Coexpression of hypoxia-inducible factors 1α and 2α, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival

Clinical Cancer Research

Volumn 8, Issue 8, 2002, Pages 2595-2604

  Hui, Edwin P ^a   Chan, Anthony T C ^a   Pezzella, Francesco ^b   Turley, Helen ^b   To, Ka Fai ^a   Poon, Terence C W ^a   Zee, Benny ^a   Mo, Frankie ^a   Teo, Peter M L ^a   Huang, Dolly P ^a   Gatter, Kevin C ^b   Johnson, Philip J ^a   Harris, Adrian L ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; ENDOTHELIAL CELL GROWTH FACTOR; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; LYMPHOKINE; SIGNAL PEPTIDE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TUMOR ANTIGEN; TUMOR MARKER; TUMOR PROTEIN; VASCULOTROPIN; VASCULOTROPIN A; CARBONATE DEHYDRATASE IX; CISPLATIN; GENE PRODUCT; HYPOXIA INDUCIBLE FACTOR 2ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ANOXIA; ARTICLE; BIOSYNTHESIS; CARCINOMA; COHORT ANALYSIS; FEMALE; GENETIC MARKER; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; NASOPHARYNX TUMOR; PROGNOSIS; TIME; UPREGULATION; ANGIOGENESIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MAJOR CLINICAL STUDY; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; TUMOR BIOPSY;

ADULT; AGED; ANOXIA; ANTIGENS, NEOPLASM; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARBONIC ANHYDRASES; CARCINOMA; COHORT STUDIES; ENDOTHELIAL GROWTH FACTORS; FEMALE; GENETIC MARKERS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NASOPHARYNGEAL NEOPLASMS; NEOPLASM PROTEINS; PROGNOSIS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; HUMAN; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T;

EID: 0036023422     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. An epidemiologic and clinical study of nasopharyngeal carcinoma
2. Significant prognosticators after primary radiotherapy in 903 nondisseminated nasopharyngeal carcinoma evaluated by computer tomography
3. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099
4. Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression-free survival analysis of a Phase III randomized Trial
5. The concentration of oxygen dissolved in tissue at the time of irradiation as a factor in radiotherapy
6. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
7. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
8. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
9. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
10. Fluorine-18 fluoromisonidazole tumour to muscle retention ratio for the detection of hypoxia in nasopharyngeal carcinoma
11. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
12. The tumour suppressor protein VHL targets hypoxia inducible factors for oxygen-dependent proteolysis
13. Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α
14. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
15. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment
16. Hypoxia-inducible expression of tumor-associated carbonic anhydrases
17. Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
18. Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in human bladder tumors and cell lines
19. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
20. Hypoxia-inducible factor-1α is an intrinsic marker for hypoxia in cervical cancer xenografts
21. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
22. A novel quasi-viral agent, MaTu, is a two-component system
23. Expression of VEGF in routinely fixed material using a new monoclonal antibody VGI
24. Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
25. Overexpression of hypoxia-inducible factor la in common human cancers and their metastases
26. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer
27. A distinct expression of CC chemokines by macrophages in nasopharyngeal carcinoma: Implication for the intense tumor infiltration by T lymphocytes and macrophages
28. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
29. Relation of hypoxia-inducible factor-2α (HIF-2α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer
30. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase ix, in invasive breast carcinoma
31. Overexpression of hypoxia-inducible factor la is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
32. Hypoxia inducible factor (HIF-1α and HIF-2α) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
33. Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
34. Expression of hypoxia-inducible factor 1α in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
35. Expression of hypoxiainducible factor-1α in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
36. Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
37. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
38. Expression of hypoxiainducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
39. Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy
40. Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma
41. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck
42. Association of vascular endothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma
43. The relationship between microvessel density, the expression of vascular endothelial growth factor (VEGF), and the extension of nasopharyngeal carcinoma
44. Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer
45. Therapeutic targets in radiotherapy
46. Bioreductive drugs into the next millennium