Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase

Molecular and Biochemical Parasitology

Volumn 143, Issue 1, 2005, Pages 121-124

  Pang, Cullen K T ^a   De, Surya Kanta ^a   White, John ^a   Buckner, Frederick S ^a   Varani, Gabriele ^a,b   Rathod, Pradipsinh K ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Conformation; Enzyme; Inhibitor; Kinetics; Malaria; Species specific

Indexed keywords

FOLIC ACID DERIVATIVE; METESIND GLUCURONATE; NOLATREXED; THYMIDYLATE SYNTHASE;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG STRUCTURE; MOLECULE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; THERMODYNAMICS;

ANIMALS; ANTIMALARIALS; BINDING SITES; CONSERVED SEQUENCE; HUMANS; KINETICS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; THYMIDYLATE SYNTHASE;

PLASMODIUM FALCIPARUM;

EID: 22844434876     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.02.016     Document Type: Article

References (24)

1. J. Yuvaniyama, P. Chitnumsub, and S. Kamchonwongpaisan Insights into antifolate resistance from malarial DHFR-TS structures Nat Struct Biol 10 2003 357 365
2. P.K. Rathod, and M.A. Phillips Prized malaria drug target nailed Nat Struct Biol 10 2003 316 318
3. M. Hekmat-Nejad, and P.K. Rathod Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694 Antimicrob Agents Chemother 40 1996 1628 1632
4. L. Jiang, P.C. Lee, J. White, and P.K. Rathod Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum Antimicrob Agents Chemother 44 2000 1047 1050
5. H.A. Ingraham, L. Dickey, and M. Goulian DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate Biochemistry 25 1986 3225 3230
6. A. Yoshioka, S. Tanaka, and O. Hiraoka Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death J Biol Chem 262 1987 8235 8241
7. G.H. Hitchings Folate antagonists as antibacterial and antiprotozoal agents Ann N Y Acad Sci 186 1971 444 451
8. W.E. Gutteridge, and P.I. Trigg Incorporation of radioactive precursors into DNA and RNA of Plasmodium knowlesi in vitro J Protozool 17 1970 89 96
9. P. Reyes, P.K. Rathod, and D.J. Sanchez Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum Mol Biochem Parasitol 5 1982 275 290
10. E. Chu, D.M. Koeller, and J.L. Casey Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase Proc Natl Acad Sci USA 88 1991 8977 8981
11. E. Chu, C.H. Takimoto, and D. Voeller Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro Biochemistry 32 1993 4756 4760
12. K. Zhang, and P.K. Rathod Divergent regulation of dihydrofolate reductase between malaria parasite and human host Science 296 2002 545 547
13. A.L. Jackman, and A.H. Calvert Folate-based thymidylate synthase inhibitors as anticancer drugs Ann Oncol 6 1995 871 881
14. R.M. Stroud, and J.S. Finer-Moore Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie" Biochemistry 42 2003 239 247
15. J.S. Finer-Moore, W.R. Montfort, and R.M. Stroud Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase Biochemistry 29 1990 6977 6986
16. M.D. Varney, G.P. Marzoni, and C.L. Palmer Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase J Med Chem 35 1992 663 676
17. S.E. Webber, T.M. Bleckman, and J. Attard Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones J Med Chem 36 1993 733 746
18. Y. Tong, X. Liu-Chen, and E.A. Ercikan-Abali Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to Raltitrexed, Thymitaq, and BW1843U89 J Biol Chem 273 1998 31209 31214
19. J. Pedersen-Lane, G.F. Maley, E. Chu, and F. Maley High-level expression of human thymidylate synthase Protein Expr Purif 10 1997 256 262
20. S. Shallom, K. Zhang, L. Jiang, and P.K. Rathod Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains J Biol Chem 274 1999 37781 37786
21. D. Roberts An isotopic assay for thymidylate synthetase Biochemistry 5 1966 3546 3548
22. R.E. Desjardins, C.J. Canfield, J.D. Haynes, and J.D. Chulay Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique Antimicrob Agents Chemother 16 1979 710 718
23. D. Piszkiewicz Kinetics of chemical and enzyme-catalyzed reactions 1977 Oxford University Press New York p. 119-40
24. J. Wattanarangsan, S. Chusacultanachai, and J. Yuvaniyama Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity Mol Biochem Parasitol 126 2003 97 102