Δ9-Tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors

Molecular Pharmacology

Volumn 69, Issue 3, 2006, Pages 991-997

  Hejazi, Nadia ^a   Zhou, Chunyi ^b,c   Oz, Murat ^d   Sun, Hui ^a   Jiang, Hong Ye ^b,c   Zhang, Li ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b Department of Anesthesiology ^*

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; DRONABINOL; GLYCINE RECEPTOR; INHALATION ANESTHETIC AGENT; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; RIMONABANT; AMIDE; ARACHIDONIC ACID DERIVATIVE; CANNABINOID; GLYCINE; TETRAHYDROCANNABINOL;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; NERVE CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM; XENOPUS LAEVIS; ANIMAL; CYTOLOGY; DRUG POTENTIATION; GENETICS; HUMAN; MUTATION;

ANIMALS; ARACHIDONIC ACIDS; CANNABINOIDS; GLYCINE; HUMANS; MUTATION; NEURONS; OOCYTES; POLYUNSATURATED ALKAMIDES; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTORS, GLYCINE; TETRAHYDROCANNABINOL; VENTRAL TEGMENTAL AREA; XENOPUS LAEVIS;

EID: 33644835159     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.019174     Document Type: Article

References (51)

1. Barann M, Molderings G, Bruss M, Bonisch H, Urban BW, and Gothert M (2002) Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site. Br J Pharmacol 137:589-596.
2. Betz H, Kuhse J, Schmieden V, Laube B, Kirsch J, and Harvey RJ (1999) Structure and functions of inhibitory and excitatory glycine receptors. Ann NY Acad Sci 868:667-676.
3. Bradaia A, Schlichter R, and Trouslard J (2004) Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol 559:169-186.
4. Chait LD and Perry JL (1994) Effects of alcohol pretreatment on human marijuana self-administration. Psychopharmacology (Berl) 113:346-350.
5. Cravatt BF and Lichtman AH (2004) The endogenous cannabinoid system and its role in nociceptive behavior. J Neurobiol 61:149-160.
6. Diana MA and Bregestovski P (2005) Calcium and endocannabinoids in the modulation of inhibitory synaptic transmission. Cell Calcium 37:497-505.
7. 2 receptor-mediated actions of anandamide in mouse brain. J Neurochem 75:2434-2444.
8. Di Marzo V, De Petrocellis L, Fezza F, Ligresti A, and Bisogno T (2002) Anandamide receptors. Prostaglandins Leukot Essent Fatty Acids 66:377-391.
9. Doty P, Dysktra LA, and Picker MJ (1992) Delta 9-tetrahydrocannabinol interactions with phencyclidine and ethanol: effects on accuracy and rate of responding. Pharmacol Biochem Behav 43:61-70.
10. Eulenburg V, Armsen W, Betz H, and Gomeza J (2005) Glycine transporters: essential regulators of neurotransmission. Trends Biochem Sci 30:325-333.
11. Fan P (1995) Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons. J Neurophysiol 73:907-910.
12. Gerdeman GL, Ronesi J, and Lovinger DM (2002) Postsynaptic endocannabinoid release is critical to long-term depression in the striatum. Nat Neurosci 5:446-451.
13. Gomeza J, Hulsmann S, Ohno K, Eulenburg V, Szoke K, Richter D, and Betz H (2003) Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron 40:785-796.
14. Henry DJ and Chavkin C (1995) Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes. Neurosci Lett 186:91-94.
15. + channels. Receptors Channels 6:363-374.
16. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, et al. (2002) International Union of Pharmacology, XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202.
17. Huestis MA and Cone EJ (2004) Relationship of Delta 9- tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis. J Anal Toxicol 28:394-399.
18. Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, and Mackie K (1999) Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. J Neurosci 19:3773-3780.
19. Kim SR, Lee da Y, Chung ES, Oh UT, Kim SU, and Jin BK (2005) Transient receptor potential vanilloid subtype 1 mediates cell death of mesencephalic dopaminergic neurons in vivo and in vitro. J Neurosci 25:662-671.
20. Lester HA, Dibas MI, Dahan DS, Leite JF, and Dougherty DA (2004) Cys-loop receptors: new twists and turns. Trends Neurosci 27:329-336.
21. Liguori A, Gatto CP, and Jarrett DB (2002) Separate and combined effects of marijuana and alcohol on mood, equilibrium and simulated driving. Psychopharmacology (Berl) 163:399-405.
22. Lovinger DM and Zhou Q (1998) Alcohol effects on the 5-HT3 ligand-gated ion channel. Toxicol Lett 100-101:239-246.
23. Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, and Burnashev N (2005) Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids. J Neurosci 25:7499-7506.
24. Lynch JW (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol Rev 84:1051-1095.
25. + channel TASK-1. EMBO (Eur Mol Biol Organ) J 20:47-54.
26. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, et al. (1997) Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors. Nature (Lond) 389:385-389.
27. Molander A and Soderpalm B (2005a) Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcohol Clin Exp Res 29:27-37.
28. Molander A and Soderpalm B (2005b) Glycine receptors regulate dopamine release in the rat nucleus accumbens. Alcohol Clin Exp Res 29:17-26.
29. Munro S, Thomas KL, and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Lond) 365:61-65.
30. + channels by membrane lipids. Science (Wash DC) 304:265-270.
31. Oz M (2006) Direct effects of endocannabinoids on ion channels. Curr Pharm Des 12:227-239.
32. 7- nocotinic acetylcholine receptor-mediated responses in Xenopus oocytes. J Pharmacol Exp Ther 313:1272-1280.
33. Oz M, Ravindran A, Diaz-Ruiz O, Zhang L, and Morales M (2003) The endogenous cannabinoid anandamide inhibits α7 nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. J Pharmacol Exp Ther 306:1003-1010.
34. 2+ fluxes in rabbit T-tubule membranes. Eur J Pharmacol 404:13-20.
35. Oz M, Zhang L, and Morales M (2002) Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. Synapse 46:150-156.
36. + channels. Neuropharmacology 35:983-991.
37. Premkumar LS and Ahern GP (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature (Lond) 408:985-990.
38. Schumacher MA, Moff I, Sudanagunta SP, and Levine JD (2000) Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. J Biol Chem 275:2756-2762.
39. Sigel E and Kannenberg K (1996) GABAA-receptor subtypes. Trends Neurosci 19:386.
40. Tanda G and Goldberg SR (2003) Cannabinoids: reward, dependence and underlying neurochemical mechanisms - a review of recent preclinical data. Psychopharmacology (Berl) 169:115-134.
41. Tao L and Ye JH (2002) Inhibition of glycine receptor function of native neurons by aliphatic n-alcohols. Br J Pharmacol 136:629-635.
42. A receptor alpha subunit: effects on channel gating and regulation by ethanol. Br J Pharmacol 131:296-302.
43. Venance L, Piomelli D, Glowinski J, and Giaume C (1995) Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature (Lond) 376:590-594.
44. Walker JM and Huang SM (2002) Cannabinoid analgesia. Pharmacol Ther 95:127-135.
45. Whitehead KJ, Manning JP, Smith CG, and Bowery NG (2001) Determination of the extracellular concentration of glycine in the rat spinal cord dorsal horn by quantitative microdialysis. Brain Res 910:192-194.
46. Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL, and Harris RA (1998) Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci USA 95:6504-6509.
47. Ye JH, Tao L, Ren J, Schaefer R, Krnjevic K, Liu PL, Schiller DA, and McArdle JJ (2001) Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area. J Pharmacol Exp Ther 296:77-83.
48. Ye JH, Zalcman SS, and Tao L (2005) Kainate-activated currents in the ventral tegmental area of neonatal rats are modulated by interleukin-2. Brain Res 1049:227-233.
49. Zhang L, Hosoi M, Fukuzawa M, Sun H, Rawlings RR, and Weight FF (2002) Distinct molecular basis for differential sensitivity of the 5-HT3A receptor to ethanol in the absence and presence of agonist. J Biol Chem 277:46256-46264.
50. Zhu PJ and Lovinger DM (2005) Retrograde endocannabinoid signaling in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala. J Neurosci 25:6199-6207.
51. Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, and Bonner TI (1999) Increased mortality, hypoactivity and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96:5780-5785.