Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with CDc13

Genes and Development

Volumn 11, Issue 4, 1997, Pages 512-527

  Grandin, Nathalie ^a,b,c   Reed, Steven I ^b   Charbonneau, Michel ^a  

^a CNRS   (France)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITÉ DE LYON   (France)

Author keywords

Cdc13; mitotic checkpoints; S phase; Stn2; telomeres; yeast cell cycle

Indexed keywords

HYBRID PROTEIN; SINGLE STRANDED DNA;

ALLELE; ANIMAL CELL; ARTICLE; CELL SIZE; CHROMOSOMAL LOCALIZATION; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE; TELOMERE; TEMPERATURE SENSITIVE MUTANT;

ANIMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0031029001     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.4.512     Document Type: Article

References (53)

1. Altschul, S.F., W. Gish, W. Miller, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
2. Ausubel, F.A., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl, ed. 1995. Current protocols in molecular biology. John Wiley and Sons, New York, NY.
3. Boulet, S., M. Simon, G. Faye, G.A. Bauer, and P.M.J. Burgers. 1989. Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III. EMBO J. 8: 1849-1854.
4. Brewer, B.J., J.D. Diller, K.L. Friedman, K.M. Kolor, M.K. Raghuraman, and W.L. Fangman. 1993. The topography of chromosome replication in yeast. Cold Spring Harbor Quant. Biol. 58: 425-433.
5. Carson, M.J. and L. Hartwell. 1985. CDC17: An essential gene that prevents telomere elongation in yeast. Cell 42: 249-257.
6. Conrad, M.N., J.H. Wright, A.J. Wolf, and V.A. Zakian. 1990. RAP1 protein interacts with yeast telomeres in vivo: Over-production alters telomere structure and decreases chromosome stability. Cell 63: 739-750.
7. Durfee, T., K. Becherer, P.-L. Chen, S.-H. Yeh, Y. Yang, A.E. Kilburn, W.-H. Lee, and S.J. Elledge. 1993. The retinoblasto-ma protein associates with the protein phosphatase type I catalytic subunit. Genes & Dev. 7: 555-569.
8. Ferguson, B.M. and W.L. Fangman. 1992. A position effect on the time of replication origin activation in yeast. Cell 68: 333-339.
9. Fields, S. and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340: 245-246.
10. Garvik, B., M. Carson, and L. Hartwell. 1995. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell. Biol. 15: 6128-6138.
11. Gietz, R.D. and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527-534.
12. Gilson, E. and S.M. Gasser. 1995. Repressor Activator Protein 1 and its ligands: Organising chromatin domains. Nucleic Acids Mol Biol. 9: 308-327.
13. Gilson, E., T. Laroche, and S.M. Gasser. 1993. Telomeres and the functional architecture of the nucleus. Trends Cell Biol. 3: 128-134.
14. Gottschling, D.E., O.M. Aparicio, B.L. Billington, and V.A. Zakian. 1990. Position effect at S. cerevisiae telomeres: Reversible repression of Po1II transcription. Cell 63: 751-762.
15. Greider, C. 1995. Telomerase biochemistry and regulation. In Telomeres (ed. E. Blackburn and C. Greider), pp. 35-68. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
16. Hardy, C.F., L. Sussel, and D. Shore. 1992. A Rap 1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes & Dev. 6: 801-814.
17. Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816.
18. Jacobs, C.W., A.E.M. Adams, P.J. Szaniszlo, and J.R. Pringle. 1988. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 107: 1409-1426.
19. Johnston, L.H. and K.A. Nasmyth. 1978. Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase. Nature 274: 891-893.
20. Krauskopf, K. and E.H. Blackburn. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354-357.
21. Kyrion, G., K.A. Boakye, and A.J. Lustig. 1992. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell. Biol. 12: 5159-5173.
22. Li, B. and A.J. Lustig. 1996. A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes & Dev. 10: 1310-1326.
23. Lin, J.J. and V.A. Zakian. 1995. An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81: 1127-1135.
24. Louis, E.J. and R.H. Borts. 1995. A complete set of marked telomeres in Saccharomyces cerevisiae for physical mapping and cloning. Genetics 139: 125-136.
25. Lundblad, V. and J.W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633-643.
26. Lustig, A.J., S. Kurtz, and D. Shore. 1990. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 250: 549-553.
27. Lydall, D. and T. Weinert. 1995. Yeast checkpoints genes in DNA damage processing: Implications for repair and arrest. Science 270: 1488-1491.
28. McClintock, B. 1941. The stability of broken ends of chromosomes in Zea mays. Genetics 26: 234-282.
29. McEachern, M.J. and E.H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376: 403-409.
30. Moretti, P., K. Freeman, L. Coodly, and D. Shore. 1994. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes &. Dev. 8: 2257-2269.
31. Nugent, C.I., T.R. Hughes, N.F. Lue, and V. Lundblad. 1996. Cdcl3p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252.
32. Philippsen, P., A. Stotz, and C. Scherf. 1991. DNA of Saccharomyces cerevisiae. In Guide to yeast genetics and molecular biology (ed. C. Guthrie and G.R. Fink), pp. 169-182. Academic Press, San Diego, CA.
33. Pringle, J.R. and L.H. Hartwell. 1981. The Saccharomyces cerevisiae cell cycle. In Molecular biology of the yeast Saccharomyces cerevisiae: Life and inheritance (ed. J.N. Strathern, E.W. Jones, and J.R. Broach), pp. 97-142. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
34. Pringle, J.R., A.E.M. Adams, D.G. Drubin, and B.K. Haarer. 1991. Immunofluorescence methods for yeast. In Guide to yeast genetics and molecular biology (ed. C. Guthrie and G.R. Fink), pp. 565-602. Academic Press, San Diego, CA.
35. Richardson, H.D., C. Wittenberg, F. Cross, and S.I. Reed. 1989. An essential G1 function for cyclin-like proteins in yeast. Cell 59: 1227-1133.
36. Rose, M. and D. Botstein. 1983. Construction and use of gene fusions lacZ (β-galactosidase) which are expressed in yeast. Methods Enzymol. 101: 167-180.
37. Rose, M.D., P. Novick, J.H. Thomas, D. Botstein, and G.R. Fink. 1987. A Saccharomyces cerevisiae genomic plasmid hank based on a centromere-containing shuttle vector. Gene 60: 237-243.
38. Rothstein, R. 1983. One-step gene disruption in yeast. Methods Enzymol. 101: 202-211.
39. Sandell, L.L. and V.A. Zakian. 1992. Telomeric position effect in yeast. Trends Cell Biol. 2: 10-14.
40. _. 1993. Loss of a yeast telomere: Arrest, recovery and chromosome loss. Cell 75: 729-739.
41. Sherman, F. 1991. Getting started with yeast. In Guide to yeast genetics and molecular biology (ed. C. Guthrie and G.R. Fink), pp. 3-21. Academic Press Inc., San Diego, CA.
42. Sherman, F., G. Fink, and J.B. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
43. Singer, M.S. and D.E. Gottschling. 1994. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266: 404-409.
44. Steiner, B.R., K. Hidaka, and B. Futcher. 1996. Association of the Est1 protein with telomerase activity in yeast. Proc. Natl. Acad. Sci. 93: 2817-2821.
45. Weinert, T.A. and L.H. Hartwell. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.
46. _. 1993. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Genetics 134: 63-80.
47. Weinert, T.A., G.L. Kiser, and L.H. Hartwell. 1994. Mitotic chekpoints genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes & Dev. 8: 652-665.
48. Wellinger, R.J., K. Ethier, P. Labrecque, and V.A. Zakian. 1996. Evidence for a new step in telomere maintenance. Cell 85: 423-433.
49. Wellinger, R.J., A.J. Wolf, and V.A. Zakian. 1992. Use of non-denaturing Southern hybridization and two dimensional agarose gels to detect putative intermediates in telomere replication in Saccharomyces cerevisiae. Chromosoma 102: S150-S156.
50. 1-3 tails occur sequentially in late S phase on a yeast linear plasmid. Mol Cell. Biol. 13: 4057-4065.
51. Wu, J.R. and D.M. Gilbert. 1995. Rapid DNA preparation for 2D gel analysis of replication intermediates. Nucleic Acids Res. 23: 3997-3998.
52. Zakian, V.A. 1995a. Saccharomyces telomeres: Function, structure, and replication. In Telomeres (ed. E. Blackburn and C. Greider), pp. 107-137. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
53. _. 1995b. Telomeres: Beginning to understand the end. Science 270: 1601-1607.