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Volumn 9, Issue 10, 2007, Pages 1591-1603

Treating neurodegeneration by modifying mitochondria: Potential solutions to a "complex" problem

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENOSINE DIPHOSPHATE; ALPHA TOCOPHEROL; GA BINDING PROTEIN; IDEBENONE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; UBIQUINONE;

EID: 34648819814     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2007.1676     Document Type: Review
Times cited : (64)

References (187)
  • 1
    • 33644543761 scopus 로고    scopus 로고
    • Expanding insights of mitochondrial dysfunction in Parkinson's disease
    • Abou-Sleiman PM, Muqit MM, and Wood NW. Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci 7: 207-219, 2006.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 207-219
    • Abou-Sleiman, P.M.1    Muqit, M.M.2    Wood, N.W.3
  • 2
    • 0037083131 scopus 로고    scopus 로고
    • Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma
    • Abramova NA, Cassarino DS, Khan SM, Painter TW, and Bennett JP Jr. Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. J Neurosci Res 67: 494-500, 2002.
    • (2002) J Neurosci Res , vol.67 , pp. 494-500
    • Abramova, N.A.1    Cassarino, D.S.2    Khan, S.M.3    Painter, T.W.4    Bennett Jr., J.P.5
  • 3
    • 0016652087 scopus 로고
    • Brain peroxidase and catalase in Parkinson disease
    • Ambani LM, Van Woert MH, and Murphy S. Brain peroxidase and catalase in Parkinson disease. Arch Neurol 32: 114-118, 1975.
    • (1975) Arch Neurol , vol.32 , pp. 114-118
    • Ambani, L.M.1    Van Woert, M.H.2    Murphy, S.3
  • 4
    • 33644875954 scopus 로고    scopus 로고
    • Neuronal protection by sirtuins in Alzheimer's disease
    • Anekonda TS and Reddy PH. Neuronal protection by sirtuins in Alzheimer's disease. J Neurochem 96: 305-313, 2006.
    • (2006) J Neurochem , vol.96 , pp. 305-313
    • Anekonda, T.S.1    Reddy, P.H.2
  • 6
    • 0026711197 scopus 로고
    • Abnormal brain and muscle energy metabolism shown by 3IP magnetic resonance spectroscopy in patients affected by migraine with aura
    • Barbirolli B, Montagna P, Cortelli P, Fanicello R, Iotti S, and Munari L. Abnormal brain and muscle energy metabolism shown by 3IP magnetic resonance spectroscopy in patients affected by migraine with aura. Neurology 42: 1209-1214, 1992.
    • (1992) Neurology , vol.42 , pp. 1209-1214
    • Barbirolli, B.1    Montagna, P.2    Cortelli, P.3    Fanicello, R.4    Iotti, S.5    Munari, L.6
  • 7
    • 8444250688 scopus 로고    scopus 로고
    • Mitochondria-derived oxidative stress induces a heat shock protein response
    • Barrett MJ, Alones V, Wang KX, Phan L, and Swerdlow RH. Mitochondria-derived oxidative stress induces a heat shock protein response. J NEurosci Res 78: 420-429, 2004.
    • (2004) J NEurosci Res , vol.78 , pp. 420-429
    • Barrett, M.J.1    Alones, V.2    Wang, K.X.3    Phan, L.4    Swerdlow, R.H.5
  • 9
    • 25444474703 scopus 로고    scopus 로고
    • Mitochondria take center stage in aging and neurodegeneration
    • Beal MF. Mitochondria take center stage in aging and neurodegeneration. Ann Neurol 58: 495-505, 2005.
    • (2005) Ann Neurol , vol.58 , pp. 495-505
    • Beal, M.F.1
  • 10
    • 0032413244 scopus 로고    scopus 로고
    • Mitochondrial aging: Open questions
    • Beckman KB and Ames BN. Mitochondrial aging: Open questions. Ann NY Acad Sci 854: 118-127, 1998.
    • (1998) Ann NY Acad Sci , vol.854 , pp. 118-127
    • Beckman, K.B.1    Ames, B.N.2
  • 11
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman KB and Ames BN. The free radical theory of aging matures. Physiologic Rev 78: 548-581, 1998.
    • (1998) Physiologic Rev , vol.78 , pp. 548-581
    • Beckman, K.B.1    Ames, B.N.2
  • 15
    • 17844385363 scopus 로고    scopus 로고
    • Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    • Bogacka I, Xie H, Bray GA, and Smith SR. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 54: 1392-1399, 2005.
    • (2005) Diabetes , vol.54 , pp. 1392-1399
    • Bogacka, I.1    Xie, H.2    Bray, G.A.3    Smith, S.R.4
  • 17
    • 0028936986 scopus 로고
    • Bioenergetic and oxidative stress in neurodegenerative diseases
    • Bowling AC and Beal MF. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sci 56: 1151-1171, 1995.
    • (1995) Life Sci , vol.56 , pp. 1151-1171
    • Bowling, A.C.1    Beal, M.F.2
  • 18
    • 0021883670 scopus 로고
    • Regional mitochondrial respiratory activity in Huntington's disease brain
    • Brennan WA, Bird ED, and Aprille JR. Regional mitochondrial respiratory activity in Huntington's disease brain. J Neurochem 44: 1948-1950, 1985.
    • (1985) J Neurochem , vol.44 , pp. 1948-1950
    • Brennan, W.A.1    Bird, E.D.2    Aprille, J.R.3
  • 19
    • 0035042470 scopus 로고    scopus 로고
    • Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA)
    • Brown AM, Sheu, RK, Mohs R, Haroutunian V, and Blass JP. Correlation of the clinical severity of Alzheimer's disease with an aberration in mitochondrial DNA (mtDNA). J Mol Neurosci 16: 41-18, 2001.
    • (2001) J Mol Neurosci , vol.16 , pp. 41-18
    • Brown, A.M.1    Sheu, R.K.2    Mohs, R.3    Haroutunian, V.4    Blass, J.P.5
  • 21
    • 33947675275 scopus 로고    scopus 로고
    • Oxidative damage in Huntington's disease pathogenesis
    • Browne SE and Beal MF. Oxidative damage in Huntington's disease pathogenesis. Antioxid Redox Signal 8: 2061-2073, 2006.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 2061-2073
    • Browne, S.E.1    Beal, M.F.2
  • 22
    • 0026663037 scopus 로고
    • A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis
    • Brunk UT, Jones CB, and Sohal RS. A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res 275: 395-103, 1992.
    • (1992) Mutat Res , vol.275 , pp. 395-103
    • Brunk, U.T.1    Jones, C.B.2    Sohal, R.S.3
  • 23
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E and Davies KJA. Mitochondrial free radical generation, oxidative stress, and aging. Free Rad Biol Med 29: 222-230, 2000.
    • (2000) Free Rad Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.A.2
  • 28
    • 0029871412 scopus 로고    scopus 로고
    • Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of the Alzheimer's type - place of the extracellular glutathione peroxidase
    • Ceballos-Picot I, Merad-Boudia M, Nicole A, Thevenin M, Hellier G, Legrain S, and Berr C. Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of the Alzheimer's type - place of the extracellular glutathione peroxidase. Free Radic Biol Med 20: 579-587, 1996.
    • (1996) Free Radic Biol Med , vol.20 , pp. 579-587
    • Ceballos-Picot, I.1    Merad-Boudia, M.2    Nicole, A.3    Thevenin, M.4    Hellier, G.5    Legrain, S.6    Berr, C.7
  • 30
    • 0033516529 scopus 로고    scopus 로고
    • Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population
    • Chagnon P, Gee M, Filion M, Robitaille Y, Belouchi M, and Gauvreau D. Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population. Am J Med Genet 85: 20-30, 1999.
    • (1999) Am J Med Genet , vol.85 , pp. 20-30
    • Chagnon, P.1    Gee, M.2    Filion, M.3    Robitaille, Y.4    Belouchi, M.5    Gauvreau, D.6
  • 32
    • 3543141113 scopus 로고    scopus 로고
    • Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
    • Choo YS, Johnson GV, MacDonald M, Detloff PJ, and Lesort M. Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. Hum Mol Genet 13: 1407-1420, 2004.
    • (2004) Hum Mol Genet , vol.13 , pp. 1407-1420
    • Choo, Y.S.1    Johnson, G.V.2    MacDonald, M.3    Detloff, P.J.4    Lesort, M.5
  • 33
  • 34
    • 3242668604 scopus 로고    scopus 로고
    • Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
    • Coskun PE, Beal MF, and Wallace DC. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc Natl Acad Sci USA 101: 10726-10731, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10726-10731
    • Coskun, P.E.1    Beal, M.F.2    Wallace, D.C.3
  • 35
    • 33845468713 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer disease: Pathophysiologic mechanisms and therapeutic implications
    • Craft S. Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications. Alzheimer Dis Assoc Disord 20: 298-301, 2006.
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , pp. 298-301
    • Craft, S.1
  • 36
    • 33749042331 scopus 로고    scopus 로고
    • Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    • Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, and Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127: 59-69, 2006.
    • (2006) Cell , vol.127 , pp. 59-69
    • Cui, L.1    Jeong, H.2    Borovecki, F.3    Parkhurst, C.N.4    Tanese, N.5    Krainc, D.6
  • 38
    • 12644257598 scopus 로고    scopus 로고
    • Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, and Parker WD Jr. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci USA 94: 4526-4531, 1997.
    • Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, and Parker WD Jr. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci USA 94: 4526-4531, 1997.
  • 42
    • 0031985802 scopus 로고    scopus 로고
    • Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
    • Digby JE, Montague CT, Sewter CP, Sanders L, Wilkison WO, O'Rahilly S, and Prins JB. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes. Diabetes 47: 138-141, 1998.
    • (1998) Diabetes , vol.47 , pp. 138-141
    • Digby, J.E.1    Montague, C.T.2    Sewter, C.P.3    Sanders, L.4    Wilkison, W.O.5    O'Rahilly, S.6    Prins, J.B.7
  • 44
    • 19344362520 scopus 로고    scopus 로고
    • Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: A meta-analysis
    • Etminan M, Gill SS, and Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurol 4: 362-365, 2005.
    • (2005) Lancet Neurol , vol.4 , pp. 362-365
    • Etminan, M.1    Gill, S.S.2    Samii, A.3
  • 46
    • 33645116252 scopus 로고    scopus 로고
    • Genetics of Parkinson disease: Paradigm shifts and future prospects
    • Farrer MJ. Genetics of Parkinson disease: paradigm shifts and future prospects. Nat Rev Genet 7: 306-318, 2006.
    • (2006) Nat Rev Genet , vol.7 , pp. 306-318
    • Farrer, M.J.1
  • 50
  • 51
    • 24644468116 scopus 로고    scopus 로고
    • LRRK2: Both a cause and a risk factor for Parkinson disease?
    • Foroud T. LRRK2: both a cause and a risk factor for Parkinson disease? Neurology 65: 664-665, 2005.
    • (2005) Neurology , vol.65 , pp. 664-665
    • Foroud, T.1
  • 54
    • 3342978711 scopus 로고
    • Enzyme histochemical studies of senile plaques
    • Friede RI. Enzyme histochemical studies of senile plaques. J Neuropathol Exp Neurol 24: 477-191, 1965.
    • (1965) J Neuropathol Exp Neurol , vol.24 , pp. 477-191
    • Friede, R.I.1
  • 57
    • 34347337120 scopus 로고    scopus 로고
    • A double-blind, placebo controlled, 18 month pilot study of the PPAR-gamma agonist pioglitazone in Alzheimer's disease
    • Geldmacher DS, Fritsch T, McClendon MJ, Lerner AJ, and Landreth GE. A double-blind, placebo controlled, 18 month pilot study of the PPAR-gamma agonist pioglitazone in Alzheimer's disease. Alzheimer's Dementia 2(Supplement): S366, 2006.
    • (2006) Alzheimer's Dementia , vol.2 , Issue.SUPPL.EMENT
    • Geldmacher, D.S.1    Fritsch, T.2    McClendon, M.J.3    Lerner, A.J.4    Landreth, G.E.5
  • 60
    • 0023732664 scopus 로고
    • Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease
    • Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, and Perrino P. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch Neurol 45: 836-840, 1988.
    • (1988) Arch Neurol , vol.45 , pp. 836-840
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3    Baker, A.4    Carlson, K.C.5    Harding, B.6    Perrino, P.7
  • 61
    • 33846654677 scopus 로고    scopus 로고
    • Huntington's disease-making connections
    • Greenamyre JT. Huntington's disease-making connections. N Engl J Med 356: 518-520, 2007.
    • (2007) N Engl J Med , vol.356 , pp. 518-520
    • Greenamyre, J.T.1
  • 64
    • 85153980494 scopus 로고    scopus 로고
    • Hamblet NS, Ragland B, Ali M, Conyers B, and Castora FJ. Mutations in mitochondrial-encoded cytochrome c oxidase subunits I, II, and III genes detected in Alzheimer's disease using single-strand conformation polymorphism. Electrophoresis 27: 398-108, 2006.
    • Hamblet NS, Ragland B, Ali M, Conyers B, and Castora FJ. Mutations in mitochondrial-encoded cytochrome c oxidase subunits I, II, and III genes detected in Alzheimer's disease using single-strand conformation polymorphism. Electrophoresis 27: 398-108, 2006.
  • 65
    • 33845596500 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism
    • Handschin C and Spiegelman BM. Peroxisome proliferators-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism Endocrine Rev 27: 728-735, 2006.
    • (2006) Endocrine Rev , vol.27 , pp. 728-735
    • Handschin, C.1    Spiegelman, B.M.2
  • 66
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harmon D. The biologic clock: the mitochondria? J Am Geriatr Soc 20: 145-147, 1972.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harmon, D.1
  • 68
    • 20444499367 scopus 로고    scopus 로고
    • Acute treatment with the PPARgamma agonist pioglitazone and Ibuprofen reduces glial inflammation and Abetal-42 levels in APPV717I transgenic mice
    • Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Klockgether T, and Van Leuven F. Acute treatment with the PPARgamma agonist pioglitazone and Ibuprofen reduces glial inflammation and Abetal-42 levels in APPV717I transgenic mice. Brain 128: 1442-1453, 2005.
    • (2005) Brain , vol.128 , pp. 1442-1453
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3    Hanke, A.4    Dewachter, I.5    Klockgether, T.6    Van Leuven, F.7
  • 70
    • 5344247243 scopus 로고    scopus 로고
    • Turbocharging mitochondria
    • Houten SM and Auwerx J. Turbocharging mitochondria. Cell 119: 5-7, 2004.
    • (2004) Cell , vol.119 , pp. 5-7
    • Houten, S.M.1    Auwerx, J.2
  • 71
    • 0024561803 scopus 로고
    • Mitochondrial encephalomyopathy (MELAS): Pathological study and successful therapy with coenzyme Q10 and idebenone
    • Ihara Y, Namba R, Kuroda S, Sato T, and Shirabe T. Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. J Neurol Sci 90: 263-271, 1989.
    • (1989) J Neurol Sci , vol.90 , pp. 263-271
    • Ihara, Y.1    Namba, R.2    Kuroda, S.3    Sato, T.4    Shirabe, T.5
  • 74
    • 22044443172 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: Overview of its multiple roles
    • Kang D and Hamaski N. Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles. Ann NY Acad Sci 1042: 101-108, 2005.
    • (2005) Ann NY Acad Sci , vol.1042 , pp. 101-108
    • Kang, D.1    Hamaski, N.2
  • 76
    • 10244252759 scopus 로고    scopus 로고
    • Development of mitochondrial gene replacement therapy
    • Khan SM and Bennett JP Jr. Development of mitochondrial gene replacement therapy. J Bioenerg Biomembr 36: 387-393, 2004.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 387-393
    • Khan, S.M.1    Bennett Jr., J.P.2
  • 77
    • 3242734795 scopus 로고    scopus 로고
    • Where and when do somatic mtDNA mutations occur?
    • Khrapko K, Ebralidse K, and Kraytsberg Y. Where and when do somatic mtDNA mutations occur? Ann NY Acad Sci 1019: 240-244, 2004.
    • (2004) Ann NY Acad Sci , vol.1019 , pp. 240-244
    • Khrapko, K.1    Ebralidse, K.2    Kraytsberg, Y.3
  • 78
    • 1942486792 scopus 로고    scopus 로고
    • Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
    • Kieran D, Kalmar B, Dick JR, Riddoch-Contreras J, Burnstock G, and Greensmith L. Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat Med 10: 402-105, 2004.
    • (2004) Nat Med , vol.10 , pp. 402-105
    • Kieran, D.1    Kalmar, B.2    Dick, J.R.3    Riddoch-Contreras, J.4    Burnstock, G.5    Greensmith, L.6
  • 79
    • 33846504706 scopus 로고    scopus 로고
    • Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, and Gottesman MM. A silent polymorphism in the MDR1 gene changes substrate specificity. Science 315: 525-528, 2007.
    • Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE, Calcagno AM, Ambudkar SV, and Gottesman MM. A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 315: 525-528, 2007.
  • 80
    • 0022665705 scopus 로고
    • Brain glutathione peroxidase in neurodegenerative disorders
    • Kish SJ, Morito CL, and Hornykiewicz O. Brain glutathione peroxidase in neurodegenerative disorders. Neurochem Pathol 4: 23-28, 1986.
    • (1986) Neurochem Pathol , vol.4 , pp. 23-28
    • Kish, S.J.1    Morito, C.L.2    Hornykiewicz, O.3
  • 82
    • 33846588874 scopus 로고    scopus 로고
    • SNPs, silent but not invisible
    • Komar AA. SNPs, silent but not invisible. Science 315: 466-167, 2007.
    • (2007) Science , vol.315 , pp. 466-167
    • Komar, A.A.1
  • 83
    • 0030813487 scopus 로고    scopus 로고
    • Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin
    • Koutnikova H, Campuzano V, Foury F, Dolle P, Cazzalini O, and Koenig M. Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin. Nat Genet 16: 345-351, 1997.
    • (1997) Nat Genet , vol.16 , pp. 345-351
    • Koutnikova, H.1    Campuzano, V.2    Foury, F.3    Dolle, P.4    Cazzalini, O.5    Koenig, M.6
  • 84
    • 0037287897 scopus 로고    scopus 로고
    • Mutation and intracellular clonal expansion of mitochondrial genomes: Two synergistic components of the aging process?
    • Kraytsberg Y, Nekhaeva E, Bodyak NB, and Khrapko K. Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process? Mech Ageing Dev 124: 49-53, 2003.
    • (2003) Mech Ageing Dev , vol.124 , pp. 49-53
    • Kraytsberg, Y.1    Nekhaeva, E.2    Bodyak, N.B.3    Khrapko, K.4
  • 85
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, and Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 38: 518-520, 2006.
    • (2006) Nat Genet , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 87
    • 0036331936 scopus 로고    scopus 로고
    • Endogenouos sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: Neural regulation of genomic function
    • Kumar AR and Kurup PA. Endogenouos sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: Neural regulation of genomic function. Neurology India 50: 174-180, 2002.
    • (2002) Neurology India , vol.50 , pp. 174-180
    • Kumar, A.R.1    Kurup, P.A.2
  • 90
    • 33745265189 scopus 로고    scopus 로고
    • PPAR? agonists as new therapeutic agents for the treatment of Alzheimer's disease
    • Landreth G. PPAR? agonists as new therapeutic agents for the treatment of Alzheimer's disease. Exp Neurol 199: 245-248, 2006.
    • (2006) Exp Neurol , vol.199 , pp. 245-248
    • Landreth, G.1
  • 91
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard PA, Tetrud JW, and Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219: 979-980, 1983.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.A.2    Tetrud, J.W.3    Irwin, I.4
  • 92
    • 2342608923 scopus 로고    scopus 로고
    • Midlife dietary intake of antioxidants and risk of late-life incident dementia: The Honolulu-Asia Aging Study
    • Laurin D, Masaki KH, Foley DJ, White LR, and Launer LJ. Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am J Epidemiol 159: 959-967, 2004.
    • (2004) Am J Epidemiol , vol.159 , pp. 959-967
    • Laurin, D.1    Masaki, K.H.2    Foley, D.J.3    White, L.R.4    Launer, L.J.5
  • 93
    • 13444271923 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress
    • Lee HC and Wei YH. Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol 37: 822-834, 2005.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 822-834
    • Lee, H.C.1    Wei, Y.H.2
  • 94
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • Lehrke M and Lazar MA. The many faces of PPARgamma. Cell 123: 993-999, 2005.
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 96
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • Lin MT, Simon DK, Ahn CH, Kim LM, and Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet 11: 133-145, 2002.
    • (2002) Hum Mol Genet , vol.11 , pp. 133-145
    • Lin, M.T.1    Simon, D.K.2    Ahn, C.H.3    Kim, L.M.4    Beal, M.F.5
  • 97
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • Linnane AW, Marzuki S, Ozawa T, and Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1: 642-645, 1989.
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 98
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • Lovell MA, Ehmann WD, Butler SM, and Markesbery WR. Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45: 1594-1601, 1995.
    • (1995) Neurology , vol.45 , pp. 1594-1601
    • Lovell, M.A.1    Ehmann, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 99
    • 0037320324 scopus 로고    scopus 로고
    • Antioxidant vitamin intake and risk of Alzheimer disease
    • Luchsinger JA, Tang MX, Shea S, and Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 60: 203-208, 2003.
    • (2003) Arch Neurol , vol.60 , pp. 203-208
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 100
    • 0028558576 scopus 로고
    • The development of mitochondrial medicine
    • Luft R. The development of mitochondrial medicine. Proc Natl Acad Sci USA 91: 8731-8738, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8731-8738
    • Luft, R.1
  • 101
    • 0032568610 scopus 로고    scopus 로고
    • Localization of the Wilson's disease protein product to mitochondria
    • Lutsenko O and Cooper MJ. Localization of the Wilson's disease protein product to mitochondria. Proc Natl Acad Sci USA 95: 6004-6009, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6004-6009
    • Lutsenko, O.1    Cooper, M.J.2
  • 103
    • 2342628596 scopus 로고    scopus 로고
    • Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: Implications for early mitochondrial dysfunction and oxidative damage
    • Manczak M, Park BS, Jung Y, and Reddy PH. Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med 5: 147-162, 2004.
    • (2004) Neuromolecular Med , vol.5 , pp. 147-162
    • Manczak, M.1    Park, B.S.2    Jung, Y.3    Reddy, P.H.4
  • 104
    • 13244292394 scopus 로고    scopus 로고
    • Time-course of mitochondrial gene expressions in mice brains: Implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging
    • Manczak M, Jung Y, Park BS, Partovi D, and Reddy PH. Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging. J Neurochem 92: 494-504, 2005.
    • (2005) J Neurochem , vol.92 , pp. 494-504
    • Manczak, M.1    Jung, Y.2    Park, B.S.3    Partovi, D.4    Reddy, P.H.5
  • 105
    • 1542283630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha target genes
    • Mandred S, Muller M, and Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 61: 393-116, 2004.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 393-116
    • Mandred, S.1    Muller, M.2    Kersten, S.3
  • 107
    • 0032902974 scopus 로고    scopus 로고
    • Oxidative alterations in Alzheimer's disease
    • Markesbery WR and Carney JM. Oxidative alterations in Alzheimer's disease. Brain Pathol 9: 133-146, 1999.
    • (1999) Brain Pathol , vol.9 , pp. 133-146
    • Markesbery, W.R.1    Carney, J.M.2
  • 108
    • 0023766185 scopus 로고
    • Oxygen toxicity protecting enzymes in Parkinson's disease. Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus
    • Marttila RJ, Lorentz H, and Rinne UK. Oxygen toxicity protecting enzymes in Parkinson's disease. Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus. J Neurol Sci 86: 321-331, 1988.
    • (1988) J Neurol Sci , vol.86 , pp. 321-331
    • Marttila, R.J.1    Lorentz, H.2    Rinne, U.K.3
  • 109
    • 0021181568 scopus 로고
    • Neurochemical enzyme changes in Alzheimer's and Pick's disease
    • Meier-Ruge W, Iwangoff P, and Reichlmeier K. Neurochemical enzyme changes in Alzheimer's and Pick's disease. Arch Gerontol Geriatr 3: 161-165, 1984.
    • (1984) Arch Gerontol Geriatr , vol.3 , pp. 161-165
    • Meier-Ruge, W.1    Iwangoff, P.2    Reichlmeier, K.3
  • 110
    • 0033912405 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging
    • Melov S. Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging. Ann NY Acad Sci 908: 219-225, 2000.
    • (2000) Ann NY Acad Sci , vol.908 , pp. 219-225
    • Melov, S.1
  • 111
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, and Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286: 774-779, 1999.
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 114
    • 0026718556 scopus 로고
    • The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): Genetic, biochemical, and morphological correlations in skeletal muscle
    • Moraes CT, Ricci E, Bonilla E, DiMauro S, and Schon EA. The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): genetic, biochemical, and morphological correlations in skeletal muscle. Am J Hum Genet 50: 934-949, 1992.
    • (1992) Am J Hum Genet , vol.50 , pp. 934-949
    • Moraes, C.T.1    Ricci, E.2    Bonilla, E.3    DiMauro, S.4    Schon, E.A.5
  • 116
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • Navarro A and Boveris AA. The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 292: C670-686, 2007.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Navarro, A.1    Boveris, A.A.2
  • 118
    • 0021810979 scopus 로고    scopus 로고
    • Nicklas WJ, Vyas I, and Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 36: 2503-2508, 1985.
    • Nicklas WJ, Vyas I, and Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 36: 2503-2508, 1985.
  • 119
    • 33645894705 scopus 로고    scopus 로고
    • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
    • NINDS NET-PD Investigators
    • NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology 66: 664-671, 2006.
    • (2006) Neurology , vol.66 , pp. 664-671
  • 122
    • 0024848034 scopus 로고
    • Electron transport chain abnormalities in idiopathic Parkinson's disease
    • Parker WD, Boyson SJ, and Parks JK. Electron transport chain abnormalities in idiopathic Parkinson's disease. Ann Neurol 26: 719-723, 1989.
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 123
    • 0025024024 scopus 로고
    • Cytochrome oxidase deficiency in Alzheimer's disease
    • Parker WD, Filley CM, and Parks JK. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40: 1302-1303, 1990.
    • (1990) Neurology , vol.40 , pp. 1302-1303
    • Parker, W.D.1    Filley, C.M.2    Parks, J.K.3
  • 125
    • 0025087726 scopus 로고
    • Evidence for a defect in NADH:ubiquinone oxidoreductase (complex I) in Huntington's disease
    • Parker WD Jr, Boyson SJ, Luders AS, and Parks JK. Evidence for a defect in NADH:ubiquinone oxidoreductase (complex I) in Huntington's disease. Neurology 40: 1231-1234, 1990.
    • (1990) Neurology , vol.40 , pp. 1231-1234
    • Parker Jr, W.D.1    Boyson, S.J.2    Luders, A.S.3    Parks, J.K.4
  • 126
    • 0029055772 scopus 로고
    • Cytochrome c oxidase in Alzheimer's disease brain: Purification and characterization
    • Parker WD Jr and Parks JK. Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization. Neurology 45: 482-486, 1995.
    • (1995) Neurology , vol.45 , pp. 482-486
    • Parker Jr, W.D.1    Parks, J.K.2
  • 127
    • 10444243239 scopus 로고    scopus 로고
    • Mitochondrial ND5 mutations in idiopathic Parkinson's disease
    • Parker WD Jr and Parks JK. Mitochondrial ND5 mutations in idiopathic Parkinson's disease. Biochem Biophys Res Commun 326: 667-669, 2005.
    • (2005) Biochem Biophys Res Commun , vol.326 , pp. 667-669
    • Parker Jr, W.D.1    Parks, J.K.2
  • 128
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group
    • Parkinson Study Group
    • Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group. N Engl J Med 328: 176-183, 1993.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 129
    • 0020308323 scopus 로고
    • Parkinson's disease: A disorder due to nigral glutathione deficiency?
    • Perry TL, Godin DV, and Hansen S. Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci Lett 33: 305-310, 1982.
    • (1982) Neurosci Lett , vol.33 , pp. 305-310
    • Perry, T.L.1    Godin, D.V.2    Hansen, S.3
  • 131
    • 0028643642 scopus 로고
    • Superoxide dismutase expression in Parkinson's disease
    • Poirier J, Dea D, Baccichet A, and Thiffault C. Superoxide dismutase expression in Parkinson's disease. Ann NY Acad Sci 738: 116-120, 1994.
    • (1994) Ann NY Acad Sci , vol.738 , pp. 116-120
    • Poirier, J.1    Dea, D.2    Baccichet, A.3    Thiffault, C.4
  • 132
    • 3042736860 scopus 로고    scopus 로고
    • Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
    • Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, Jung Y, Yau V, Searles R, Mori M, and Quinn J. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Hum Mol Genet 13: 1225-1240, 2004.
    • (2004) Hum Mol Genet , vol.13 , pp. 1225-1240
    • Reddy, P.H.1    McWeeney, S.2    Park, B.S.3    Manczak, M.4    Gutala, R.V.5    Partovi, D.6    Jung, Y.7    Yau, V.8    Searles, R.9    Mori, M.10    Quinn, J.11
  • 133
    • 33646349444 scopus 로고    scopus 로고
    • Mitochondrial oxidative damage in aging and Alzheimer's disease: Implications for mitochondrially targeted antioxidant therapeutics
    • Reddy PH. Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J Biomed Biotechnol 2006: 31372, 2006.
    • (2006) J Biomed Biotechnol , vol.2006 , pp. 31372
    • Reddy, P.H.1
  • 135
    • 33847293352 scopus 로고    scopus 로고
    • Complex disease-associated pharmacogenetics: Drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)
    • Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, and Mahley RW. Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J 7: 10-28, 2007.
    • (2007) Pharmacogenomics J , vol.7 , pp. 10-28
    • Roses, A.D.1    Saunders, A.M.2    Huang, Y.3    Strum, J.4    Weisgraber, K.H.5    Mahley, R.W.6
  • 136
    • 33750706557 scopus 로고    scopus 로고
    • Transcription meets metabolism in neurodegeneration
    • Ross CA and Thompson LM. Transcription meets metabolism in neurodegeneration. Nat Med 12: 1239-1241, 2006.
    • (2006) Nat Med , vol.12 , pp. 1239-1241
    • Ross, C.A.1    Thompson, L.M.2
  • 137
    • 0024321178 scopus 로고
    • A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra
    • Saggu H, Cooksey J, Dexter D, Wells FR, Lees A, Jenner P, and Marsden CD. A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra. J Neurochem 53: 692-697, 1989.
    • (1989) J Neurochem , vol.53 , pp. 692-697
    • Saggu, H.1    Cooksey, J.2    Dexter, D.3    Wells, F.R.4    Lees, A.5    Jenner, P.6    Marsden, C.D.7
  • 138
    • 0031886330 scopus 로고    scopus 로고
    • Effects of dichloroacetate in three patients with MELAS
    • Saitoh S, Momoi MY, Yamagata T, Mori Y, and Imai M. Effects of dichloroacetate in three patients with MELAS. Neurology 50: 531-534, 1998.
    • (1998) Neurology , vol.50 , pp. 531-534
    • Saitoh, S.1    Momoi, M.Y.2    Yamagata, T.3    Mori, Y.4    Imai, M.5
  • 140
    • 33744823262 scopus 로고    scopus 로고
    • The mitochondrial myopathy encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: A review of treatment options
    • Scaglia F and Northrop JL. The mitochondrial myopathy encephalopathy, lactic acidosis with stroke-like episodes (MELAS) syndrome: a review of treatment options. CNS Drugs 20: 443-464, 2006.
    • (2006) CNS Drugs , vol.20 , pp. 443-464
    • Scaglia, F.1    Northrop, J.L.2
  • 142
    • 0037029049 scopus 로고    scopus 로고
    • Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells
    • Scarpulla RC. Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells. Gene 286: 81-89, 2002.
    • (2002) Gene , vol.286 , pp. 81-89
    • Scarpulla, R.C.1
  • 143
    • 33645011201 scopus 로고    scopus 로고
    • Nuclear control of respiratory gene expression in mammalian cells
    • Scarpulla RC. Nuclear control of respiratory gene expression in mammalian cells. J Cell Biochem 97: 673-683, 2006.
    • (2006) J Cell Biochem , vol.97 , pp. 673-683
    • Scarpulla, R.C.1
  • 145
    • 0031909628 scopus 로고    scopus 로고
    • Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial
    • Schoenen J, Jacquy J, and Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 50: 466-170, 1998.
    • (1998) Neurology , vol.50 , pp. 466-170
    • Schoenen, J.1    Jacquy, J.2    Lenaerts, M.3
  • 148
    • 0036100742 scopus 로고    scopus 로고
    • Environment, mitochondria, and Parkinson's disease
    • Sherer TB, Betarbet R, and Greenamyre JT. Environment, mitochondria, and Parkinson's disease. Neuroscientist 8: 192-197, 2002.
    • (2002) Neuroscientist , vol.8 , pp. 192-197
    • Sherer, T.B.1    Betarbet, R.2    Greenamyre, J.T.3
  • 149
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer TB, Kim JH, Betarbet R, and Greenamyre JT. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp Neurol 179: 9-16, 2003.
    • (2003) Exp Neurol , vol.179 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 150
  • 153
    • 3042717908 scopus 로고    scopus 로고
    • Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease
    • Shults CW, Flint Beal M, Song D, and Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp Neurol 188: 491-494, 2004.
    • (2004) Exp Neurol , vol.188 , pp. 491-494
    • Shults, C.W.1    Flint Beal, M.2    Song, D.3    Fontaine, D.4
  • 155
    • 0021064115 scopus 로고
    • Metabolic processes in Alzheimer's disease: Adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex
    • Sims NR, Bowen DM, Neary D, and Davison AN. Metabolic processes in Alzheimer's disease: adenine nucleotide content and production of 14CO2 from [U-14C]glucose in vitro in human neocortex. J Neurochem 41: 1329-1334, 1983.
    • (1983) J Neurochem , vol.41 , pp. 1329-1334
    • Sims, N.R.1    Bowen, D.M.2    Neary, D.3    Davison, A.N.4
  • 156
    • 0023191781 scopus 로고
    • Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease
    • Sims NR, Finegan JM, and Blass JP. Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease. Ann Neurol 21: 451-457, 1987.
    • (1987) Ann Neurol , vol.21 , pp. 451-457
    • Sims, N.R.1    Finegan, J.M.2    Blass, J.P.3
  • 157
    • 0023627915 scopus 로고
    • Mitochondrial function in brain tissue in primary degenerative dementia
    • Sims NR, Finegan JM, Blass JP, Bowen DM, and Neary D. Mitochondrial function in brain tissue in primary degenerative dementia. Brain Res 436: 30-38, 1987.
    • (1987) Brain Res , vol.436 , pp. 30-38
    • Sims, N.R.1    Finegan, J.M.2    Blass, J.P.3    Bowen, D.M.4    Neary, D.5
  • 158
    • 4644351698 scopus 로고    scopus 로고
    • High frequency of mitochondrial complex I mutations in Parkinson's disease and aging
    • Smigrodzki R, Parks J, and Parker WD. High frequency of mitochondrial complex I mutations in Parkinson's disease and aging. Neurobiol Aging 25: 1273-1281, 2004.
    • (2004) Neurobiol Aging , vol.25 , pp. 1273-1281
    • Smigrodzki, R.1    Parks, J.2    Parker, W.D.3
  • 159
    • 24944435398 scopus 로고    scopus 로고
    • Mitochondrial microheteroplasmy and a theory of aging and age-related disease
    • Smigrodzki RM and Khan SM. Mitochondrial microheteroplasmy and a theory of aging and age-related disease. Rejuvenation Res 8: 172-198, 2005.
    • (2005) Rejuvenation Res , vol.8 , pp. 172-198
    • Smigrodzki, R.M.1    Khan, S.M.2
  • 160
    • 29644434199 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
    • Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, and Ross CA. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14: 3801-3811, 2005.
    • (2005) Hum Mol Genet , vol.14 , pp. 3801-3811
    • Smith, W.W.1    Jiang, H.2    Pei, Z.3    Tanaka, Y.4    Morita, H.5    Sawa, A.6    Dawson, V.L.7    Dawson, T.M.8    Ross, C.A.9
  • 161
    • 0020685951 scopus 로고
    • Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
    • Sorbi S, Bird ED, and Blass JP. Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain. Ann Neurol 13: 72-78, 1983.
    • (1983) Ann Neurol , vol.13 , pp. 72-78
    • Sorbi, S.1    Bird, E.D.2    Blass, J.P.3
  • 163
    • 1642463791 scopus 로고    scopus 로고
    • Leigh syndrome caused by mitochondrial DNA G13513A mutation: Frequency and clinical features in Japan
    • Sudo A, Honzawa S, Nonaka I, and Goto Y. Leigh syndrome caused by mitochondrial DNA G13513A mutation: frequency and clinical features in Japan. J Hum Genet 49: 92-96, 2004.
    • (2004) J Hum Genet , vol.49 , pp. 92-96
    • Sudo, A.1    Honzawa, S.2    Nonaka, I.3    Goto, Y.4
  • 165
    • 0031785692 scopus 로고    scopus 로고
    • Swerdlow RH. Is NADH effective in the treatment of Parkinson's disease? Drugs Aging 13: 263-268, 1998.
    • Swerdlow RH. Is NADH effective in the treatment of Parkinson's disease? Drugs Aging 13: 263-268, 1998.
  • 166
    • 0005427216 scopus 로고    scopus 로고
    • Role of mitochondria in Parkinson's disease
    • Chesselet MF ed, New Jersey, Humana Press Inc
    • Swerdlow RH. Role of mitochondria in Parkinson's disease. In: Molecular Mechanisms of Neurodegenerative Diseases, Chesselet MF (ed): New Jersey, Humana Press Inc, 2000, pp. 233-270.
    • (2000) Molecular Mechanisms of Neurodegenerative Diseases , pp. 233-270
    • Swerdlow, R.H.1
  • 168
    • 0036982389 scopus 로고    scopus 로고
    • Mitochondria in Alzheimer's disease
    • Swerdlow RH and Kish SJ. Mitochondria in Alzheimer's disease. Int Rev Neurobiol 53: 341-385, 2002.
    • (2002) Int Rev Neurobiol , vol.53 , pp. 341-385
    • Swerdlow, R.H.1    Kish, S.J.2
  • 169
    • 33748137342 scopus 로고    scopus 로고
    • Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease
    • Swerdlow RH, Weaver B, Grawey A, Wenger C, Freed E, and Worrall BB. Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease. J Neurol Sci 247: 224-230, 2006.
    • (2006) J Neurol Sci , vol.247 , pp. 224-230
    • Swerdlow, R.H.1    Weaver, B.2    Grawey, A.3    Wenger, C.4    Freed, E.5    Worrall, B.B.6
  • 170
    • 34347353834 scopus 로고    scopus 로고
    • Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies
    • Epub ahead of print
    • Swerdlow RH. Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies. J Neurosci Res [Epub ahead of print], 2007.
    • (2007) J Neurosci Res
    • Swerdlow, R.H.1
  • 171
    • 0035002174 scopus 로고    scopus 로고
    • Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
    • Tarnopolsky MA and Beal MF. Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann Neurol 49: 561-574, 2001.
    • (2001) Ann Neurol , vol.49 , pp. 561-574
    • Tarnopolsky, M.A.1    Beal, M.F.2
  • 173
    • 0031038812 scopus 로고    scopus 로고
    • Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids
    • Taylor RW, Chinnery PF, Turnbull DM, and Lightowlers RN. Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids. Nat Genet 15: 212-215, 1997.
    • (1997) Nat Genet , vol.15 , pp. 212-215
    • Taylor, R.W.1    Chinnery, P.F.2    Turnbull, D.M.3    Lightowlers, R.N.4
  • 179
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • Wallace, DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256: 628-632, 1992.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 181
    • 0031864678 scopus 로고    scopus 로고
    • Current opinions in headache pathogenesis: Introduction and synthesis
    • Welch KMA. Current opinions in headache pathogenesis: introduction and synthesis. Curr Opin Neurol 11: 193-197, 1998.
    • (1998) Curr Opin Neurol , vol.11 , pp. 193-197
    • Welch, K.M.A.1
  • 184
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jarvinen H. Thiazolidinediones. New Engl J Med 351: 1106-1118, 2004.
    • (2004) New Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.