Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy

Clinical Cancer Research

Volumn 7, Issue 11, 2001, Pages 3399-3403

  Koukourakis, Michael I ^a   Giatromanolaki, Alexandra ^a   Sivridis, Efthimios ^a   Simopoulos, Konstantinos ^a   Pastorek, Jaromir ^b   Wykoff, Charles C ^c   Gatter, Kevin C ^c   Harris, Adrian L ^c  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b INSTITUTE OF VIROLOGY   (Slovakia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE IX; CARBOPLATIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER SURVIVAL; DISEASE ASSOCIATION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NECROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR VASCULARIZATION;

ANOXIA; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DRUG RESISTANCE, NEOPLASM; DRUG THERAPY; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; RADIOTHERAPY; SURVIVAL ANALYSIS;

EID: 0035181306     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
2. The hypoxic cell: A target for selective cancer therapy-eighteenth Bruce F. Cain memorial award lecture
3. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney
4. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
5. Hypoxia inducible regulation of tumor associated carbonic anhydrases
6. Angiogenesis vs. response after combined chemo-radiotherapy of squamous cell head and neck cancer
7. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
8. Loss of PTEN facilitates HIF-1 mediated gene expression
9. Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime
10. Intermitent blood flow in a murine tumor: Radiobiological effects
11. Angiogenesis, thymidine phosphorylase and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
12. High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy
13. Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas
14. Inverse correlation between apoptotic (Fas ligand, caspase-3) and angiogenic factors (VEGF, microvessel density) in squamous cell lung carcinomas
15. Blockade of the vascular endothelial growth factor stress response increases the antitumor effect of ionizing radiation
16. X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human xenografts
17. Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas
18. What have we learnt from hyperbaric oxygen