E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity

Journal of Cell Biology

Volumn 154, Issue 6, 2001, Pages 1185-1196

  Stockinger, Andreas ^a   Eger, Andreas ^a   Wolf, Julia ^a   Beug, Hartmut ^b   Foisner, Roland ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

Carcinogenesis; Catenins; Cell proliferation; E cadherin; LEF 1

Indexed keywords

BETA CATENIN; UVOMORULIN;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL ADHESION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FIBROBLAST; MOLECULAR STABILITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; BETA CATENIN; CADHERINS; CELL ADHESION; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; CYTOSKELETAL PROTEINS; EPITHELIAL CELLS; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION; MICE; PEPTIDE FRAGMENTS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0035904231     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200104036     Document Type: Article

References (73)

1. Beta-catenin is a target for the ubiquitin-proteasome pathway
2. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein
3. The p120 catenin family: Complex roles in adhesion, signaling and cancer
4. Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1
5. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
6. Catenins, wnt signaling and cancer
7. Functional interaction of beta-catenin with the transcription factor LEF-1
8. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
9. Linking colorectal cancer to Wnt signaling
10. Epithelial-mesenchymal transitions in cancer progression
11. Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
12. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
13. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis
14. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity
15. Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus
16. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
17. E-cadherin suppresses cellular transformation by inhibiting beta-carenin signaling in an adhesion-independent manner
18. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression
19. Regulation of cadherin adhesive activity
20. Lack of beta-catenin affects mouse development at gastrulation
21. The hallmark of cancer
22. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
23. Identification ofc-MYC as a target of the APC pathway
24. Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
25. Curbing the nuclear activities of β-catenin
26. Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro
27. The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
28. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
29. Requirement for beta-catenin in anterior-posterior axis formation in mice
30. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
31. Cadherin-mediated adhesion is required for normal growth regulation of human gingival epithelial cells
32. Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin
33. Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
34. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin
35. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
36. Depletion of epithelial stem-cell compartments the small intestine of mice lacking Tcf-4
37. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
38. A role for cadherins in tissue formation
39. Increased cell-substratum adhesion, and decreased gelatinase secretion and cell growth, induced by E-cadherin transfection of human colon carcinoma cells
40. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
41. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
42. Defining interactions and distributions of cadhetin and catenin complexes in polarized epithelial cells
43. p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
44. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
45. Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest
46. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
47. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity
48. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
49. A causal role for E-cadherin in the transition from adenoma to carcinoma
50. Wnt signaling and cancer
51. Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion
52. TCF transcription factors: Molecular switches in carcinogenesis
53. TheXenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
54. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1
55. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
56. Stabilization of beta-catenin by genetic defects in melanoma cell lines
57. Inhibition of beta-catenin-mediated transactivation by cadherin derivatives
58. Structural basis of cell-cell adhesion by cadherins
59. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
60. Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin
61. E-cadherin-dependent growth suppression is mediated by the cyc[in-dependent kinase inhibitor p27(KIP1)
62. Regulation of beta-catenin transformation by the p300 transcriptional coactivator
63. Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion
64. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
65. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
66. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion
67. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line
68. Beta-catenin: A key mediator of Wnt signaling
69. The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn
70. The axis-inducing activity, stability, and subcellular distribution of betacatenin is regulated in Xenopus embryos by glycogen synthase kinase 3
71. Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts
72. Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin
73. Plakoglobin and beta-catenin: Protein interactions, regulation and biological roles