Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry

Nature Cell Biology

Volumn 5, Issue 2, 2003, Pages 166-170

  Albertson, Roger ^a   Doe, Chris Q ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; MYOSIN II; PROTEIN DLG; PROTEIN LGL; PROTEIN SCRIB; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

APICAL MEMBRANE; ARTICLE; ASYMMETRIC SYNTHESIS; BACTERIUM; BASEMENT MEMBRANE; CELL CYCLE; CELL DIVISION; CELL POLARITY; CELL SIZE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; MAMMAL; METAPHASE; MITOSIS SPINDLE; NEUROBLAST; NONHUMAN; PRIORITY JOURNAL; PROPHASE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SPINDLE POLE BODY;

ANIMALS; CELL CYCLE PROTEINS; CELL DIVISION; CELL POLARITY; CELL SIZE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; INSECT PROTEINS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MITOTIC SPINDLE APPARATUS; NEURONS; TUMOR SUPPRESSOR PROTEINS;

ARACHNIDA; BACTERIA (MICROORGANISMS); DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA; MELANOGASTER;

EID: 0037318955     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb922     Document Type: Article

References (29)

1. Knoblich, J. A. Asymmetric cell division during animal development. Nature Rev. Mol. Cell Biol. 2, 11-20 (2001).
2. Doe, C. Q. & Bowerman, B. Asymmetric cell division: fly neuroblast meets worm zygote. Curr. Opin. Cell Biol. 13, 68-75 (2001).
3. Ohshiro, T., Yagami, T., Zhang, C. & Matsuzaki, F. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408, 593-596 (2000).
4. Peng, C. Y., Manning, L., Albertson, R. & Doe, C. Q. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408, 596-600 (2000).
5. Mathew, D. et al. Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr. Biol. 12, 531-539 (2002).
6. Strand, D. et al. A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Oncogene 11, 291-301 (1995).
7. Bilder, D., Li, M. & Perrimon, N. Cooperative regulation of cell polarity and growth by Drosophila tumour suppressors. Science 289, 113-116 (2000).
8. Kraut, R., Chia, W., Jan, L. Y., Jan, Y. N. & Knoblich, J. A. Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383, 50-55 (1996).
9. Schober, M., Schaefer, M. & Knoblich, J. A. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402, 548-551 (1999).
10. Petronczki, M. & Knoblich, J. A. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nature Cell Biol. 3, 43-49 (2001).
11. Wodartz, A., Ramrath, A., Grimm, A. & Knust, E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol. 150, 1361-1374 (2000).
12. Schaefer, M., Shevchenko, A. & Knoblich, J. A. A protein complex containing Inscuteable and the Gα binding protein Pins orients asymmetric cell divisions in Drosophila. Curr. Biol. 10, 353-362 (2000).
13. Schaefer, M., Petronczki, M., Dorner, D., Forte, M. & Knoblich, J. A. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell 107, 183-194 (2001).
14. Wodarz, A., Ramrath, A., Kuchinke, U. & Knust, E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402, 544-547 (1999).
15. Brenman, J. E. et al. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J. Nuerosci. 18, 8805-8813 (1998).
16. Niethammer, M. et al. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron 20, 693-707 (1998).
17. Matsumine, A. et al. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272, 1020-1023 (1996).
18. Hanada, T., Lin, L., Tibaldi, E. V., Reinherz, E. L. & Chishti, A. H. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J. Biol. Chem. 275, 28774-28784 (2000).
19. Gomes, J. E. et al. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos. Development 128, 4301-4314 (2001).
20. Guertin, D. A., Trautmann, S. & McCollum, D. Cytokinesis in eukaryotes. Microbiol. Mol. Biol. Rev. 66, 155-178 (2002).
21. Parmentier, M. L. et al. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J. Neurosci. (Online) 20, RC84 (2000).
22. Koh, Y. H., Popova, E., Thomas, U., Griffith, L. C. & Budnik, V. Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation. Cell 98, 353-363 (1999).
23. Morin, X., Daneman, R., Zavortink, M. & Chia, W. A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Proc. Natl Acad. Sci. USA 98, 15050-15055 (2001).
24. Bilder, D. & Perrimon, N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403, 676-680 (2000).
25. Broadus, J. & Doe, C. Q. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Curr. Biol. 7, 827-835 (1997).
26. Zito, K., Fetter, R. D., Goodman, C. S. & Isacoff, E. Y. Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg. Neuron 19, 1007-1016 (1997).
27. Spana, E. P. & Doe, C. Q. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121, 3187-3195 (1995).
28. Vaessin, H. et al. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67, 941-953 (1991).
29. Cai, Y., Chia, W. & Yang, X. A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions. EMBO J. 20, 1704-1714 (2001).