Characterization and comparison of recombinant human and rat TRPV1 receptors: Effects of exo- and endocannabinoids

British Journal of Anaesthesia

Volumn 94, Issue 5, 2005, Pages 649-656

  Lam, P M W ^a   McDonald, J ^a   Lambert, D G ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Agonist, capsaicin; Analgesia; Cannabinoids, anandamide; Receptors, nociception; Receptors, vanilloid

Indexed keywords

ALCOHOL; ANANDAMIDE; CALCIUM ION; CANNABINOID; CANNABINOID 1 RECEPTOR; CAPSAICIN; CAPSAZEPINE; DRONABINOL; ENDOCANNABINOID; FURA 2; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ION CHANNEL; SOLVENT; SULFUR 35; VANILLOID RECEPTOR 1;

ANALGESIA; ANIMAL CELL; ARTICLE; BINDING ASSAY; CELL STRAIN HEK293; CEREBELLUM; CHANNEL GATING; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SPECIES DIFFERENCE; TEMPERATURE; TEMPERATURE DEPENDENCE;

EID: 18144379186     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aei098     Document Type: Article

References (35)

1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-24
2. Cortright DN, Crandall M, Sanchez JF, Zou T, Krause JE, White G. The tissue distribution and functional characterization of human VR1. Biochem Biophys Res Commun 2001; 281: 1183-9
3. Hayes P, Meadows HJ, Gunthorpe MJ, et al. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain 2000; 88: 205-15
4. Jerman JC, Brough SJ, Prinjha R, Harries MH, Davis JB, Smart D. Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology. Br J Pharmacol 2000; 130: 916-22
5. Benham CD, Gunthorpe MJ, Davis JB. TRPV channels as temperature sensors. Cell Calcium 2003; 33: 479-87
6. Bevan S, Szolcsányi J. Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol Sci 1990; 11: 330-3
7. Pertwee RG. Cannabinoid receptors and pain. Prog Neurobiol 2001; 63: 569-611
8. Campbell FA, Tramer MR, Carroll D, Reynolds DJM, Moore RA, McQuay HJ. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review Br Med J 2001; 323: 13-16
9. Goutopoulos A, Makriyannis A. From cannabis to cannabinergics: new therapeutic opportunities. Pharmacol Ther 2002; 95: 103-17
10. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 1999; 397: 259-63
11. Zygmunt PM, Petersson J, Andersson DA, et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999; 400: 452-7
12. Di Marzo V, Blumberg PM, Szallasi A. Endovanilloid signaling in pain. Curr Opin Neurobiol 2002; 12: 372-9
13. Smart D, Jerman JC, Gunthorpe MJ, et al. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. Eur J Pharmacol 2001; 417: 51-8
14. Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000; 288: 306-13
15. Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ. Systematic review of topical capsaicin for the treatment of chronic pain. Br Med J 2004; 328: 991-4
16. Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 2001; 24: 487-517
17. 2+ by vanilloid receptor 1 in rat dorsal root ganglion neurons. J Biol Chem 2003; 278: 5462-72
18. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50
19. c: basic practical considerations. In: Lambert DG, ed. Calcium Signalling Protocols. Totowa, NJ: Humana Press, 1999; 3-30
20. Berger H, Calo G, Albrecht E, Guerrini R, Bienert M. [Nphe(1)]NC(1-13)NH(2) selectively antagonizes nociceptin/orphanin FQ-stimulated G-protein activation in rat brain. J Pharmacol Exp Ther 2000; 294: 428-33
21. 35S binding and cAMP formation in Chinese hamster ovary cells expressing the human nociceptin /orphanin FQ receptor. Eur J Pharmacol 2002; 443: 7-12
22. Lowry OH, Nira J, Rosenbrough A, Farr L, Randall RJ. Protein measurements with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75
23. Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999; 51: 159-212
24. Sprague J, Harrison C, Rowbotham DJ, Smart D, Lambert DG. Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide. Eur J Pharmacol 2001; 423: 121-5
25. Smart D, Gunthorpe MJ, Jerman JC, et al. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol 2000; 129: 227-30
26. Jerman JC, Gray J, Brough SJ, et al. Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors. Br J Anaesth 2002; 89: 882-7
27. Calignano A, La Rana G, Giuffrida A, Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature 1998; 394: 277-81
28. Zygmunt PM, Petersson J, Andersson DA, et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999; 400: 452-7
29. Walpole CS, Bevan S, Bovermann G, et al. The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. J Med Chem 1994; 37: 1942-54
30. Nagy I, Rang HP. Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin. J Neurosci 1999; 19: 10647-55
31. McIntyre P, McLatchie LM, Chambers A, et al. Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). Br J Pharmacol 2001; 132: 1084-94
32. Belvisi MG, Miura M, Stretton D, Barnes PJ. Capsazepine as a selective antagonist of capsaicin-induced activation of C-fibres in guinea-pig bronchi. Eur J Pharmacol 1992; 215: 341-4
33. Ellis JL, Undem BJ. Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea. J Pharmacol Exp Ther 1994; 268: 85-9
34. Trevisani M, Smart D, Gunthorpe MJ, et al. Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 2002; 5: 546-51
35. Kearn CS, Greenberg MJ, DiCamelli R, Kurzawa K, Hillard CJ. Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange. J Neurochem 1999; 72: 2379-87