Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 6, 2006, Pages 1941-1946

  Cai, Dongming ^a   Netzer, William J ^a   Zhong, Minghao ^b   Lin, Yixin ^c   Du, Guangwei ^d   Frohman, Michael ^d   Foster, David A ^b   Sisodia, Sangram S ^e   Xu, Huaxi ^f   Gorelick, Fred S ^a,g   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c CIPHERGEN BIOSYSTEMS INC   (United States)

^d STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f BURNHAM INSTITUTE   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amyloid precursor protein; secretase complex activity; Negative regulator; Protein interaction; Trans Golgi network

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; NOTCH1 RECEPTOR; PHOSPHOLIPASE D1; PRESENILIN 1; PROTEIN PEN2; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CATALYSIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GOLGI COMPLEX; HUMAN; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; SECRETORY VESICLE; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TRANS GOLGI NETWORK;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PHOSPHOLIPASE D; PRESENILIN-1; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; TRANS-GOLGI NETWORK;

ANIMALIA;

EID: 32444434357     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510708103     Document Type: Article

References (36)

1. Haass, C. & De Strooper, B. (1999) Science 286, 916-919.
2. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K. & Van Leuven, F. (1998) Nature 391, 387-390.
3. Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C. M., Kim, G., Seekins, S., Yager, D., et al. (1996) Neuron 17, 1005-1013.
4. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) Nat. Med. 2, 864-870.
5. Sisodia, S. S. & St George-Hyslop, P. H. (2002) Nat. Rev. Neurosci. 3, 281-290.
6. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) Nature 398, 518-522.
7. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., et al. (2002) Dev. Cell 3, 85-97.
8. Goutte, C., Tsunozaki, M., Hale, V. A. & Priess, J. R. (2002) Proc. Natl. Acad. Sci. USA 99, 775-779.
9. Ray, W. J., Yao, M., Mumm, J., Schroeter, E. H., Saftig, P., Wolfe, M., Selkoe, D. J., Kopan, R. & Goate, A. M. (1999) J. Biol. Chem. 274, 36801-36807.
10. Struhl, G. & Greenwald, I. (1999) Nature 398, 522-525.
11. De Strooper, B. & Konig, G. (1999) Nature 402, 471-472.
12. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H. & Haass, C. (2003) Nat. Cell Biol. 5, 486-488.
13. Fraering, P. C., Ye, W., Strub, J. M., Dolios, G., LaVoie, M. J., Ostaszewski, B. L., van Dorsselaer, A., Wang, R., Selkoe, D. J. & Wolfe, M. S. (2004) Biochemistry 43, 9774-9789.
14. Greenfield, J. P., Leung, L. W., Cai, D., Kaasik, K., Gross, R. S., Rodriguez-Boulan, E., Greengard, P. & Xu, H. (2002) J. Biol. Chem. 277, 12128-12136.
15. Lee, H. C., Fellenz-Maloney, M. P., Liscovitch, M. & Blusztajn, J. K. (1993) Proc. Natl. Acad. Sci. USA 90, 10086-10090.
16. Kanfer, J. N., Hattori, H. & Orihel, D. (1986) Ann. Neurol. 20, 265-267.
17. Annaert, W. G., Esselens, C., Baert, V., Boeve, C., Snellings, G., Cupers, P., Craessaerts, K. & De Strooper, B. (2001) Neuron 32, 579-589.
18. Cai, D., Leem, J. Y., Greenfield, J. P., Wang, P., Kim, B. S., Wang, R., Lopes, K. O., Kim, S. H., Zheng, H., Greengard, P., et al. (2003) J. Biol. Chem. 278, 3446-3454.
19. Leem, J. Y., Saura, C. A., Pietrzik, C., Christianson, J., Wanamaker, C., King, L. T., Veselits, M. L., Tomita, T., Gasparini, L., Iwatsubo, T., et al. (2002) Neurobiol. Dis. 11, 64-82.
20. Naruse, S., Thinakaran, G., Luo, J. J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., et al. (1998) Neuron 21, 1213-1221.
21. Wang, H., Luo, W. J., Zhang, Y. W., Li, Y. M., Thinakaran, G., Greengard, P. & Xu, H. (2004) J. Biol. Chem. 279, 40560-40566.
22. Cai, D., Zhong, M., Wang, R., Netzer, W. J., Shields, D., Zheng, H., Sisodia, S. S., Foster, D. A., Gorelick, F. S., Xu, H., et al. (2006) Proc. Natl. Acad. Sci. USA 103, 1936-1940.
23. Geling, A., Steiner, H., Willem, M., Bally-Cuif, L. & Haass, C. (2002) EMBO Rep. 3, 688-694.
24. Grimm, M. O., Grimm, H. S., Patzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschape, J. A., Strooper, B. D., Muller, U., Shen, J., et al. (2005) Nat. Cell Biol. 7, 1118-1123.
25. Xu, H. & Shields, D. (1993) J. Cell Biol. 122, 1169-1184.
26. Berechid, B. E., Thinakaran, G., Wong, P. C., Sisodia, S. S. & Nye, J. S. (1999) Curr. Biol. 9, 1493-1496.
27. Leem, J. Y., Vijayan, S., Han, P., Cai, D., Machura, M., Lopes, K. O., Veselits, M. L., Xu, H. & Thinakaran, G. (2002) J. Biol. Chem. 277, 19236-19240.
28. Hammond, S. M., Altshuller, Y. M., Sung, T. C., Rudge, S. A., Rose, K., Engebrecht, J., Morris, A. J. & Frohman, M. A. (1995) J. Biol. Chem. 270, 29640-29643.
29. Sung, T. C., Roper, R. L., Zhang, Y., Rudge, S. A., Temel, R., Hammond, S. M., Morris, A. J., Moss, B., Engebrecht, J. & Frohman, M. A. (1997) EMBO J. 16, 4519-4530.
30. Du, G., Huang, P., Liang, B. T. & Frohman, M. A. (2004) Mol. Biol. Cell 15, 1024-1030.
31. Huang, P., Altshuller, Y. M., Hou, J. C., Pessin, J. E. & Frohman, M. A. (2005) Mol. Biol. Cell 16, 2614-2623.
32. Freyberg, Z., Sweeney, D., Siddhanta, A., Bourgoin, S., Frohman, M. & Shields, D. (2001) Mol. Biol. Cell 12, 943-955.
33. Musch, A., Xu, H., Shields, D. & Rodriguez-Boulan, E. (1996) J. Cell Biol. 133, 543-558.
34. Caporaso, G. L., Takei, K., Gandy, S.E., Matteoli, M., Mundigl, O., Greengard, P. & De Camilli, P. (1994) J. Neurosci. 14, 3122-3138.
35. Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B., Naslund, J., Mazzarelli, L., Fried, G., Jovanovic, J. N., Seeger, M., Relkin, N. R., et al. (1998) Nat. Med. 4, 447-451.
36. Kopan, R., Schroeter, E. H., Weintraub, H. & Nye, J. S. (1996) Proc. Natl. Acad. Sci. USA 93, 1683-1688.