Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 7, 2006, Pages 2197-2208

  Ersmark, Karolina ^a   Nervall, Martin ^a   Gutiérrez De Terán, Hugo ^a   Hamelink, Elizabeth ^b   Janka, Linda K ^c   Clemente, Jose C ^c   Dunn, Ben M ^c   Gogoll, Adolf ^a   Samuelsson, Bertil ^b   Åqvist, Johan ^a   Hallberg, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Malaria; Plasmepsin; Protease inhibitors and molecular dynamics

Indexed keywords

1,2 DIHYDROXYETHYLENE; 2 BENZYLOXY 3,4 DIHYDROXY N [2 HYDROXYINDAN 1 YL] 4 [3 OXO 1 OXA 4 AZACYCLOTRIDEC 11 EN 2 YL] BUTYRAMIDE; 2 BENZYLOXY 3,4 DIHYDROXY N [2 HYDROXYINDAN 1 YL] 4 [3 OXO 1 OXA 4 AZACYCLOTRIDEC 2 YL] BUTYRAMIDE; 5 BENZYLOXY 3,4 DIHYDROXY 6 OXO 1 OXA 7 AZACYCLOHEXADEC 14 ENE 2 CARBOXYLIC ACID [2 HYDROXYINDAN 1 YL] AMIDE; 5 BENZYLOXY 3,4 DIHYDROXY 6 OXO 1 OXA 7 AZACYCLOHEXADEC 2 CARBOXYLIC ACID[2 HYDROXINDAN 1 YL]AMIDE; ASPARTIC PROTEINASE; CATHEPSIN D; ETHYLENE DERIVATIVE; MACROCYCLIC COMPOUND; PLASMEPSIN 4; PLASMEPSIN I; PLASMEPSIN II; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYST; CYCLIZATION; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENERGY; HUMAN; NONHUMAN; PLASMODIUM FALCIPARUM; RING CLOSING METATHESIS;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; BINDING, COMPETITIVE; CATHEPSIN D; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; DRUG DESIGN; HUMANS; MACROCYCLIC COMPOUNDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 32944470879     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.11.003     Document Type: Article

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