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Volumn 56, Issue 3, 2007, Pages 417-425

The canonical Wnt signalling pathway and its APC partner in colon cancer development

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; NONSTEROID ANTIINFLAMMATORY AGENT; WNT PROTEIN; APC PROTEIN;

EID: 33847397617     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.093310     Document Type: Review
Times cited : (244)

References (101)
  • 1
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 2
    • 31544433363 scopus 로고    scopus 로고
    • EphB/EphrinB receptors and Wnt signaling in colorectal cancer
    • Clevers H, Batlle E. EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Res 2006;66:2-5.
    • (2006) Cancer Res , vol.66 , pp. 2-5
    • Clevers, H.1    Batlle, E.2
  • 3
    • 19544375032 scopus 로고    scopus 로고
    • Wnt control of stem cells and differentiation in the intestinal epithelium
    • Pinto D, Clevers H. Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res 2005;306:357-63.
    • (2005) Exp Cell Res , vol.306 , pp. 357-363
    • Pinto, D.1    Clevers, H.2
  • 4
    • 33644967242 scopus 로고    scopus 로고
    • Wnt signaling: Complexity at the surface
    • Cadigan KM, Liu YI. Wnt signaling: complexity at the surface. J Cell Sci 2006;119:395-402.
    • (2006) J Cell Sci , vol.119 , pp. 395-402
    • Cadigan, K.M.1    Liu, Y.I.2
  • 6
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 7
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997;11:3286-305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 9
    • 33646134826 scopus 로고    scopus 로고
    • Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
    • Banziger C, Soldini D, Schutt C, et al. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 2006;125:509-22.
    • (2006) Cell , vol.125 , pp. 509-522
    • Banziger, C.1    Soldini, D.2    Schutt, C.3
  • 10
    • 33646123992 scopus 로고    scopus 로고
    • Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
    • Bartscherer K, Pelte N, Ingelfinger D, et al. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 2006;125:523-33.
    • (2006) Cell , vol.125 , pp. 523-533
    • Bartscherer, K.1    Pelte, N.2    Ingelfinger, D.3
  • 11
    • 33646592268 scopus 로고    scopus 로고
    • Wnt gradient formation requires retromer function in Wnt-producing cells
    • Coudreuse DY, Roel G, Betist MC, et al. Wnt gradient formation requires retromer function in Wnt-producing cells. Science 2006;312:921-4.
    • (2006) Science , vol.312 , pp. 921-924
    • Coudreuse, D.Y.1    Roel, G.2    Betist, M.C.3
  • 13
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of beta-catenin with the transcription factor LEF-1
    • Behrens J, von Kries JP, Kuhl M, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996;382:638-42.
    • (1996) Nature , vol.382 , pp. 638-642
    • Behrens, J.1    von Kries, J.P.2    Kuhl, M.3
  • 14
    • 0001003110 scopus 로고    scopus 로고
    • XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    • Molenaar M, van de Wetering M, Oosterwegel M, et al. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell 1996;86:391-9.
    • (1996) Cell , vol.86 , pp. 391-399
    • Molenaar, M.1    van de Wetering, M.2    Oosterwegel, M.3
  • 15
    • 33644763022 scopus 로고    scopus 로고
    • The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
    • Sierra J, Yoshida T, Joazeiro CA, et al. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev 2006;20:586-600.
    • (2006) Genes Dev , vol.20 , pp. 586-600
    • Sierra, J.1    Yoshida, T.2    Joazeiro, C.A.3
  • 16
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • Kuhnert F, Davis CR, Wang HT, et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A 2004;101:266-71.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.T.3
  • 17
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek V, Barker N, Moerer P, et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-83.
    • (1998) Nat Genet , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3
  • 18
    • 2142709556 scopus 로고    scopus 로고
    • Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of beta-catenin
    • Ireland H, Kemp R, Houghton C, et al. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 2004;126:1236-46.
    • (2004) Gastroenterology , vol.126 , pp. 1236-1246
    • Ireland, H.1    Kemp, R.2    Houghton, C.3
  • 19
    • 0029047954 scopus 로고
    • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
    • Oshima M, Oshima H, Kitagawa K, et al. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A 1995;92:4482-6.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4482-4486
    • Oshima, M.1    Oshima, H.2    Kitagawa, K.3
  • 20
    • 0030843461 scopus 로고    scopus 로고
    • Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
    • Shibata H, Toyama K, Shioya H, et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 1997;278:120-3.
    • (1997) Science , vol.278 , pp. 120-123
    • Shibata, H.1    Toyama, K.2    Shioya, H.3
  • 21
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Sansom OJ, Reed KR, Hayes AJ, et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 2004;18:1385-90.
    • (2004) Genes Dev , vol.18 , pp. 1385-1390
    • Sansom, O.J.1    Reed, K.R.2    Hayes, A.J.3
  • 22
    • 0033230616 scopus 로고    scopus 로고
    • Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    • Harada N, Tamai Y, Ishikawa T, et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 1999;18:5931-42.
    • (1999) EMBO J , vol.18 , pp. 5931-5942
    • Harada, N.1    Tamai, Y.2    Ishikawa, T.3
  • 23
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • Nateri AS, Spencer-Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005;437:281-5.
    • (2005) Nature , vol.437 , pp. 281-285
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3
  • 24
    • 0033545845 scopus 로고    scopus 로고
    • The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    • Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A 1999;96:5522-7.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5522-5527
    • Shtutman, M.1    Zhurinsky, J.2    Simcha, I.3
  • 25
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-6.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 26
    • 23344433876 scopus 로고    scopus 로고
    • Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine
    • Sansom OJ, Reed KR, van de Wetering M, et al. Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. J Biol Chem 2005;280:28463-7.
    • (2005) J Biol Chem , vol.280 , pp. 28463-28467
    • Sansom, O.J.1    Reed, K.R.2    van de Wetering, M.3
  • 27
    • 4344689970 scopus 로고    scopus 로고
    • Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    • Hulit J, Wang C, Li Z, et al. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol 2004;24:7598-611.
    • (2004) Mol Cell Biol , vol.24 , pp. 7598-7611
    • Hulit, J.1    Wang, C.2    Li, Z.3
  • 28
    • 0037102312 scopus 로고    scopus 로고
    • Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice
    • Wilding J, Straub J, Bee J, et al. Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Cancer Res 2002;62:4562-5.
    • (2002) Cancer Res , vol.62 , pp. 4562-4565
    • Wilding, J.1    Straub, J.2    Bee, J.3
  • 29
    • 0032884884 scopus 로고    scopus 로고
    • beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    • Brabletz T, Jung A, Dag S, et al. beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999;155:1033-8.
    • (1999) Am J Pathol , vol.155 , pp. 1033-1038
    • Brabletz, T.1    Jung, A.2    Dag, S.3
  • 30
    • 0033529126 scopus 로고    scopus 로고
    • The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors
    • Crawford HC, Fingleton BM, Rudolph-Owen LA, et al. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 1999;18:2883-91.
    • (1999) Oncogene , vol.18 , pp. 2883-2891
    • Crawford, H.C.1    Fingleton, B.M.2    Rudolph-Owen, L.A.3
  • 31
    • 33644859051 scopus 로고    scopus 로고
    • The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development
    • Malliri A, Rygiel TP, van der Kammen RA, et al. The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 2006;281:543-8.
    • (2006) J Biol Chem , vol.281 , pp. 543-548
    • Malliri, A.1    Rygiel, T.P.2    van der Kammen, R.A.3
  • 32
    • 21344460054 scopus 로고    scopus 로고
    • EphB receptor activity suppresses colorectal cancer progression
    • Batlle E, Bacani J, Begthel H, et al. EphB receptor activity suppresses colorectal cancer progression. Nature 2005;435:1126-30.
    • (2005) Nature , vol.435 , pp. 1126-1130
    • Batlle, E.1    Bacani, J.2    Begthel, H.3
  • 33
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 35
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    • Behrens J, Jerchow BA, Wurtele M, et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 1998;280:596-9.
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1    Jerchow, B.A.2    Wurtele, M.3
  • 36
    • 0033563226 scopus 로고    scopus 로고
    • Apc1638T: A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
    • Smits R, Kielman MF, Breukel C, et al. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev 1999;13:1309- 21.
    • (1999) Genes Dev , vol.13 , pp. 1309-1321
    • Smits, R.1    Kielman, M.F.2    Breukel, C.3
  • 37
    • 0037440429 scopus 로고    scopus 로고
    • Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
    • Fabbro M, Henderson BR. Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Exp Cell Res 2003;282:59-69.
    • (2003) Exp Cell Res , vol.282 , pp. 59-69
    • Fabbro, M.1    Henderson, B.R.2
  • 38
    • 0037416148 scopus 로고    scopus 로고
    • Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription
    • Rosin-Arbesfeld R, Cliffe A, Brabletz T, et al. Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription. EMBO J 2003;22:1101-13.
    • (2003) EMBO J , vol.22 , pp. 1101-1113
    • Rosin-Arbesfeld, R.1    Cliffe, A.2    Brabletz, T.3
  • 39
    • 33646583259 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention
    • Krieghoff E, Behrens J, Mayr B. Nucleo-cytoplasmic distribution of {beta}-catenin is regulated by retention. J Cell Sci 2006;119:1453-63.
    • (2006) J Cell Sci , vol.119 , pp. 1453-1463
    • Krieghoff, E.1    Behrens, J.2    Mayr, B.3
  • 40
    • 0034662626 scopus 로고    scopus 로고
    • Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
    • Estoller M, Sparks A, Toyota M, et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 2000;60:4366-71.
    • (2000) Cancer Res , vol.60 , pp. 4366-4371
    • Estoller, M.1    Sparks, A.2    Toyota, M.3
  • 41
    • 25444497707 scopus 로고    scopus 로고
    • The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis
    • Li Q, Ishikawa TO, Oshima M, et al. The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res 2005;65:8622-7.
    • (2005) Cancer Res , vol.65 , pp. 8622-8627
    • Li, Q.1    Ishikawa, T.O.2    Oshima, M.3
  • 42
    • 8444236025 scopus 로고    scopus 로고
    • The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium
    • Nathke IS. The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol 2004;20:337-66.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 337-366
    • Nathke, I.S.1
  • 43
    • 33646498125 scopus 로고    scopus 로고
    • Truncated APC is required for cell proliferation and DNA replication
    • Schneikert J, Behrens J. Truncated APC is required for cell proliferation and DNA replication. Int J Cancer 2006;119:74-9.
    • (2006) Int J Cancer , vol.119 , pp. 74-79
    • Schneikert, J.1    Behrens, J.2
  • 44
    • 0037341566 scopus 로고    scopus 로고
    • Mutated APC and Asef are involved in the migration of colorectal tumour cells Asef, a link between the tumor suppressor APC and G-protein signaling
    • Kawasaki Y, Sato R, Akiyama T, et al. Mutated APC and Asef are involved in the migration of colorectal tumour cells Asef, a link between the tumor suppressor APC and G-protein signaling. Nat Cell Biol 2003;5:211-5.
    • (2003) Nat Cell Biol , vol.5 , pp. 211-215
    • Kawasaki, Y.1    Sato, R.2    Akiyama, T.3
  • 45
    • 13444261036 scopus 로고    scopus 로고
    • Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
    • Tighe A, Johnson VL, Taylor SS. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci 2004;117:6339-53.
    • (2004) J Cell Sci , vol.117 , pp. 6339-6353
    • Tighe, A.1    Johnson, V.L.2    Taylor, S.S.3
  • 46
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin PJ, Sparks AB, Korinek V, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787-90.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3
  • 47
    • 0030813048 scopus 로고    scopus 로고
    • Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors
    • Kitaeva MN, Grogan L, Williams JP, et al. Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res 1997;57:4478-81.
    • (1997) Cancer Res , vol.57 , pp. 4478-4481
    • Kitaeva, M.N.1    Grogan, L.2    Williams, J.P.3
  • 48
    • 0033780630 scopus 로고    scopus 로고
    • Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling
    • Liu W, Dong X, Mai M, et al. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat Genet 2000;26:146-7.
    • (2000) Nat Genet , vol.26 , pp. 146-147
    • Liu, W.1    Dong, X.2    Mai, M.3
  • 49
    • 2342613578 scopus 로고    scopus 로고
    • Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer
    • Lammi L, Arte S, Somer M, et al. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet 2004;74:1043-50.
    • (2004) Am J Hum Genet , vol.74 , pp. 1043-1050
    • Lammi, L.1    Arte, S.2    Somer, M.3
  • 50
    • 0032843036 scopus 로고    scopus 로고
    • Cadherins and catenins: Role in signal transduction and tumor progression
    • Behrens J. Cadherins and catenins: role in signal transduction and tumor progression. Cancer Metastasis Rev 1999;18:15-30.
    • (1999) Cancer Metastasis Rev , vol.18 , pp. 15-30
    • Behrens, J.1
  • 51
    • 0038581169 scopus 로고    scopus 로고
    • Changing neighbours, changing behaviour: Cell adhesion molecule-mediated signalling during tumour progression
    • Christofori G. Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. EMBO J 2003;22:2318-23.
    • (2003) EMBO J , vol.22 , pp. 2318-2323
    • Christofori, G.1
  • 52
    • 28344439885 scopus 로고    scopus 로고
    • Alpha-catenin is a molecular switch that binds E-cadherin-beto-catenin and regulates actin-filament assembly
    • Drees F, Pokutta S, Yamada S, et al. Alpha-catenin is a molecular switch that binds E-cadherin-beto-catenin and regulates actin-filament assembly. Cell 2005;123:903-15.
    • (2005) Cell , vol.123 , pp. 903-915
    • Drees, F.1    Pokutta, S.2    Yamada, S.3
  • 53
    • 28344433073 scopus 로고    scopus 로고
    • Deconstructing the cadherin-catenin-actin complex
    • Yamada S, Pokutta S, Drees F, et al. Deconstructing the cadherin-catenin-actin complex. Cell 2005;123:889-901.
    • (2005) Cell , vol.123 , pp. 889-901
    • Yamada, S.1    Pokutta, S.2    Drees, F.3
  • 54
    • 0028572556 scopus 로고
    • E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    • Hulsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 1994;127:2061-9.
    • (1994) J Cell Biol , vol.127 , pp. 2061-2069
    • Hulsken, J.1    Birchmeier, W.2    Behrens, J.3
  • 55
    • 29144536745 scopus 로고    scopus 로고
    • E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not after Wnt-independent gene expression in fibroblasts
    • Kuphal F, Behrens J. E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not after Wnt-independent gene expression in fibroblasts. Exp Cell Res 2006;312:457-67.
    • (2006) Exp Cell Res , vol.312 , pp. 457-467
    • Kuphal, F.1    Behrens, J.2
  • 56
    • 30644458570 scopus 로고    scopus 로고
    • Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
    • Brembeck FH, Rosario M, Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 2006;16:51-9.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 51-59
    • Brembeck, F.H.1    Rosario, M.2    Birchmeier, W.3
  • 57
    • 0029982877 scopus 로고    scopus 로고
    • The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
    • Nathke IS, Adams CL, Polakis P, et al. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol 1996;134:165-79.
    • (1996) J Cell Biol , vol.134 , pp. 165-179
    • Nathke, I.S.1    Adams, C.L.2    Polakis, P.3
  • 58
    • 0027930066 scopus 로고
    • The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
    • Munemitsu S, Souza B, Muller O, et al. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res 1994;54:3676-81.
    • (1994) Cancer Res , vol.54 , pp. 3676-3681
    • Munemitsu, S.1    Souza, B.2    Muller, O.3
  • 59
    • 0035176077 scopus 로고    scopus 로고
    • Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
    • Zumbrunn J, Kinoshita K, Hyman AA, et al. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol 2001;11:44-9.
    • (2001) Curr Biol , vol.11 , pp. 44-49
    • Zumbrunn, J.1    Kinoshita, K.2    Hyman, A.A.3
  • 60
    • 4444360489 scopus 로고    scopus 로고
    • EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration
    • Wen Y, Eng CH, Schmoranzer J, et al. EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat Cell Biol 2004;6:820-30.
    • (2004) Nat Cell Biol , vol.6 , pp. 820-830
    • Wen, Y.1    Eng, C.H.2    Schmoranzer, J.3
  • 61
    • 0034789121 scopus 로고    scopus 로고
    • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    • McCartney BM, McEwen DG, Grevengoed E, et al. Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nat Cell Biol 2001;3:933-8.
    • (2001) Nat Cell Biol , vol.3 , pp. 933-938
    • McCartney, B.M.1    McEwen, D.G.2    Grevengoed, E.3
  • 62
    • 0141483737 scopus 로고    scopus 로고
    • Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
    • Yamashita YM, Jones DL, Fuller MT. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 2003;301:1547-50.
    • (2003) Science , vol.301 , pp. 1547-1550
    • Yamashita, Y.M.1    Jones, D.L.2    Fuller, M.T.3
  • 63
    • 18344370261 scopus 로고    scopus 로고
    • APC is a component of an organizing template for cortical microtubule networks
    • Reilein A, Nelson WJ. APC is a component of an organizing template for cortical microtubule networks. Nat Cell Biol 2005;7:463-73.
    • (2005) Nat Cell Biol , vol.7 , pp. 463-473
    • Reilein, A.1    Nelson, W.J.2
  • 64
    • 0029835278 scopus 로고    scopus 로고
    • Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium
    • Wong MH, Hermiston ML, Syder AJ, et al. Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium. Proc Natl Acad Sci U S A 1996;93:9588-93.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9588-9593
    • Wong, M.H.1    Hermiston, M.L.2    Syder, A.J.3
  • 65
    • 0037434790 scopus 로고    scopus 로고
    • Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity
    • Etienne-Manneville S, Hall A. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 2003;421:753-6.
    • (2003) Nature , vol.421 , pp. 753-756
    • Etienne-Manneville, S.1    Hall, A.2
  • 66
    • 10644281068 scopus 로고    scopus 로고
    • Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    • Watanabe T, Wang S, Noritake J, et al. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 2004;7:871-83.
    • (2004) Dev Cell , vol.7 , pp. 871-883
    • Watanabe, T.1    Wang, S.2    Noritake, J.3
  • 67
    • 2942735115 scopus 로고    scopus 로고
    • NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC
    • Zhou FQ, Zhou J, Dedhar S, et al. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 2004;42:897-912.
    • (2004) Neuron , vol.42 , pp. 897-912
    • Zhou, F.Q.1    Zhou, J.2    Dedhar, S.3
  • 68
    • 0037459077 scopus 로고    scopus 로고
    • Sticky business: Orchestrating cellular signals at adherens junctions
    • Perez-Moreno M, Jamora C, Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 2003;112:535-48.
    • (2003) Cell , vol.112 , pp. 535-548
    • Perez-Moreno, M.1    Jamora, C.2    Fuchs, E.3
  • 69
    • 4444240943 scopus 로고    scopus 로고
    • Adenomatous polyposis coli proteins and cell adhesion
    • Bienz M, Hamada F. Adenomatous polyposis coli proteins and cell adhesion. Curr Opin Cell Biol 2004;16:528-35.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 528-535
    • Bienz, M.1    Hamada, F.2
  • 70
    • 0035945614 scopus 로고    scopus 로고
    • Adherens junctions inhibit asymmetric division in the Drosophila epithelium
    • Lu B, Roegiers F, Jan LY, et al. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 2001;409:522-5.
    • (2001) Nature , vol.409 , pp. 522-525
    • Lu, B.1    Roegiers, F.2    Jan, L.Y.3
  • 71
    • 33645132429 scopus 로고    scopus 로고
    • Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli
    • Takizowa S, Nagasaka K, Nakagawa S, et al. Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 2006;11:453-64.
    • (2006) Genes Cells , vol.11 , pp. 453-464
    • Takizowa, S.1    Nagasaka, K.2    Nakagawa, S.3
  • 72
    • 0037318955 scopus 로고    scopus 로고
    • Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
    • Albertson R, Doe CQ. Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 2003;5:166-70.
    • (2003) Nat Cell Biol , vol.5 , pp. 166-170
    • Albertson, R.1    Doe, C.Q.2
  • 73
    • 4043170088 scopus 로고    scopus 로고
    • Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors
    • Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004;18:1909-25.
    • (2004) Genes Dev , vol.18 , pp. 1909-1925
    • Bilder, D.1
  • 74
    • 29144469472 scopus 로고    scopus 로고
    • The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
    • Qin Y, Capaldo C, Gumbiner BM, et al. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J Cell Biol 2005;171:1061-71.
    • (2005) J Cell Biol , vol.171 , pp. 1061-1071
    • Qin, Y.1    Capaldo, C.2    Gumbiner, B.M.3
  • 75
    • 33745919542 scopus 로고    scopus 로고
    • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila
    • McCartney BM, Price MH, Webb RL, et al. Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 2006;133:2407-18.
    • (2006) Development , vol.133 , pp. 2407-2418
    • McCartney, B.M.1    Price, M.H.2    Webb, R.L.3
  • 76
    • 0035070046 scopus 로고    scopus 로고
    • Mutations in the APC tumour suppressor gene cause chromosomal instability
    • Fodde R, Kuipers J, Rosenberg C, et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 2001;3:433-8.
    • (2001) Nat Cell Biol , vol.3 , pp. 433-438
    • Fodde, R.1    Kuipers, J.2    Rosenberg, C.3
  • 77
    • 0035067391 scopus 로고    scopus 로고
    • A role for the adenomatous polyposis coli protein in chromosome segregation
    • Kaplan KB, Burds AA, Swedlow JR, et al. A role for the adenomatous polyposis coli protein in chromosome segregation. Nat Cell Biol 2001;3:429-32.
    • (2001) Nat Cell Biol , vol.3 , pp. 429-432
    • Kaplan, K.B.1    Burds, A.A.2    Swedlow, J.R.3
  • 78
    • 1642499116 scopus 로고    scopus 로고
    • A divergent canonical WNT-signaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules
    • Ciani L, Krylova O, Smalley MJ, et al. A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol 2004;164:243-53.
    • (2004) J Cell Biol , vol.164 , pp. 243-253
    • Ciani, L.1    Krylova, O.2    Smalley, M.J.3
  • 79
    • 1642442739 scopus 로고    scopus 로고
    • Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle
    • Kaplan DD, Meigs TE, Kelly P, et al. Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem 2004.
    • (2004) J Biol Chem
    • Kaplan, D.D.1    Meigs, T.E.2    Kelly, P.3
  • 80
    • 0037442990 scopus 로고    scopus 로고
    • A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment
    • Wakefield JG, Stephens DJ, Tavare JM. A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. J Cell Sci 2003;116:637-46.
    • (2003) J Cell Sci , vol.116 , pp. 637-646
    • Wakefield, J.G.1    Stephens, D.J.2    Tavare, J.M.3
  • 81
    • 0035904231 scopus 로고    scopus 로고
    • E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity
    • Stockinger A, Eger A, Wolf J, et al. E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 2001;154:1185-96.
    • (2001) J Cell Biol , vol.154 , pp. 1185-1196
    • Stockinger, A.1    Eger, A.2    Wolf, J.3
  • 82
    • 10744219596 scopus 로고    scopus 로고
    • Specific inhibition of gene expression using a stably integrated, inducible small-intertering-RNA vector
    • van de Wetering M, Oving I, Muncan V, et al. Specific inhibition of gene expression using a stably integrated, inducible small-intertering-RNA vector. EMBO Rep 2003;4:609-15.
    • (2003) EMBO Rep , vol.4 , pp. 609-615
    • van de Wetering, M.1    Oving, I.2    Muncan, V.3
  • 83
    • 0037062430 scopus 로고    scopus 로고
    • Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation
    • Chan TA, Wang Z, Dang LH, et al. Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. Proc Natl Acad Sci U S A 2002;99:8265-70.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8265-8270
    • Chan, T.A.1    Wang, Z.2    Dang, L.H.3
  • 84
    • 0035420212 scopus 로고    scopus 로고
    • Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
    • Roh H, Green DW, Boswell CB, et al. Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res 2001;61:6563-8.
    • (2001) Cancer Res , vol.61 , pp. 6563-6568
    • Roh, H.1    Green, D.W.2    Boswell, C.B.3
  • 85
    • 0034760407 scopus 로고    scopus 로고
    • Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts
    • Green DW, Roh H, Pippin JA, et al. Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts. J Surg Res 2001;101:16-20.
    • (2001) J Surg Res , vol.101 , pp. 16-20
    • Green, D.W.1    Roh, H.2    Pippin, J.A.3
  • 86
    • 11144344179 scopus 로고    scopus 로고
    • Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics
    • Dihlmann S, von Knebel DM. Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics. Int J Cancer 2005;113:515-24.
    • (2005) Int J Cancer , vol.113 , pp. 515-524
    • Dihlmann, S.1    von Knebel, D.M.2
  • 87
    • 3042788940 scopus 로고    scopus 로고
    • COX-2 inhibition and colorectal cancer
    • Koehne CH, Dubois RN. COX-2 inhibition and colorectal cancer. Semin Oncol 2004;31(Suppl 7):12-21.
    • (2004) Semin Oncol , vol.31 , Issue.SUPPL. 7 , pp. 12-21
    • Koehne, C.H.1    Dubois, R.N.2
  • 88
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    • Castellone MD, Teramoto H, Williams BO, et al. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 2005;310:1504-10.
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3
  • 89
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • Suzuki H, Watkins DN, Jair KW, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004;36:417-22.
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3
  • 90
    • 33745765883 scopus 로고    scopus 로고
    • Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
    • Aguilera O, Fraga MF, Ballestar E, et al. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 2006.
    • (2006) Oncogene
    • Aguilera, O.1    Fraga, M.F.2    Ballestar, E.3
  • 91
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rogo C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rogo, C.3
  • 92
    • 32244435820 scopus 로고    scopus 로고
    • A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene
    • Gerner EW, Ignatenko NA, Lance P, et al. A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene. Ann N Y Acad Sci 2005;1059:97-105.
    • (2005) Ann N Y Acad Sci , vol.1059 , pp. 97-105
    • Gerner, E.W.1    Ignatenko, N.A.2    Lance, P.3
  • 93
    • 3142669010 scopus 로고    scopus 로고
    • SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
    • Blache P, van de Wetering M, Duluc I, et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol 2004;166:37-47.
    • (2004) J Cell Biol , vol.166 , pp. 37-47
    • Blache, P.1    van de Wetering, M.2    Duluc, I.3
  • 94
    • 17344392128 scopus 로고    scopus 로고
    • Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
    • Mallo GV, Rechreche H, Frigerio JM, et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 1997;74:35-44.
    • (1997) Int J Cancer , vol.74 , pp. 35-44
    • Mallo, G.V.1    Rechreche, H.2    Frigerio, J.M.3
  • 95
    • 0344826531 scopus 로고    scopus 로고
    • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    • Aoki K, Tamai Y, Horiike S, et al. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 2003;35:323-30.
    • (2003) Nat Genet , vol.35 , pp. 323-330
    • Aoki, K.1    Tamai, Y.2    Horiike, S.3
  • 96
    • 21344457432 scopus 로고    scopus 로고
    • RNA interference: From gene silencing to gene-specific therapeutics
    • Leung RK, Whittaker PA. RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 2005;107:222-39.
    • (2005) Pharmacol Ther , vol.107 , pp. 222-239
    • Leung, R.K.1    Whittaker, P.A.2
  • 97
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in nonhuman primates
    • Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in nonhuman primates. Nature 2006;441:111-14.
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.2    Akinc, A.3
  • 98
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells
    • Verma UN, Surabhi RM, Schmaltieg A, et al. Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res 2003;9:1291-300.
    • (2003) Clin Cancer Res , vol.9 , pp. 1291-1300
    • Verma, U.N.1    Surabhi, R.M.2    Schmaltieg, A.3
  • 99
    • 0037069330 scopus 로고    scopus 로고
    • Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways
    • Martinez LA, Naguibneva I, Lehrmann H, et al. Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways. Proc Natl Acad Sci U S A 2002;99:14849-54.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14849-14854
    • Martinez, L.A.1    Naguibneva, I.2    Lehrmann, H.3
  • 100
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006;441:537-41.
    • (2006) Nature , vol.441 , pp. 537-541
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3
  • 101
    • 33645500266 scopus 로고    scopus 로고
    • Progress towards in vivo use of siRNAs
    • Behlke MA. Progress towards in vivo use of siRNAs. Mol Ther 2006;13:644-70.
    • (2006) Mol Ther , vol.13 , pp. 644-670
    • Behlke, M.A.1


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