Cdc13 both positively and negatively regulates telomere replication

Genes and Development

Volumn 15, Issue 4, 2001, Pages 404-414

  Chandra, Abha ^a   Hughes, Timothy R ^a,b   Nugent, Constance I ^a,c   Lundblad, Victoria ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ROSETTA INPHARMATICS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cdc13; DNA replication; Stn1; Telomerase; Telomere

Indexed keywords

DNA BINDING PROTEIN; DNA POLYMERASE; TELOMERASE;

ARTICLE; CHROMATIN; DNA REPLICATION; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TELOMERE; YEAST;

EID: 0035115859     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.861001     Document Type: Article

References (44)

1. Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae
2. The function of DNA polymerase α at telomeric G tails is important for telomere homeostasis
3. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
4. Extension of life-span by introduction of telomerase into normal human cells
5. CDC17: An essential gene that prevents telomere elongation in yeast
6. P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
7. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases α and β
8. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase
9. DNA damage and cell cycle regulation of ribonucleotide reductase
10. Est1 and Cdc13 as comediators of telomerase access
11. Positive and negative regulation of telomerase access to the telomere
12. Coordinate regulation of G- and C-strand length during new telomere synthesis
13. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
14. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
15. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13
16. Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment
17. Yeast Ku as a regulator of chromosomal DNA end structure
18. Telomere length regulation
19. Mammalian telomeres end in a large duplex loop
20. Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae
21. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
22. The Est3 protein is a subunit of yeast telomerase
23. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
24. Essential role of mouse telomerase in highly proliferative organs
25. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
26. 1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
27. Telomerase and DNA end replication: No longer a lagging strand problem?
28. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
29. -senescence
30. A mutant with a defect in telomere elongation leads to senescence in yeast
31. Cell cycle restriction of telomere elongation
32. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
33. Cdc13 delivers separate complexes to the telomere for end protection and replication
34. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
35. Synthesis of the telomeric C-strand: A review
36. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein
37. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae
38. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
39. Control of human telomere length by TRF1 and TRF2
40. TRF2 protects human telomeres from end-to-end fusions
41. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint
42. 1-3 tails late in S phase
43. Evidence for a new step in telomere maintenance