Wnt gradient formation requires retromer function in Wnt-producing cells

Science

Volumn 312, Issue 5775, 2006, Pages 921-924

  Coudreuse, Damien Y M ^a   Roël, Giulietta ^a   Betist, Marco C ^a   Destrée, Olivier ^a   Korswagen, Hendrik C ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; CONCENTRATION (PROCESS); GENETIC ENGINEERING; PROTEINS; TISSUE;

LONG-RANGE PATTERNING; RETROMER; WNT GRADIENT FORMATION; WNT-PRODUCING CELLS;

CELLS;

MORPHOGEN; MULTIPROTEIN COMPLEX; PROTEIN EGL20; RETROMER; UNCLASSIFIED DRUG; WNT PROTEIN;

GENE; GENE EXPRESSION; PROTEIN; VERTEBRATE;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; BODY PATTERNING; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; GENE EXPRESSION; GLYCOPROTEINS; HUMANS; MULTIPROTEIN COMPLEXES; MUTATION; NEURONS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSGENES; VESICULAR TRANSPORT PROTEINS; WNT PROTEINS; XENOPUS;

CAENORHABDITIS ELEGANS; VERTEBRATA;

EID: 33646592268     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124856     Document Type: Article

References (24)

1. J. Whangbo, C. Kenyon, Mol. Cell 4, 851 (1999).
2. J. Harris, L. Honigberg, N. Robinson, C. Kenyon, Development 122, 3117 (1996).
3. J. Whangbo, J. Harris, C. Kenyon, Development 127, 4587 (2000).
4. S. J. Salser, C. Kenyon, Nature 355, 255 (1992).
5. A. G. Fraser et al., Nature 408, 325 (2000).
6. M. N. Seaman, J. M. McCaffery, S. D. Emr, J. Cell Biol. 142, 665 (1998).
7. M. Verges et al., Nat. Cell Biol. 6, 763 (2004).
8. B. F. Horazdovsky et al., Mol. Biol. Cell 5, 1529 (1997).
9. H. C. Korswagen, Bioessays 24, 801 (2002).
10. C. J. Thorpe, A. Schlesinger, J. C. Carter, B. Bowerman, Cell 90, 695 (1997).
11. M. A. Herman, H. R. Horvitz, Development 120, 1035 (1994).
12. K. M. Cadigan, M. P. Fish, E. J. Rulifson, R. Nusse, Cell 93, 767 (1998).
13. F. J. Staal, B. M. Burgering, M. van de Wetering, H. C. Clevers, Int. Immunol. 11, 317 (1999).
14. J. Noordermeer, F. Meijlink, P. Verrijzer, F. Rijsewijk, O. Destree, Nucleic Acids Res. 17, 11 (1989).
15. A. P. McMahon, R. T. Moon, Cell 58, 1075 (1989).
16. J. Roose et al., Nature 395, 608 (1998).
17. S. Hoppler, J. D. Brown, R. T. Moon, Genes Dev. 10, 2805 (1996).
18. J. Vallin et al., J. Biol. Chem. 276, 30350 (2001).
19. T. Kadowaki, E. Wilder, J. Klingensmith, K. Zachary, N. Perrimon, Genes Dev. 10, 3116 (1996).
20. K. Tanaka, Y. Kitagawa, T. Kadowaki, J. Biol. Chem. 277, 12816 (2002).
21. C. E. Rocheleau et al., Cell 90, 707 (1997).
22. D. Panakova, H. Sprong, E. Marois, C. Thiele, S. Eaton, Nature 435, 58 (2005).
23. J. E. Sulston, H. R. Horvitz, Dev. Biol. 56, 110 (1977).
24. We thank C. McNulty, H. Clevers, and R. Plasterk for critically reading the manuscript; J. Ahringer, A. Fire, C. Haft, D. Hermand, R. Moon, J. Smith, and C. Wolkow for reagents; B. Bowerman, J. Kuipers, W. Stoorvogel, and M. van de Wetering for help and advice; Shohei Mitani (National Bioresource Project for the Nematode, Tokyo) for deletion mutants; and the Caenorhabditis Genetic Center (University of Minnesota, Minneapolis) for strains. This work was supported by the Dutch Cancer Foundation, the EU FP6 program Cells into Organs (H.C.K.), and EU grant QLRT-2000-01275 (O.D.).