-
2
-
-
0033944273
-
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling
-
(2000)
J. Neurochem.
, vol.75
, pp. 583-593
-
-
Berezovska, O.1
Jack, C.2
McLean, P.3
Aster, J.C.4
Hicks, C.5
Xia, W.6
Wolfe, M.S.7
Kimberly, W.T.8
-
3
-
-
0030293676
-
1-42/1-40 ratio in vitro and in vivo
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Lee, M.K.2
Thinakaran, G.3
Rarovitsky, T.4
Prada, C.M.5
Kim, G.6
Seeger, M.7
Levey, A.8
Gandy, S.9
Copeland, N.G.10
-
5
-
-
0033783140
-
Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 205-211
-
-
Capell, A.1
Steiner, H.2
Romig, H.3
Keck, S.4
Baadeer, M.5
Grim, M.G.6
Baumeister, R.7
Haass, C.8
-
8
-
-
0025759161
-
An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types
-
(1991)
Neurosci. Lett.
, vol.125
, pp. 223-226
-
-
Chen, M.1
Yankner, B.A.2
-
11
-
-
0030769092
-
(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
-
(1997)
Nat. Med.
, vol.3
, pp. 1021-1023
-
-
Cook, D.G.1
Forman, M.S.2
Sung, J.C.3
Leight, S.4
Kolson, D.L.5
Iwatsubo, T.6
Lee, V.M.7
Doms, R.W.8
-
15
-
-
0033535504
-
A presenilin-1-dependent γ-secrerase-like protease mediates release of Notch intracellular domain
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
-
17
-
-
0033780472
-
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin 1
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 428-434
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
Diehl, T.S.4
Moore, C.L.5
Tsai, J.-Y.6
Rahmati, T.7
Xia, W.8
Selkoe, D.J.9
Wolfe, M.S.10
-
18
-
-
0033972887
-
Presenilin I expression in yeast lowers secretion of the amyloid precursor protein
-
(2000)
Neuroreport
, vol.11
, pp. 405-408
-
-
Evin, G.1
Le Brocque, D.2
Culvenor, J.G.3
Galatis, D.4
Weidemann, A.5
Beyreuther, K.6
Masters, C.L.7
Cappai, R.8
-
20
-
-
0033034785
-
1-42, respectively
-
(1999)
J. Neurochem.
, vol.72
, pp. 1417-1422
-
-
Figueiredo-Pereira, M.E.1
Efthimiopoulos, S.2
Tezapsidis, N.3
Buku, A.4
Ghiso, J.5
Mehta, P.6
Robakis, N.K.7
-
23
-
-
0032525964
-
Lin-12/Notch signaling lessons from worms and flies
-
(1998)
Genes Dev.
, vol.12
, pp. 1751-1762
-
-
Greenwald, I.1
-
24
-
-
0026646604
-
Amyloid β-peptide is produced by cultured cells during normal metabolism
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
Lieberburg, I.7
Koo, E.H.8
Schenk, D.9
Teplow, D.B.10
Selkoe, D.J.11
-
29
-
-
0034047739
-
Isolation and characterization of a novel presenilin binding protein
-
(2000)
J. Neurochem.
, vol.75
, pp. 109-116
-
-
Kashiwa, A.1
Yoshida, H.2
Lee, S.3
Paladino, T.4
Liu, Y.5
Chen, Q.6
Dargusch, R.7
Schubett, D.8
Kimura, H.9
-
30
-
-
0033258544
-
Presenilin-1 mutations down-regulate the signalling pathway of the unfolded protein response
-
(2000)
Nat. Cell Biol.
, vol.1
, pp. 479-485
-
-
Katayama, T.1
Imaizumi, K.2
Sato, N.3
Miyoshi, K.4
Kudo, T.5
Hitomi, J.6
Morihara, T.7
Yoneda, T.8
Gomi, F.9
-
34
-
-
18344380083
-
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
-
(2002)
EMBO J.
, vol.21
, pp. 1948-1956
-
-
Marambaud, P.1
Shioi, J.2
Georgakopoulos, A.3
Satner, S.4
Nagy, V.5
Baki, L.6
Wen, P.7
Ethimiopoulos, S.8
Shao, Z.9
Wishiewski, T.10
-
35
-
-
0033621047
-
Expoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 10403-10408
-
-
Meng, L.1
Mohan, R.2
Kwok, B.H.B.3
Elofsson, M.4
Sin, N.5
Crews, C.6
-
37
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
Kusiak, J.W.4
Tomita, T.5
Iwatsubo, T.6
Qian, X.7
Ginty, D.D.8
Price, D.L.9
Borchelt, D.R.10
-
40
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome I related to the Alzheimer's disease type 3 gene
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
41
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
-
42
-
-
0027421474
-
The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix
-
(1993)
Brain Res.
, vol.629
, pp. 275-282
-
-
Schubert, D.1
Behl, C.2
-
43
-
-
0016358141
-
Clonal cell lines from the rat central nervous system
-
(1974)
Nature
, vol.249
, pp. 224-227
-
-
Schubert, D.1
Heinemann, S.2
Carlisle, W.3
Tarikas, H.4
Kimes, B.5
Patrick, J.6
Steinbach, J.H.7
Culp, W.8
Brandt, B.L.9
-
47
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
50
-
-
0034730295
-
An accomplice for γ-secretase brought into focus
-
(2000)
Science
, vol.289
, pp. 2296-2297
-
-
Sisodia, S.S.1
-
58
-
-
0033551099
-
Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving asparty protease
-
(1999)
Biochemistry
, vol.38
, pp. 4720-4727
-
-
Wolfe, M.S.1
Xia, W.2
Moore, C.L.3
Leatherwood, D.D.4
Ostaszewski, B.B.5
Rahmati, T.T.6
Donkor, I.O.7
Selkoe, D.J.8
-
60
-
-
0034255029
-
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9299-9304
-
-
Xia, W.1
Ray, W.J.2
Ostaszewski, B.L.3
Rahmati, T.4
Kimberly, W.T.5
Wolfe, M.S.6
Zhang, J.7
Goate, A.M.8
Selkoe, D.J.9
-
61
-
-
0030963605
-
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3748-3752
-
-
Xu, H.1
Sweeney, D.2
Wang, R.3
Thinakaran, G.4
Lo, A.C.5
Sisodia, S.S.6
Greengard, P.7
Gandy, S.8
-
66
-
-
0033605588
-
Calpain inhibitor I increases β-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase: Evidence that substrate availability limits β-amyloid peptide production
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8966-8972
-
-
Zhang, L.1
Song, L.2
Parker, E.M.3
|