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Volumn 22, Issue 5, 2003, Pages 1101-1113

Nuclear export of the APC tumour suppressor controls β-catenin function in transcription

Author keywords

catenin; Adenomatous polyposis coli; Colorectal carcinomas; FLIP; Nuclear export

Indexed keywords

APC PROTEIN; BETA CATENIN;

EID: 0037416148     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg105     Document Type: Article
Times cited : (159)

References (45)
  • 2
    • 0032871895 scopus 로고    scopus 로고
    • APC: The plot thickens
    • Bienz, M. (1999) APC: the plot thickens. Curr. Opin. Genet. Dev., 9, 595-603.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 595-603
    • Bienz, M.1
  • 3
    • 0036270763 scopus 로고    scopus 로고
    • The subcellular destinations of APC proteins
    • Bienz, M. (2002) The subcellular destinations of APC proteins. Nat. Rev. Mol. Cell Biol., 3, 328-338.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 328-338
    • Bienz, M.1
  • 4
    • 0032884884 scopus 로고    scopus 로고
    • Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    • Brabletz, T., Jung, A., Dag, S., Hlubek, F. and Kirchner, T. (1999)Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am. J. Pathol., 155, 1033-1038.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1033-1038
    • Brabletz, T.1    Jung, A.2    Dag, S.3    Hlubek, F.4    Kirchner, T.5
  • 6
    • 0035854645 scopus 로고    scopus 로고
    • Nuclear export of human β-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor
    • Eleftheriou, A., Yoshida, M. and Henderson, B.R. (2001) Nuclear export of human β-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor. J. Biol. Chem., 276, 25883-25888.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25883-25888
    • Eleftheriou, A.1    Yoshida, M.2    Henderson, B.R.3
  • 7
    • 0032510103 scopus 로고    scopus 로고
    • Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin
    • Fagotto, F., Gluck, U. and Gumbiner, B.M. (1998) Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin. Curr. Biol., 8, 181-190.
    • (1998) Curr. Biol. , vol.8 , pp. 181-190
    • Fagotto, F.1    Gluck, U.2    Gumbiner, B.M.3
  • 8
    • 0035496104 scopus 로고    scopus 로고
    • APC, signal transduction and genetic instability in colorectal cancer
    • Fodde, R., Smits, R. and Clevers, H. (2001) APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer, 1, 55-67.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 9
    • 0035824622 scopus 로고    scopus 로고
    • ARM domaindependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56α sub-unit of protein phosphatase 2A
    • Galea, M., Eleftheriou, A. and Henderson, B.R. (2001) ARM domaindependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56α sub-unit of protein phosphatase 2A. J. Biol. Chem., 276, 45833-45839.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45833-45839
    • Galea, M.1    Eleftheriou, A.2    Henderson, B.R.3
  • 10
  • 11
    • 0034282097 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover
    • Henderson, B.R. (2000) Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover. Nat. Cell Biol., 2, 653-660.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 653-660
    • Henderson, B.R.1
  • 12
    • 0036747385 scopus 로고    scopus 로고
    • The ins and outs of APC and β-catenin nuclear transport
    • Henderson, B.R. and Fagotto, F. (2002) The ins and outs of APC and β-catenin nuclear transport. EMBO Rep., 3, 834-839.
    • (2002) EMBO Rep. , vol.3 , pp. 834-839
    • Henderson, B.R.1    Fagotto, F.2
  • 13
    • 0037025361 scopus 로고    scopus 로고
    • Lymphoid enhancer factor-1 blocks APC-mediated nuclear export and degradation of β-catenin: Regulation by histone deacetylase 1
    • Henderson, B.R., Galea, M., Schuechner, S. and Leung, L. (2002) Lymphoid enhancer factor-1 blocks APC-mediated nuclear export and degradation of β-catenin: regulation by histone deacetylase 1. J. Biol. Chem., 277, 24258-24264.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24258-24264
    • Henderson, B.R.1    Galea, M.2    Schuechner, S.3    Leung, L.4
  • 14
    • 0037062434 scopus 로고    scopus 로고
    • Attenuated APC alleles produce functional protein from internal translation initiation
    • Heppner Goss, K.H., Trzepacz, C., Tuohy, T.M. and Groden, J. (2002) Attenuated APC alleles produce functional protein from internal translation initiation. Proc. Natl Acad. Sci. USA, 99, 8161-8166.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8161-8166
    • Heppner Goss, K.H.1    Trzepacz, C.2    Tuohy, T.M.3    Groden, J.4
  • 15
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K.W. and Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 17
    • 0037119970 scopus 로고    scopus 로고
    • A yeast model system for functional analysis of β-catenin signaling
    • Lee, M.S., D'Amour, K.A. and Papkoff, J. (2002) A yeast model system for functional analysis of β-catenin signaling. J. Cell Biol., 158, 1067-1078.
    • (2002) J. Cell Biol. , vol.158 , pp. 1067-1078
    • Lee, M.S.1    D'Amour, K.A.2    Papkoff, J.3
  • 19
    • 0028291928 scopus 로고
    • Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors
    • Miyaki, M. et al. (1994) Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res., 54, 3011-3020.
    • (1994) Cancer Res. , vol.54 , pp. 3011-3020
    • Miyaki, M.1
  • 20
    • 0029102368 scopus 로고
    • Subcellular localization of the APC protein: Immunoelectron microscopic study of the association of the APC protein with catenin
    • Miyashiro, I. et al. (1995) Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene, 11, 89-96.
    • (1995) Oncogene , vol.11 , pp. 89-96
    • Miyashiro, I.1
  • 21
    • 0037054547 scopus 로고    scopus 로고
    • The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized cells
    • Mogensen, M.M., Tucker, J.B., Mackie, J.B., Prescott, A.R. and Näthke, I.S. (2002) The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized cells. J. Cell Biol., 157, 1041-1048.
    • (2002) J. Cell Biol. , vol.157 , pp. 1041-1048
    • Mogensen, M.M.1    Tucker, J.B.2    Mackie, J.B.3    Prescott, A.R.4    Näthke, I.S.5
  • 22
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
    • Morin, P.J., Sparks, A.B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B. and Kinzler, K.W. (1997) Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science, 275, 1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 23
    • 0027930066 scopus 로고
    • The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
    • Munemitsu, S., Souza, B., Muller, O., Albert, I., Rubinfeld, B. and Polakis, P. (1994) The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res., 54, 3676-3681.
    • (1994) Cancer Res. , vol.54 , pp. 3676-3681
    • Munemitsu, S.1    Souza, B.2    Muller, O.3    Albert, I.4    Rubinfeld, B.5    Polakis, P.6
  • 24
    • 0028987249 scopus 로고
    • Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B. and Polakis, P. (1995) Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl Acad. Sci. USA, 92, 3046-3050.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3046-3050
    • Munemitsu, S.1    Albert, I.2    Souza, B.3    Rubinfeld, B.4    Polakis, P.5
  • 25
    • 0027146559 scopus 로고
    • Mutations of the APC (adenomatous polyposis coli) gene
    • Nagase, H. and Nakamura, Y. (1993) Mutations of the APC (adenomatous polyposis coli) gene. Hum. Mutat., 2, 425-434.
    • (1993) Hum. Mutat. , vol.2 , pp. 425-434
    • Nagase, H.1    Nakamura, Y.2
  • 26
    • 0029982877 scopus 로고    scopus 로고
    • The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
    • Näthke, I.S., Adams, C.L., Polakis, P., Sellin, J.H. and Nelson, W.J. (1996) The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol., 134, 165-179.
    • (1996) J. Cell Biol. , vol.134 , pp. 165-179
    • Näthke, I.S.1    Adams, C.L.2    Polakis, P.3    Sellin, J.H.4    Nelson, W.J.5
  • 27
    • 0030987826 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein
    • Neufeld, K.L. and White, R.L. (1997) Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein. Proc. Natl Acad. Sci. USA, 94, 3034-3039.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3034-3039
    • Neufeld, K.L.1    White, R.L.2
  • 28
    • 0034710914 scopus 로고    scopus 로고
    • Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
    • Neufeld, K.L., Nix, D.A., Bogerd, H., Kang, Y., Beckerle, M.C., Cullen, B.R. and White, R.L. (2000a) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc. Natl Acad. Sci. USA, 97, 12085-12090.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12085-12090
    • Neufeld, K.L.1    Nix, D.A.2    Bogerd, H.3    Kang, Y.4    Beckerle, M.C.5    Cullen, B.R.6    White, R.L.7
  • 29
    • 0034576628 scopus 로고    scopus 로고
    • APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export
    • Neufeld, K.L., Zhang, F., Cullen, B.R. and White, R.L. (2000b) APC-mediated downregulation of β-catenin activity involves nuclear sequestration and nuclear export. EMBO Rep., 1, 519-523.
    • (2000) EMBO Rep. , vol.1 , pp. 519-523
    • Neufeld, K.L.1    Zhang, F.2    Cullen, B.R.3    White, R.L.4
  • 30
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P. (2000) Wnt signaling and cancer. Genes Dev., 14, 1837-1851.
    • (2000) Genes Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 31
    • 0035809193 scopus 로고    scopus 로고
    • Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the β-catenin destruction complex in polarized epithelial cells
    • Reinacher-Schick, A. and Gumbiner, B.M. (2001) Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the β-catenin destruction complex in polarized epithelial cells. J. Cell Biol., 152, 491-502.
    • (2001) J. Cell Biol. , vol.152 , pp. 491-502
    • Reinacher-Schick, A.1    Gumbiner, B.M.2
  • 32
    • 0034739023 scopus 로고    scopus 로고
    • The APC tumour suppressor has a nuclear export function
    • Rosin-Arbesfeld, R., Townsley, F. and Bienz, M. (2000) The APC tumour suppressor has a nuclear export function. Nature, 406, 1009-1012.
    • (2000) Nature , vol.406 , pp. 1009-1012
    • Rosin-Arbesfeld, R.1    Townsley, F.2    Bienz, M.3
  • 33
    • 0035502933 scopus 로고    scopus 로고
    • Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells
    • Rosin-Arbesfeld, R., Ihrke, G. and Bienz, M. (2001) Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells. EMBO J., 20, 5929-5939.
    • (2001) EMBO J. , vol.20 , pp. 5929-5939
    • Rosin-Arbesfeld, R.1    Ihrke, G.2    Bienz, M.3
  • 35
    • 0035914460 scopus 로고    scopus 로고
    • Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1ε
    • Rubinfeld, B., Tice, D.A. and Polakis, P. (2001) Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1ε. J. Biol. Chem., 276, 39037-39045.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39037-39045
    • Rubinfeld, B.1    Tice, D.A.2    Polakis, P.3
  • 36
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • Satoh, S. et al. (2000) AXIN1 mutations in hepatocellular carcinomas and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat. Genet., 24, 245-250.
    • (2000) Nat. Genet. , vol.24 , pp. 245-250
    • Satoh, S.1
  • 37
    • 0034653689 scopus 로고    scopus 로고
    • The β-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
    • Shih, I.M., Yu, J., He, T.C., Vogelstein, B. and Kinzler, K.W. (2000) The β-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res., 60, 1671-1676.
    • (2000) Cancer Res. , vol.60 , pp. 1671-1676
    • Shih, I.M.1    Yu, J.2    He, T.C.3    Vogelstein, B.4    Kinzler, K.W.5
  • 38
    • 0027394231 scopus 로고
    • The APC gene product in normal and tumor cells
    • Smith, K.J. et al. (1993) The APC gene product in normal and tumor cells. Proc. Natl Acad. Sci. USA, 90, 2846-2850.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2846-2850
    • Smith, K.J.1
  • 39
    • 0033563226 scopus 로고    scopus 로고
    • Apc1638T: A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
    • Smits, R. et al. (1999) Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev., 13, 1309-1321.
    • (1999) Genes Dev. , vol.13 , pp. 1309-1321
    • Smits, R.1
  • 40
    • 18644373146 scopus 로고    scopus 로고
    • The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering, M. et al. (2002) The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell, 111, 241-250.
    • (2002) Cell , vol.111 , pp. 241-250
    • Van de Wetering, M.1
  • 42
    • 0035182145 scopus 로고    scopus 로고
    • CRM1- and Ran-independent nuclear export of β-catenin
    • Wiechens, N. and Fagotto, F. (2001) CRM1- and Ran-independent nuclear export of β-catenin. Curr. Biol., 11, 18-27.
    • (2001) Curr. Biol. , vol.11 , pp. 18-27
    • Wiechens, N.1    Fagotto, F.2
  • 43
    • 0032910953 scopus 로고    scopus 로고
    • β-catenin can be transported into the nucleus in a Ran-unassisted manner
    • Yokoya, F., Imamoto, N., Tachibana, T. and Yoneda, Y. (1999) β-Catenin can be transported into the nucleus in a Ran-unassisted manner. Mol. Biol. Cell, 10, 1119-1131.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1119-1131
    • Yokoya, F.1    Imamoto, N.2    Tachibana, T.3    Yoneda, Y.4
  • 44
    • 0033740339 scopus 로고    scopus 로고
    • Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein
    • Zhang, F., White, R.L. and Neufeld, K.L. (2000) Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. Proc. Natl Acad. Sci. USA, 97, 12577-12582.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12577-12582
    • Zhang, F.1    White, R.L.2    Neufeld, K.L.3
  • 45
    • 0035167598 scopus 로고    scopus 로고
    • Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein
    • Zhang, F., White, R.L. and Neufeld, K.L. (2001) Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Mol. Cell. Biol., 21, 8143-8156.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8143-8156
    • Zhang, F.1    White, R.L.2    Neufeld, K.L.3


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