Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei

Journal of Medicinal Chemistry

Volumn 49, Issue 5, 2006, Pages 1499-1502

  Dax, Chantal ^a   Duffieux, Francis ^c,d   Chabot, Nicolas ^a   Coincon, Mathieu ^b   Sygusch, Jurgen ^b   Michels, Paul A M ^c   Blonski, Casimir ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c DE DUVE INSTITUTE   (Belgium)

^d SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ANTITRYPANOSOMAL AGENT; ENZYME INHIBITOR; FRUCTOSE 1,6 BISPHOSPHATE ALDOLASE INHIBITOR; FRUCTOSE BISPHOSPHATE ALDOLASE; HYDROXYNAPHTHALDEHYDE PHOSPHATE; ISOENZYME; LYSINE; SCHIFF BASE; SERINE; TBK 1; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ARTICLE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; GEOMETRY; NONHUMAN; REACTION ANALYSIS; SIMULATION; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI;

ALDEHYDES; ANIMALS; FRUCTOSE-BISPHOSPHATE ALDOLASE; KINETICS; MODELS, MOLECULAR; NAPHTHOLS; PHOSPHORIC ACID ESTERS; SCHIFF BASES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 33644869449     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050237b     Document Type: Article

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