Stabilization of pH-induced degradation of porcine insulin in biodegradable polyester microspheres

Pharmaceutical Development and Technology

Volumn 4, Issue 4, 1999, Pages 633-642

  Shao, Pushpa G ^a   Bailey, Leonard C ^b  

^a PFIZER INC   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Insulin; PLGA; Poly(DL lactide co glycolide); Polymer; Stability

Indexed keywords

BICARBONATE; DIMER; DRUG METABOLITE; EXCIPIENT; INSULIN DERIVATIVE; MICROSPHERE; PIG INSULIN; POLYESTER; POLYGLACTIN; POLYLACTIDE;

ARTICLE; DIMERIZATION; DRUG DEGRADATION; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; HYDROLYSIS; INSULIN RELEASE; KINETICS; PH; PRIORITY JOURNAL;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; LACTIC ACID; MICROSPHERES; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; SODIUM BICARBONATE; SWINE;

EID: 0032724241     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101402     Document Type: Article

References (8)

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