Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development

Behavioural Pharmacology

Volumn 15, Issue 1, 2004, Pages 1-12

  De Vry, J ^a,b   Jentzsch, K R ^a   Kuhl, E ^a   Eckel, G ^a  

^a CNS Research   (Germany)

^b GRÜNENTHAL GMBH   (Germany)

Author keywords

9 tetrahydrocannabinol; 212 2; 940.hot plate test; Analgesia; Body temperature; CP 55; HU 210; Operant behavior; Rat; SR141716A; WIN 55

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID; CANNABINOID RECEPTOR; DEXANABINOL; RIMONABANT;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; HYPOTHERMIA; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; RAT; REINFORCEMENT;

ANALGESICS; ANIMALS; BODY TEMPERATURE; CANNABINOIDS; CONDITIONING, OPERANT; CYCLOHEXANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MORPHOLINES; NAPHTHALENES; PAIN THRESHOLD; RATS; RATS, WISTAR; REACTION TIME; RECEPTOR, CANNABINOID, CB1; TETRAHYDROCANNABINOL;

EID: 1242272173     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200402000-00001     Document Type: Article

References (34)

1. Abood ME, Martin BR (1992). Neurobiology of marijuana abuse. Trends Pharmacol Sci 13:201-206.
2. Ameri A (1999). The effects of cannabinoids on the brain. Prog Neurobiol 58:315-348.
3. 9-Tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neurosci Biobehav Rev 16:55-62.
4. Bennett GI, Xie YK (1988). A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33: 87-107.
5. 9-tetrahydrocannabinol physical dependence on brain cannabinoid receptors. Eur J Pharmacol 459:139-150.
6. Carriero D, Aberman J, Lin SY, Hill A, Makriyannis A, Salamone JD (1998). A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing. Psychopharmacology (Berl) 137:147-156.
7. 9-tetrahydrocannabinol. J Pharmacol Exp Ther 263:1118-1126.
8. De Vry J (2002). Behavioral pharmacology of cannabinoids in animals. Eur Neuropsychopharmacol 12:S129.
9. De Vry J, Jentzsch KR (2002). Discriminative stimulus effects of BAY 38-7271, a novel cannabinoid receptor agonist. Eur J Pharmacol 457:147-152.
10. 1 receptor ligands in a drug discrimination paradigm. Behav Pharmacol 14:471-476.
11. 1/2 receptor agonists in a limited-access oprant food intake paradigm in the rat. Eur Neuropsychopharmacol 13:337-345.
12. De Vry J, Eckel G, Jentzsch KR (2004a). Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm. Behav Pharmacol 15:13-20.
13. De Vry J, Schreiber R, Eckel G, Jentzsch KR (2004b). Behavioral mechanisms underlying inhibition of food-maintained responding by the cannabinoid receptor antagonist/inverse agonist SR141716A. Eur J Pharmacol 483: 55-63.
14. De Vry J, Denzer D, Reißmueller E, Eijckenboom M, Heil M, Meier H, Mauler F (2004c). 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro- 1-butanesulfonate (BAY 59-3074): a novel cannabinoid receptor agonist with antihyperalgesic and anti-allodynic effects. J Pharmacol Exp Ther (in press).
15. 9-tetrahydrocannabinol, CP 55,940 and WIN 55,212. J Pharmacol Exp Ther 271:1383-1390.
16. Felder CC, Glass M (1998). Cannabinoid receptors and their endogenous agonists. Annu Rev Pharmacol Toxicol 38:179-200.
17. Gaoni Y, Mechoulam R (1964). Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 86:1646-1647.
18. Gifford AN, Bruneus M, Gatley SJ, Lan R, Makriyannis A, Volkow ND (1999). Large receptor reserve for cannabinoid actions in the central nervous system. J Pharmacol Exp Ther 288:478-483.
19. Herzberg U, Eliav E, Bennett GJ, Kopin IJ (1997). The analgesic effects of R(+)· WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci Lett 221:157-160.
20. 8-tetrahydro-cannabinol in rats and pigeons. J Pharmacol Exp Ther 250:1000-1005.
21. 9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A. Eur J Pharmacol 466:121-127.
22. Johnson MR, Melvin LS (1986.) The discovery of nonclassical cannabinoid analgesics. In: Mechoulam R (editor): Cannabinoids as Therapeutic Agents. Boca Raton: CRC Press; pp. 121-145.
23. Kirkham TC, Williams CM (2001). Endogenous cannabinoids and appetite. Nutr Res Rev 14:65-86.
24. 9- tetrahydrocannabinol dosing. Eur J Pharmacol 398:251-258.
25. Martin BR, Compton DR, Thomas BF, Prescott WR, Little PJ, Razdan RK, et al. (1991). Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav 40:471-478.
26. Mauler F, Mittendorf J, Horvaαth E, [8]De [8]Vry J (2002). Characterization of the diarylether sulfonylester (-)-(R)-3-(2- hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties. J Pharmacol Exp Ther 302:1-10.
27. 1 cannabinoid receptor in rat brain. An immunohistochemical study. Peptides 21:1735-1742.
28. Pério A, Rinaldi-Carmona M, Maruani J, Barth F, Le Fur G, Soubrié P (1996). Central mediation of the cannabinoid cue: activity of a selective CB1 antagonist, SR 141716A. Behav Pharmacol 7:65-71.
29. Pertwee RG (1999). Pharmacology of cannabinoid receptor ligands. Cur Med Chem 6:635-664.
30. Pertwee RG (2001). Cannabinoid receptors and pain. Prog Neurobiol 63:569-611.
31. 9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors. Life Sci 63:1-6.
32. Rinaldi-Carmona M, Barth F, Héaulme M, Shire D, Calandra B, Congy C, et al. (1994). SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244.
33. 1 receptor upregulation in a rat model of chronic neuropathic pain. Eur J Pharmacol 415:R5-R7.
34. Wiley JL, Barrett RL, Lowe J, Balster RL, Martin BR (1995). Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats. Neuropharmacology 34:669-676.