The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

Current Biology

Volumn 10, Issue 22, 2000, Pages 1459-1462

  Liu, Y ^a   Snow, B E ^a   Hande, M P ^b   Yeung, D ^a,c   Erdmann, N J ^a   Wakeham, A ^a   Itie, A ^a   Siderovski, D P ^d   Lansdorp, P M ^e   Robinson, M O ^c   Harrington, L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Columbia University ^*  (United States)

^c AMGEN INC   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MAMMALIA;

EID: 17844373798     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00805-8     Document Type: Article

References (27)

1. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
2. -/- embryos is associated with failure to close the neural tube
3. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
4. Essential role of mouse telomerase in highly proliferative organs
5. Longevity, stress response, and cancer in aging telomerase-deficient mice
6. Human telomerase contains evolutionarily conserved catalytic and structural subunits
7. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
8. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
9. Extension of life-span by introduction of telomerase into normal human cells
10. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
11. Reconstitution of human telomerase activity in vitro
12. Severe growth defect in mouse cells lacking the telomerase RNA component
13. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice
14. Specific association of human telomerase activity with immortal cells and cancer
15. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
16. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
17. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
18. Reverse transcriptase motifs in the catalytic subunit of telomerase
19. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
20. Telomerase catalytic subunit homologs from fission yeast and human
21. Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA
22. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
23. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
24. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
25. Inhibition of telomerase limits the growth of human cancer cells
26. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
27. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats