Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium Falciparum with its substrates and inhibitors

Biochemical and Biophysical Research Communications

Volumn 289, Issue 4, 2001, Pages 832-837

  Kapoor, Mili ^a   Jamal Dar, M ^b   Surolia, Avadhesha ^a   Surolia, Namita ^b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Crotonyl coenzyme A; Enoyl ACP reductase; Fatty acid biosynthesis; Plasmodium falciparum; Triclosan

Indexed keywords

ACYL CARRIER PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRICLOSAN;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; FATTY ACID SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM;

EID: 0035861962     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6061     Document Type: Article

References (23)

1. Upsurge of malaria related convulsions in paediatric emergency room in Nigeria. Consequences of emergence of chloroquine resistance Plasmodium falciparum
2. Involvement of cytochrome P450 in conferring chloroquine resistance to the malarial parasite Plasmodium falciparum
3. Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
4. Studies on the mechanisms of fatty acid synthesis 18. Preparation and general properties of the enoyl acyl carrier protein reductase from Escherichia coli
5. envM genes of Salmonella typhimurium and Escherichia coli
6. Protein EnvM is the NADH dependent enoyl ACP reductase (FabI) of Escherichia coli
7. Bacterial fatty-acid biosynthesis: An antibacterial drug target waiting to be exploited
8. Enoyl acyl carrier protein reductase (FabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli
9. Triclosan targets lipid synthesis
10. Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis
11. Triclosan and fatty acid synthesis in Plasmodium falciparum: New weapon for an old enemy
12. Triclosan offers protection against blood stages of malaria by inhibiting enoyl ACP reductase of Plasmodium falciparum
13. Structural basis for triclosan and NAD binding to enoyl ACP reductase of Plasmodium falciparum
14. Composition, fluorescence and circular dichroism of rat lysozyme
15. Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan
16. Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid like organelle with thiostrepton
17. Nuclear encoded proteins target to the plastid in Toxoplasma gondi and Plasmodium falciparum
18. Effects of rare codon clusters on high level expression of heterologous proteins in Escherichia coli
19. Kinetic mechanism of NADH enoyl ACP reductase from Brassica napus
20. The enoyl (acyl carrier protein) reductase (FabI) of Escherichia coli which catalyses a key regulating step in fatty acid biosynthesis accepts NADH and NADPH as cofactors and is inhibited by palmitoyl CoA