Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors

Cancer Research

Volumn 57, Issue 20, 1997, Pages 4478-4481

  Kitaeva, Maria N ^a   Grogan, Liam ^a,c   Williams, John P ^b   Dimond, Eileen ^a   Nakahara, Kenneth ^a   Hausner, Petr ^a,c   DeNobile, John W ^b   Soballe, Peter W ^b,d   Kirsch, Ilan R ^a  

^a Division of Clinical Sciences   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^d UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MICROSATELLITE DNA;

ARTICLE; CELL INTERACTION; COLON CARCINOGENESIS; COLORECTAL CANCER; GENE MUTATION; GENE REPLICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADULT; AGED; ALANINE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BETA CATENIN; CADHERINS; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; DNA REPLICATION; EXONS; FEMALE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM STAGING; PHENOTYPE; POINT MUTATION; THREONINE; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0030813048     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Rubinfeld, B., Robbins, P., El-Gamil, M., Albert, I., Porfiri, E., and Polakis, P. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science (Washington DC), 275: 1790-1792, 1997.
2. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Washington DC), 275: 1787-1790, 1997.
3. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science (Washington DC), 275: 1784-1787, 1997.
4. Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destree, O., and Clevers, H. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell, 86: 391-399, 1996.
5. Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. Functional interaction of β-catenin with the transcription factor LEF-1. Nature (Lond.), 382: 638-642, 1996.
6. Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B. G., and Kemler, R. Nuclear localization of β-catenin by interaction with transcription factor LEF-1. Mech. Dev., 59: 3-10, 1996.
7. Rubinfeld, B., Souza, B., Albert, I., Munemitsu, S., and Polakis, P. The APC protein and E-cadherin form similar but independent complexes with α-catenin, β-catenin, and plakoglobin. J. Biol. Chem., 270: 5549-5555, 1995.
8. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92: 3046-3050, 1995.
9. Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., and Polakis, P. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science (Washington DC), 272: 1023-1026, 1996.
10. Kinzler, K. W., and Vogelstein, B. Lessons from hereditary colorectal cancer. Cell, 87: 159-170, 1996.
11. Munemitsu, S., Albert. I., Rubinfeld, B., and Polakis, P. Deletion of an amino-terminal sequence β-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Mol. Cell. Biol., 16: 4088-4094, 1996.
12. Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro-Wolff, A., Gray-Goodrich, M., Campbell, H., Mayo, J., and Boyd, M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. 3. Natl. Cancer Inst. (Bethesda), 83: 757-766, 1991.
13. Mao, L., Lee, D. J., Tockman, M. S., Erozan, Y. S., Askin, F., and Sidransky, D. Microsatellite alterations as clonal markers for the detection of human cancer. Proc. Natl. Acad. Sci. USA, 91: 9871-9875, 1994.
14. Hoang, J. M., Cottu, P. H., Thuille, B., Salmon, R. J., Thomas, G., and Hamelin, R. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines. Cancer Res., 57: 300-303, 1997.
15. Bhattacharyya, N. P., Skandalis, A., Ganesh, A., Groden, J., and Meuth, M. Mutator phenotypes in human colorectal carcinoma cell lines, Proc. Natl. Acad. Sci. USA, 91: 6319-6323, 1994.
16. Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Willson, J. K., Kinzler, K. W., Jiricny, J., and Vogelstein, B. Mutations of GTBP in genetically unstable cells, Science (Washington DC), 268: 1915-1917, 1995.
17. Orth, K., Hung, J., Gazdar, A., Bowcock, A., Mathis, J. M., and Sambrook, J. Genetic instability in human ovarian cancer cell lines. Proc. Natl. Acad. Sci. USA, 91: 9495-9499, 1994.
18. Peifer, M. β-catenin as oncogene: the smoking gun. Science (Washington DC), 275: 1752-1753, 1997.
19. Liu, B., Nicolaides, N. C., Markowitz, S., Willson, J. K., Parsons, R. E., Jen, J., Papadopolous, N., Peltomaki, P., de la Chapelle, A., Hamilton, S. R., Kinzler, K. W., and Vogelstein, B. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat. Genet., 9: 48-55, 1995.
20. Papadopoulos, N., Nicolaides, N. C., Wei, Y. F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Hamilton, S. R., Petersen, G. M., Watson, P., Lynch, H. T., Peltomaki, P., Mecklin, J. P., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. Mutation of a mutL homolog in hereditary colon cancer. Science (Washington DC), 263: 1625-1629, 1994.
21. Tomlinson, I. P., Beck, N. E., and Bodmer, W. F. Allele loss on chromosome 11q and microsatellite instability in malignant melanoma. Eur. J. Cancer, 32A: 1797-1802, 1996.
22. Peris, K., Keller, G., Chimenti, S., Amantea, A., Kerl, H., and Hofler, H. Microsatellite instability and loss of heterozygosity in melanoma. J. Invest. Dermatol., 105: 625-628, 1995.