메뉴 건너뛰기




Volumn 447, Issue 7147, 2007, Pages 924-931

Replication and protection of telomeres

Author keywords

[No Author keywords available]

Indexed keywords

BUFFERING; CHROMOSOME; DNA; GENOME;

EID: 34250841785     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05976     Document Type: Review
Times cited : (397)

References (100)
  • 1
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith, J. D. et al. Mammalian telomeres end in a large duplex loop. Cell 97, 503-514 (1999).
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1
  • 2
    • 1842683257 scopus 로고    scopus 로고
    • T-loops and the origin of telomeres
    • de Lange, T. T-loops and the origin of telomeres. Nature Rev. Mol. Cell Biol. 5, 323-329 (2004).
    • (2004) Nature Rev. Mol. Cell Biol , vol.5 , pp. 323-329
    • de Lange, T.1
  • 3
    • 0023037564 scopus 로고
    • Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA
    • Gottschling, D. E. & Zakian, V. A. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47, 195-205 (1986).
    • (1986) Cell , vol.47 , pp. 195-205
    • Gottschling, D.E.1    Zakian, V.A.2
  • 4
    • 0023433713 scopus 로고
    • Telomeric DNA-protein interactions of Oxytricha macronuclear DNA
    • Price, C. M. & Cech, T. R. Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes Dev. 1, 783-793 (1987).
    • (1987) Genes Dev , vol.1 , pp. 783-793
    • Price, C.M.1    Cech, T.R.2
  • 5
    • 0025984268 scopus 로고
    • Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex
    • Gray, J. T., Celander, D. W., Price, C. M. & Cech, T. R. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell 67, 807-814 (1991).
    • (1991) Cell , vol.67 , pp. 807-814
    • Gray, J.T.1    Celander, D.W.2    Price, C.M.3    Cech, T.R.4
  • 6
    • 0032431057 scopus 로고    scopus 로고
    • Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA
    • Horvath, M. P., Schweiker, V. L., Bevilacqua, J. M., Ruggles, J. A. & Schultz, S. C. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA. Cell 95, 963-974 (1998).
    • (1998) Cell , vol.95 , pp. 963-974
    • Horvath, M.P.1    Schweiker, V.L.2    Bevilacqua, J.M.3    Ruggles, J.A.4    Schultz, S.C.5
  • 7
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange, T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100-2110 (2005).
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 8
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1. Nature 385, 740-743 (1997).
    • (1997) Nature , vol.385 , pp. 740-743
    • van Steensel, B.1    de Lange, T.2
  • 9
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 (1998).
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 10
    • 0033961281 scopus 로고    scopus 로고
    • Control of human telomere length by TRF1 and TRF2
    • Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20, 1659-1668 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 1659-1668
    • Smogorzewska, A.1
  • 11
    • 0041689966 scopus 로고    scopus 로고
    • Targeted deletion reveals an essential function for the telomere length regulator Trf1
    • Karlseder, J. et al. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol. 23, 6533-6541 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 6533-6541
    • Karlseder, J.1
  • 12
    • 0015515155 scopus 로고
    • Origin of concatemeric T7 DNA
    • Watson, J. D. Origin of concatemeric T7 DNA. Nature New Biol. 239, 197-201 (1972).
    • (1972) Nature New Biol , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 13
    • 0015844590 scopus 로고
    • A theory of marginotomy
    • Olovnikov, A. M. A theory of marginotomy. J. Theor. Biol. 41, 181-190 (1973).
    • (1973) J. Theor. Biol , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 14
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961).
    • (1961) Exp. Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 15
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad, V. & Szostak, J. W. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57, 633-643 (1989).
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 16
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998).
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 17
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer, M. S. & Gottschling, D. E. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266, 404-409 (1994).
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 18
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay, T. S., Morris, D. K., Sah, J., Balasubramanian, B. & Lundblad, V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144, 1399-1412 (1996).
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 19
    • 0030938901 scopus 로고    scopus 로고
    • Reverse transcriptase motifs in the catalytic subunit of telomerase
    • Lingner, J. et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567 (1997).
    • (1997) Science , vol.276 , pp. 561-567
    • Lingner, J.1
  • 20
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990).
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 21
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter, C. M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929 (1992).
    • (1992) EMBO J , vol.11 , pp. 1921-1929
    • Counter, C.M.1
  • 22
  • 23
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange, T. Protection of mammalian telomeres. Oncogene 21, 532-540 (2002).
    • (2002) Oncogene , vol.21 , pp. 532-540
    • de Lange, T.1
  • 24
    • 0027421043 scopus 로고
    • Loss of a yeast telomere: Arrest, recovery, and chromosome loss
    • Sandell, L. L. & Zakian, V. A. Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell 75, 729-739 (1993).
    • (1993) Cell , vol.75 , pp. 729-739
    • Sandell, L.L.1    Zakian, V.A.2
  • 25
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A. & de Lange, T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348 (2002).
    • (2002) EMBO J , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    de Lange, T.2
  • 26
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • Karlseder, J., Smogorzewska, A. & de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295, 2446-2449 (2002).
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    de Lange, T.3
  • 27
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 28
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
    • (2003) Nature , vol.426 , pp. 194-198
    • d'Adda di Fagagna, F.1
  • 29
    • 0033529563 scopus 로고    scopus 로고
    • For better or worse? Telomerase inhibition and cancer
    • de Lange, T. & Jacks, T. For better or worse? Telomerase inhibition and cancer. Cell 98, 273-275 (1999).
    • (1999) Cell , vol.98 , pp. 273-275
    • de Lange, T.1    Jacks, T.2
  • 30
    • 19044390359 scopus 로고    scopus 로고
    • Transformation of normal human cells in the absence of telomerase activation
    • Seger, Y. R. et al. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2, 401-413 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 401-413
    • Seger, Y.R.1
  • 31
    • 85120144180 scopus 로고    scopus 로고
    • Artandi, S. E. & DePinho, R. A. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr. Opin. Genet. Dev. 10, 39-46 (2000).
    • Artandi, S. E. & DePinho, R. A. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr. Opin. Genet. Dev. 10, 39-46 (2000).
  • 32
    • 0038392859 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Dangerous road less travelled
    • Reddel, R. R. & Bryan, T. M. Alternative lengthening of telomeres: dangerous road less travelled. Lancet 361, 1840-1841 (2003).
    • (2003) Lancet , vol.361 , pp. 1840-1841
    • Reddel, R.R.1    Bryan, T.M.2
  • 34
    • 0036510162 scopus 로고    scopus 로고
    • Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells
    • Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R. & Royle, N. J. Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genet. 30, 301-305 (2002).
    • (2002) Nature Genet , vol.30 , pp. 301-305
    • Varley, H.1    Pickett, H.A.2    Foxon, J.L.3    Reddel, R.R.4    Royle, N.J.5
  • 35
    • 0032924343 scopus 로고    scopus 로고
    • Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
    • Morales, C. P. et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet. 21, 115-118 (1999).
    • (1999) Nature Genet , vol.21 , pp. 115-118
    • Morales, C.P.1
  • 36
    • 0023034140 scopus 로고
    • Variability at the telomeres of the human X/Y pseudoautosomal region
    • Cooke, H. J. & Smith, B. A. Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harb. Symp. Quant. Biol. 51, 213-219 (1986).
    • (1986) Cold Spring Harb. Symp. Quant. Biol , vol.51 , pp. 213-219
    • Cooke, H.J.1    Smith, B.A.2
  • 38
    • 2642530948 scopus 로고    scopus 로고
    • Long lifespan in worms with long telomeric DNA
    • Joeng, K. S., Song, E. J., Lee, K. J. & Lee, J. Long lifespan in worms with long telomeric DNA. Nature Genet. 36, 607-611 (2004).
    • (2004) Nature Genet , vol.36 , pp. 607-611
    • Joeng, K.S.1    Song, E.J.2    Lee, K.J.3    Lee, J.4
  • 39
    • 33644796076 scopus 로고    scopus 로고
    • Raices, M., Maruyama, H., Dillin, A. & Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 1, e30 (2005).
    • Raices, M., Maruyama, H., Dillin, A. & Karlseder, J. Uncoupling of longevity and telomere length in C. elegans. PLoS Genet. 1, e30 (2005).
  • 40
    • 2042534735 scopus 로고    scopus 로고
    • Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states
    • Teixeira, M. T., Arneric, M., Sperisen, P. & Lingner, J. Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states. Cell 117, 323-335 (2004).
    • (2004) Cell , vol.117 , pp. 323-335
    • Teixeira, M.T.1    Arneric, M.2    Sperisen, P.3    Lingner, J.4
  • 41
    • 32544443342 scopus 로고    scopus 로고
    • Telomere length homeostasis requires that telomerase levels are limiting
    • Cristofari, G. & Lingner, J. Telomere length homeostasis requires that telomerase levels are limiting. EMBO J. 25, 565-574 (2006).
    • (2006) EMBO J , vol.25 , pp. 565-574
    • Cristofari, G.1    Lingner, J.2
  • 42
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34 (1997).
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1
  • 43
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • Lee, H. W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574 (1998).
    • (1998) Nature , vol.392 , pp. 569-574
    • Lee, H.W.1
  • 44
    • 17844373798 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
    • Liu, Y. et al. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr. Biol. 10, 1459-1462 (2000).
    • (2000) Curr. Biol , vol.10 , pp. 1459-1462
    • Liu, Y.1
  • 45
    • 0030807761 scopus 로고    scopus 로고
    • Coordinate regulation of G- and C strand length during new telomere synthesis
    • Fan, X. & Price, C. M. Coordinate regulation of G- and C strand length during new telomere synthesis. Mol. Biol. Cell 8, 2145-2155 (1997).
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2145-2155
    • Fan, X.1    Price, C.M.2
  • 46
    • 0033598944 scopus 로고    scopus 로고
    • Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases α and δ
    • Diede, S. J. & Gottschling, D. E. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases α and δ. Cell 99, 723-733 (1999).
    • (1999) Cell , vol.99 , pp. 723-733
    • Diede, S.J.1    Gottschling, D.E.2
  • 47
    • 0035830494 scopus 로고    scopus 로고
    • Cdc13 delivers separate complexes to the telomere for end protection and replication
    • Pennock, E., Buckley, K. & Lundblad, V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104, 387-396 (2001).
    • (2001) Cell , vol.104 , pp. 387-396
    • Pennock, E.1    Buckley, K.2    Lundblad, V.3
  • 48
    • 4944265507 scopus 로고    scopus 로고
    • Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1
    • Bianchi, A., Negrini, S. & Shore, D. Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1. Mol. Cell 16, 139-146 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 139-146
    • Bianchi, A.1    Negrini, S.2    Shore, D.3
  • 49
    • 0035115859 scopus 로고    scopus 로고
    • Cdc13 both positively and negatively regulates telomere replication
    • Chandra, A., Hughes, T. R., Nugent, C. I. & Lundblad, V. Cdc13 both positively and negatively regulates telomere replication. Genes Dev. 15, 404-414 (2001).
    • (2001) Genes Dev , vol.15 , pp. 404-414
    • Chandra, A.1    Hughes, T.R.2    Nugent, C.I.3    Lundblad, V.4
  • 50
    • 2442564703 scopus 로고    scopus 로고
    • Pol12, the B subunit of DNA polymerase ?, functions in both telomere capping and length regulation
    • Grossi, S., Puglisi, A., Dmitriev, P. V., Lopes, M. & Shore, D. Pol12, the B subunit of DNA polymerase ?, functions in both telomere capping and length regulation. Genes Dev. 18, 992-1006 (2004).
    • (2004) Genes Dev , vol.18 , pp. 992-1006
    • Grossi, S.1    Puglisi, A.2    Dmitriev, P.V.3    Lopes, M.4    Shore, D.5
  • 51
    • 28544438284 scopus 로고    scopus 로고
    • Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase α
    • Nakamura, M., Nabetani, A., Mizuno, T., Hanaoka, F. & Ishikawa, F. Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase α. Mol. Cell. Biol. 25, 11073-11088 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , pp. 11073-11088
    • Nakamura, M.1    Nabetani, A.2    Mizuno, T.3    Hanaoka, F.4    Ishikawa, F.5
  • 53
    • 33645747064 scopus 로고    scopus 로고
    • Semi-conservative DNA replication through telomeres requires Taz1
    • Miller, K. M., Rog, O. & Cooper, J. P. Semi-conservative DNA replication through telomeres requires Taz1. Nature 440, 824-828 (2006).
    • (2006) Nature , vol.440 , pp. 824-828
    • Miller, K.M.1    Rog, O.2    Cooper, J.P.3
  • 54
    • 10344256183 scopus 로고    scopus 로고
    • Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
    • Crabbe, L., Verdun, R. E., Haggblom, C. I. & Karlseder, J. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306, 1951-1953 (2004).
    • (2004) Science , vol.306 , pp. 1951-1953
    • Crabbe, L.1    Verdun, R.E.2    Haggblom, C.I.3    Karlseder, J.4
  • 55
    • 3543043128 scopus 로고    scopus 로고
    • Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    • Chang, S. et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genet. 36, 877-882 (2004).
    • (2004) Nature Genet , vol.36 , pp. 877-882
    • Chang, S.1
  • 56
    • 0035421965 scopus 로고    scopus 로고
    • G-overhang dynamics at Tetrahymena telomeres
    • Jacob, N. K., Skopp, R. & Price, C. M. G-overhang dynamics at Tetrahymena telomeres. EMBO J. 20, 4299-4308 (2001).
    • (2001) EMBO J , vol.20 , pp. 4299-4308
    • Jacob, N.K.1    Skopp, R.2    Price, C.M.3
  • 57
    • 0029953557 scopus 로고    scopus 로고
    • Evidence for a new step in telomere maintenance
    • Wellinger, R. J., Ethier, K., Labrecque, P. & Zakian, V. A. Evidence for a new step in telomere maintenance. Cell 85, 423-433 (1996).
    • (1996) Cell , vol.85 , pp. 423-433
    • Wellinger, R.J.1    Ethier, K.2    Labrecque, P.3    Zakian, V.A.4
  • 58
    • 0030460748 scopus 로고    scopus 로고
    • Dionne, I. & Wellinger, R. J. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc. Natl Acad. Sci. USA 93, 13902-13907 (1996).
    • Dionne, I. & Wellinger, R. J. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc. Natl Acad. Sci. USA 93, 13902-13907 (1996).
  • 59
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V. L., Hirose, Y. & Langmore, J. P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657-666 (1997).
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 60
    • 31544466516 scopus 로고    scopus 로고
    • Human telomeres have different overhang sizes at leading versus lagging strands
    • Chai, W., Du, Q., Shay, J. W. & Wright, W. E. Human telomeres have different overhang sizes at leading versus lagging strands. Mol. Cell 21, 427-435 (2006).
    • (2006) Mol. Cell , vol.21 , pp. 427-435
    • Chai, W.1    Du, Q.2    Shay, J.W.3    Wright, W.E.4
  • 61
    • 0037623348 scopus 로고    scopus 로고
    • Generation of telomeric G strand overhangs involves both G and C strand cleavage
    • Jacob, N. K., Kirk, K. E. & Price, C. M. Generation of telomeric G strand overhangs involves both G and C strand cleavage. Mol. Cell 11, 1021-1032 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 1021-1032
    • Jacob, N.K.1    Kirk, K.E.2    Price, C.M.3
  • 62
    • 15944368044 scopus 로고    scopus 로고
    • Telomere-end processing the terminal nucleotides of human chromosomes
    • Sfeir, A. J., Chai, W., Shay, J. W. & Wright, W. E. Telomere-end processing the terminal nucleotides of human chromosomes. Mol. Cell 18, 131-138 (2005).
    • (2005) Mol. Cell , vol.18 , pp. 131-138
    • Sfeir, A.J.1    Chai, W.2    Shay, J.W.3    Wright, W.E.4
  • 63
    • 23044500389 scopus 로고    scopus 로고
    • POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
    • Hockemeyer, D., Sfeir, A. J., Shay, J. W., Wright, W. E. & de Lange, T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J. 24, 2667-2678 (2005).
    • (2005) EMBO J , vol.24 , pp. 2667-2678
    • Hockemeyer, D.1    Sfeir, A.J.2    Shay, J.W.3    Wright, W.E.4    de Lange, T.5
  • 64
    • 0035106262 scopus 로고    scopus 로고
    • The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions
    • Ferreira, M. G. & Cooper, J. P. The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol. Cell 7, 55-63 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 55-63
    • Ferreira, M.G.1    Cooper, J.P.2
  • 65
    • 0141814665 scopus 로고    scopus 로고
    • Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae
    • Mieczkowski, P. A., Mieczkowska, J. O., Dominska, M. & Petes, T. D. Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc. Natl Acad. Sci. USA 100, 10854-10859 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 10854-10859
    • Mieczkowski, P.A.1    Mieczkowska, J.O.2    Dominska, M.3    Petes, T.D.4
  • 67
    • 16544390953 scopus 로고    scopus 로고
    • Cell cycle-dependent regulation of yeast telomerase by Ku
    • Fisher, T. S., Taggart, A. K. & Zakian, V. A. Cell cycle-dependent regulation of yeast telomerase by Ku. Nature Struct. Mol. Biol. 11, 1198-1205 (2004).
    • (2004) Nature Struct. Mol. Biol , vol.11 , pp. 1198-1205
    • Fisher, T.S.1    Taggart, A.K.2    Zakian, V.A.3
  • 68
    • 27544471936 scopus 로고    scopus 로고
    • Fisher, T. S. & Zakian, V. A. Ku: a multifunctional protein involved in telomere maintenance. DNA Repair (Amst.) 4, 1215-1226 (2005).
    • Fisher, T. S. & Zakian, V. A. Ku: a multifunctional protein involved in telomere maintenance. DNA Repair (Amst.) 4, 1215-1226 (2005).
  • 69
    • 0030447657 scopus 로고    scopus 로고
    • 1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc. Natl Acad. Sci. USA 93, 13760-13765 (1996).
    • 1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc. Natl Acad. Sci. USA 93, 13760-13765 (1996).
  • 70
    • 0031029001 scopus 로고    scopus 로고
    • Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13
    • Grandin, N., Reed, S. I. & Charbonneau, M. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev. 11, 512-527 (1997).
    • (1997) Genes Dev , vol.11 , pp. 512-527
    • Grandin, N.1    Reed, S.I.2    Charbonneau, M.3
  • 71
    • 0035282781 scopus 로고    scopus 로고
    • Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13
    • Grandin, N., Damon, C. & Charbonneau, M. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 20, 1173-1183 (2001).
    • (2001) EMBO J , vol.20 , pp. 1173-1183
    • Grandin, N.1    Damon, C.2    Charbonneau, M.3
  • 72
    • 0028822203 scopus 로고    scopus 로고
    • Garvik, B., Carson, M. & Hartwell, L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15, 6128-6138 (1995); erratum 16, 457 (1996).
    • Garvik, B., Carson, M. & Hartwell, L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15, 6128-6138 (1995); erratum 16, 457 (1996).
  • 73
    • 0035504409 scopus 로고    scopus 로고
    • Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction
    • Booth, C., Griffith, E., Brady, G. & Lydall, D. Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction. Nucleic Acids Res. 29, 4414-4422 (2001).
    • (2001) Nucleic Acids Res , vol.29 , pp. 4414-4422
    • Booth, C.1    Griffith, E.2    Brady, G.3    Lydall, D.4
  • 74
    • 0031038170 scopus 로고    scopus 로고
    • Regulation of telomere length and function by a Myb-domain protein in fission yeast
    • Cooper, J. P., Nimmo, E. R., Allshire, R. C. & Cech, T. R. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385, 744-747 (1997).
    • (1997) Nature , vol.385 , pp. 744-747
    • Cooper, J.P.1    Nimmo, E.R.2    Allshire, R.C.3    Cech, T.R.4
  • 75
    • 0035844082 scopus 로고    scopus 로고
    • Pot1, the putative telomere end-binding protein in fission yeast and humans
    • Baumann, P. & Cech, T. R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171-1175 (2001).
    • (2001) Science , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 76
    • 0038451396 scopus 로고    scopus 로고
    • POT1 as a terminal transducer of TRF1 telomere length control
    • Loayza, D. & de Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 423, 1013-1018 (2003).
    • (2003) Nature , vol.423 , pp. 1013-1018
    • Loayza, D.1    de Lange, T.2
  • 77
    • 0038413786 scopus 로고    scopus 로고
    • Human POT1 facilitates telomere elongation by telomerase
    • Colgin, L. M., Baran, K., Baumann, P., Cech, T. R. & Reddel, R. R. Human POT1 facilitates telomere elongation by telomerase. Curr. Biol. 13, 942-946 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 942-946
    • Colgin, L.M.1    Baran, K.2    Baumann, P.3    Cech, T.R.4    Reddel, R.R.5
  • 78
    • 33745685066 scopus 로고    scopus 로고
    • Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
    • Hockemeyer, D., Daniels, J. P., Takai, H. & de Lange, T. Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126, 63-77 (2006).
    • (2006) Cell , vol.126 , pp. 63-77
    • Hockemeyer, D.1    Daniels, J.P.2    Takai, H.3    de Lange, T.4
  • 79
    • 33745713451 scopus 로고    scopus 로고
    • Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
    • Wu, L. et al. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126, 49-62 (2006).
    • (2006) Cell , vol.126 , pp. 49-62
    • Wu, L.1
  • 80
    • 22144490491 scopus 로고    scopus 로고
    • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    • Celli, G. B. & de Lange, T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nature Cell Biol. 7, 712-718 (2005).
    • (2005) Nature Cell Biol , vol.7 , pp. 712-718
    • Celli, G.B.1    de Lange, T.2
  • 81
    • 7044232011 scopus 로고    scopus 로고
    • Homologous recombination generates T-loop-sized deletions at human telomeres
    • Wang, R. C., Smogorzewska, A. & de Lange, T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119, 355-368 (2004).
    • (2004) Cell , vol.119 , pp. 355-368
    • Wang, R.C.1    Smogorzewska, A.2    de Lange, T.3
  • 82
    • 0032554797 scopus 로고    scopus 로고
    • Telomere maintenance is dependent on activities required for end repair of double-strand breaks
    • Nugent, C. I. et al. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 8, 657-660 (1998).
    • (1998) Curr. Biol , vol.8 , pp. 657-660
    • Nugent, C.I.1
  • 83
    • 0035806977 scopus 로고    scopus 로고
    • The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
    • Tsukamoto, Y., Taggart, A. K. & Zakian, V. A. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres. Curr. Biol. 11, 1328-1335 (2001).
    • (2001) Curr. Biol , vol.11 , pp. 1328-1335
    • Tsukamoto, Y.1    Taggart, A.K.2    Zakian, V.A.3
  • 84
    • 13944265075 scopus 로고    scopus 로고
    • Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae
    • Takata, H., Tanaka, Y. & Matsuura, A. Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol. Cell 17, 573-583 (2005).
    • (2005) Mol. Cell , vol.17 , pp. 573-583
    • Takata, H.1    Tanaka, Y.2    Matsuura, A.3
  • 85
    • 0036670615 scopus 로고    scopus 로고
    • Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres
    • Nakamura, T. M., Moser, B. A. & Russell, P. Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161, 1437-1452 (2002).
    • (2002) Genetics , vol.161 , pp. 1437-1452
    • Nakamura, T.M.1    Moser, B.A.2    Russell, P.3
  • 86
    • 2442595631 scopus 로고    scopus 로고
    • Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo
    • Takata, H., Kanoh, Y., Gunge, N., Shirahige, K. & Matsuura, A. Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol. Cell 14, 515-522 (2004).
    • (2004) Mol. Cell , vol.14 , pp. 515-522
    • Takata, H.1    Kanoh, Y.2    Gunge, N.3    Shirahige, K.4    Matsuura, A.5
  • 87
    • 0035928740 scopus 로고    scopus 로고
    • Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
    • Chan, S. W., Chang, J., Prescott, J. & Blackburn, E. H. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr. Biol. 11, 1240-1250 (2001).
    • (2001) Curr. Biol , vol.11 , pp. 1240-1250
    • Chan, S.W.1    Chang, J.2    Prescott, J.3    Blackburn, E.H.4
  • 88
    • 0037716757 scopus 로고    scopus 로고
    • Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining
    • Chan, S. W. & Blackburn, E. H. Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol. Cell 11, 1379-1387 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 1379-1387
    • Chan, S.W.1    Blackburn, E.H.2
  • 89
    • 0030761351 scopus 로고    scopus 로고
    • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
    • Vaziri, H. et al. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16, 6018-6033 (1997).
    • (1997) EMBO J , vol.16 , pp. 6018-6033
    • Vaziri, H.1
  • 90
    • 0035954284 scopus 로고    scopus 로고
    • Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
    • Ranganathan, V. et al. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr. Biol. 11, 962-966 (2001).
    • (2001) Curr. Biol , vol.11 , pp. 962-966
    • Ranganathan, V.1
  • 91
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • Zhu, X. D., Kuster, B., Mann, M., Petrini, J. H. & de Lange, T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genet. 25, 347-352 (2000).
    • (2000) Nature Genet , vol.25 , pp. 347-352
    • Zhu, X.D.1    Kuster, B.2    Mann, M.3    Petrini, J.H.4    de Lange, T.5
  • 92
    • 27944496124 scopus 로고    scopus 로고
    • Functional human telomeres are recognized as DNA damage in G2 of the cell cycle
    • Verdun, R. E., Crabbe, L., Haggblom, C. & Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell 20, 551-561 (2005).
    • (2005) Mol. Cell , vol.20 , pp. 551-561
    • Verdun, R.E.1    Crabbe, L.2    Haggblom, C.3    Karlseder, J.4
  • 93
    • 33750801681 scopus 로고    scopus 로고
    • The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres
    • Verdun, R. E. & Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127, 709-720 (2006).
    • (2006) Cell , vol.127 , pp. 709-720
    • Verdun, R.E.1    Karlseder, J.2
  • 94
    • 7644237444 scopus 로고    scopus 로고
    • Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops
    • Cesare, A. J. & Griffith, J. D. Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol. Cell. Biol. 24, 9948-9957 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 9948-9957
    • Cesare, A.J.1    Griffith, J.D.2
  • 95
    • 3142699748 scopus 로고    scopus 로고
    • Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells
    • Bailey, S. M., Brenneman, M. A. & Goodwin, E. H. Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res. 32, 3743-3751 (2004).
    • (2004) Nucleic Acids Res , vol.32 , pp. 3743-3751
    • Bailey, S.M.1    Brenneman, M.A.2    Goodwin, E.H.3
  • 96
    • 4644336189 scopus 로고    scopus 로고
    • The frequency of homologous recombination in human ALT cells
    • Bechter, O. E., Shay, J. W. & Wright, W. E. The frequency of homologous recombination in human ALT cells. Cell Cycle 3, 547-549 (2004).
    • (2004) Cell Cycle , vol.3 , pp. 547-549
    • Bechter, O.E.1    Shay, J.W.2    Wright, W.E.3
  • 97
    • 33745474120 scopus 로고    scopus 로고
    • Break-induced replication and recombinational telomere elongation in yeast
    • McEachern, M. J. & Haber, J. E. Break-induced replication and recombinational telomere elongation in yeast. Annu. Rev. Biochem. 75, 111-135 (2006).
    • (2006) Annu. Rev. Biochem , vol.75 , pp. 111-135
    • McEachern, M.J.1    Haber, J.E.2
  • 98
    • 0037148275 scopus 로고    scopus 로고
    • Telomere maintenance without telomerase
    • Lundblad, V. Telomere maintenance without telomerase. Oncogene 21, 522-531 (2002).
    • (2002) Oncogene , vol.21 , pp. 522-531
    • Lundblad, V.1
  • 99
    • 0345732687 scopus 로고    scopus 로고
    • The Mre11 complex is required for ATM activation and the G2/M checkpoint
    • Carson, C. T. et al. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 22, 6610-6620 (2003).
    • (2003) EMBO J , vol.22 , pp. 6610-6620
    • Carson, C.T.1
  • 100
    • 0034195218 scopus 로고    scopus 로고
    • Partners and pathways repairing a double-strand break
    • Haber, J. E. Partners and pathways repairing a double-strand break. Trends Genet. 16, 259-264 (2000).
    • (2000) Trends Genet , vol.16 , pp. 259-264
    • Haber, J.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.