Self-refinement of notch activity through the transmembrane protein crumbs: Modulation of γ-secretase activity

EMBO Reports

Volumn 7, Issue 3, 2006, Pages 297-302

  Herranz, Héctor ^a   Stamataki, Evaggelia ^b   Feiguin, Fabián ^c   Milán, Marco ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Crumbs; Drosophila wing; Notch; Presenilin

Indexed keywords

GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; PROTEIN CRUMBS; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; EMBRYO; ENZYME ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GENE IDENTIFICATION; LIMB DEVELOPMENT; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYONIC STRUCTURES; ENDOPEPTIDASES; EPISTASIS, GENETIC; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MEMBRANE PROTEINS; MUTATION; PHENOTYPE; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; WING;

EID: 33645777828     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400617     Document Type: Article

References (25)

1. Bachmann A, Schneider M, Theilenberg E, Grawe F, Knust E (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-643
2. Bardot B, Mok LP, Thayer T, Ahimou F, Wesley C (2005) The Notch amino terminus regulates protein levels and Delta-induced clustering of Drosophila Notch receptors. Exp Cell Res 304: 202-223
3. Bhat MA, Izaddoost S, Lu Y, Cho KO, Choi KW, Bellen HJ (1999) Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 96: 833-845
4. Bruckner K, Perez L, Clausen H, Cohen S (2000) Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406: 411-415
5. de Celis JF, Bray S (1997) Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124: 3241-3251
6. de Celis JF, Garcia Bellido A (1994) Roles of the Notch gene in Drosophila wing morphogenesis. Mech Dev 46: 109-122
7. de Celis JF, Garcia-Bellido A, Bray SJ (1996) Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122: 359-369
8. den Hollander AI (1999) Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). Nat Genet 23: 217-221
9. Diaz-Benjumea FJ, Cohen SM (1995) Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121: 4215-4225
10. Doherty D, Fenger G, Younger-Shepherd S, Jan L-Y, Jan Y-N (1996) Dorsal and ventral cells respond differently to the Notch ligands Delta and Serrate during Drosophila wing development. Genes Dev 10: 421-434
11. Fleming RJ, Gu Y, Hukriede NA (1997) Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124: 2973-2981
12. Giraldez AJ, Perez L, Cohen SM (2002) A naturally occurring alternative product of the mastermind locus that represses notch signalling. Mech Dev 115: 101-105
13. Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA (2003) A reporter for amyloid precursor protein γ-secretase activity in Drosophila. Hum Mol Genet 12: 2669-2678
14. Izaddoost S, Nam SC, Bhat MA, Bellen HJ, Choi KW (2002) Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature 416: 178-183
15. Lai EC (2004) Notch signaling: Control of cell communication and cell fate. Development 131: 965-973
16. Micchelli CA, Rulifson EJ, Blair SS (1997) The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124: 1485-1495
17. Moloney DJ (2000) Fringe is a glycosyltransferase that modifies Notch. Nature 406: 369-375
18. Nolo R, Abbott LA, Bellen HJ (2000) Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102: 349-362
19. Panin VM, Papayannopoulos V, Wilson R, Irvine KD (1997) Fringe modulates Notch-ligand interactions. Nature 387: 908-913
20. Parks AL, Klueg KM, Stout JR, Muskavitch MA (2000) Ligand endocytosis drives receptor dissociation and activation in the notch pathway. Development 127: 1373-1385
21. Pellikka M, Tanentzapf G, Pinto M, Smith C, McGlade CJ, Ready DF, Tepass U (2002) Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature 416: 143-149
22. Struhl G, Adachi A (1998) Nuclear access and action of Notch in vivo. Cell 93: 649-660
23. Struhl G, Adachi A (2000) Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol Cell 6: 625-636
24. Sun X, Artavanis-Tsakonas S (1997) Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development 124: 3439-3448
25. Tepass U, Theres C, Knust E (1990) crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61: 787-799