-
1
-
-
0036727125
-
γ-Secretase-mediated proteolysis in cell-surface-receptor signaling
-
Fortini M.E. γ-Secretase-mediated proteolysis in cell-surface-receptor signaling. Nat. Rev. Mol. Cell Biol. 3 (2002) 673-684
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 673-684
-
-
Fortini, M.E.1
-
2
-
-
3142512452
-
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
-
Koo E.H., and Kopan R. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat. Med. 10 (2004) S26-S33
-
(2004)
Nat. Med.
, vol.10
-
-
Koo, E.H.1
Kopan, R.2
-
3
-
-
33745614108
-
The γ-secretase complex: membrane-embedded proteolytic ensemble
-
Wolfe M.S. The γ-secretase complex: membrane-embedded proteolytic ensemble. Biochemistry 45 (2006) 7931-7939
-
(2006)
Biochemistry
, vol.45
, pp. 7931-7939
-
-
Wolfe, M.S.1
-
4
-
-
7944233158
-
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
-
Selkoe D.J. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat. Cell Biol. 6 (2004) 1054-1061
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1054-1061
-
-
Selkoe, D.J.1
-
5
-
-
33747623018
-
Notch signalling: a simple pathway becomes complex
-
Bray S.J. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 7 (2006) 678-689
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
6
-
-
0033639117
-
Requirements for Presenilin-dependent cleavage of Notch and other transmembrane proteins
-
Struhl G., and Adachi A. Requirements for Presenilin-dependent cleavage of Notch and other transmembrane proteins. Mol. Cell 6 (2000) 625-636
-
(2000)
Mol. Cell
, vol.6
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
7
-
-
2942557122
-
γ-Secretase: proteasome of the membrane?
-
Kopan R., and Ilagan M.X. γ-Secretase: proteasome of the membrane?. Nat. Rev. Mol. Cell Biol. 5 (2004) 499-504
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
8
-
-
13844299709
-
Presenilin attenuates receptor-mediated signaling and synaptic function
-
Parent A.T., et al. Presenilin attenuates receptor-mediated signaling and synaptic function. J. Neurosci. 25 (2005) 1540-1549
-
(2005)
J. Neurosci.
, vol.25
, pp. 1540-1549
-
-
Parent, A.T.1
-
9
-
-
33749072019
-
Nuclear signaling by receptor tyrosine kinases: the first robin of spring
-
Schlessinger J., and Lemmon M.A. Nuclear signaling by receptor tyrosine kinases: the first robin of spring. Cell 127 (2006) 45-48
-
(2006)
Cell
, vol.127
, pp. 45-48
-
-
Schlessinger, J.1
Lemmon, M.A.2
-
10
-
-
8444243682
-
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
-
Williams C.C., et al. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167 (2004) 469-478
-
(2004)
J. Cell Biol.
, vol.167
, pp. 469-478
-
-
Williams, C.C.1
-
11
-
-
33748087796
-
Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells
-
Zhu Y., et al. Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells. Cancer Res. 66 (2006) 7991-7998
-
(2006)
Cancer Res.
, vol.66
, pp. 7991-7998
-
-
Zhu, Y.1
-
12
-
-
33745714207
-
The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells
-
Naresh A., et al. The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 66 (2006) 6412-6420
-
(2006)
Cancer Res.
, vol.66
, pp. 6412-6420
-
-
Naresh, A.1
-
13
-
-
33749072714
-
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
-
Sardi S.P., et al. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127 (2006) 185-197
-
(2006)
Cell
, vol.127
, pp. 185-197
-
-
Sardi, S.P.1
-
14
-
-
0035816661
-
A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X., and Sudhof T.C. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293 (2001) 115-120
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
15
-
-
20444398562
-
Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by intracellular domains of βAPP and APLP
-
Pardossi-Piquard R., et al. Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by intracellular domains of βAPP and APLP. Neuron 46 (2005) 541-554
-
(2005)
Neuron
, vol.46
, pp. 541-554
-
-
Pardossi-Piquard, R.1
-
16
-
-
2642582435
-
Dissection of amyloid-β precursor protein-dependent transcriptional transactivation
-
Cao X., and Sudhof T.C. Dissection of amyloid-β precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279 (2004) 24601-24611
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24601-24611
-
-
Cao, X.1
Sudhof, T.C.2
-
17
-
-
25144490620
-
Presenilins in the developing, adult, and aging cerebral cortex
-
Wines-Samuelson M., and Shen J. Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist 11 (2005) 441-451
-
(2005)
Neuroscientist
, vol.11
, pp. 441-451
-
-
Wines-Samuelson, M.1
Shen, J.2
-
18
-
-
33846403492
-
Pathological and physiological functions of presenilins
-
10.1186/1750-1326-1-4
-
Vetrivel K.S., et al. Pathological and physiological functions of presenilins. Mol. Neurodegener. 1 (2006) 4. www.molecularneurodegeneration.com 10.1186/1750-1326-1-4
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 4
-
-
Vetrivel, K.S.1
-
19
-
-
30744465376
-
Reduced Aph-1b expression causes tissue- and substrate-specific changes in γ-secretase activity in rats with a complex phenotype
-
Coolen M.W., et al. Reduced Aph-1b expression causes tissue- and substrate-specific changes in γ-secretase activity in rats with a complex phenotype. FASEB J. 20 (2006) 175-177
-
(2006)
FASEB J.
, vol.20
, pp. 175-177
-
-
Coolen, M.W.1
-
20
-
-
4744375540
-
Identification of distinct γ-secretase complexes with different APH-1 variants
-
Shirotani K., et al. Identification of distinct γ-secretase complexes with different APH-1 variants. J. Biol. Chem. 279 (2004) 41340-41345
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41340-41345
-
-
Shirotani, K.1
-
21
-
-
21144447065
-
Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases
-
Mastrangelo P., et al. Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 8972-8977
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 8972-8977
-
-
Mastrangelo, P.1
-
22
-
-
13444268952
-
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
-
Serneels L., et al. Differential contribution of the three Aph1 genes to γ-secretase activity in vivo. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1719-1724
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 1719-1724
-
-
Serneels, L.1
-
23
-
-
21844448354
-
Spatial segregation of γ-secretase and substrates in distinct membrane domains
-
Vetrivel K.S., et al. Spatial segregation of γ-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 (2005) 25892-25900
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25892-25900
-
-
Vetrivel, K.S.1
-
24
-
-
33745853091
-
Presenilin-1 is an unprimed glycogen synthase kinase-3β substrate
-
Twomey C., and McCarthy J.V. Presenilin-1 is an unprimed glycogen synthase kinase-3β substrate. FEBS Lett. 580 (2006) 4015-4020
-
(2006)
FEBS Lett.
, vol.580
, pp. 4015-4020
-
-
Twomey, C.1
McCarthy, J.V.2
-
25
-
-
0035903090
-
Glycogen synthase kinase-3β regulates presenilin 1 C-terminal fragment levels
-
Kirschenbaum F., et al. Glycogen synthase kinase-3β regulates presenilin 1 C-terminal fragment levels. J. Biol. Chem. 276 (2001) 30701-30707
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30701-30707
-
-
Kirschenbaum, F.1
-
26
-
-
0035831453
-
Substitution of a glycogen synthase kinase-3β phosphorylation site in presenilin 1 separates presenilin function from β-catenin signaling
-
Kirschenbaum F., et al. Substitution of a glycogen synthase kinase-3β phosphorylation site in presenilin 1 separates presenilin function from β-catenin signaling. J. Biol. Chem. 276 (2001) 7366-7375
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7366-7375
-
-
Kirschenbaum, F.1
-
27
-
-
0345826185
-
Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis
-
Fluhrer R., et al. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. J. Biol. Chem. 279 (2004) 1585-1593
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1585-1593
-
-
Fluhrer, R.1
-
28
-
-
33646177464
-
Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers
-
Mahoney M.B., et al. Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. Genetics 172 (2006) 2309-2324
-
(2006)
Genetics
, vol.172
, pp. 2309-2324
-
-
Mahoney, M.B.1
-
29
-
-
14844302825
-
Overexpression of calsenilin enhances γ-secretase activity
-
Jo D.G., et al. Overexpression of calsenilin enhances γ-secretase activity. Neurosci. Lett. 378 (2005) 59-64
-
(2005)
Neurosci. Lett.
, vol.378
, pp. 59-64
-
-
Jo, D.G.1
-
30
-
-
0038265452
-
Microtubular interactions of presenilin direct kinesis of Aβ peptide and its precursors
-
Tezapsidis N., et al. Microtubular interactions of presenilin direct kinesis of Aβ peptide and its precursors. FASEB J. 17 (2003) 1322-1324
-
(2003)
FASEB J.
, vol.17
, pp. 1322-1324
-
-
Tezapsidis, N.1
-
31
-
-
33645777828
-
Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of γ-secretase activity
-
Herranz H., et al. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of γ-secretase activity. EMBO Rep. 7 (2006) 297-302
-
(2006)
EMBO Rep.
, vol.7
, pp. 297-302
-
-
Herranz, H.1
-
32
-
-
33646369950
-
TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity
-
Chen F., et al. TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity. Nature 440 (2006) 1208-1212
-
(2006)
Nature
, vol.440
, pp. 1208-1212
-
-
Chen, F.1
-
33
-
-
19644389648
-
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
-
Zhou S., et al. CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 7499-7504
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 7499-7504
-
-
Zhou, S.1
-
34
-
-
4644257963
-
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
-
Esselens C., et al. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J. Cell Biol. 166 (2004) 1041-1054
-
(2004)
J. Cell Biol.
, vol.166
, pp. 1041-1054
-
-
Esselens, C.1
-
35
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
Saura C.A., et al. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42 (2004) 23-36
-
(2004)
Neuron
, vol.42
, pp. 23-36
-
-
Saura, C.A.1
-
36
-
-
4944225803
-
NTR homolog NRADD
-
NTR homolog NRADD. J. Cell Sci. 117 (2004) 4099-4111
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4099-4111
-
-
Gowrishankar, K.1
-
37
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse S., et al. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21 (1998) 1213-1221
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
-
38
-
-
0141816599
-
Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane
-
Uemura K., et al. Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane. J. Neurosci. Res. 74 (2003) 184-191
-
(2003)
J. Neurosci. Res.
, vol.74
, pp. 184-191
-
-
Uemura, K.1
-
39
-
-
25844499702
-
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2
-
Wang H.Q., et al. Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum. Mol. Genet. 14 (2005) 1889-1902
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 1889-1902
-
-
Wang, H.Q.1
-
40
-
-
33845655221
-
Presenilin/γ-secretase activity regulates protein clearance from the endocytic recycling compartment
-
Zhang M., et al. Presenilin/γ-secretase activity regulates protein clearance from the endocytic recycling compartment. FASEB J. 20 (2006) 1176-1178
-
(2006)
FASEB J.
, vol.20
, pp. 1176-1178
-
-
Zhang, M.1
-
41
-
-
31044438340
-
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation
-
Wang R., et al. Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 353-358
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 353-358
-
-
Wang, R.1
-
42
-
-
0037146553
-
Nectin-1α, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/γ-secretase-like cleavage
-
Kim D.Y., et al. Nectin-1α, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/γ-secretase-like cleavage. J. Biol. Chem. 277 (2002) 49976-49981
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49976-49981
-
-
Kim, D.Y.1
-
43
-
-
20744458852
-
Presenilin/γ-secretase-mediated cleavage of the voltage-gated sodium channel β2-subunit regulates cell adhesion and migration
-
Kim D.Y., et al. Presenilin/γ-secretase-mediated cleavage of the voltage-gated sodium channel β2-subunit regulates cell adhesion and migration. J. Biol. Chem. 280 (2005) 23251-23261
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23251-23261
-
-
Kim, D.Y.1
-
44
-
-
15744388308
-
Presenilin-dependent processing and nuclear function of γ-protocadherins
-
Haas I.G., et al. Presenilin-dependent processing and nuclear function of γ-protocadherins. J. Biol. Chem. 280 (2005) 9313-9319
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9313-9319
-
-
Haas, I.G.1
-
45
-
-
18144427413
-
γ-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expression
-
Hambsch B., et al. γ-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expression. J. Biol. Chem. 280 (2005) 15888-15897
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15888-15897
-
-
Hambsch, B.1
-
46
-
-
18744410937
-
γ Protocadherins are required for survival of spinal interneurons
-
Wang X., et al. γ Protocadherins are required for survival of spinal interneurons. Neuron 36 (2002) 843-854
-
(2002)
Neuron
, vol.36
, pp. 843-854
-
-
Wang, X.1
-
47
-
-
11844301330
-
γ Protocadherins are required for synaptic development in the spinal cord
-
Weiner J.A., et al. γ Protocadherins are required for synaptic development in the spinal cord. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 8-14
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 8-14
-
-
Weiner, J.A.1
-
48
-
-
23644451506
-
Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1
-
Rubio M.E., et al. Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1. Mol. Cell. Neurosci. 30 (2005) 611-623
-
(2005)
Mol. Cell. Neurosci.
, vol.30
, pp. 611-623
-
-
Rubio, M.E.1
-
49
-
-
9244253754
-
Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription
-
Parisiadou L., et al. Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription. Neurodegener. Dis. 1 (2004) 184-191
-
(2004)
Neurodegener. Dis.
, vol.1
, pp. 184-191
-
-
Parisiadou, L.1
-
50
-
-
18344380083
-
A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
-
Marambaud P., et al. A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 (2002) 1948-1956
-
(2002)
EMBO J.
, vol.21
, pp. 1948-1956
-
-
Marambaud, P.1
-
51
-
-
33645104764
-
The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of Aβ precursors
-
Agiostratidou G., et al. The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of Aβ precursors. J. Neurochem. 96 (2006) 1182-1188
-
(2006)
J. Neurochem.
, vol.96
, pp. 1182-1188
-
-
Agiostratidou, G.1
-
52
-
-
0141429160
-
A CBP binding transcriptional repressor produced by the PS1/ε-cleavage of N-cadherin is inhibited by PS1 FAD mutations
-
Marambaud P., et al. A CBP binding transcriptional repressor produced by the PS1/ε-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114 (2003) 635-645
-
(2003)
Cell
, vol.114
, pp. 635-645
-
-
Marambaud, P.1
-
53
-
-
33646834890
-
Activity-dependent regulation of β-catenin via ε-cleavage of N-cadherin
-
Uemura K., et al. Activity-dependent regulation of β-catenin via ε-cleavage of N-cadherin. Biochem. Biophys. Res. Commun. 345 (2006) 951-958
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.345
, pp. 951-958
-
-
Uemura, K.1
-
54
-
-
0037014456
-
Depolarization drives β-catenin into neuronal spines promoting changes in synaptic structure and function
-
Murase S., et al. Depolarization drives β-catenin into neuronal spines promoting changes in synaptic structure and function. Neuron 35 (2002) 91-105
-
(2002)
Neuron
, vol.35
, pp. 91-105
-
-
Murase, S.1
-
55
-
-
33644989671
-
Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of β-catenin/Tcf-4-dependent transcription
-
Raurell I., et al. Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of β-catenin/Tcf-4-dependent transcription. J. Biol. Chem. 281 (2006) 1401-1411
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1401-1411
-
-
Raurell, I.1
-
56
-
-
3343005434
-
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
-
Baki L., et al. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 (2004) 2586-2596
-
(2004)
EMBO J.
, vol.23
, pp. 2586-2596
-
-
Baki, L.1
-
57
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
LaFerla F.M. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat. Rev. Neurosci. 3 (2002) 862-872
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 862-872
-
-
LaFerla, F.M.1
-
58
-
-
24644456470
-
Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals
-
Smith I.F., et al. Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium 38 (2005) 427-437
-
(2005)
Cell Calcium
, vol.38
, pp. 427-437
-
-
Smith, I.F.1
-
59
-
-
15244352734
-
Calcium dysregulation, IP3 signaling, and Alzheimer's disease
-
Stutzmann G.E. Calcium dysregulation, IP3 signaling, and Alzheimer's disease. Neuroscientist 11 (2005) 110-115
-
(2005)
Neuroscientist
, vol.11
, pp. 110-115
-
-
Stutzmann, G.E.1
-
60
-
-
33748140720
-
+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
-
+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126 (2006) 981-993
-
(2006)
Cell
, vol.126
, pp. 981-993
-
-
Tu, H.1
-
61
-
-
33845217332
-
Mutations of presenilin genes in dilated cardiomyopathy and heart failure
-
Li D., et al. Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am. J. Hum. Genet. 79 (2006) 1030-1039
-
(2006)
Am. J. Hum. Genet.
, vol.79
, pp. 1030-1039
-
-
Li, D.1
-
62
-
-
27444441308
-
A nine-transmembrane domain topology for presenilin 1
-
Laudon H., et al. A nine-transmembrane domain topology for presenilin 1. J. Biol. Chem. 280 (2005) 35352-35360
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35352-35360
-
-
Laudon, H.1
-
63
-
-
33748746861
-
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway
-
Spasic D., et al. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J. Biol. Chem. 281 (2006) 26569-26577
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26569-26577
-
-
Spasic, D.1
-
64
-
-
33646483640
-
Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores
-
Lazarov V.K., et al. Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 6889-6894
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 6889-6894
-
-
Lazarov, V.K.1
-
65
-
-
33645116480
-
Three-dimensional structure of the γ-secretase complex
-
Ogura T., et al. Three-dimensional structure of the γ-secretase complex. Biochem. Biophys. Res. Commun. 343 (2006) 525-534
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.343
, pp. 525-534
-
-
Ogura, T.1
-
66
-
-
23744491374
-
Nicastrin functions as a γ-secretase-substrate receptor
-
Shah S., et al. Nicastrin functions as a γ-secretase-substrate receptor. Cell 122 (2005) 435-447
-
(2005)
Cell
, vol.122
, pp. 435-447
-
-
Shah, S.1
-
67
-
-
33644837810
-
Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by γ-secretase
-
Chandu D., et al. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by γ-secretase. J. Neurochem. 96 (2006) 228-235
-
(2006)
J. Neurochem.
, vol.96
, pp. 228-235
-
-
Chandu, D.1
-
68
-
-
0346363758
-
Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events
-
Wilhelmsen K., and van der Geer P. Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events. Mol. Cell. Biol. 24 (2004) 454-464
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 454-464
-
-
Wilhelmsen, K.1
van der Geer, P.2
-
69
-
-
0034702303
-
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
-
Huppert S.S., et al. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405 (2000) 966-970
-
(2000)
Nature
, vol.405
, pp. 966-970
-
-
Huppert, S.S.1
-
70
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter E.H., et al. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393 (1998) 382-386
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
-
71
-
-
21244487829
-
Presenilin-dependent γ-secretase processing regulates multiple ERBB4/HER4 activities
-
Vidal G.A., et al. Presenilin-dependent γ-secretase processing regulates multiple ERBB4/HER4 activities. J. Biol. Chem. 280 (2005) 19777-19783
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19777-19783
-
-
Vidal, G.A.1
-
72
-
-
0038322593
-
γ-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins
-
Walsh D.M., et al. γ-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry 42 (2003) 6664-6673
-
(2003)
Biochemistry
, vol.42
, pp. 6664-6673
-
-
Walsh, D.M.1
-
73
-
-
27144504391
-
F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein
-
Hoe H.S., et al. F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol. Cell. Biol. 25 (2005) 9259-9268
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 9259-9268
-
-
Hoe, H.S.1
-
74
-
-
0141733204
-
Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase
-
May P., et al. Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase. J. Biol. Chem. 278 (2003) 37386-37392
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37386-37392
-
-
May, P.1
-
75
-
-
0347785491
-
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide
-
Lammich S., et al. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide. J. Biol. Chem. 277 (2002) 44754-44759
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44754-44759
-
-
Lammich, S.1
-
76
-
-
0037435016
-
Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44
-
Murakami D., et al. Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 22 (2003) 1511-1516
-
(2003)
Oncogene
, vol.22
, pp. 1511-1516
-
-
Murakami, D.1
-
77
-
-
30444441681
-
The intracellular domain of CD44 promotes the fusion of macrophages
-
Cui W., et al. The intracellular domain of CD44 promotes the fusion of macrophages. Blood 107 (2006) 796-805
-
(2006)
Blood
, vol.107
, pp. 796-805
-
-
Cui, W.1
-
78
-
-
0043235625
-
Presenilin-dependent 'γ-secretase' processing of deleted in colorectal cancer (DCC)
-
Taniguchi Y., et al. Presenilin-dependent 'γ-secretase' processing of deleted in colorectal cancer (DCC). J. Biol. Chem. 278 (2003) 30425-30428
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30425-30428
-
-
Taniguchi, Y.1
-
79
-
-
0141817915
-
The Notch ligands, Jagged and Delta, are sequentially processed by α-secretase and presenilin/γ-secretase and release signaling fragments
-
LaVoie M.J., and Selkoe D.J. The Notch ligands, Jagged and Delta, are sequentially processed by α-secretase and presenilin/γ-secretase and release signaling fragments. J. Biol. Chem. 278 (2003) 34427-34437
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34427-34437
-
-
LaVoie, M.J.1
Selkoe, D.J.2
-
80
-
-
0038610845
-
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
-
Six E., et al. The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7638-7643
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 7638-7643
-
-
Six, E.1
-
81
-
-
33847014741
-
Presenilin-dependent intramembrane cleavage of ephrin-B1
-
10.1186/1750-1326-1-2
-
Tomita T., et al. Presenilin-dependent intramembrane cleavage of ephrin-B1. Mol. Neurodegener. 1 (2006) 2. www.molecularneurodegeneration.com 10.1186/1750-1326-1-2
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 2
-
-
Tomita, T.1
-
82
-
-
33645277094
-
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
-
Georgakopoulos A., et al. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 25 (2006) 1242-1252
-
(2006)
EMBO J.
, vol.25
, pp. 1242-1252
-
-
Georgakopoulos, A.1
-
83
-
-
21444457762
-
Growth hormone receptor is a target for presenilin-dependent γ-secretase cleavage
-
Cowan J.W., et al. Growth hormone receptor is a target for presenilin-dependent γ-secretase cleavage. J. Biol. Chem. 280 (2005) 19331-19342
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19331-19342
-
-
Cowan, J.W.1
-
84
-
-
0037592332
-
Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by γ-secretase
-
Meyer E.L., et al. Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by γ-secretase. J. Biol. Chem. 278 (2003) 23786-23796
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23786-23796
-
-
Meyer, E.L.1
-
85
-
-
33846322244
-
Presenilin/γ-secretase and α-secretase-like peptidases cleave human MHC class I proteins
-
Carey B.W., et al. Presenilin/γ-secretase and α-secretase-like peptidases cleave human MHC class I proteins. Biochem. J. 401 (2007) 121-127
-
(2007)
Biochem. J.
, vol.401
, pp. 121-127
-
-
Carey, B.W.1
-
86
-
-
0142103374
-
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65
-
Kinoshita A., et al. The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278 (2003) 41182-41188
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 41182-41188
-
-
Kinoshita, A.1
-
87
-
-
0037166319
-
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain
-
May P., et al. Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277 (2002) 18736-18743
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18736-18743
-
-
May, P.1
-
88
-
-
0038045714
-
Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability
-
Kanning K.C., et al. Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J. Neurosci. 23 (2003) 5425-5436
-
(2003)
J. Neurosci.
, vol.23
, pp. 5425-5436
-
-
Kanning, K.C.1
-
89
-
-
20444365447
-
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth
-
Domeniconi M., et al. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 46 (2005) 849-855
-
(2005)
Neuron
, vol.46
, pp. 849-855
-
-
Domeniconi, M.1
-
90
-
-
27744497085
-
p75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1
-
Mirnics Z.K., et al. p75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol. Dis. 20 (2005) 969-985
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 969-985
-
-
Mirnics, Z.K.1
-
91
-
-
1542677095
-
Syndecan 3 intramembrane proteolysis is presenilin/γ-secretase-dependent and modulates cytosolic signaling
-
Schulz J.G., et al. Syndecan 3 intramembrane proteolysis is presenilin/γ-secretase-dependent and modulates cytosolic signaling. J. Biol. Chem. 278 (2003) 48651-48657
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48651-48657
-
-
Schulz, J.G.1
-
92
-
-
23844529915
-
Involvement of presenilins in cell-survival signalling pathways
-
McCarthy J.V. Involvement of presenilins in cell-survival signalling pathways. Biochem. Soc. Trans. 33 (2005) 568-572
-
(2005)
Biochem. Soc. Trans.
, vol.33
, pp. 568-572
-
-
McCarthy, J.V.1
-
93
-
-
0034669203
-
Presenilin affects arm/β-catenin localization and function in Drosophila
-
Noll E., et al. Presenilin affects arm/β-catenin localization and function in Drosophila. Dev. Biol. 227 (2000) 450-464
-
(2000)
Dev. Biol.
, vol.227
, pp. 450-464
-
-
Noll, E.1
-
94
-
-
29644434488
-
Ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca2+-signals to Alzheimer's disease-related presenilin 2 in forebrain
-
Blazejczyk M., et al. Ca2+-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca2+-signals to Alzheimer's disease-related presenilin 2 in forebrain. Biochim. Biophys. Acta 1762 (2006) 66-72
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 66-72
-
-
Blazejczyk, M.1
-
95
-
-
24144440041
-
In vivo evidence of CHIP up-regulation attenuating tau aggregation
-
Sahara N., et al. In vivo evidence of CHIP up-regulation attenuating tau aggregation. J. Neurochem. 94 (2005) 1254-1263
-
(2005)
J. Neurochem.
, vol.94
, pp. 1254-1263
-
-
Sahara, N.1
-
97
-
-
24744459453
-
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling
-
Kang D.E., et al. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J. Biol. Chem. 280 (2005) 31537-31547
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31537-31547
-
-
Kang, D.E.1
-
98
-
-
0037119365
-
A new splice variant of glial fibrillary acidic protein, GFAPε, interacts with the presenilin proteins
-
Nielsen A.L., et al. A new splice variant of glial fibrillary acidic protein, GFAPε, interacts with the presenilin proteins. J. Biol. Chem. 277 (2002) 29983-29991
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29983-29991
-
-
Nielsen, A.L.1
-
99
-
-
0037145062
-
Presenilin couples the paired phosphorylation of β-catenin independent of axin: implications for β-catenin activation in tumorigenesis
-
Kang D.E., et al. Presenilin couples the paired phosphorylation of β-catenin independent of axin: implications for β-catenin activation in tumorigenesis. Cell 110 (2002) 751-762
-
(2002)
Cell
, vol.110
, pp. 751-762
-
-
Kang, D.E.1
-
100
-
-
0037043330
-
A novel mechanism for the regulation of amyloid precursor protein metabolism
-
Chen Q., et al. A novel mechanism for the regulation of amyloid precursor protein metabolism. J. Cell Biol. 158 (2002) 79-89
-
(2002)
J. Cell Biol.
, vol.158
, pp. 79-89
-
-
Chen, Q.1
-
101
-
-
8544245734
-
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity
-
Gupta S., et al. The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity. J. Biol. Chem. 279 (2004) 45844-45854
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45844-45854
-
-
Gupta, S.1
-
102
-
-
32444434357
-
Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation
-
Cai D., et al. Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 1941-1946
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 1941-1946
-
-
Cai, D.1
-
103
-
-
0037073733
-
The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein
-
Xu X., et al. The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. J. Biol. Chem. 277 (2002) 48913-48922
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48913-48922
-
-
Xu, X.1
-
104
-
-
28744456107
-
2+ signaling
-
2+ signaling. FASEB J. 19 (2005) 2069-2071
-
(2005)
FASEB J.
, vol.19
, pp. 2069-2071
-
-
Takeda, T.1
-
105
-
-
0036736222
-
SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-β peptide production
-
Li J., et al. SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-β peptide production. J. Neurochem. 82 (2002) 1540-1548
-
(2002)
J. Neurochem.
, vol.82
, pp. 1540-1548
-
-
Li, J.1
-
106
-
-
22244454702
-
Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of βAPP in neuronal cells
-
Suga K., et al. Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of βAPP in neuronal cells. J. Neurochem. 94 (2005) 425-439
-
(2005)
J. Neurochem.
, vol.94
, pp. 425-439
-
-
Suga, K.1
-
107
-
-
4344594413
-
Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects β-amyloid peptide production
-
Suga K., et al. Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects β-amyloid peptide production. Biochem. J. 381 (2004) 619-628
-
(2004)
Biochem. J.
, vol.381
, pp. 619-628
-
-
Suga, K.1
-
108
-
-
33748746862
-
Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader
-
Thomas A.V., et al. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J. Biol. Chem. 281 (2006) 26400-26407
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26400-26407
-
-
Thomas, A.V.1
-
109
-
-
27744468749
-
Ubiquilin regulates presenilin endoproteolysis and modulates γ-secretase components, Pen-2 and nicastrin
-
Massey L.K., et al. Ubiquilin regulates presenilin endoproteolysis and modulates γ-secretase components, Pen-2 and nicastrin. Biochem. J. 391 (2005) 513-525
-
(2005)
Biochem. J.
, vol.391
, pp. 513-525
-
-
Massey, L.K.1
-
110
-
-
0032972547
-
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin
-
Levesque G., et al. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin. J. Neurochem. 72 (1999) 999-1008
-
(1999)
J. Neurochem.
, vol.72
, pp. 999-1008
-
-
Levesque, G.1
|