X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy

Journal of Biological Chemistry

Volumn 282, Issue 35, 2007, Pages 25436-25444

  Freundlich, Joel S ^a,d   Wang, Feng ^b   Tsai, Han Chun ^b   Kuo, Mack ^b   Shieh, Hong Ming ^a   Anderson, John W ^a   Nkrumah, Louis J ^c   Valderramos, Juan Carlos ^c,e   Yu, Min ^c,e   Kumar, T R Santha ^c   Valderramos, Stephanie G ^c,e   Jacobs Jr , William R ^c   Schiehser, Guy A ^a   Jacobus, David P ^a   Fidock, David A ^c,e   Sacchettini, James C ^b  

^a Jacobus Pharmaceutical Co Inc   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d PRINCETON UNIVERSITY   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DISEASES; HYDROPHOBICITY; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

CULTURED PARASITES; LOW MICROMOLAR POTENCY; PLASMODIUM PARASITES; TRICLOSAN ANTIMALARIAL EFFICACY;

ENZYMES;

ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); TRICLOSAN;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; HYDROPHOBICITY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIMALARIALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE; MODELS, MOLECULAR; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; TRICLOSAN;

PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES;

EID: 34548480189     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701813200     Document Type: Article

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