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Volumn 7, Issue 9, 2007, Pages 865-878

Carbonic anhydrase inhibitors and the management of cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DENDRITIC CELL VACCINE; DICLOFENAMIDE; DOXORUBICIN; ETHOXZOLAMIDE; FLUORESCEIN; FLUORESCEIN ISOTHIOCYANATE; IDIOTYPIC ANTIBODY; METHAZOLAMIDE; MONOCLONAL ANTIBODY G250; SULFANILAMIDE DERIVATIVE; SULFONAMIDE; THIOUREIDOHOMOSULFANILAMIDE; UNCLASSIFIED DRUG;

EID: 34249670767     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607780636708     Document Type: Review
Times cited : (57)

References (176)
  • 1
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumour growth
    • Harris, A. L. Hypoxia - a key regulatory factor in tumour growth. Nat. Rev. Cancer 2002, 2, 38-47.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 2
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumor acidity and implications for treatment
    • Stubbs, M.; McSheehy, P. M. J.; Griffiths, J. R.; Bashford, C. L. Causes and consequences of tumor acidity and implications for treatment. Mol. Med. Today 2000, 6, 15-19.
    • (2000) Mol. Med. Today , vol.6 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.M.J.2    Griffiths, J.R.3    Bashford, C.L.4
  • 4
    • 2442579987 scopus 로고    scopus 로고
    • Carbonic anhydrases: Catalytic mechanisms, distribution and physiological roles
    • C. T. Supuran; A. Scozzafava; J. Conway Eds, CRC Press Boca Raton-London-New York-Washington D.C
    • Supuran, C. T. Carbonic anhydrases: Catalytic mechanisms, distribution and physiological roles. In: Carbonic Anhydrase: Its Inhibitors and Activators. C. T. Supuran; A. Scozzafava; J. Conway (Eds), 2004, pp. 1-24, CRC Press Boca Raton-London-New York-Washington D.C.
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 1-24
    • Supuran, C.T.1
  • 5
    • 3442883664 scopus 로고    scopus 로고
    • Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects
    • Pastorekova, S.; Parkkila, S.; Pastorek, J.; Supuran, C. T. Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects. J. Enz. Inhib. Med. Chem. 2004, 19, 199-229.
    • (2004) J. Enz. Inhib. Med. Chem , vol.19 , pp. 199-229
    • Pastorekova, S.1    Parkkila, S.2    Pastorek, J.3    Supuran, C.T.4
  • 6
    • 14844356668 scopus 로고    scopus 로고
    • Carbonic anhydrase-related proteins
    • C. T. Supuran; A. Scozzafava; J. Conway Eds, CRC Press Boca Raton-London-New York-Washington D.C
    • Nishimori, I. Acatalytic CAs: Carbonic anhydrase-related proteins. In: Carbonic Anhydrase: Its Inhibitors and Activators. C. T. Supuran; A. Scozzafava; J. Conway (Eds). 2004, pp. 25-44, CRC Press Boca Raton-London-New York-Washington D.C.
    • (2004) Carbonic Anhydrase: Its Inhibitors and Activators , pp. 25-44
    • Nishimori, I.1    Acatalytic, C.A.2
  • 9
    • 0034788480 scopus 로고    scopus 로고
    • Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors
    • Kivela, A. J.; Saarnio, J.; Karttunen, T. J.; Kivela, J.; Parkkila, A. K.; Pastorekova, S.; Pastorek, J.; Waheed, A.; Sly, W. S.; Parkkila, T. S.; Rajaniemi, H. Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. Dig. Dis. Sci. 2001, 46, 2179-2186.
    • (2001) Dig. Dis. Sci , vol.46 , pp. 2179-2186
    • Kivela, A.J.1    Saarnio, J.2    Karttunen, T.J.3    Kivela, J.4    Parkkila, A.K.5    Pastorekova, S.6    Pastorek, J.7    Waheed, A.8    Sly, W.S.9    Parkkila, T.S.10    Rajaniemi, H.11
  • 10
    • 0037114365 scopus 로고    scopus 로고
    • The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer
    • Chiang, W. L.; Chu, S. C.; Yang, S. S.; Li, M. C.; Lai, J. C.; Yang, S. F.; Chiou, H. L.; Hsieh, Y. S. The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer. Cancer Lett. 2002, 188, 199-205.
    • (2002) Cancer Lett , vol.188 , pp. 199-205
    • Chiang, W.L.1    Chu, S.C.2    Yang, S.S.3    Li, M.C.4    Lai, J.C.5    Yang, S.F.6    Chiou, H.L.7    Hsieh, Y.S.8
  • 11
    • 0042090407 scopus 로고    scopus 로고
    • The differential expression of cytosolic carbonic anhydrase in human hepatocellular carcinoma
    • Kuo, W. H.; Chiang, W. L.; Yang, S. F.; Yeh, K. T.; Yeh, C. M.; Hsieh, Y. S.; Chu, S. C. The differential expression of cytosolic carbonic anhydrase in human hepatocellular carcinoma. Life Sci. 2003, 73, 2211-2223.
    • (2003) Life Sci , vol.73 , pp. 2211-2223
    • Kuo, W.H.1    Chiang, W.L.2    Yang, S.F.3    Yeh, K.T.4    Yeh, C.M.5    Hsieh, Y.S.6    Chu, S.C.7
  • 14
    • 0141626705 scopus 로고    scopus 로고
    • Overexpression of carbonic anhydrase-related protein VIII in human colorectal cancer
    • Miyaji, E.; Nishimori, I.; Taniuchi, K.; Takeuchi, T.; Ohtsuki, Y.; Onishi, S. Overexpression of carbonic anhydrase-related protein VIII in human colorectal cancer. J. Pathol. 2003, 201, 37-45.
    • (2003) J. Pathol , vol.201 , pp. 37-45
    • Miyaji, E.1    Nishimori, I.2    Taniuchi, K.3    Takeuchi, T.4    Ohtsuki, Y.5    Onishi, S.6
  • 18
    • 0027981949 scopus 로고
    • Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas
    • Liao, S. Y.; Brewer, C.; Zavada, J.; Pastorek, J.; Pastorekova, S.; Manetta, A.; Berman, M. L.; DiSaia, P. J.; Stanbridge, E. J. Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. Am. J. Pathol. 1994, 145, 598-609.
    • (1994) Am. J. Pathol , vol.145 , pp. 598-609
    • Liao, S.Y.1    Brewer, C.2    Zavada, J.3    Pastorek, J.4    Pastorekova, S.5    Manetta, A.6    Berman, M.L.7    DiSaia, P.J.8    Stanbridge, E.J.9
  • 21
    • 0030076314 scopus 로고    scopus 로고
    • Functional diversity, consrevation and convergence in the evolution of the alpha, beta and gamma carbonic anhydrase gene families
    • Hewett-Emmett, D.; Tashian, R.E. Functional diversity, consrevation and convergence in the evolution of the alpha, beta and gamma carbonic anhydrase gene families. Mol. Phyl. Evol. 1996, 5, 50-77.
    • (1996) Mol. Phyl. Evol , vol.5 , pp. 50-77
    • Hewett-Emmett, D.1    Tashian, R.E.2
  • 22
    • 0034024783 scopus 로고
    • Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion
    • Zavada, J.; Zavadova, Z.; Pastorek, J.; Biesova, Z.; Jezek, K.; Velek, J. Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion. Br. J. Cancer 2000, 82, 1808-1813.
    • (1808) Br. J. Cancer , vol.2000 , pp. 82
    • Zavada, J.1    Zavadova, Z.2    Pastorek, J.3    Biesova, Z.4    Jezek, K.5    Velek, J.6
  • 23
    • 0142121458 scopus 로고    scopus 로고
    • Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin. Exp
    • Svastova, E.; Zilka, N.; Zatovicova, M.; Gibadulinova, A.; Ciampor, F.; Pastorek, J.; Pastorekova, S. Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin. Exp. Cell Res. 2003, 290, 332-345
    • (2003) Cell Res , vol.290 , pp. 332-345
    • Svastova, E.1    Zilka, N.2    Zatovicova, M.3    Gibadulinova, A.4    Ciampor, F.5    Pastorek, J.6    Pastorekova, S.7
  • 24
    • 0026754494 scopus 로고
    • A human transmembrane protein-tyrosinephosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases
    • Krueger, N.X.; Saito, H. A human transmembrane protein-tyrosinephosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc. Natl. Acad. Sci. USA 1992, 89, 7417-7421.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7417-7421
    • Krueger, N.X.1    Saito, H.2
  • 25
    • 0028235153 scopus 로고
    • Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin
    • Barnea, G.; Grumet, M.; Milev, P.; Silvennoinen, O.; Levy, J. B.; Sap, J.; Schlessinger, J. Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin. J. Biol. Chem. 1994, 269, 14349-14352
    • (1994) J. Biol. Chem , vol.269 , pp. 14349-14352
    • Barnea, G.1    Grumet, M.2    Milev, P.3    Silvennoinen, O.4    Levy, J.B.5    Sap, J.6    Schlessinger, J.7
  • 26
    • 28244451574 scopus 로고    scopus 로고
    • Biological significance of overexpression of carbonic anhydrase IX in renal cell carcinoma: EGF-induced phosphorylation of carbonic anhydrase IX leads to activation of PI-3-kinase pathway in renal cell carcinoma
    • Dorai, T.; Sawczuk, I. S.; Pastorek, J.; Wiernik, P. H.; Dutcher, J. P. Biological significance of overexpression of carbonic anhydrase IX in renal cell carcinoma: EGF-induced phosphorylation of carbonic anhydrase IX leads to activation of PI-3-kinase pathway in renal cell carcinoma. Eur. J. Cancer 2005, 41, 2935-2947.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2935-2947
    • Dorai, T.1    Sawczuk, I.S.2    Pastorek, J.3    Wiernik, P.H.4    Dutcher, J.P.5
  • 27
    • 0031040821 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementery DNA sequence and expression in human and rat alimentary tracts
    • Pastorekova, S.; Parkkila, S.; Parkkila, A. K.; Opavsky, R.; Zelnik, V.; Saarnio, J.; Pastorek, J. Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementery DNA sequence and expression in human and rat alimentary tracts. Gastroenterology 1997, 112, 398-408.
    • (1997) Gastroenterology , vol.112 , pp. 398-408
    • Pastorekova, S.1    Parkkila, S.2    Parkkila, A.K.3    Opavsky, R.4    Zelnik, V.5    Saarnio, J.6    Pastorek, J.7
  • 31
    • 0034944417 scopus 로고    scopus 로고
    • Karhumaa, P.; Kaunisto, K.; Parkkila, S.; Waheed, A.; Pastorekova, S.; Pastorek, J.; Sly, W. S.; Rajaniemi, H. Expression of the transmembrane Carbonic Anhydrase Inhibitors and the Management of Cancer Current Topics in Medicinal Chemistry, 2007, 7, No. 9 875 carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts. Mol. Hum. Reprod. 2001, 7, 611-616.
    • Karhumaa, P.; Kaunisto, K.; Parkkila, S.; Waheed, A.; Pastorekova, S.; Pastorek, J.; Sly, W. S.; Rajaniemi, H. Expression of the transmembrane Carbonic Anhydrase Inhibitors and the Management of Cancer Current Topics in Medicinal Chemistry, 2007, Vol. 7, No. 9 875 carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts. Mol. Hum. Reprod. 2001, 7, 611-616.
  • 32
    • 0030835515 scopus 로고    scopus 로고
    • Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney
    • Liao, S. Y.; Aurelio, O. N.; Jan, K.; Zavada, J.; Stanbridge, E. J. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res. 1997, 57, 2827-2831.
    • (1997) Cancer Res , vol.57 , pp. 2827-2831
    • Liao, S.Y.1    Aurelio, O.N.2    Jan, K.3    Zavada, J.4    Stanbridge, E.J.5
  • 34
    • 0030972193 scopus 로고    scopus 로고
    • MN antigen expression in normal, preneoplastic and neoplastic esophagus: A clinicopathological study of a new cancer-associated biomarker
    • Turner, J. R.; Odze, R. D.; Crum, C. P.; Resnick, M. B. MN antigen expression in normal, preneoplastic and neoplastic esophagus: A clinicopathological study of a new cancer-associated biomarker. Hum. Pathol. 1997, 28, 740-744.
    • (1997) Hum. Pathol , vol.28 , pp. 740-744
    • Turner, J.R.1    Odze, R.D.2    Crum, C.P.3    Resnick, M.B.4
  • 35
    • 0032755017 scopus 로고    scopus 로고
    • Carbonic anhydrase IX antigen differentiates between preneoplastic and malignant lesions in non-small cell lung carcinomas
    • Vermylen, P.; Roufosse, C.; Burny, A.; Verhest, A.; Bossehaerts, T.; Pastorekova, S.; Ninane, V.; Sculier, J. P. Carbonic anhydrase IX antigen differentiates between preneoplastic and malignant lesions in non-small cell lung carcinomas. Eur. Respir. J. 1999, 14, 806-811.
    • (1999) Eur. Respir. J , vol.14 , pp. 806-811
    • Vermylen, P.1    Roufosse, C.2    Burny, A.3    Verhest, A.4    Bossehaerts, T.5    Pastorekova, S.6    Ninane, V.7    Sculier, J.P.8
  • 37
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio, J.; Parkkila, S.; Parkkila, A. K.; Haukipuro, K.; Pastorekova, S.; Pastorek, J.; Kairaluoma, M. I., Karttunen, T. J. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am. J. Pathol. 1998, 153, 279-285.
    • (1998) Am. J. Pathol , vol.153 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3    Haukipuro, K.4    Pastorekova, S.5    Pastorek, J.6    Kairaluoma, M.I.7    Karttunen, T.J.8
  • 40
    • 0032731194 scopus 로고    scopus 로고
    • Transcriptional regulation of the MN/CA9 gene coding for the tumor-associated carbonic anhydrase IX. Identification and characterization of a proximal silencer element
    • Kaluz, S.; Kaluzova, M.; Opavsky, R.; Pastorekova, S.; Gibadulinova, A.; Dequiedt, F.; Kettmann, R.; Pastorek, J. Transcriptional regulation of the MN/CA9 gene coding for the tumor-associated carbonic anhydrase IX. Identification and characterization of a proximal silencer element. J. Biol. Chem. 1999, 274, 32588-32595.
    • (1999) J. Biol. Chem , vol.274 , pp. 32588-32595
    • Kaluz, S.1    Kaluzova, M.2    Opavsky, R.3    Pastorekova, S.4    Gibadulinova, A.5    Dequiedt, F.6    Kettmann, R.7    Pastorek, J.8
  • 45
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon, P. C.; Hirota, K.; Semenza, G. L. FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001, 15, 2675-2686.
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 46
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza, G. L. Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 2002, 64, 993-998.
    • (2002) Biochem. Pharmacol , vol.64 , pp. 993-998
    • Semenza, G.L.1
  • 47
    • 1542344522 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 and oncogenic signaling
    • Bardos, J.; Ashcroft, M. Hypoxia-inducible factor-1 and oncogenic signaling. BioEssays 2004, 26, 262-269.
    • (2004) BioEssays , vol.26 , pp. 262-269
    • Bardos, J.1    Ashcroft, M.2
  • 48
    • 0035012605 scopus 로고    scopus 로고
    • HER2(neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner, E.; Taghavi, P.; Chiles, K.; Mahon, P. C.; Semenza, G. L. HER2(neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell Biol. 2001, 21, 3995-4004.
    • (2001) Mol. Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 49
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
    • Richard, D. E.; Berra, E.; Gothie, E.; Roux, D.; Pouyssegur, J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 1999, 274, 32631-32637.
    • (1999) J. Biol. Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 50
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 51
    • 0037374179 scopus 로고    scopus 로고
    • Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer
    • Kaluz, S.; Kaluzova, M.; Stanbridge, E. J. Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. Cancer Res. 2003, 63, 917-922.
    • (2003) Cancer Res , vol.63 , pp. 917-922
    • Kaluz, S.1    Kaluzova, M.2    Stanbridge, E.J.3
  • 52
    • 0036682009 scopus 로고    scopus 로고
    • Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization : A role for phosphatidylinositol 3′-kinase
    • Kaluz, S.; Kaluzova, M.; Chrastina, A.; Olive, P. L.; Pastorekova, S.; Pastorek, J.; Lerman, M. I.; Stanbridge, E. J. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization : A role for phosphatidylinositol 3′-kinase. Cancer Res. 2002, 62, 4469-4477.
    • (2002) Cancer Res , vol.62 , pp. 4469-4477
    • Kaluz, S.1    Kaluzova, M.2    Chrastina, A.3    Olive, P.L.4    Pastorekova, S.5    Pastorek, J.6    Lerman, M.I.7    Stanbridge, E.J.8
  • 55
    • 0033565672 scopus 로고
    • The von Hippel-Lindau tumor suppressor is a component of a E3 ubiquitin-protein ligase activity
    • Lisztwan, J.; Imbert, G.; Wirbelauer, C.; Gstaiger, M.; Krek, W. The von Hippel-Lindau tumor suppressor is a component of a E3 ubiquitin-protein ligase activity. Genes Dev. 1999, 13, 1822-1833
    • (1822) Genes Dev , vol.1999 , pp. 13
    • Lisztwan, J.1    Imbert, G.2    Wirbelauer, C.3    Gstaiger, M.4    Krek, W.5
  • 57
    • 33846562017 scopus 로고    scopus 로고
    • Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia
    • Ihnatko, R.; Kubes, M.; Takacova, M.; Sedlakova, O.; Sedlak, J.; Pastorek, J.; Kopacek, J.; Pastorekova, S. Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Int. J. Oncol. 2006, 29, 1925-1033.
    • (2006) Int. J. Oncol , vol.29 , pp. 1925-1033
    • Ihnatko, R.1    Kubes, M.2    Takacova, M.3    Sedlakova, O.4    Sedlak, J.5    Pastorek, J.6    Kopacek, J.7    Pastorekova, S.8
  • 58
    • 0036032329 scopus 로고    scopus 로고
    • Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma
    • Ashida, S.; Nishimori, I.; Tanimura, M.; Onishi, S.; Shuin, T. Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma. J. Cancer Res. Clin. Oncol. 2002, 128, 561-568.
    • (2002) J. Cancer Res. Clin. Oncol , vol.128 , pp. 561-568
    • Ashida, S.1    Nishimori, I.2    Tanimura, M.3    Onishi, S.4    Shuin, T.5
  • 59
    • 22844444398 scopus 로고    scopus 로고
    • Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines
    • Jakubickova, L.; Biesova, Z.; Pastorekova, S.; Kettmann, R.; Pastorek, J. Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines. Int. J. Oncol. 2005, 26, 1121-1127.
    • (2005) Int. J. Oncol , vol.26 , pp. 1121-1127
    • Jakubickova, L.1    Biesova, Z.2    Pastorekova, S.3    Kettmann, R.4    Pastorek, J.5
  • 60
    • 1842852597 scopus 로고    scopus 로고
    • Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells
    • Rafajova, M.; Zatovicova, M.; Kettmann, R.; Pastorek, J.; Pastorekova, S. Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int. J. Oncol. 2004, 24, 995-1004.
    • (2004) Int. J. Oncol , vol.24 , pp. 995-1004
    • Rafajova, M.1    Zatovicova, M.2    Kettmann, R.3    Pastorek, J.4    Pastorekova, S.5
  • 61
    • 0141887319 scopus 로고    scopus 로고
    • Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
    • Zavada, J.; Zavadova, Z.; Zatovicova, M.; Hyrsl, L.; Kawaciuk, I. Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br. J. Cancer 2003, 89, 1067-1071.
    • (2003) Br. J. Cancer , vol.89 , pp. 1067-1071
    • Zavada, J.1    Zavadova, Z.2    Zatovicova, M.3    Hyrsl, L.4    Kawaciuk, I.5
  • 62
    • 27944500753 scopus 로고    scopus 로고
    • Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
    • Zatovicova, M.; Sedlakova, O.; Svastova, E.; Ohradanova, A.; Ciampor, F.; Arribas, J.; Pastorek, J.; Pastorekova, S. Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17. Br. J. Cancer 2005, 93, 1267-1276
    • (2005) Br. J. Cancer , vol.93 , pp. 1267-1276
    • Zatovicova, M.1    Sedlakova, O.2    Svastova, E.3    Ohradanova, A.4    Ciampor, F.5    Arribas, J.6    Pastorek, J.7    Pastorekova, S.8
  • 64
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov, S. V.; Kuzmin, I.; Wei, M. H.; Pack, S.; Geil, L.; Johnson, B. E., Stanbridge, E. J.; Lerman, M. I. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl. Acad. Sci. USA 1998, 95, 12596-12601.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12596-12601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6    Stanbridge, E.J.7    Lerman, M.I.8
  • 69
    • 0037374846 scopus 로고    scopus 로고
    • Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: Overexpression of CA12 (CAXII) in glaucoma
    • Liao, S. Y.; Ivanov, S.; Ivanova, A.; Ghosh, S.; Cote, M. A.; Keefe, K.; Coca-Prados, M.; Stanbridge, E. J.; Lerman, M. I. Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: Overexpression of CA12 (CAXII) in glaucoma. J. Med. Genet. 2003, 40, 257-261.
    • (2003) J. Med. Genet , vol.40 , pp. 257-261
    • Liao, S.Y.1    Ivanov, S.2    Ivanova, A.3    Ghosh, S.4    Cote, M.A.5    Keefe, K.6    Coca-Prados, M.7    Stanbridge, E.J.8    Lerman, M.I.9
  • 71
    • 0035859892 scopus 로고    scopus 로고
    • Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
    • Whittington, D. A.; Waheed, A.; Ulmasov, B.; Shah, G. N.; Grubb, J. H.; Sly, W. S.; Christianson, D. W. Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proc. Natl. Acad. Sci. USA 2001, 98, 9545-9550.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9545-9550
    • Whittington, D.A.1    Waheed, A.2    Ulmasov, B.3    Shah, G.N.4    Grubb, J.H.5    Sly, W.S.6    Christianson, D.W.7
  • 73
    • 0034687801 scopus 로고    scopus 로고
    • Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers
    • Ulmasov, B.; Waheed, A.; Shah, G. N.; Grubb, J. H.; Sly, W. S.; Tu, C.; Silverman, D. N. Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers. Proc. Natl. Acad. Sci. USA 2000, 97, 14212-14217.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14212-14217
    • Ulmasov, B.1    Waheed, A.2    Shah, G.N.3    Grubb, J.H.4    Sly, W.S.5    Tu, C.6    Silverman, D.N.7
  • 74
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger, G.; Yuan, F.; Dellian, M.; Jain, R. K. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation. Nat. Med. 1997, 3, 177-182.
    • (1997) Nat. Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 75
    • 0035930581 scopus 로고    scopus 로고
    • A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers
    • Sterling, D.; Reithmeier, R. A.; Casey, J. R. A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. J. Biol. Chem. 2001, 276, 47886-47894
    • (2001) J. Biol. Chem , vol.276 , pp. 47886-47894
    • Sterling, D.1    Reithmeier, R.A.2    Casey, J.R.3
  • 77
    • 0142095047 scopus 로고    scopus 로고
    • Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter
    • Alvarez, B. V.; Loiselle, F. B.; Supuran, C. T.; Schwartz, G. J.; Casey, J. R. Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Biochemistry 2003, 42, 12321-12329.
    • (2003) Biochemistry , vol.42 , pp. 12321-12329
    • Alvarez, B.V.1    Loiselle, F.B.2    Supuran, C.T.3    Schwartz, G.J.4    Casey, J.R.5
  • 78
    • 0034625056 scopus 로고    scopus 로고
    • Identification of the carbonic anhydrase II binding site in the Cl-/HCO3- anion exchanger AE1
    • Vince, J. W.; Reithmeier, R. A. Identification of the carbonic anhydrase II binding site in the Cl-/HCO3- anion exchanger AE1. Biochemistry 2000, 39, 5527-5533.
    • (2000) Biochemistry , vol.39 , pp. 5527-5533
    • Vince, J.W.1    Reithmeier, R.A.2
  • 79
    • 0037156347 scopus 로고    scopus 로고
    • Carbonic anhydrase activators: Hunam isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1
    • Scozzafava, A.; Supuran, C. T. Carbonic anhydrase activators: Hunam isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1. Bioorg. Med. Chem. Lett. 2002, 12, 1177-1180.
    • (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 1177-1180
    • Scozzafava, A.1    Supuran, C.T.2
  • 80
    • 0035795336 scopus 로고    scopus 로고
    • VHL tumor suppressor regulates CL-/HCO3+ exchange and Na+/H+ exchange activities in renal carcinoma cells. Physiol
    • Karumanchi, S. A.; Jiang, L.; Knebelmann, B.; Stuart-Tilley, A. K.; Alper, S. L.; Sukhatme, V. P. VHL tumor suppressor regulates CL-/HCO3+ exchange and Na+/H+ exchange activities in renal carcinoma cells. Physiol. Genomics 2001, 5, 119-128.
    • (2001) Genomics , vol.5 , pp. 119-128
    • Karumanchi, S.A.1    Jiang, L.2    Knebelmann, B.3    Stuart-Tilley, A.K.4    Alper, S.L.5    Sukhatme, V.P.6
  • 81
    • 33748044898 scopus 로고    scopus 로고
    • Functional and physical interaction between bicarbonate transport proteins and the transmembrane carbonic anhydrase, CA IX. XXV
    • March 31-April 5, San Diego, CA, Abstract No 366.5
    • Morgan, P. E.; Pastorekova, S.; Casey, J. R. Functional and physical interaction between bicarbonate transport proteins and the transmembrane carbonic anhydrase, CA IX. XXV. International Congress of Physiological Sciences, March 31-April 5 2005, San Diego, CA, Abstract No 366.5
    • (2005) International Congress of Physiological Sciences
    • Morgan, P.E.1    Pastorekova, S.2    Casey, J.R.3
  • 83
    • 4344699403 scopus 로고    scopus 로고
    • Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion
    • Robertson, N.; Potter, C.; Harris, A. L. Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res. 2004, 64, 6160-6165.
    • (2004) Cancer Res , vol.64 , pp. 6160-6165
    • Robertson, N.1    Potter, C.2    Harris, A.L.3
  • 84
    • 25144484490 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment
    • Zavadova, Z.; Zavada, J. Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment. Oncol. Rep. 2005, 13, 977-82.
    • (2005) Oncol. Rep , vol.13 , pp. 977-982
    • Zavadova, Z.1    Zavada, J.2
  • 85
    • 0032786530 scopus 로고    scopus 로고
    • Regulation of E-cadherin: Does hypoxia initiate the metastatic cascade?
    • Beavon, I. R. G. Regulation of E-cadherin: Does hypoxia initiate the metastatic cascade? J. Clin. Pathol. Mol. Pathol. 1999, 52, 179-188.
    • (1999) J. Clin. Pathol. Mol. Pathol , vol.52 , pp. 179-188
    • Beavon, I.R.G.1
  • 91
    • 0041836180 scopus 로고    scopus 로고
    • Interferons can upregulate the expression of the tumor associated antigen G250-MN/CA IX, a potential target for (radio) immunotherapy of renal cell carcinoma
    • Brouwers, A. H.; Frielink, C.; Oosterwijk, E.; Oyen, W. J.; Corstens, F. H.; Boerman, O. C. Interferons can upregulate the expression of the tumor associated antigen G250-MN/CA IX, a potential target for (radio) immunotherapy of renal cell carcinoma. Cancer Biother. Radiopharm. 2003, 18, 539-547.
    • (2003) Cancer Biother. Radiopharm , vol.18 , pp. 539-547
    • Brouwers, A.H.1    Frielink, C.2    Oosterwijk, E.3    Oyen, W.J.4    Corstens, F.H.5    Boerman, O.C.6
  • 93
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
    • Pantuck, A. J.; Zeng, G.; Belldegrun, A. S.; Figlin, R. A. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway. Clin. Cancer Res. 2003, 9, 4641-4652.
    • (2003) Clin. Cancer Res , vol.9 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 95
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a potential new intrinsic marker of hypoxia: Correlations with tumour oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster, J. A.; Harris, A. L.; Davidson, S. E.; Logue, J. P.; Hunter, R. D.; Wykoff, C. C.; Pastorek, J.; Ratcliffe, P.; Stratford, I. J.; West, C. M. L. Carbonic anhydrase IX expression, a potential new intrinsic marker of hypoxia: Correlations with tumour oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 2001, 61, 6394-6399.
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wykoff, C.C.6    Pastorek, J.7    Ratcliffe, P.8    Stratford, I.J.9    West, C.M.L.10
  • 100
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki, A.; Koukourakis, M. I.; Sivridis, E.; Pastorek, J.; Wykoff, C. C.; Gatter, K. C.; Harris, A. L. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001, 61, 7992-7998.
    • (2001) Cancer Res , vol.61 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Pastorek, J.4    Wykoff, C.C.5    Gatter, K.C.6    Harris, A.L.7
  • 101
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis and microvessel density
    • Beasley, N. J. P.; Wykoff, C. C.; Watson, P. H.; Leek, R.; Turley, H.; Gatter, K.; Pastorek, J.; Cox, G. J.; Ratcliffe, P. J.; Harris, A. L. Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis and microvessel density. Cancer Res. 2001, 61, 5262-5267.
    • (2001) Cancer Res , vol.61 , pp. 5262-5267
    • Beasley, N.J.P.1    Wykoff, C.C.2    Watson, P.H.3    Leek, R.4    Turley, H.5    Gatter, K.6    Pastorek, J.7    Cox, G.J.8    Ratcliffe, P.J.9    Harris, A.L.10
  • 102
    • 25144464638 scopus 로고    scopus 로고
    • Comparison of hypoxia transcriptiome in vitro with in vivo gene expression in human bladder cancer
    • Ord, J. J.; Streeter, E. H.; Roberts, I. S.; Cranston, D.; Harris, A. L. Comparison of hypoxia transcriptiome in vitro with in vivo gene expression in human bladder cancer. Br. J. Cancer 2005, 93, 346-354.
    • (2005) Br. J. Cancer , vol.93 , pp. 346-354
    • Ord, J.J.1    Streeter, E.H.2    Roberts, I.S.3    Cranston, D.4    Harris, A.L.5
  • 104
    • 0036023422 scopus 로고    scopus 로고
    • Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival
    • Hui, E. P.; Chan, A. T.; Pezzella, F.; Turley, H.; To, K. F.; Poon, T. C.; Zee, B.; Mo, F.; Teo, P. M.; Huang, D. P.; Gatter, K. C.; Johnson, P. J.; Harris, A. L. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin. Cancer Res. 2002, 8, 2595-2604.
    • (2002) Clin. Cancer Res , vol.8 , pp. 2595-2604
    • Hui, E.P.1    Chan, A.T.2    Pezzella, F.3    Turley, H.4    To, K.F.5    Poon, T.C.6    Zee, B.7    Mo, F.8    Teo, P.M.9    Huang, D.P.10    Gatter, K.C.11    Johnson, P.J.12    Harris, A.L.13
  • 105
    • 0242298213 scopus 로고    scopus 로고
    • GLUT1 and CA IX as intrinsic markers of hypoxia in bladder cancer: Relationship with vascularity and proliferation as predictors of outcome of ARCON
    • Hoskin, P. J.; Sibtain, A.; Daley, F. M.; Wilson, G. D. GLUT1 and CA IX as intrinsic markers of hypoxia in bladder cancer: Relationship with vascularity and proliferation as predictors of outcome of ARCON. Br. J. Cancer 2003, 89, 1290-1297.
    • (2003) Br. J. Cancer , vol.89 , pp. 1290-1297
    • Hoskin, P.J.1    Sibtain, A.2    Daley, F.M.3    Wilson, G.D.4
  • 106
    • 3042816190 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
    • Swinson, D. E.; Jones, J. L.; Cox, G.; Richardson, D.; Harris, A. L.; O'Byrne, K. J. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways. Int. J. Cancer 2004, 111, 43-50.
    • (2004) Int. J. Cancer , vol.111 , pp. 43-50
    • Swinson, D.E.1    Jones, J.L.2    Cox, G.3    Richardson, D.4    Harris, A.L.5    O'Byrne, K.J.6
  • 107
    • 19944429962 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix
    • Hutchison, G. J.; Valentine, H. R.; Loncaster, J. A.; Davidson, S. E.; Hunter, R. D.; Roberts, S. A.; Harris, A. L.; Stratford, I. J.; Price, P. M.; West, C. M. Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix. Clin. Cancer Res. 2004, 10, 8405-8412.
    • (2004) Clin. Cancer Res , vol.10 , pp. 8405-8412
    • Hutchison, G.J.1    Valentine, H.R.2    Loncaster, J.A.3    Davidson, S.E.4    Hunter, R.D.5    Roberts, S.A.6    Harris, A.L.7    Stratford, I.J.8    Price, P.M.9    West, C.M.10
  • 109
    • 26844468059 scopus 로고    scopus 로고
    • The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/- chemotherapy
    • De Schutter, H.; Landuyt, W.; Verbeken, E.; Goethals, L.; Hermans, R.; Nuyts, S. The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/- chemotherapy. BMC Cancer 2005, 5, 42.
    • (2005) BMC Cancer , vol.5 , pp. 42
    • De Schutter, H.1    Landuyt, W.2    Verbeken, E.3    Goethals, L.4    Hermans, R.5    Nuyts, S.6
  • 112
    • 14844288340 scopus 로고    scopus 로고
    • Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells
    • Vordermark, D.; Kaffer, A.; Riedl, S.; Katzer, A.; Flentje, M. Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells. Int. J. Radiat. Oncol. Biol. Phys. 2005, 61, 1197-1207.
    • (2005) Int. J. Radiat. Oncol. Biol. Phys , vol.61 , pp. 1197-1207
    • Vordermark, D.1    Kaffer, A.2    Riedl, S.3    Katzer, A.4    Flentje, M.5
  • 113
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura, D.; Xu, L.; Chen, Y.; Gohongi, T.; Seed, B.; Jain, R. K. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res. 2001, 61, 6020-6024.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 114
    • 0038509263 scopus 로고    scopus 로고
    • Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition
    • Colpaert, C. G.; Vermeulen, P. B.; Van Beest, P.; Soubry, A.; Goovaerts, G.; Dirix, L. Y.; Harris, A. L.; Van Marck, E. A. Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition. Histopathology 2003, 42, 530-540.
    • (2003) Histopathology , vol.42 , pp. 530-540
    • Colpaert, C.G.1    Vermeulen, P.B.2    Van Beest, P.3    Soubry, A.4    Goovaerts, G.5    Dirix, L.Y.6    Harris, A.L.7    Van Marck, E.A.8
  • 115
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome
    • Span, P. N.; Bussink, J.; Manders, P.; Beex, L. V.; Sweep, C. G. Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome. Br. J. Cancer 2003, 89, 271-276.
    • (2003) Br. J. Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 116
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson, D. E.; Jones, J. L.; Richardson, D.; Wykoff, C.; Turley, H.; Pastorek, J.; Taub, N.; Harris, A. L.; O'Byrne, K. J. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J. Clin. Oncol. 2003, 21, 473-482.
    • (2003) J. Clin. Oncol , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3    Wykoff, C.4    Turley, H.5    Pastorek, J.6    Taub, N.7    Harris, A.L.8    O'Byrne, K.J.9
  • 118
    • 0035181306 scopus 로고    scopus 로고
    • Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy
    • Koukourakis, M. I.; Giatromanolaki, A.; Sivridis, E.; Simopoulos, K.; Pastorek, J.; Wykoff, C. C.; Gatter, K. C.; Harris, A. L. Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy. Clin. Cancer Res. 2001, 7, 3399-3403.
    • (2001) Clin. Cancer Res , vol.7 , pp. 3399-3403
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Simopoulos, K.4    Pastorek, J.5    Wykoff, C.C.6    Gatter, K.C.7    Harris, A.L.8
  • 124
    • 0029760316 scopus 로고    scopus 로고
    • Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma
    • Luiten, R. M.; Coney, L. R.; Fleuren, G. J.; Warnaar, S. O.; Litvinov, S. V. Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma. Brit. J. Cancer 1996, 74, 735-744.
    • (1996) Brit. J. Cancer , vol.74 , pp. 735-744
    • Luiten, R.M.1    Coney, L.R.2    Fleuren, G.J.3    Warnaar, S.O.4    Litvinov, S.V.5
  • 126
    • 0033119192 scopus 로고    scopus 로고
    • Intratumoral distribution of two consecutive injections of chimeric antibody G250 in primary renal cell carcinoma: Implications for fractionated dose radioimmunotherapy
    • Steffens, M. G.; Boerman, O. C.; Oyen, W. J.; Kniest, P. H.; Witjes, J. A.; Oosterhof, G. O.; van Leenders, G. J.; Debruyne, F. M.; Corstens, F. H.; Oosterwijk, E. Intratumoral distribution of two consecutive injections of chimeric antibody G250 in primary renal cell carcinoma: Implications for fractionated dose radioimmunotherapy. Cancer Res. 1999, 59, 1615-1619.
    • (1999) Cancer Res , vol.59 , pp. 1615-1619
    • Steffens, M.G.1    Boerman, O.C.2    Oyen, W.J.3    Kniest, P.H.4    Witjes, J.A.5    Oosterhof, G.O.6    van Leenders, G.J.7    Debruyne, F.M.8    Corstens, F.H.9    Oosterwijk, E.10
  • 127
    • 0033230634 scopus 로고    scopus 로고
    • The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytes
    • Vissers, J. L.; De Vries, I. J.; Schreurs, M. W.; Engelen, L. P.; Oosterwijk, E.; Figdor, C. G.; Adema, G. J. The renal cell carcinoma-associated antigen G250 encodes a human leukocyte antigen (HLA)-A2.1-restricted epitope recognized by cytotoxic T lymphocytes. Cancer Res. 1999, 59, 5554-5559.
    • (1999) Cancer Res , vol.59 , pp. 5554-5559
    • Vissers, J.L.1    De Vries, I.J.2    Schreurs, M.W.3    Engelen, L.P.4    Oosterwijk, E.5    Figdor, C.G.6    Adema, G.J.7
  • 128
    • 0028347450 scopus 로고
    • Internal image anti-idiotype antibodies related to renal-cell carcinoma-associated antigen G250
    • Uemura, H.; Okajima, E.; Debruyne, F. M. J.; Oosterwijk, E. Internal image anti-idiotype antibodies related to renal-cell carcinoma-associated antigen G250. Int. J. Cancer 1994, 56, 609-614.
    • (1994) Int. J. Cancer , vol.56 , pp. 609-614
    • Uemura, H.1    Okajima, E.2    Debruyne, F.M.J.3    Oosterwijk, E.4
  • 129
    • 0027981347 scopus 로고
    • Vaccination with anti-idiotype antibodies mimicking a renal cell carcinoma-associated antigen induces tumor immunity
    • Uemura, H.; Beniers, A. J.; Okajima, E.; Debruyne, F. M. J.; Oosterwijk, E. Vaccination with anti-idiotype antibodies mimicking a renal cell carcinoma-associated antigen induces tumor immunity. Int. J. Cancer 1994, 58, 555-561.
    • (1994) Int. J. Cancer , vol.58 , pp. 555-561
    • Uemura, H.1    Beniers, A.J.2    Okajima, E.3    Debruyne, F.M.J.4    Oosterwijk, E.5
  • 130
    • 58149365060 scopus 로고
    • Anti-tumor effect induced by vaccination with anti-idiotype antibodies in 7 mice with established human renal cell carcinoma xenografts
    • Uemura, H.; Okajima, E.; Debruyne, F. M. J.; Oosterwijk, E. Anti-tumor effect induced by vaccination with anti-idiotype antibodies in 7 mice with established human renal cell carcinoma xenografts. Urol. Oncol. 1995, 1, 73-79.
    • (1995) Urol. Oncol , vol.1 , pp. 73-79
    • Uemura, H.1    Okajima, E.2    Debruyne, F.M.J.3    Oosterwijk, E.4
  • 131
    • 0030014521 scopus 로고    scopus 로고
    • Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle their lytic capacity
    • Weijtens, M. E. M.; Willemsen, R. A.; Valerio, D.; Stam, K.; Bolhus, R. L. H. Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle their lytic capacity. J. Immunol. 1996, 157, 836-843
    • (1996) J. Immunol , vol.157 , pp. 836-843
    • Weijtens, M.E.M.1    Willemsen, R.A.2    Valerio, D.3    Stam, K.4    Bolhus, R.L.H.5
  • 132
    • 0043128070 scopus 로고    scopus 로고
    • Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accesory molecules
    • Weijtens, M. E.; Willemsen, R. A.; van-Krimpen, B. A.; Bolhuis, R. L. Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accesory molecules. Int. J. Cancer 1998, 77, 181-187.
    • (1998) Int. J. Cancer , vol.77 , pp. 181-187
    • Weijtens, M.E.1    Willemsen, R.A.2    van-Krimpen, B.A.3    Bolhuis, R.L.4
  • 134
    • 0034018870 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and their therapeutic potential
    • Supuran, C. T.; Scozzafava, A. Carbonic anhydrase inhibitors and their therapeutic potential. Expert Opin. Ther. Patents 2000, 10, 575-600.
    • (2000) Expert Opin. Ther. Patents , vol.10 , pp. 575-600
    • Supuran, C.T.1    Scozzafava, A.2
  • 136
    • 2542592581 scopus 로고    scopus 로고
    • Modulation of carbonic anhydrase activity and its applications in therapy
    • Scozzafava, A.; Mastrolorenzo, A.; Supuran, C. T. Modulation of carbonic anhydrase activity and its applications in therapy. Expert Opin. Ther. Patents 2004, 14, 667-702
    • (2004) Expert Opin. Ther. Patents , vol.14 , pp. 667-702
    • Scozzafava, A.1    Mastrolorenzo, A.2    Supuran, C.T.3
  • 137
    • 0037463790 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
    • Vullo, D.; Franchi, M.; Gallori, E.; Pastorek, J.; Scozzafava, A.; Pastorekova, S.; Supuran, C.T. Carbonic anhydrase inhibitors. Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 2003, 13, 1005-1009.
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , pp. 1005-1009
    • Vullo, D.1    Franchi, M.2    Gallori, E.3    Pastorek, J.4    Scozzafava, A.5    Pastorekova, S.6    Supuran, C.T.7
  • 138
    • 2442428176 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: The first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides
    • Jaiswal, M.; Khadikar, P. V.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: The first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 2004, 14, 3283-90.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 3283-3290
    • Jaiswal, M.1    Khadikar, P.V.2    Scozzafava, A.3    Supuran, C.T.4
  • 139
    • 25144498040 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isoenzymes IX and XII with a library of aromatic and heteroaromatic sulfonamides
    • Ozensoy, O.; Pucetti, L.; Fasolis, G.; Arslan, O.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isoenzymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg. Med. Chem. Lett. 2005, 15, 4862-4866.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 4862-4866
    • Ozensoy, O.1    Pucetti, L.2    Fasolis, G.3    Arslan, O.4    Scozzafava, A.5    Supuran, C.T.6
  • 140
    • 0037911231 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenyl-aminobenzolamide derivatives
    • Ilies, M. A.; Vullo, D.; Pastorek, J.; Scozzafava, A.; Ilies, M.; Caproiu, M. T.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenyl-aminobenzolamide derivatives. J. Med. Chem. 2003, 46, 2187-2196
    • (2003) J. Med. Chem , vol.46 , pp. 2187-2196
    • Ilies, M.A.1    Vullo, D.2    Pastorek, J.3    Scozzafava, A.4    Ilies, M.5    Caproiu, M.T.6    Pastorekova, S.7    Supuran, C.T.8
  • 141
    • 0043198462 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides
    • Franchi, M.; Vullo, D.; Gallori, E.; Pastorek, J.; Russo, A.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides. J. Enzyme Inhib. Med. Chem. 2003, 18, 333-338.
    • (2003) J. Enzyme Inhib. Med. Chem , vol.18 , pp. 333-338
    • Franchi, M.1    Vullo, D.2    Gallori, E.3    Pastorek, J.4    Russo, A.5    Scozzafava, A.6    Pastorekova, S.7    Supuran, C.T.8
  • 142
    • 0038587356 scopus 로고    scopus 로고
    • Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Tumor-Associated Isozyme IX with Sulfamates Including EMATE Also Acting as Steroid Sulfatase Inhibitors
    • Winum, J. Y.; Vullo, D.; Casini, A.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Tumor-Associated Isozyme IX with Sulfamates Including EMATE Also Acting as Steroid Sulfatase Inhibitors. J. Med. Chem. 2003, 46, 2197-2204.
    • (2003) J. Med. Chem , vol.46 , pp. 2197-2204
    • Winum, J.Y.1    Vullo, D.2    Casini, A.3    Montero, J.L.4    Scozzafava, A.5    Supuran, C.T.6
  • 143
    • 0344981308 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes 1 and II with aliphatic sulfamates
    • Winum, J. Y.; Vullo, D.; Casini, A.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes 1 and II with aliphatic sulfamates. J. Med. Chem. 2003, 46, 5471-5477.
    • (2003) J. Med. Chem , vol.46 , pp. 5471-5477
    • Winum, J.Y.1    Vullo, D.2    Casini, A.3    Montero, J.L.4    Scozzafava, A.5    Supuran, C.T.6
  • 144
    • 1842790839 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered
    • Vullo, D.; Scozzafava, A.; Pastorekova, S.; Pastorek, J.; Supuran, C. T. Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered. Bioorg. Med. Chem. Lett. 2004, 14, 2351-2356.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 2351-2356
    • Vullo, D.1    Scozzafava, A.2    Pastorekova, S.3    Pastorek, J.4    Supuran, C.T.5
  • 145
    • 5344225272 scopus 로고    scopus 로고
    • Garaj, V.; Pucetti, L.; Fasolis, G.; Winum, J. Y.; Montero, J. L.; Scozzafava, A.; Vullo, D.; Innocenti, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/ tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg. Med. Chem. Lett. 2004, 14, 5427-5433.
    • Garaj, V.; Pucetti, L.; Fasolis, G.; Winum, J. Y.; Montero, J. L.; Scozzafava, A.; Vullo, D.; Innocenti, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/ tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg. Med. Chem. Lett. 2004, 14, 5427-5433.
  • 146
    • 19944401083 scopus 로고    scopus 로고
    • Garaj, V.; Pucetti, L.; Fasolis, G.; Winum, J. Y.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX. Bioorg. Med. Chem. Lett. 2005, 15, 3102-3108.
    • Garaj, V.; Pucetti, L.; Fasolis, G.; Winum, J. Y.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX. Bioorg. Med. Chem. Lett. 2005, 15, 3102-3108.
  • 147
    • 7044241041 scopus 로고    scopus 로고
    • Cecchi, A.; Winum, J. Y.; Innocenti, A.; Vullo, D.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. Bioorg. Med. Chem. Lett. 2004, 14, 5775-5780.
    • Cecchi, A.; Winum, J. Y.; Innocenti, A.; Vullo, D.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. Bioorg. Med. Chem. Lett. 2004, 14, 5775-5780.
  • 148
    • 0348147633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
    • Abbate, F.; Casini, A.; Owa, T.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg. Med. Chem. Lett. 2004, 14, 225-229.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 225-229
    • Abbate, F.1    Casini, A.2    Owa, T.3    Scozzafava, A.4    Supuran, C.T.5
  • 149
    • 17144387904 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds
    • Pucetti, L.; Fasolis, G.; Cecchi, A.; Winum, J. Y.; Gamberi, A.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg. Med. Chem. Lett. 2005, 15, 2359-64.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 2359-2364
    • Pucetti, L.1    Fasolis, G.2    Cecchi, A.3    Winum, J.Y.4    Gamberi, A.5    Montero, J.L.6    Scozzafava, A.7    Supuran, C.T.8
  • 150
    • 10644254283 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II and the tumor-associated isozymes IX
    • Turkmen, H.; Dugrun, M.; Yilmaztekin, S.; Emul, M.; Innocenti, A.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inibitors: novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II and the tumor-associated isozymes IX. Bioorg. Med. Chem. Lett. 2005, 17, 367-372.
    • (2005) Bioorg. Med. Chem. Lett , vol.17 , pp. 367-372
    • Turkmen, H.1    Dugrun, M.2    Yilmaztekin, S.3    Emul, M.4    Innocenti, A.5    Vullo, D.6    Scozzafava, A.7    Supuran, C.T.8
  • 152
    • 15444377021 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Synthesis and inhibition of cytosolic/ tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating hydrazine moieties
    • Winum, J. Y.; Dogne, J. M.; Casini, A.; de Leval, X.; Montero, J. L.; Scozzafava, A.; Vullo, D.; Innocenti, A.; Supuran, C. T. Carbonic anhydrase inibitors: Synthesis and inhibition of cytosolic/ tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating hydrazine moieties. J. Med. Chem. 2005, 48, 2121-2125.
    • (2005) J. Med. Chem , vol.48 , pp. 2121-2125
    • Winum, J.Y.1    Dogne, J.M.2    Casini, A.3    de Leval, X.4    Montero, J.L.5    Scozzafava, A.6    Vullo, D.7    Innocenti, A.8    Supuran, C.T.9
  • 153
    • 17144398878 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols
    • Almajan, G. L.; Innocenti, A.; Pucetti, L.; Manole, G.; Berbuceanu, S.; Saramet, I.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inibitors: Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols. Bioorg. Med. Chem. Lett. 2005, 15, 2347-2352.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 2347-2352
    • Almajan, G.L.1    Innocenti, A.2    Pucetti, L.3    Manole, G.4    Berbuceanu, S.5    Saramet, I.6    Scozzafava, A.7    Supuran, C.T.8
  • 154
    • 17244376080 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with N-hydroxysulfamides - a new zinc-binding function in the design of inhibitors
    • Winum, J. Y.; Innocenti, A.; Nasr, J.; Montero, J. L.; Scozzafava, A.; Vullo, D.; Supuran, C. T. Carbonic anhydrase inibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with N-hydroxysulfamides - a new zinc-binding function in the design of inhibitors. Bioorg. Med. Chem. Lett. 2005, 15, 2353-2358.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 2353-2358
    • Winum, J.Y.1    Innocenti, A.2    Nasr, J.3    Montero, J.L.4    Scozzafava, A.5    Vullo, D.6    Supuran, C.T.7
  • 155
    • 22544439682 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Synthesis and inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides
    • Pastorekova, S.; Vullo, D.; Casini, A.; Scozzafava, A.; Pastorek, J.; Nishimori, I.; Supuran, C. T. Carbonic anhydrase inibitors: Synthesis and inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides. J. Enzyme Inhib. Med. Chem. 2005, 20, 211-217.
    • (2005) J. Enzyme Inhib. Med. Chem , vol.20 , pp. 211-217
    • Pastorekova, S.1    Vullo, D.2    Casini, A.3    Scozzafava, A.4    Pastorek, J.5    Nishimori, I.6    Supuran, C.T.7
  • 156
    • 25144469687 scopus 로고    scopus 로고
    • Carbonic anhydrase inibitors: Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with benzo[b]thiophene 1,1 dioxide sulfonamides
    • Innocenti, A.; Villar, R.; Martinez-Merino, V.; Gil, M. J.; Scozzafava, A.; Vullo, D.; Supuran, C. T. Carbonic anhydrase inibitors: Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with benzo[b]thiophene 1,1 dioxide sulfonamides. Bioorg. Med. Chem. Lett. 2005, 15, 4872-4876.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 4872-4876
    • Innocenti, A.1    Villar, R.2    Martinez-Merino, V.3    Gil, M.J.4    Scozzafava, A.5    Vullo, D.6    Supuran, C.T.7
  • 157
    • 26844469638 scopus 로고    scopus 로고
    • Cecchi, A.; Taylor, S. D.; Liu, Y.; Hill, B.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inibitors: Inhibition of the human isozymes I, II, VA and IX with a library of substituted difluoromethanesulfinamides. Bioorg. Med. Chem. Lett. 2005, 15, 5192-5196.
    • Cecchi, A.; Taylor, S. D.; Liu, Y.; Hill, B.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inibitors: Inhibition of the human isozymes I, II, VA and IX with a library of substituted difluoromethanesulfinamides. Bioorg. Med. Chem. Lett. 2005, 15, 5192-5196.
  • 158
    • 33646446585 scopus 로고    scopus 로고
    • Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX
    • Thiry, A.; Ledecq, M.; Cecchi, A.; Dogne, J. M.; Wouters, J.; Supuran, C. T.; Masereel, B. Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J. Med. Chem. 2006, 49, 2743-2749.
    • (2006) J. Med. Chem , vol.49 , pp. 2743-2749
    • Thiry, A.1    Ledecq, M.2    Cecchi, A.3    Dogne, J.M.4    Wouters, J.5    Supuran, C.T.6    Masereel, B.7
  • 159
    • 1842628633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX
    • Casey, J. R.; Morgan, P. E.; Vullo, D.; Scozzafava, A.; Mastrolorenzo, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX. J. Med. Chem. 2004, 47, 2337-2347.
    • (2004) J. Med. Chem , vol.47 , pp. 2337-2347
    • Casey, J.R.1    Morgan, P.E.2    Vullo, D.3    Scozzafava, A.4    Mastrolorenzo, A.5    Supuran, C.T.6
  • 160
    • 0842281270 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX
    • Pastorekova, S.; Casini, A.; Scozzafava, A.; Vullo, D.; Pastorek, J.; Supuran, C. T. Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. Bioorg. Med. Chem. Lett. 2004, 14, 869-873
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 869-873
    • Pastorekova, S.1    Casini, A.2    Scozzafava, A.3    Vullo, D.4    Pastorek, J.5    Supuran, C.T.6
  • 161
    • 0141649426 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Interaction of cytosolic isozymes I and II and transmembrane cancer-associated isozyme IX with anions
    • Vullo, D.; Franchi, M.; Gallori, E.; Pastorek, J.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Interaction of cytosolic isozymes I and II and transmembrane cancer-associated isozyme IX with anions. J. Enzyme Inhib. Med. Chem. 2003, 18, 403-406.
    • (2003) J. Enzyme Inhib. Med. Chem , vol.18 , pp. 403-406
    • Vullo, D.1    Franchi, M.2    Gallori, E.3    Pastorek, J.4    Scozzafava, A.5    Pastorekova, S.6    Supuran, C.T.7
  • 162
    • 12444339728 scopus 로고    scopus 로고
    • Innocenti, A.; Vullo, D.; Scozzafava, A.; Casey, J. R.; Supuran, C. T. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med. Chem. Lett. 2005, 15, 573-578.
    • Innocenti, A.; Vullo, D.; Scozzafava, A.; Casey, J. R.; Supuran, C. T. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med. Chem. Lett. 2005, 15, 573-578.
  • 163
    • 12444317530 scopus 로고    scopus 로고
    • Innocenti, A.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate and carbonate. Bioorg. Med. Chem. Lett. 2005, 15, 567-571.
    • Innocenti, A.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate and carbonate. Bioorg. Med. Chem. Lett. 2005, 15, 567-571.
  • 164
    • 22744446294 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
    • Cecchi, A.; Hulikova, A.; Pastorek, J.; Pastorekova, S.; Scozzafava, A.; Winum, J. Y.; Montero, J. L.; Supuran, C. T. Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J. Med. Chem. 2005, 48, 4834-4841.
    • (2005) J. Med. Chem , vol.48 , pp. 4834-4841
    • Cecchi, A.1    Hulikova, A.2    Pastorek, J.3    Pastorekova, S.4    Scozzafava, A.5    Winum, J.Y.6    Montero, J.L.7    Supuran, C.T.8
  • 165
    • 0034662635 scopus 로고    scopus 로고
    • Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells
    • Xu, L.; Fidler, I. J. Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Cancer Res. 2000, 60, 4610-4616.
    • (2000) Cancer Res , vol.60 , pp. 4610-4616
    • Xu, L.1    Fidler, I.J.2
  • 166
    • 0033963979 scopus 로고    scopus 로고
    • Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression
    • D'Arcangelo, D.; Facchiano, F.; Barlucchi, L. M.; Melillo, G.; Illi, B.; Testolin, L.; Gaetano, C.; Apogrossi, M. C. Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression. Circ. Res. 1999, 86, 312-318.
    • (1999) Circ. Res , vol.86 , pp. 312-318
    • D'Arcangelo, D.1    Facchiano, F.2    Barlucchi, L.M.3    Melillo, G.4    Illi, B.5    Testolin, L.6    Gaetano, C.7    Apogrossi, M.C.8
  • 167
    • 0026667311 scopus 로고
    • Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines
    • Kato, Y.; Nakayama, Y.; Umeda, M.; Miyazaki, K. Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. J. Biol. Chem. 1992, 267, 11424-11430.
    • (1992) J. Biol. Chem , vol.267 , pp. 11424-11430
    • Kato, Y.1    Nakayama, Y.2    Umeda, M.3    Miyazaki, K.4
  • 169
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds, T. Y.; Rockwell, S.; Glazer, P. M. Genetic instability induced by the tumor microenvironment. Cancer Res. 1996, 56, 5754-5757.
    • (1996) Cancer Res , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 171
    • 0030942009 scopus 로고    scopus 로고
    • Influence of the pH on cytotoxicity of paclitaxel, mitoxanthrone and topotecan
    • Vukovic, V.; Tannock, I. F. Influence of the pH on cytotoxicity of paclitaxel, mitoxanthrone and topotecan. Br. J. Cancer 1997, 75, 1167-1172.
    • (1997) Br. J. Cancer , vol.75 , pp. 1167-1172
    • Vukovic, V.1    Tannock, I.F.2
  • 172
    • 8844224030 scopus 로고    scopus 로고
    • Microenvironmental and cellular consequences of altered blood flow in tumors
    • Raghunand, N.; Gatenby, R. A.; Gillies, R. J. Microenvironmental and cellular consequences of altered blood flow in tumors. Br. J. Radiol. 2003, 76, S11-S22.
    • (2003) Br. J. Radiol , vol.76
    • Raghunand, N.1    Gatenby, R.A.2    Gillies, R.J.3
  • 173
    • 0035874951 scopus 로고    scopus 로고
    • The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics
    • Kozin, S. V.; Shkarin, P.; Gerweck, L. E. The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics. Cancer Res. 2001, 61, 4740-4743.
    • (2001) Cancer Res , vol.61 , pp. 4740-4743
    • Kozin, S.V.1    Shkarin, P.2    Gerweck, L.E.3
  • 174
    • 0031927798 scopus 로고    scopus 로고
    • Tumor pH: Implications for treatment and novel drug design
    • Gerweck, L. E. Tumor pH: Implications for treatment and novel drug design. Semin. Radiat. Oncol. 1998, 8, 176-182
    • (1998) Semin. Radiat. Oncol , vol.8 , pp. 176-182
    • Gerweck, L.E.1
  • 175
    • 0027367258 scopus 로고
    • A carbonic anhydrase inhibitor is potential modulator of cancer therapies
    • Teicher, B. A.; Liu, S. D.; Liu, J. T.; Holden, S. A.; Herman, T. S. A carbonic anhydrase inhibitor is potential modulator of cancer therapies. Anticancer Res. 1993, 13, 1549-1556.
    • (1993) Anticancer Res , vol.13 , pp. 1549-1556
    • Teicher, B.A.1    Liu, S.D.2    Liu, J.T.3    Holden, S.A.4    Herman, T.S.5
  • 176
    • 20444409690 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with oron-containing sulfonamides, sulfamides and sulfamates: Towards agents for boron neutron capture therapy of hypoxic tumors
    • Winum, J. Y.; Cecchi, A.; Montero, J. L.; Innocenti, A.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with oron-containing sulfonamides, sulfamides and sulfamates: Towards agents for boron neutron capture therapy of hypoxic tumors. Bioorg. Med. Chem. Lett. 2005, 15, 3302-3306.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 3302-3306
    • Winum, J.Y.1    Cecchi, A.2    Montero, J.L.3    Innocenti, A.4    Scozzafava, A.5    Supuran, C.T.6


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