Inducible Cre-Mediated Control of Gene Expression in the Murine Gastrointestinal Tract: Effect of Loss of β-Catenin

Gastroenterology

Volumn 126, Issue 5, 2004, Pages 1236-1246

  Ireland, Heather ^a   Kemp, Richard ^a   Houghton, Carol ^a   Howard, Louise ^a   Clarke, Alan R ^b   Sansom, Owen J ^b   Winton, Douglas J ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BETA GALACTOSIDASE; BETA NAPHTHOFLAVONE; CRE RECOMBINASE; CYTOCHROME P450; WNT PROTEIN; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME REGULATION; ESOPHAGUS; EXTRACELLULAR MATRIX; GALLBLADDER; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GOBLET CELL; INTESTINE; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE VILLUS; LIVER; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIGNAL TRANSDUCTION; STEM CELL; STOMACH; TRANSGENE; UPREGULATION;

EID: 2142709556     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.03.020     Document Type: Article

References (34)

1. Sauer B, Henderson N. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc Natl Acad Sci U S A 1988;85:5166-5170.
2. Kühn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science 1995;269:1427-1429.
3. Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lubbert H, Bujard H. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A 1996;93:10933-10938.
4. Schonig K, Schwenk F, Rajewsky K, Bujard H. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res 2002;30:e134.
5. Saam JR, Gordon JI. Inducible gene knockouts in the small intestinal and colonic epithelium. J Biol Chem 1999;274:38071-38082.
6. Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P. Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A 1996;93:10887-10890.
7. Indra AK, Warot X, Brocard J, Bomert JM, Xiao JH, Chambon P, Metzger D. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res 1999;27:4324-4327.
8. Kellendonk C, Tronche F, Casanova E, Anlag K, Opherk C, Schutz G. Inducible site-specific recombination in the brain. J Mol Biol 1999;285:175-182.
9. Vooijs M, Jonkers J, Berns A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep 2001;2:292-297.
10. Campbell SJ, Carlotti F, Hall PA, Clark AJ, Wolf CR. Regulation of the CYP1A1 promoter in transgenic mice: an exquisitely sensitive on-off system for cell specific gene regulation. J Cell Sci 1996;109:2619-2625.
11. Matsushita N, Sogawa K, Ema M, Yoshida A, Jujii-Kuriyama Y. A factor binding to the xenobiotic responsive element (XRE) of P-450 1A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt. J Biol Chem 1993;268:21002-21006.
12. Pinto D, Gregorieff A, Begthel H, Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 2003;17:1709-1713.
13. Kuhnert F, Davis CR, Wang H-T, Chu P, Lee M, Yuan J, Nusse R, Kuo CJ. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dikkopf-1. Proc Natl Acad Sci U S A 2004;101:266-271.
14. Sauer B. Manipulation of transgenes by site-specific recombination: use of Cre recombinase. Methods Enzymol 1993;225:890-900.
15. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999;21:70-71.
16. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R. Inactivation of the b-catenin gene by Wnt1-Cre mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 2001;128:1253-1264.
17. Ema M, Ohe N, Suzuki M, Mimura J, Sogawa K, Ikawa S, Jujii-Kuriyama Y. Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem 1994;269:27337-27343.
18. Kellendonk C, Tronche F, Monaghan A-P, Angrand P-O, Stewart F, Schultz G. Regulation of Cre recombinase activity by the synthetic steroid RU486. Nucleic Acids Res 1996;24:1404-1411.
19. Winton DJ, Ponder BAJ. Stem cell organisation in mouse small intestine. Proc R Soc Lond B Biol Sci 1990;241:13-18.
20. Merritt AJ, Allen TD, Potten CS, Hickman JA. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 1997;14:2759-2766.
21. Marshman E, Ottewell PD, Potten CS, Watson AJ. Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine. J Pathol 2001;195:285-292.
22. Bjerknes M, Cheng H. Methods for the isolation of intact epithelium from the mouse intestine. Anat Rec 1981;199:565-574.
23. Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 1993;9:317-321.
24. Schneider A, Zhang Y, Guan Y, Davis LS, Breyer MD. Differential, inducible gene targeting in renal epithelium, vascular endothelium, and viscera of Mx1cre mice. Am J Physiol 2003;284:F411-F417.
25. Tannour-Louet M, Porteu A, Vaulont S, Kahn A, Vasseur-Cognet M. A tamoxifen-inducible chimeric cre recombinase specifically effective in the fetal and adult mouse liver. Hepatology 2002;35:1072-1081.
26. Wong MH, Saam JR, Stappenbeck TS, Rexer CH, Gordon JI. Genetic mosaic analysis based on cre recombinase and navigated laser capture microdissection. Proc Natl Acad Sci U S A 2000;97:12601-12606.
27. Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ, Clevers H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-383.
28. Finneman S, Kuhl M, Otto G, Wedlich D. Cadherin transfection of Xenopus XTC cells downregulates expression of substrate adhesion molecules. Mol Cell Biol 1995;15:5082-5091.
29. Fagotto F, Gumbiner BM. Cell contact dependent signaling. Dev Biol 1996;180:445-454.
30. Heasman J, Crawford A, Goldstone K, Garner-Hamrick P, Gumbiner C, Yoshida-Noro C, Wylie C. Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 1994;79:791-803.
31. Hodivala KJ, Watt FM. Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J Cell Biol 1994;124:589-600.
32. Zhu AJ, Watt FM. Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epithelial keratinocytes. J Cell Sci 1996;109:3013-3023.
33. Huynh-Do U, Vindis C, Uu H, Cerretti DP, McGrew JT, Enriquez M, Chen J, Daniel TO. Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis. J Cell Sci 2002;115:3073-3081.
34. Batlle A, Henderson JT, Beghtel H, van den Born MM, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T, Clevers H. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002;111:251-263.