Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II

Journal of Medicinal Chemistry

Volumn 48, Issue 13, 2005, Pages 4400-4409

  Johansson, Per Ola ^a   Lindberg, Jimmy ^b   Blackman, Michael J ^c   Kvarnström, Ingemar ^a   Vrang, Lotta ^d   Hamelink, Elizabeth ^d   Hallberg, Anders ^b   Rosenquist, Åsa ^a,d   Samuelsson, Bertil ^d,e  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d MEDIVIR AB   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMEPSIN I; PLASMEPSIN II; PROTEINASE INHIBITOR; PYRIDINE 2 CARBOXYLIC ACID [1 [ 1 (4 BENZO [1,3]DIOXOL 5 YLBENZYLOXYMETHYL) 3 [ 1 (1 CARBAMOYL 3 METHYLBUTYLCARBAMOYL] 2 HYDROXYPROPYLCARBAMOYL] 2 METHYLPROPYL]AMIDE; PYRIDINE 2 CARBOXYLIC ACID [1 [ 1 (BIPHENYL 4 YLMETHOXYMETHYL) 3 [( 1 CARBAMOYL 3 METHYLBUTYLCARBAMOYL) ETHYLCARBAMOYL] 2 HYDROXYPROPYLCARBAMOYL] 2 METHYLPROPYL]AMIDE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; MICROBIAL GROWTH; PLASMODIUM FALCIPARUM; STRUCTURE ANALYSIS; SUZUKI REACTION;

ANIMALS; ANTIPROTOZOAL AGENTS; ASPARTIC ENDOPEPTIDASES; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21244494482     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040884n     Document Type: Article

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