The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase

International Journal for Parasitology

Volumn 37, Issue 7, 2007, Pages 787-793

  Kamchonwongpaisan, Sumalee ^a   Vanichtanankul, Jarunee ^a   Taweechai, Supannee ^a   Chitnumsub, Penchit ^a   Yuthavong, Yongyuth ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

Dihydrofolate reductase; Malaria; Mutagenesis; Plasmodium falciparum

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; PYRIMETHAMINE; TRIMETHOPRIM; TRYPTOPHAN;

AMINO ACID; CATALYSIS; CHEMICAL BINDING; COLIFORM BACTERIUM; ENZYME ACTIVITY; INHIBITION; MUTATION; PARASITE; PROTOZOAN; REACTION KINETICS;

ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DRUG BINDING; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; MUTANT; NONHUMAN; PLASMODIUM FALCIPARUM; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ANIMALS; CATALYSIS; CHLOROGUANIDE; DNA, PROTOZOAN; ENZYME STABILITY; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; GENETIC COMPLEMENTATION TEST; KINETICS; MUTAGENESIS, INSERTIONAL; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES; TRYPTOPHAN;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; PLASMODIUM FALCIPARUM; PROKARYOTA;

EID: 34247516898     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2006.12.017     Document Type: Article

References (17)

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