Single chain Ig/γ gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity

Journal of Immunology

Volumn 157, Issue 2, 1996, Pages 836-843

  Weijtens, Mo E M ^a   Willemsen, Ralph A ^a   Valerio, Dinko ^b   Stam, Kees ^a   Bolhuis, Reinder L H ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY;

ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; KIDNEY CARCINOMA; PRIORITY JOURNAL;

BASE SEQUENCE; CARCINOMA, RENAL CELL; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; GENES, IMMUNOGLOBULIN; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA; RECEPTORS, IGE; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030014521     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Stoter, G., S. H. Goey, D. Batchelor, A. M. Eggermont, C. Lamers, J. W. Gratama, and R. L. H. Bolhuis. 1992. Treatment of disseminated renal cell cancer with combinations of interleukin-2, lymphokine-activated killer cells, and α-interferon. In EORTC Genitourinary Group Monograph 11: Recent Progress in Bladder and Kidney Cancer. F. H. Schröder, ed. Wiley-Liss, Inc., New York, p. 225.
2. Rosenberg, S. A., J. R. Yannnelli, J. C. Yang, S. L. Topalian, D. J. Schwartzentruber, J. S. Weber, D. R. Parkinson, C. A. Seipp, J. H. Einhorn, and D. E. White. 1994. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J. Natl. Cancer Inst. 86:1159.
3. Weidmann, E., M. Trucco, and T. L. Whiteside. 1994. Relevance of the T cell receptor for immunotherapy of cancer. Cancer Immunol. Immunother. 39:1.
4. Lanzavecchia, A., and D. Scheidegger. 1987. The use of hybrid hybridomas to target human cytotoxic T lymphocytes. Eur. J. Immunol. 17:105.
5. Van Dijk, J., S. O. Warnaar, J. D. H. van Eendenburg, M. Thienpont, E. Braakman, J. H. A. Boot, G. J. Fleuren, and R. L. H. Bolhuis,. 1989. Induction of tumor cell lysis by bi-specific monoclonal antibodies recognizing renal cell carcinoma and CD3 antigen. Int. J. Cancer 43:344.
6. Bolhuis, R. L. H., C. H. J. Lamers, S. H. Goey, A. M. M. Eggermont, J. B. M. Z. Trimbos, G. Stoter, A. Lanzavecchia, E. Di Re, S. Miotti, F. Raspagliesi, L. Rivoltini, and M. I. Colnaghi. 1992. Adoptive immunotherapy of ovarian carcinoma with bsmAb-targeted lymphocytes: a multicenter study. Int. J. Cancer Suppl. 7:78.
7. Renner, C., W. Jung, U. Sahin, R. Denfeld, C. Pohl, L. Trümper, F. Hartmann, V. Diehl, R. van Lier, and M. Pfreundschuh. 1994. Cure of xenografted human tumors by bispecific antibodies and human T cells. Science 264:833.
8. 2 antibody prolong host survival in a murine xenograft model. Cancer Res. 51:5716.
9. Jain, R. K. 1989. Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl. Cancer Inst. 81:570.
10. Blank-Voorthuis, C. J. A. C., E. Braakman, C. P. M. Ronteltap, B. C. Tilly, E. Sturm, S. O. Warnaar, and R. L. H. Bolhuis. 1993. Clustered CD3/TCR complexes do not transduce activation signals after bispecific monoclonal antibody-triggered lysis by CTL via CD3. J. Immunol. 151:2904.
11. Eshhar, Z., T. Waks, G. Gross, and D. G. Schindler. 1993. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc. Natl. Acad. Sci. USA 90:720.
12. Stancovski, I., D. G. Schindler, T. Waks, Y. Yarden, M. Sela, and Z. Eshhar. 1993. Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J. Immunol. 151:6577.
13. Bird, R. E., K. D. Hardman, J. W. Jacobson, S. Johnson, B. M. Kaufman, S. M. Lee, T. Lee, S. H. Pope, G. S. Riordan, and M. Whitlow. 1988. Single chain antigen-binding proteins. Science 242:423.
14. Colcher, D., R. Bird, M. Roselli, K. D. Hardman, S. Johnson, S. Pope, S. W. Dodd, M. W. Pantoliano, D. E. Milenic, and J. Schlom. 1990. In vivo tumor targeting of a recombinant single chain antigen-binding protein. J. Natl. Cancer Inst. 82:1191.
15. Wels, W., I. M. Harwerth, N. E. Hynes, and B. Groner. 1992. Diminution of antibodies directed against tumor cell surface epitopes: a single chain Fv fusion molecule specifically recognizes the extracellular domain of the c-erb B2 receptor. J. Steroid Biochem. Mol. Biol. 43:1.
16. Brocker, T., A. Peter, A. Traunecker, and K. Karjalainen. 1993. New simplified molecular design for functional T cell receptor. Eur. J. Immunol. 23:1435.
17. Moritz, D., W. Wels, J. Mattern, and B. Groner. 1994. Cytotoxic T lymphocytes with grafted recognition specificity for ERBB2-expressing tumor cells. Proc. Natl. Acad. Sci. USA 91:4318.
18. Hwu, P., G. E. Shafer, J. Treisman, D. G. Schindler, G. Gross, R. Cowherd, S. A. Rosenberg, and Z. Eshhar. 1993. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor γ chain. J. Exp. Med. 178:361.
19. + T lymphocytes armed with universal T-cell receptors. Blood 84:2878.
20. Oosterwijk, E., D. J. Ruiter, P. J. Hoedemaker, E. K. J Pauwels, U. Jonas, J. Zwartendijk, and S. O. Warnaar. 1986. Monoclonal antibody G250 recognizes a determinant present in renal cell carcinoma and absent from normal kidney. Int. J. Cancer 38:489.
21. Van Dijk, J., E. Oosterwijk, M. J. P. G. van Kroonenburg, U. Jonas, G. J. Fleuren, E. K. J. Pauwels, and S. O. Warnaar. 1988. Perfusion of tumor-bearing kidneys as a model for scintigraphic screening of monoclonal antibodies. J. Nucl. Med. 29:1078.
22. Küster, H., H. Thompson, and J.-P. Kinet. 1990. Characterization and expression of the gene for the human Fc receptor γ subunit. J. Biol. Chem. 265:6448.
23. Berke, G., K. A. Sullivan, and D. B. Amos. 1972. Tumor immunity in vitro: destruction of a mouse ascites tumor through a cycling pathway. Science 177: 433.
24. Zagury, D., J. Bernard, N. Thierness, M. Feldman, and G. Berke. 1975. Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: conjugation, killing and recycling at the single cell level. Eur. J. Immunol. 5:818.
25. Lamers, C. H. J., R. J. van de Griend, E. Braakman, C. P. M. Ronteltap, J. Bénard, G. Stoter, J. W. Gratama, and R. L. H. Bolhuis. 1992. Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for bispecific antibody-directed cellular immunotherapy. Int. J. Cancer 51:973.
26. Loh, E. Y., J. F. Elliot, S. Cwirla, L. L. Lanier, and M. M. Davis. 1989. Polymerase chain reaction with single-sided specificity: analysis of T cell receptor δ chain. Science 243:217.
27. Weissman, A. M., D. Hou, D. G. Orloff, W. S. Modi, H. Seuanez, S. J. O'Brien, and R. D. Klausner. 1988. Molecular cloning and chromosomal localization of the human T-cell receptor ζ chain: distinction from the molecular CD3 complex. Proc. Natl. Acad. Sci. USA 85:9709.
28. Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980.
29. Van de Griend, R. J., B. A. van Krimpen, S. J. L. Bol, A. Thompson, and R. L. H. Bolhuis. 1984. Rapid expansion of human cytotoxic T cell clones: growth promotion by a heat-labile serum component and by various types of feeder cells. J. Immunol. Methods 66:285.
30. Van de Griend, R. J., and R. L. H. Bolhuis. 1984. Rapid expansion of allospecific cytotoxic T cell clones using nonspecific feeder cell lines without further addition of exogenous IL-2. Transplantation 38:401.
31. Kasid, A., S. Morecki, P. Aebersold, K. Cornetta, K. Culver, S. Freeman, E. Director, M. T. Lotze, R. M. Blease, W. F. Anderson, and S. A. Rosenberg. 1990. Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. Proc. Natl. Acad. Sci. USA 87:473.
32. Braakman, E., V. W. van Beusechem, B. A. van Krimpen, A. Fisher, R. L. H. Bolhuis, and D. Valerio. 1992. Genetic correction of cultured T cells from an adenosine deaminase-deficient patient: characteristics of non-transduced and transduced T cells. Eur. J. Immunol. 22:63.
33. Uemura, H., E. Okajima, F. M. J. Debruyne, and E. Oosterwijk. 1994. Internal image anti-idiotype antibodies related to renal cell carcinoma-associated antigen G250. Int. J. Cancer 56:609.
34. Nitta, T., K. Sato, H. Yagita, K. Okumura, and S. Ishii. 1990. Preliminary trial of specific targeting therapy against malignant melanoma. Lancet 335:368.
35. Canevari, S., G. Stoter, F. Arienti, G. Bolis, M. I. Colnaghi, E. M. Di Re, A. M. M. Eggermont, S. H. Goey, J. W. Gratama, C. H. J. Lamers, M. A. Nooy, G. Parmiani, F. Raspagliesi, F. Ravagnani, G. Scarfone, J. B. Trimbos, S. O. Warnaar, and R. L. H. Bolhuis. 1995. Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecitic monoclonal antibody: clinical proof of concept. J. Natl. Cancer Inst. 87:1463.
36. Qian, J.-H., J. A. Titus, S. M. Andrew, D. Mezzanzanica, M. A. Garrido, J. R. Wunderlich, and D. M. Segal. 1991. Human peripheral blood lymphocytes targeted with, bispecific antibodies release cytokines that are essential for inhibiting tumor growth. J. Immunol. 146:3250.
37. Lind, P., P. Lechner, B. Hausmann, M. G. Smola, P. Koeltringee, P. Steindorfer, H. Cesnik, R. Passl, and O. Eber. 1991. Development of human anti-mouse antibodies (HAMA) after single and repealed diagnostic application of intact murine monoclonal antibodies. Antib. Immunoconjug. Radiopharm. 4:811.
38. Lamers, C. H. J., J. W. Gratama, S. O. Warnaar, G. Stoter, and R. L. H. Bolhuis. 1995. Inhibition of bispecific monoclonal antibody (bsAb)-targeted cytolysis by human anti-mouse antibodies in ovarian carcinoma patients treated with bsAb-targeted activated T lymphocytes. Int. J. Cancer 60:450.
39. Reinherz, E. L., S. Meuer, K. A. Fitzgerald, R. E. Hussey, H. Levine, and S. F. Schlossman. 1982. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell 30:735.
40. Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
41. Refisto, N. P., Y. Kawakami, F. Marincola, P. Shamamian, A. Taggarse, F. Esquivel, and S. A. Rosenberg. 1993. Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I. J. Immunother. 14:182.