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The authors give a detailed account on the expression and crystallizability of plasmodial proteins and report the plasmodial structures solved by the structural genomics consortium (SGC).
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Crystal structure of a Fab complex formed with PfMSP1-19, the C-terminal fragment of merozoite surface protein 1 from Plasmodium falciparum: a malaria vaccine candidate
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Structure and inter-domain interactions of domain II from the blood-stage malarial protein, apical membrane antigen 1
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Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain
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The features of the DARC-binding site and strategies for inhibiting the invasion of the parasite on the basis of the interaction between DBL and DARC are discussed.
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Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum
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Tolia N.H., Enemark E.J., Sim B.K., and Joshua-Tor L. Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell 122 (2005) 183-193
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The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms
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The structural features of P25 and P28 that are potential candidates for transmission blocking vaccines are described.
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Saxena A.K., Singh K., Su H.P., Klein M.M., Stowers A.W., Saul A.J., Long C.A., and Garboczi D.N. The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms. Nat Struct Mol Biol 13 (2006) 90-91. The structural features of P25 and P28 that are potential candidates for transmission blocking vaccines are described.
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Functional and immunological insights from the three-dimensional structures of Plasmodium surface proteins
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The review covers the reports on structural studies of malarial surface proteins that are potential vaccine candidates.
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Bentley G.A. Functional and immunological insights from the three-dimensional structures of Plasmodium surface proteins. Curr Opin Microbiol 9 (2006) 395-400. The review covers the reports on structural studies of malarial surface proteins that are potential vaccine candidates.
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Disguising itself-insights into Plasmodium falciparum binding and immune evasion from the DBL crystal structure
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Howell D.P., Samudrala R., and Smith J.D. Disguising itself-insights into Plasmodium falciparum binding and immune evasion from the DBL crystal structure. Mol Biochem Parasitol 148 (2006) 1-9
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The crystal structure of P. knowlesi DBP-α DBL domain and its implications for immune evasion
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McHenry, A.M.1
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Structure of C-terminal fragment of merozoite surface protein-1 from Plasmodium vivax determined by homology modeling and molecular dynamics refinement
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Serrano M.L., Perez H.A., and Medina J.D. Structure of C-terminal fragment of merozoite surface protein-1 from Plasmodium vivax determined by homology modeling and molecular dynamics refinement. Bioorg Med Chem 14 (2006) 8359-8365
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Serrano, M.L.1
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Synthesis, solution structure and immune recognition of an epidermal growth factor-like domain from Plasmodium falciparum merozoite surface protein-1
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This work shows that a chemically synthesized domain of MSP-I adopts a native-like structure, and studies using virosomes can be used for optimization of the antigenicity of the protein.
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James S., Moehle K., Renard A., Mueller M.S., Vogel D., Zurbriggen R., Pluschke G., and Robinson J.A. Synthesis, solution structure and immune recognition of an epidermal growth factor-like domain from Plasmodium falciparum merozoite surface protein-1. Chembiochem 7 (2006) 1943-1950. This work shows that a chemically synthesized domain of MSP-I adopts a native-like structure, and studies using virosomes can be used for optimization of the antigenicity of the protein.
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Chembiochem
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Merozoite surface protein 2 (MSP2) of Plasmodium falciparum: expression, structure, dynamics and fibril formation of the conserved N-terminal domain
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Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation
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The paper reports the structure of PfAMA-I complexed with F8.12.19 and provides an explanation for the structural basis of cross reactivity.
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Igonet S., Vulliez-Le Normand B., Faure G., Riottot M.M., Kocken C.H., Thomas A.W., and Bentley G.A. Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation. J Mol Biol 366 (2007) 1523-1537. The paper reports the structure of PfAMA-I complexed with F8.12.19 and provides an explanation for the structural basis of cross reactivity.
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33645531531
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Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor
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The crystal structure of MTIP-MyoA complex captures three different conformations of the C-terminal domain and describes the binding of MyoA tail.
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Bosch J., Turley S., Daly T.M., Bogh S.M., Villasmil M.L., Roach C., Zhou N., Morrisey J.M., Vaidya A.B., Bergman L.W., et al. Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor. Proc Natl Acad Sci USA 103 (2006) 4852-4857. The crystal structure of MTIP-MyoA complex captures three different conformations of the C-terminal domain and describes the binding of MyoA tail.
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Proc Natl Acad Sci USA
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Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite
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Proc Natl Acad Sci USA
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22
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The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site
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The solution NMR structure of the TSR domain of TRAP and its heparin-binding properties that facilitate cell recognition are described.
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Tossavainen, H.1
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Kilpelainen, I.7
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Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease
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The novel structural features of falcipain-2 and their role in folding and binding of haemoglobin are described.
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Wang S.X., Pandey K.C., Somoza J.R., Sijwali P.S., Kortemme T., Brinen L.S., Fletterick R.J., Rosenthal P.J., and McKerrow J.H. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci USA 103 (2006) 11503-11508. The novel structural features of falcipain-2 and their role in folding and binding of haemoglobin are described.
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Proc Natl Acad Sci USA
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Wang, S.X.1
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Fletterick, R.J.7
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McKerrow, J.H.9
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24
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33748746156
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Structural and functional characterization of falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum
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The biochemical characterization of falcipain-2 with respect to its pH dependence of activity and binding to haemoglobin are correlated with the crystal structure.
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Hogg T., Nagarajan K., Herzberg S., Chen L., Shen X., Jiang H., Wecke M., Blohmke C., Hilgenfeld R., and Schmidt C.L. Structural and functional characterization of falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum. J Biol Chem 281 (2006) 25425-25437. The biochemical characterization of falcipain-2 with respect to its pH dependence of activity and binding to haemoglobin are correlated with the crystal structure.
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J Biol Chem
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Hogg, T.1
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Schmidt, C.L.10
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Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
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Ersmark K., Nervall M., Gutierrez-de-Teran H., Hamelink E., Janka L.K., Clemente J.C., Dunn B.M., Gogoll A., Samuelsson B., Qvist J., et al. Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV. Bioorg Med Chem 14 (2006) 2197-2208
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Ersmark, K.1
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Clemente, J.C.6
Dunn, B.M.7
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33748256153
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Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum
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Gutierrez-de-Teran H., Nervall M., Ersmark K., Liu P., Janka L.K., Dunn B., Hallberg A., and Aqvist J. Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum. Biochemistry 45 (2006) 10529-10541
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Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II
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Johansson P.O., Lindberg J., Blackman M.J., Kvarnstrom I., Vrang L., Hamelink E., Hallberg A., Rosenquist A., and Samuelsson B. Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. J Med Chem 48 (2005) 4400-4409
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33646573016
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Structure of the aspartic protease plasmepsin IV from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor
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Clemente J.C., Govindasamy L., Madabushi A., Fisher S.Z., Moose R.E., Yowell C.A., Hidaka K., Kimura T., Hayashi Y., Kiso Y., et al. Structure of the aspartic protease plasmepsin IV from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. Acta Crystallogr D Biol Crystallogr 62 (2006) 246-252
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The crystal structure of superoxide dismutase from Plasmodium falciparum
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This report of the crystal structure explores the differences between human and Plasmodium superoxide dismutases.
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Boucher I.W., Brzozowski A.M., Brannigan J.A., Schnick C., Smith D.J., Kyes S.A., and Wilkinson A.J. The crystal structure of superoxide dismutase from Plasmodium falciparum. BMC Struct Biol 6 (2006) 20. This report of the crystal structure explores the differences between human and Plasmodium superoxide dismutases.
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BMC Struct Biol
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Boucher, I.W.1
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Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum
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Boucher I.W., McMillan P.J., Gabrielsen M., Akerman S.E., Brannigan J.A., Schnick C., Brzozowski A.M., Wilkinson A.J., and Muller S. Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum. Mol Microbiol 61 (2006) 948-959
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Mol Microbiol
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Boucher, I.W.1
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Plasmodium falciparum glutathione S-transferase-structural and mechanistic studies on ligand binding and enzyme inhibition
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Hiller N., Fritz-Wolf K., Deponte M., Wende W., Zimmermann H., and Becker K. Plasmodium falciparum glutathione S-transferase-structural and mechanistic studies on ligand binding and enzyme inhibition. Protein Sci 15 (2006) 281-289
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Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site
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Robien M.A., Bosch J., Buckner F.S., Van Voorhis W.C., Worthey E.A., Myler P., Mehlin C., Boni E.E., Kalyuzhniy O., Anderson L., et al. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins 62 (2006) 570-577
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Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum
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Caruthers J., Bosch J., Buckner F., Van Voorhis W., Myler P., Worthey E., Mehlin C., Boni E., DeTitta G., Luft J., et al. Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum. Proteins 62 (2006) 338-342
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Proteins
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