of polylactic acid microspheres containing bovine insulin by a w/o/w emulsion solvent evaporation method
23. A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid
24. Preparation of porous and nonporous biodegradable hollow microspheres
25. Effect of the emulsion stability on the morphology and porosity of semicrystalline poly L-lactide microparticles prepared by w/o/w double emulsion-evaporation
26. Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: Effect of the protein and polymer properties and of the co-encapsulation of surfactants
27. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres
28. A polysorbate-based non-ionic surfactant can modulate loading and release of beta-lactoglobulin entrapped in multiphase poly(DL-lactide-co-glycolide) microspheres