Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design

Structure

Volumn 10, Issue 3, 2002, Pages 357-367

  Kumar, Abhinav ^a,c   Nguyen, Kiet T ^b   Srivathsan, Sumant ^b   Ornstein, Brad ^c   Turley, Stewart ^a   Hirsh, Irwin ^a   Pei, Dehua ^b   Hol, Wim G J ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Deformylation; Drug design; Malaria; Metalloenzyme; PDF; Plasmodium

Indexed keywords

AMINO ACID; COBALT; PEPTIDE DEFORMYLASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME SPECIFICITY; ENZYME SUBUNIT; ESCHERICHIA COLI; METAL BINDING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANIMALS; ANTIMALARIALS; BINDING SITES; CATALYSIS; COBALT; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; HUMANS; METALLOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0036124280     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00719-0     Document Type: Article

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