Role of neuropeptides in appetite regulation and obesity - A review

Neuropeptides

Volumn 40, Issue 6, 2006, Pages 375-401

  Arora, Sarika ^a   Anubhuti, ^a  

^a LADY HARDINGE MEDICAL COLLEGE   (India)

Author keywords

Agouti related peptide (AGRP); Amylin; Appetite regulation; Cocaine and amphetamine related transcript (CART); Gut peptides; Insulin; Leptin; Neuropeptide Y (NPY); Pro opiomelanocortins (POMC); Role of hypothalamus in appetite regulation

Indexed keywords

2 [[1 (7 CHLORO 4 QUINOLINYL) 5 (2,6 DIMETHOXYPHENYL) 3 PYRAZOLYL]CARBONYLAMINO] 2 ADAMANTANECARBOXYLIC ACID; 2 ARACHIDONOYLGLYCEROL; AC 162352; ADP 356; AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; ANANDAMIDE; BETA ENDORPHIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; CORTICOTROPIN RELEASING FACTOR; DYNORPHIN; ENDOCANNABINOID; ENKEPHALIN; GALANIN; GLUCAGON LIKE PEPTIDE; INSULIN; LEPTIN; MELANIN CONCENTRATING HORMONE; MELANOCORTIN; NALOXONE; NALTREXONE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTENSIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NOLADIN ETHER; OREXIN; PRAMLINTIDE; RIMONABANT; SEROTONIN; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRODHAMINE;

ABDOMINAL CRAMP; ABSORPTION; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; DIETARY INTAKE; DRUG STRUCTURE; FEEDBACK SYSTEM; FEEDING; FLATULENCE; FOOD INTAKE; GASTROINTESTINAL TRACT FUNCTION; HUMAN; HYPOTHALAMUS; INCONTINENCE; LIQUID FECES; MALABSORPTION; METABOLIC REGULATION; MOTOR DEVELOPMENT; NONHUMAN; NUTRIENT AVAILABILITY; OBESITY; PEPTIDE SYNTHESIS; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN STRUCTURE; PULMONARY HYPERTENSION; REVIEW; SECRETION; SPOTTING;

AMYLOID; ANALGESICS, OPIOID; ANIMALS; APPETITE; CANNABINOIDS; HUMANS; HYPOTHALAMUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NEUROPEPTIDE Y; NEUROPEPTIDES; OBESITY; PRO-OPIOMELANOCORTIN;

AGOUTI; RODENTIA;

EID: 33751191841     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2006.07.001     Document Type: Review

References (336)

1. Adams L.D., Gong W., Vechia S.D., Hunter R.G., and Kuhar M.J. CART: from gene to function. Brain Res. 848 1-2 (1999) 137-140
2. Adrian T.E., Ferri G.L., Bacarese-Hamilton A.J., Fuessl H.S., Polak J.M., and Bloom S.R. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89 (1985) 1070-1077
3. Adrian T.E., Savage A.P., Sagor G.R., Allen J.M., Bacarese-Hamilton A.J., Tatemoto K., Polak J.M., and Bloom S.R. Effect of peptide YY on gastric, pancreatic, and biliary function in humans. Gastroenterology 89 (1985) 494-499
4. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., and Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature 382 (1996) 250-252
5. Air E.L., Strowski M.Z., Benoit S.C., Conarello S.L., Salituro G.M., Guan X.M., Liu K., Woods S.C., and Zhang B.B. Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat. Med. 8 2 (2002) 179-183
6. Alexander M.J., Miller M.A., Dorsa D.M., Bullock B.P., Melloni Jr. R.H., Dobner P.R., and Leeman S.E. Distribution of neurotensin/neuromedin mRNA in rat forebrain: Unexpected abundance in hippocampus and subiculum. Proc. Natl. Acad. Sci. USA 86 (1989) 5202-5206
7. Allen Y.S., Adrian T.E., Allen J.M., Tatemoto K., Crow T.J., Bloom S.R., and Polak J.M. Neuropeptide Y distribution in the rat brain. Science 221 (1983) 877-879
8. Alvarez B.M., Borque M., Martinez-Sarmiento J., Aparicio E., Hernandez C., Cabrerizo L., and Fernandez-Represa J.A. Peptide YY secretion in morbidly obese patients before and after vertical banded gastroplasty. Obes. Surg. 12 (2002) 324-327
9. Araki E., Lipes M.A., Patti M.E., Bruning J.C., Haag III B., Johnson R.S., and Kahn C.R. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372 (1994) 186-190
10. Ariyasu H., Takaya K., Tagami T., Ogawa Y., Hosoda K., Akamisu T., Suda M., Koh T., Natsui K., Toyooka S., Shrikami G., Usui T., Shimatsu A., Doi K., Hosoda H., Kojima M., Kangawa K., and Nakao K. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 86 10 (2001) 4753-4758
11. Arvat E., Maccario M., Di Vito L., Broglio F., Benso A., Gottero C., Papotti M., Muccioli G., Dieguez C., Casanueva F.F., Deghenghi R., Camanni F., and Ghigo E. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J. Clin. Endocrinol. Metab. 86 3 (2001) 1169-1174
12. Asakawa A., Inui A., Ueno N., Makino S., Fujino M.A., and Kasuga M. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. Gastroenterology 116 6 (1999) 1287-1292
13. Atkinson R.L., and Brent E.L. Appetite suppressant activity in plasma of rats after intestinal bypass surgery. Am. J. Physiol. 243 1 (1982) R60-R64
14. Bado A., Levasseur S., Attoub S., Kermorgant S., Laigneau J.-P., Bortoluzzi M.-N., Moizo L., Lehy T., Guerre-Millo M., Marchand-Brustel Y.L., and Lewin M.J.M. The stomach is a source of leptin. Nature 394 (1998) 790-793
15. Bagdade J.D., Bierman E.L., and Porte D.J. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J. Clin. Invest. 46 (1967) 1549-1557
16. Baile C.A., McLaughlin C.L., and Della-Fera M.A. Role of cholecystokinin and opioid peptides in control of food intake. Physiol. Rev. 66 (1986) 172-234
17. Banks W.A. The source of cerebral insulin. Eur. J. Pharmacol. 490 (2004) 5-12
18. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., and Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 17 (1996) 305-311
19. Barrachina M.D., Martinez V., Wang L., Wei J.Y., and Taché Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc. Natl. Acad. Sci. USA 94 19 (1997) 10455-10460
20. Baskin D.G., Schwartz M.W., Sipols A.J., D'Alessio D.A., Goldstein B.J., and White M.F. Insulin receptor substrate-1 (IRS-1) expression in rat brain. Endocrinology 134 (1994) 1952-1955
21. Baskin D.G., Breininger J.F., and Schwartz M.W. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 48 4 (1999) 828-833
22. Batterham R.L., Cowley M.A., Small C.J., Herzog H., Cohen M.A., Dakin C.L., Wren A.M., Brynes A.E., Low M.J., Ghatei M.A., Cone R.D., and Bloom S.R. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418 (2002) 650-654
23. Batterham R.L., Cohen M.A., Ellis S.M., Le Roux C.W., Withers D.J., Frost G.S., Ghatei M.A., and Bloom S.R. Inhibition of food intake in obese subjects by peptide YY3-36. NEJM 349 (2003) 941-948
24. Battey J.F., Way J.M., Corjay M.H., Shapira H., Kusano K., Harkins R., Wu J.M., Slattery T., Mann E., and Feldman R.I. Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Proc. Natl. Acad. Sci. USA 88 (1991) 395-399
25. Baura G.D., Foster D.M., Porte Jr. D., Kahn S.E., Bergman R.N., Cobelli C., and Schwartz M.W. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J. Clin. Invest. 92 4 (1993) 1824-1830
26. Beck B., Stricker-Krongrad A., Richy S., and Burlet C. Evidence that hypothalamic neurotensin signals leptin effects on feeding behavior in normal and fat-preferring rats. Biochem. Biophys. Res. Commun. 252 (1998) 634-638
27. Benoit S.C., Air E.L., Coolen L.M., Strauss R., Jackman A., Clegg D.J., Seeley R.J., and Woods S.C. The catabolic action of insulin in the brain is mediated by melanocortins. J. Neurosci. 22 20 (2002) 9048-9052
28. Bernardis L.L., and Bellinger L.L. The lateral hypothalamic area revisited: Ingestion behaviour. Neurosci. Biobehav. Rev. 20 (1996) 189-287
29. Bertagna X. Proopiomelanocortin-derived peptides, 1994. Endocrinol. Metab. Clin. North Am. 23 (1994) 467-485
30. Bhavsar S., Watkins J., and Young A. Synergy between amylin and cholecystokinin for inhibition of food intake in mice. Physiol. Behav. 64 4 (1998) 557-561
31. Bloomquist B.T., Eipper B.A., and Mains R.E. Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Mol. Endocrinol. 5 (1991) 2014-2024
32. Blundell J.E., and Halford J.C.G. Regulation of nutrient supply: the brain and appetite control. Proc. Nutr. Soc. 53 (1994) 407-418
33. Broberger C., De Lecea L., Sutcliffe J.G., and Hökfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 402 (1998) 460-474
34. Broberger C., Johansen J., Johansson C., Schalling M., and Hökfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA 95 (1998) 15043-15048
35. Bruning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., Klein R., Krone W., Muller-Wieland D., and Kahn C.R. Role of brain insulin receptor in control of body weight and reproduction. Science 289 (2000) 2122-2125
36. Burks D.J., de Mora J.F., Schubert M., Withers D.J., Myers M.G., Towery H.H., Altamuro S.L., Flint C.L., and White M.F. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407 (2000) 377-382
37. Campfield L.A., Smith F.J., Guisez Y., Devos R., and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269 (1995) 546-549
38. Carraway R.E., and Leeman S.E. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J. Biol. Chem. 248 (1973) 6854-6861
39. Castro M.G., and Morrison E. Post-translational processing of proopiomelanocortin in the pituitary and in the brain. Crit. Rev. Neurobiol. 11 (1997) 35-57
40. Chabry J., Labbé-Jullié C., Gully D., Kitabgi P., Vincent J.P., and Mazella J. Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms and internalization. J. Neurochem. 63 (1994) 19-27
41. Challis B.G., Pinnock S.B., Coll A.P., Carter R.N., Dickson S.L., and O'Rahilly S. Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem. Biophys. Res. Commun. 311 (2003) 915-919
42. Chalmers D.T., Lovenberg T.W., Grigoriadis D.E., Behan D.P., and De Souza E.B. Corticotropin-releasing factor receptors: from molecular biology to drug design. Trends Pharmacol. Sci. 17 (1996) 166-172
43. Chalon P., Vita N., Kaghad M., Guillemot M., Bonnin J., Delpech B., Le Fur G., Ferrara P., and Caput D. Molecular cloning of a levocabastine-sensitive neurotensin binding site. FEBS Lett. 386 (1996) 91-94
44. Chance W.T., Balasubramaniam A., Thomas I., and Fischer J.E. Amylin increases transport of tyrosine and tryptophan into the brain. Brain Res. 593 (1992) 20-24
45. Clark J.T., Kalra P.S., Crowley W.R., and Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115 (1984) 427-429
46. Clifton P.G., and Kennett G.A. Monoamine receptors in the regulation of feeding behaviour and energy balance. CNS & Neurol. Disorders - Drug Targets 5 3 (2006) 293-312
47. Conlon J.M. The origin and evolution of peptide YY (PYY) and pancreatic polypeptide (PP). Peptides 23 (2002) 269-278
48. Conrad C.D., and McEwen B.S. Acute stress increases neuropeptide Y mRNA within the arcuate nucleus and hilus of the dentate gyrus. Brain Res. Mol. Brain Res. 79 (2000) 102-109
49. Corp E.S., Woods S.C., Porte Jr. D., Dorsa D.M., Figlewicz D.P., and Baskin D.G. Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography. Neurosci. Lett. 70 (1986) 17-22
50. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., and Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 (2001) 480-484
51. Crawley J.N., and Corwin R.L. Biological actions of cholecystokinin. Peptides 15 (1994) 731-755
52. Crawley J.N., Austin M.C., Fiske S.M., Martin B., Consolo S., Berthold M., Langel U., Fisone G., and Bartfai T. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J. Neurosci. 10 (1990) 3695-3700
53. Crespi E.J., Vaudari H., and Denver R.J. Roles of corticotropin-releasing factor, neuropeptide Y and corticosterone in the regulation of food intake in Xenopus laevis. J. Neuroendocrinol. 16 3 (2004) 279-288
54. Cui H., Cai F., and Belsham D.D. Anorexigenic hormones leptin, insulin and α melanocyte stimulating hormone directly induce neurotensin (NT) gene expression in novel N-T expressing cell models. J. Neurosci. 25 41 (2005) 9497-9506
55. Cummings D.E., Pineiro V., Vega F., De La Cruz L.F., Dieguez C., and Casanueva F.F. Leptin, reproduction and sex steroids. Pituitary 4 (2001) 93-99
56. Cummings D.E., Weigle D.S., Frayo R.S., Breen P.A., Ma M.K., Dellinger E.P., and Purnell J.Q. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. NEJM 346 (2002) 1623-1630
57. Cummings D.E., Foster-Schubert K.E., and Overduin J. Ghrelin and energy balance: Focus on current controversies. Curr. Drug Targets 6 2 (2005) 153-169
58. Curzon G., Gibson E.L., and Oluyomi A.O. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18 (1997) 21-25
59. Cusack B., McCormick D.J., Pang Y.P., Souder T., Garcia R., Fauq A., and Richelson E. Pharmacological and biochemical profiles of unique neurotensin 8-13 analogs exhibiting species selectivity, stereoselectivity, and superagonism. J. Biol. Chem. 270 (1995) 18359-18366
60. Cvetkovic V., Brischoux F., Griffond B., Bernard G., Jacquemard C., Fellmann D., and Risold P.Y. Evidence of melanin-concentrating hormone-containing neurons supplying both cortical and neuroendocrine projections. Neuroscience 116 1 (2003) 31-35
61. De Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S., Frankel W.N., von den Pol A.N., Bloom F.E., Gautvik K.M., and Sutcliff J.G. The hypocretins: Hypothalamic-specific peptide with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95 (1998) 322-327
62. Di Marzo V., Goparaju S.K., Wang L., Liu J., Batkai S., Jarai Z., Fezza F., Miura G.I., Palmiter R.D., Sugiura T., and Kunos G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410 (2001) 822-825
63. Douglass J., and Daoud S. Characterization of the human cDNA and genomic DNA encoding CART: A cocaine- and amphetamine-regulated transcript. Gene 169 (1996) 241-245
64. Douglass J., Mc Kinzie A.A., and Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci. 15 (1995) 2471-2481
65. Dumont Y., Fournier A., and Quirion R. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J. Neurosci. 18 (1998) 5565-5574
66. Dyer C.J., Touchette K.J., Carroll J.A., Allee G.L., and Matteri R.J. Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs. Domest. Anim. Endocrinol. 16 (1999) 145-148
67. Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., et al. A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36). Peptides 10 (1989) 797-803
68. Edwards C.M., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., and Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 3 (1999) R7-R12
69. Edwards C.M., Stanley S.A., Davis R., Brynes A.E., Frost G.S., Seal L.J., Ghatei M.A., and Bloom S.R. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am. J. Physiol. Endocrinol. Metab. 281 (2001) E155-E161
70. Egawa M., Yoshimatsu H., and Bray G.A. Effect of β-endorphin on sympathetic nerve activity to interscapular brown adipose tissue. Am. J. Physiol. 264 (1993) R109-R115
71. Ekblad E., and Sundler F. Distribution of pancreatic polypeptide and peptide YY. Peptides 23 (2002) 251-261
72. El Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., and Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105 (2000) 1827-1832
73. Elias C.F., Lee C., Kelly J., Aschkenasi C., Ahima R.S., Coucyro P.R., Kuhar M.J., Saper C.B., and Elmquist J.K. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21 6 (1998) 1375-1385
74. Elmquist J.K., Ahimsa R.S., Elias C.F., Flier J.S., and Saper C.B. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl. Acad. Sci. USA 95 2 (1998) 741-746
75. Elmquist J.K., Elias C.F., and Saper C.B. From lesions to leptin: Hypothalamic control of food intake and body weight. Neuron 22 (1999) 221-232
76. Erwin V.G., and Radcliffe R.A. Characterization of neurotensin-stimulated phosphoinositide hydrolysis in brain regions of long sleep and short sleep mice. Brain Res. 629 (1993) 59-66
77. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., and Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 (1997) 165-168
78. Farooqi I.S., Jebb S.A., Langmack G., Lawrence E., Cheetham C.H., Prentice A.M., Hughes I.A., McCamish M.A., and O'Rahilly S. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. NEJM 341 (1999) 879-884
79. Farooqi I.S., Yeo G.S., Keogh J.M., Aminian S., Jebb S.A., Butler G., Cheetham T., and O'Rahilly S. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J. Clin. Invest. 106 (2000) 271-279
80. Fetissov S.O., Kopp J., and Hökfelt T. Distribution of NPY receptors in hypothalamus. Neuropeptides 38 4 (2004) 175-188
81. Flynn F.W. Caudal brain stem systems mediate effects of bombesin-like peptides on intake in rats. Am. J. Physiol. 262 (1992) R39-R45
82. Flynn F.W. Fourth ventricular injection of selective bombesin receptor antagonists facilitate feeding in rats. Am. J. Physiol. 264 (1993) R218-R221
83. Frandsen J., Pedersen S.B., and Richelsen B. Long term follow up of patients who underwent jejunoileal bypass for morbid obesity. Eur. J. Surg. 164 4 (1998) 281-286
84. Frederich R.C., Lollmann B., Hamann A., Napolitano-Rosen A., Kahn B.B., Lowell B.B., and Flier J.S. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest. 96 (1995) 1658-1663
85. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
86. Fride E., Bregman T., and Kirkham T.C. Endocannabinoids and food intake: Newborn suckling and appetite regulation in adulthood. Exp. Biol. Med. 230 (2005) 225-234
87. Funahashi H., Hori T., Shimoda Y., Mizushima H., Ryushi T., Katoh S., and Shioda S. Morphological evidence for neural interactions between leptin and orexin in the hypothalamus. Regulat. Pept. 92 1-3 (2000) 31-35
88. Ge H., Huang L., Pourbahrami T., and Li C. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J. Biol. Chem. 277 (2002) 45898-45903
89. Gehlert D.R. Introduction to the reviews on Neuropeptide Y. Neuropeptides 38 4 (2004) 135-140
90. Gibbs J., Young R.C., and Smith G.P. Cholecystokinin decreases food intake in rats. J. Comp. Physiol. Psychol. 84 (1973) 488-495
91. Gilbert J.A., and Richelson E. Neurotensin stimulates formation of cyclic GMP in murine neuroblastoma clone N1E-115. Eur. J. Pharmacol. 99 (1984) 245-246
92. Glass M.J., Chan J., and Pickel V.M. Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons. J. Neurosci. Res. 67 (2002) 753-765
93. Goldstone A.P., Mercer J.G., Gunn I., Moar K.M., Edwards C.M., Rossi M., Howard J.K., Rasheed S., Turton M.D., Small C., Heath M.M., O'Shea D., Steere J., Meeran K., Ghatei M.A., Hoggard N., and Bloom S.R. Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents. FEBS Lett. 415 (1997) 134-138
94. Goldstone A.P., Unmehopa U.A., Bloom S.R., and Swaab D.F. Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects. J. Clin. Endocrinol. Metab. 87 (2002) 927-937
95. Graham M., Shutter J.R., Sarmiento U., Sarosi I., and Stark K.L. Overexpression of Agrt leads to obesity in transgenic mice. Nat. Genet. 17 3 (1997) 273-274
96. Greenman Y., Golani N., Gilad S., Yaron M., Limor R., and Stern N. Ghrelin secretion is modulated in a nutrient- and gender-specific manner. Clin. Endocrinol. 60 (2004) 382-386
97. Grill H.J., and Smith G.P. Cholecystokinin decreases sucrose intake in chronic decerebrate rats. Am. J. Physiol. 254 (1988) R853-R856
98. Guan X.M., Hess J.F., Yu H., Hey P.J., and van der Ploeg L.H. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol. Cell. Endocrinol. 133 (1997) 1-7
99. Gundlach A.L. Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction. Eur. J. Pharmacol. 440 2-3 (2002) 255-268
100. Gutzwller J.-P., Drew J., Hildebrand P., Rossi L., Lauer J.Z., and Bellinger C. Effect of intravenous human gastrin-releasing peptide on food intake in humans. Gastroenterology 106 (1994) 1168-1173
101. Hagan M.M., Rushing P.A., Pritchard L.M., Schwartz M.W., Strack A.M., Van Der Ploeg L.H., Woods S.C., and Seeley R.J. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 (2000) R47-R52
102. Hagemann D., Meier J.J., Gallwitz B., and Schmidt W.E. Appetite regulation by ghrelin - a novel neuro-endocrine gastric peptide hormone in the gut-brain-axis. Z. Gastroenterol. 41 9 (2003) 929-936
103. Hahn T.M., Breininger J.F., Baskin D.G., and Schwartz M.W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1 (1998) 271-272
104. Håkansson M.L., Brown H., Ghilardi N., Skoda R.C., and Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18 (1998) 559-572
105. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., and Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
106. Halatchev I.G., Ellacott K.L., Fan W., and Cone R.D. Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 145 (2004) 2585-2590
107. Halford J.C., Harrold J.A., Lawton C.L., and Blundell J.E. Serotonin (5-HT) drugs: Effects on appetite expression and use for the treatment of obesity. Curr. Drug Targets 6 2 (2005) 201-213
108. Hampton L.L., Ladenheim E.E., Akeson M., Way J.M., Weber H.C., Sutliff V.E., Jensen R.T., Wine L.J., Arnheiter H., and Battey J.F. Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor deficient mice. Proc. Natl. Acad. Sci. USA 95 (1998) 3188-3192
109. Harfstrand A., Fuxe K., Agnati L.F., Benfenati F., and Goldstein M. Receptor autoradiographical evidence for high densities of 125I-neuropeptide Y binding sites in the nucleus tractus solitarius of the normal male rat. Acta Physiol. Scand. 128 (1986) 195-200
110. Haskell-Luevano C., Chen P., Li C., Chang K., Smith M.S., Cameron J.L., and Cone R.D. Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology 140 3 (1999) 1408-1415
111. Heinrichs S.C., Cole B.J., Pich E.M., Menzaghi F., Koob G.F., and Hauger R.L. Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor. Peptides 13 (1991) 879-884
112. Heinrichs S.C., Menzaghi F., and Koob G.F. Neuropeptide Y-induced feeding and its control. Vitam. Horm. 54 (1998) 51-66
113. Hermans E., Maloteaux J.M., and Octave J.N. Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor. Mol. Brain Res. 15 (1992) 332-338
114. Hermans E., Gailly P., Octave J.N., and Maloteaux J.M. Rapid desensitization of agonist-induced calcium mobilization in transfected PC12 cells expressing the rat neurotensin receptor. Biochem. Biophys. Res. Commun. 198 (1994) 400-407
115. Hervieu G.J. Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances. Expert Opin. Ther. Targets 10 2 (2006) 211-229
116. Hines S. Words into action-promoting successful weight loss in overweight patients. JAAPA 17 (2004) 19-28
117. Hoentjen F., Hopman W.P., and Jansen J.B. Effect of circulating peptide YY on gallbladder emptying in humans. Scand. J. Gastroenterol. 36 (2001) 1086-1091
118. Hoggard N., Hunter L., Duncan J.S., and Rayner D.V. Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signaling system. J. Mol. Endocrinol. 32 1 (2004) 145-153
119. Hoggard N., Rayner D.V., Johnston S.L., and Speakmawild J.R. Peripherally administered [Nle4, D-Phe 7)-α-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice. J. Mol. Endocrinol. 33 3 (2004) 693-703
120. Hoggard N., Mercer J.G., Rayner D.V., Moar K., Trayhurn P., and Williams L.M. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem. Biophys. Res. Commun. 232 2 (1997) 383-387
121. Hsu S.Y., and Hsueh A.J.W. Human stresscopin and stresscopin related peptides. Nat. Med. 7 (2001) 605-611
122. Huang X.F., Han M., South T., and Storlien L. Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity. Brain Res. 992 (2003) 9-19
123. Hube F., Lietz U., Igel M., Jensen P.B., Tornqvist H., Joost H.G., and Hauner H. Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm. Metab. Res. 28 12 (1996) 690-693
124. Hubina E., Goth M., and Korbonits M. Ghrelin - a hormone with multiple functions. Orv. Hetil. 146 25 (2005) 1345-1351
125. Hulsey M.G., Pless C.M., and Martin R.J. Icv administration of anti-corticotropin-releasing factor antisense oligonucleotide: effects on feeding behavior and body weight. Regul. Pept. 59 (1995) 241-246
126. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., Smith F.J., Campfield L.A., Burn P., and Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88 (1997) 131-141
127. Inui A. Transgenic approach to the study of body weight regulation. Pharmacol. Rev. 52 1 (2000) 35-62
128. Janssen J.A., van Der Toorn F.M., Hofland L.J., van Koetsveld P., Broglio F., Ghigo E., Lamberts S.W., and van Der Lely A.J. Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy. Eur. J. Endocrinol. 145 (2001) 711-766
129. Jequier E. Leptin signaling, adiposity and energy balance. Ann. NY Acad. Sci. 967 (2002) 379-388
130. Kalra S.P. Appetite and body weight regulation: Is it all in the brain?. Neuron 19 (1997) 227-230
131. Kalra S.P., and Kalra P.S. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38 4 (2004) 201-211
132. Kalra S.P., Dube M.G., Sahu A., Phelps C., and Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA 38 (1991) 10931-10935
133. Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., and Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 20 (1999) 68-100
134. Kastin A.J., and Pan W. Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul. Peptides 92 (2000) 37-43
135. Katsuura G., and Inui A. Melanin-concentrating hormone as a metabolic and cognitive regulatory factor. Curr. Med. Chem. - Central Nervous System Agents 3 3 (2003) 217-227
136. Kawai Y., Inagaki S., Shiosaka S., Shibasaki T., Ling N., Tohyama M., and Shiotani Y. The distribution and projection of gamma-melanocyte stimulating hormone in the rat brain: an immunohistochemical analysis. Brain Res. 297 (1984) 21-32
137. Kieffer B.L. Opioids: First lessons from knockout mice. Trends Pharmacol. Sci. 20 (1999) 19-26
138. Kinzig K.P., D'Alessio D.A., and Seeley R.J. The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J. Neurosci. 22 23 (2002) 10470-10476
139. Kirchgessner A.L., and Liu M. Orexin synthesis and response in the gut. Neuron 24 (1999) 941-951
140. Kirkham T.C., and Tucci S.A. Endocannabinoids in appetite control and the treatment of obesity. CNS & Neurol. Disorders - Drug Targets 5 3 (2006) 275-292
141. Kislauskis E., Bullock B., McNeil S., and Dobner P.R. The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. J. Biol. Chem. 263 (1988) 4963-4968
142. Kissileff H.R., Pi-Sunyer F.X., Thornton J., and Smith G.P. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am. J. Clin. Nutrit. 34 (1981) 154-160
143. Kissileff H.R., Carretta J.C., Geliebter A., and Pi-Sunyer F.X. Cholecystokinin and stomach distension combine to reduce food intake in humans. Am. J. Physiol. - Regulatory, Integrative and Comparative Physiology 285 (2003) R992-R998
144. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone releasing acylated peptide from stomach. Nature 402 (1999) 656-660
145. Konturek S.J., Pepera J., Zabielski K., Konturek P.C., Pawlik T., Szlachcic A., and Hahn E.G. Brain-Gut axis in pancreatic secretion and appetite control. J. Physiol. Pharmacol. 54 3 (2003) 293
146. Kopin A.S., Mathes W.F., McBride E.W., Nguyen M., Al-Haider W., Schmitz F., Bonner-Weir S., Kanarek R., and Beinborn M. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J. Clin. Invest. 103 (1999) 383-391
147. Korner J., and Aronne L.J. Pharmacological approaches to weight reduction: Therapeutic targets. J. Clin. Endocrinol. Metab. 89 6 (2004) 2616-2621
148. Kowalski T.J., Spar B.D., Weig B., Farley C., Cook J., Ghibaudi L., Fried S., O'Neill K., Del Vecchio R.A., McBriar M., Guzik H., Clader J., Hawes B.E., and Hwa J. Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice. Eur. J. Pharmacol. 535 1-3 (2006) 182-191
149. Koylu E.O., Couceyro P.R., Lambert P.D., and Kuhar M.J. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp. Neurol. 391 (1998) 115-132
150. Krasnow S.M., Fraley G.S., Schuh S.M., Baumgartner J.W., Clifton D.K., and Steiner R.A. A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse. Endocrinology 144 3 (2003) 813-822
151. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., Clausen J.T., Jensen P.B., Madsen O.D., Vrang N., Larsen P.J., and Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature (London) 393 (1998) 72-76
152. Krude H., Biebermann H., Schnabel D., Tansek M.Z., Theunissen P., Mullis P.E., and Gruters A. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J. Clin. Endocrinol. Metab. 88 10 (2003) 4633-4640
153. Kuhar M.J., and Yoho L.L. CART peptide analysis by Western blotting. Synapse 33 (1999) 15659-15664
154. Ladenheim E.E., Taylor J.E., Coy D.H., Carrigan T.S., Wohn A., and Moran T.H. Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake. Am. J. Physiol. 272 (1997) R433-R437
155. Ladenheim E.E., Hampton L.L., Whitney A.C., White W.O., Battey J.F., and Moran T.H. Disruptions in feeding and body-weight control in gastrin-releasing peptide receptor deficient mice. J. Endocrinol. 174 (2002) 273-281
156. Lambert P.D., Gross R., Nemeroff C.B., and Kilts C.D. Anatomy and mechanisms of neurotensin-dopamine interactions in the central nervous system. Ann. NY Acad. Sci. 757 (1995) 377-389
157. Lambert P.D., Couceyro P.R., McGirr K.M., Dall S.E., Smith Y., and Kuhar M.J. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 29 (1998) 293-298
158. Larhammar D. Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regulat. Pept. 65 (1996) 165-174
159. Larsen P.J., Vrang N., Petersen P.C., and Kristensen P. Chronic intracerebroventricular administration of recombinant CART (42-89) peptide inhibits food intake and causes weight loss in lean and obese Zucker (fa/fa) rats. Obes. Res. 8 (2000) 590-596
160. Lee G.H., Proenca, Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., and Friedman J.M. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 (1996) 632-635
161. Leibel R.L., Chung W.K., and Chua S.C. The molecular genetics of rodent single gene obesities. J. Biol. Chem. 272 (1997) 31937-31940
162. Leibowitz S.F. Hypothalamic neuropeptide Y, galanin, and amines: Concepts of coexistence in relation to feeding behavior. Ann. NY Acad. Sci. 575 (1989) 221-233
163. Leibowitz S.F. Neurochemical-neuroendocrine systems in the brain controlling macronutrient intake and metabolism. Trends Neurosci. 15 (1992) 491-497
164. Leibowitz S.F. Brain peptides and obesity: Pharmacologic treatment. Obes. Res. 3 (1995) 573S-589S
165. Leibowitz S.F. Differential functions of galanin cell groups in the regulation of eating and body weight. Ann. NY Acad. Sci. 863 (1998) 206-220
166. Leibowitz S.F., and Shor-Posner G. Hypothalamic monoamine systems for control of food intake: analysis of meal patterns and macronutrient selection. In: Carube M.O., and Blundell J.E. (Eds). Psychopharmacology of Eating Disorders: Theoretical and Clinical Advances 29 (1986), Raven Press, New York
167. Leibowitz S.F., Akabayashi A., and Wang J. Obesity on a high-fat diet: Role of hypothalamic galanin in neurons of the anterior paraventricular nucleus projecting to the median eminence. J. Neurosci. 18 7 (1998) 2709-2719
168. Levine A.S., and Billington C.J. Why do we eat? A neural systems approach. Ann. Rev. Nutr. 17 (1997) 597-619
169. Levine A.S., and Billington C.J. Opioids: Are they regulators of feeding?. Ann. NY Acad. Sci. 575 (1989) 209-219
170. Levine A.S., Rogers B., Kneip J., Grace M., and Morley J.E. Effect of centrally administered corticotropin releasing factor (CRF) on multiple feeding paradigms. Neuropharmacology 22 (1983) 337-339
171. Licinio J., Caglayan S., Ozata M., Yildiz B.O., de Miranda P.B., O'Kirwan F., Whitby R., Liang L., Cohen P., Bhasin S., et al. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. PNAS 101 (2004) 4531-4536
172. Liddle R.A., Goldfine I.D., Rosen M.S., Taplitz R.A., and Williams J.A. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J. Clin. Invest. 75 (1985) 1144-1152
173. Lieberman G.S., Rubinfeld H., Glick M., Kronfeld-Schor N., and Shimon I. Melanin-concentrating hormone stimulates human growth hormone secretion: a novel effect of MCH on the hypothalamic-pituitary axis. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E982-E988 10.1152/ajpendo.00138.2005
174. Li H.Y., Hwang H.W., and Hu Y.H. Functional characterizations of cocaine- and amphetamine-regulated transcript mRNA expression in rat hypothalamus. Neurosci. Lett. 323 3 (2002) 203-206
175. Lin H.C., and Chey W.Y. Cholecystokinin and peptide YY are released by fat in either proximal or distal small intestine in dogs. Regulat. Pept. 114 (2003) 131-135
176. +-ATPase activity through high affinity peptide receptor. Peptides 21 (2000) 571-576
177. Ludwig D.S., Tritos N.A., Mastaitis J.W., Kulkarni R., Kokkotou E.G., Elmquist J.L., Bradford F., Jeffrey S., and Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 107 (2001) 379-386
178. Lutz T.A. Pancreatic amylin as a centrally acting satiating hormone. Curr. Drug Targets 6 2 (2005) 181-189
179. Lutz T.A., Pieber T.R., Walzer B., Del Prete E., and Scharrer E. Different influence of CGRP (8-37), an amylin and CGRP antagonist, on the anorectic effects of cholecystokinin and bombesin in diabetic and normal rats. Peptides 18 (1997) 643-649
180. Lutz T.A., Tschudy S., Mollet A., Geary N., and Scharrer E. Dopamine D(2) receptors mediate amylin's acute satiety effect. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2001) R1697-R1703
181. Maekawa F., Quah H.-M., Tanaka K., and Ohki-Hamazaki H. Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking Bombesin receptor subtype- 3 (BRS-3). Diabetes 53 (2004) 570-576
182. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1 (1995) 1155-1161
183. Makino S., Baker R.A., Smith M.A., and Gold P.W. Differential regulation of neuropeptide Y mRNA expression in the arcuate nucleus and locus coeruleus by stress and antidepressants. J. Neuroendocrinol. 12 (2000) 387-395
184. Marks J.L., Porte Jr. D., Stahl W.L., and Baskin D.G. Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127 (1990) 3234-3236
185. Marsh D.J., Hollopeter G., Kafer K.E., and Palmiter R.D. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat. Med. 4 (1998) 718-721
186. 2 receptors. Am. J. Physiol. 274 (1998) G965-G970
187. Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H., Nishimura H., Yoshimasa Y., Tanaka I., Mori T., and Nakao K. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3 (1997) 1029-1033
188. Matson C.A., and Ritter R.C. Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. Am. J. Physiol. 276 (1999) R1038-R1045
189. Maulon-Feraille L., Della Zuana O., Suply T., Rovere-Jovene C., Audinot V., Levens N., Boutin J.A., Duhault J., and Nahon J.L. Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance. J. Pharmacol. Exp. Ther. 302 2 (2002) 766-773
190. Mazella J., Botto J.M., Guillemare E., Coppola T., Sarret P., and Vincent J.P. Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J. Neurosci. 16 (1996) 5613-5620
191. Mazella J., Zsürger N., Navarro V., Chabry J., Kaghad M., Caput D., Ferrara P., Vita N., Gully D., Maffrand J.P., and Vincent J.P. The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J. Biol. Chem. 273 (1998) 26273-26276
192. McBriar M.D., Guzik H., Shapiro S., Paruchova J., Xu R., Palani A., Clader J.W., Cox K., Greenlee W.J., Hawes B.E., Kowalski T.J., O'neill K., Spar B.D., Weig B., Weston D.J., Farley C., and Cook J. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas. J. Med. Chem. 49 7 (2006) 2294-2310
193. Meeran K., O'Shea D., Edwards C.M.B., Turton M.D., Heath M.M., Gunn I., Abusnana S., Rossi M., Small C.J., Goldstone A.P., Taylor G.M., Sunter D., Steere J., Choi S.J., Ghatei M.A., and Bloom S.R. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat. Endocrinology 140 (1999) 244-250
194. Mei N. Intestinal chemosensitivity. Physiol. Rev. 65 (1985) 211-237
195. Meister B. Control of food intake via leptin receptors in the hypothalamus. Vitam. Horm. 59 (2000) 265-304
196. Merali Z., Moody T.W., and Coy D. Blockade of brain bombesin/GRP receptors increases food intake in satiated rats. Am. J. Physiol. 264 (1993) R1031-R1034
197. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., and Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387 (1996) 113-116
198. Miltenberger R.J., Mynatt R.L., Wilkinson J.E., and Woychik R.P. The role of the agouti gene in the yellow obese syndrome. J. Nutr. 127 (1997) 1902S-1907S
199. Mitchell J.E., Lancaster K.L., Burgard M.A., Howell L.M., Krahn D.D., Crosby R.D., Wonderlich S.A., and Gosnell B.A. Long-term follow-up of patients' status after gastric bypass. Obes. Surg. 11 (2001) 464-468
200. Mollet A., Lutz T.A., Meier S., Riediger T., Rushing P.A., and Scharrer E. Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2001) R1442-R1448
201. Montague C.T., Farooqi I.S., Whitehead J.P., Soos M.A., Rau H., Wareham N.J., Sewter C.P., Digby J.E., Mohammed S.N., Hurst J.A., et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387 (1997) 903-908
202. Montague C.T., Prins J.B., Sanders L., Zhang J.L., Sewter C.P., Digby J., Byrne C.D., and O' Rahilly S. Depot-related gene-expression in human subcutaneous and omental adipocytes. Diabetes 47 (1998) 1384-1391
203. Moran T.H., and Schwartz G.J. Neurobiology of cholecystokinin. Crit. Rev. Neurobiol. 9 (1994) 1-28
204. Morley J.E. The ascent of cholecystokinin (CCK): from gut to brain. Life Sci. 30 6 (1982) 479-493
205. Morley J.E. Neuropeptide regulation of appetite and weight. Endocr. Rev. 8 (1987) 256-287
206. Morley J.E., Flood J.F., Horowitz M., Morley P.M., and Walter M.J. Modulation of food intake by peripherally administered amylin. Am. J. Physiol. 267 (1994) R178-R184
207. Morley J.E., Flood J.F., Farr S.A., Perry III H.J., Kaiser F.E., and Morley P.M. Effects of amylin on appetite regulation and memory. Can. J. Physiol. Pharmacol. 73 7 (1995) 1042-1046
208. Morgan T.H. Cholecystokinin and satiety: current perspectives. Nutrition 16 (2000) 858-865
209. Morgan T.H. Gut peptides in the control of food intake: 30 years of ideas. Physiol. Behav. 82 (2004) 175-180
210. Morris M.J., and Nguyen T. Does neuropeptide Y contribute to the anorectic action of amylin?. Peptides 22 (2001) 541-546
211. Murphy K.G. Dissecting the role of cocaine- and amphetamine-regulated transcript (CART) in the control of appetite. Brief. Funct. Genomics Proteomics 4 2 (2005) 95-111 10.1093/bfgp/4.2.95
212. Mynatt R.L., Miltenberger R.J., Klebig M.L., Zemel M.B., Wilkinson J.E., Wilkinson W.O., and Woychik R.P. Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity. Proc. Natl. Acad. Sci. USA 94 (1997) 919-922
213. Nahon J.L. The melanin-concentrating hormone: from the peptide to the gene. Crit. Rev. Neurobiol. 8 4 (1994) 221-262
214. Naslund E., Gryback P., Hellstrom P.M., Jacobsson H., Holst J.J., Theodorsson E., and Backman L. Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity. Int. J. Obes. Relat. Metab. Disord. 21 (1997) 387-392
215. Neary N.M., Goldstone A.P., and Bloom S.R. Appetite regulation: from gut to the hypothalamus. Clin. Endocrinol. 60 (2004) 153-160
216. Niimi M. The role of anorectic and orexigenic peptides (CART, NPY etc). Nippon Rinsho 59 3 (2001) 443-448
217. Niswender K.D., Morton G.J., Stearns W.H., Rhodes C.J., Myers Jr. M.G., and Schwartz M.W. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413 (2001) 794-795
218. Nowak K.W., Mackowiak P., Switonska M.M., Fabis M., and Malendowicz L.K. Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies. Life Sci. 66 (2000) 449-454
219. Obici S., Feng Z., Karkanias G., Baskin D.G., and Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci. 5 6 (2002) 566-572
220. Ogawa Y., Masuzaki H., Hosoda K., Aizawa-Abe M., Suga J., Suda M., Ebihara K., Iwai H., Matsuoka N., Satoh N., Okada H., Kasuga H., Fujisawa Y., Inoue G., Nishimura H., Yoshimasa Y., and Nakao K. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 48 (1999) 1822-1829
221. Ohki-Hamazaki H., Watase K., Yamamoto K., Ogura H., Yamano M., Yamada K., Maeno H., Imaki J., Kikuyama S., Wada E., et al. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Nature 390 (1997) 165-169
222. Ohki-Hamazaki H., Iwabuchi M., and Maekawa F. Development and function of bombesin-like peptides and their receptors. Int. J. Dev. Biol. 49 (2005) 293-300
223. Owens M.J., and Nemeroff C.B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol. Rev. 43 (1991) 425-473
224. Padwal R., Li S.K., and Lau D.C. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int. J. Obes. Relat. Metab. Disord. 27 (2003) 1437-1446
225. Pereira-da-Silva M., De Souza C.T., Gasparetti A.L., Saad M.J., and Velloso L.A. Melanin-concentrating hormone induces insulin resistance through a mechanism independent of body weight gain. J. Endocrinol. 186 1 (2005) 193-201
226. Pedrazzini T. Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts. Neuropeptides 38 4 (2004) 267-275
227. Pedrazzini T., Seydoux J., Konstner P., Aubert J., Grouzmann E., Beerman F., and Brunner H. Cardiovascular response, feeding behaviour and locomotor activity in mice lacking the NPY Y1 receptor. Nat. Med. 4 (1998) 722-726
228. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., and Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
229. Pi-Sunyer F.X., Laferrère B., Aronne L.J., and Bray G.A. Therapeutic controversy: Obesity - a modern-day epidemic. J. Clin. Endocrinol. Metab. 84 (1999) 3-12
230. Pittner R.A., Moore C.X., Bhavsar S.P., Gedulin B.R., Smith P.A., Jodka C.M., Parkes D.G., Paterniti J.R., Srivastava V.P., and Young A.A. Effects of PYY[3-36] in rodent models of diabetes and obesity. Int. J. Obes. Relat. Metab. Disord. 28 (2004) 963-971
231. Plamondon H., and Merali Z. Push-pull perfusion reveals meal-dependent changes in the release of bombesin-like peptides in the rat paraventricular nucleus. Brain Res. 668 (1994) 54-61
232. Plamondon H., and Merali Z. Anorectic action of bombesin requires receptor for corticotropin-releasing factor but not for oxytocin. Eur. J. Pharmacol. 340 (1997) 99-109
233. Polonsky K.S., Given B.D., and Van Cauter E. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81 (1988) 442-448
234. Porte Jr. D., Baskin D.G., and Schwartz M.W. Leptin and insulin action in the central nervous system. Nutr. Rev. 60 (2002) S20-S29
235. Pritchard L.E., Turnbull A.V., and White A. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. J. Endocrinol. 172 3 (2002) 411-421
236. Rampal P. Mechanisms of the control of appetite. Presse Med. 15 1 (1986) 23-25
237. Ratner R., Want L.L., Fineman M.S., Velte M.J., Ruggles J.A., Gottlieb A., Weyer C., and Kolterman O.G. Adjunctive therapy with the amylin analogue pramlintide leads to a combined improvement in glycemic and weight control in insulin-treated patients with type 2 diabetes. Diabetes Techno. Ther. 4 (2002) 51-61
238. Reda T.K., Geliebter A., and Pi-Sunyer F.X. Amylin, food intake, and obesity. Obes. Res. 10 (2002) 1087-1091
239. Reeve J.R., Eysselein V.E., Ho F.J., Chew P., Vigna S.R., Liddle R.A., and Evans C. Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology. Ann. NY Acad. Sci. 713 (1994) 11-21
240. Renshaw D., and Batterham R.L. Peptide YY: A potential therapy for obesity. Curr. Drug Targets 6 2 (2005) 171-179
241. Ricardo J.A., and Koh E.T. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res. 153 (1978) 1-26
242. Richard Denis. The role of corticotropin-releasing hormone in the regulation of energy balance. Curr. Opin. Endocrinol. & Diabetes 6 1 (1999) 10
243. Rodgers R.J., Ishii Y., Halford J.C., and Blundell J.E. Orexins and appetite regulation. Neuropeptides 36 5 (2002) 303-325
244. Rodriguez M., Beauverger P., Naime I., Rique H., Ouvry C., Souchaud S., Dromaint S., Nagel N., Suply T., Audinot V., Boutin J.A., and Galizzi J.P. Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2. Mol. Pharmacol. 60 (2001) 632-639
245. Rossi M., Kim M.S., Morgan D.G., Small C.J., Edwards C.M., Sunter D., Abusnana S., Goldstone A.P., Russell S.H., Stanley S.A., Smith D.M., Yagaloff K., Ghatei M.A., and Bloom S.R. A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo. Endocrinology 139 (1998) 4428-4431
246. Roux C.W.L., and Bloom S.R. Peptide YY, appetite and food intake. Proc. Nutrn. Soc. 64 2 (2005) 213-216
247. Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 139 (1998) 795-798
248. Sahu A., Carraway R.E., and Wang Y.P. Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res. 888 (2001) 343-347
249. Sakurai T. Role of orexin in regulation of energy homeostasis. Curr. Med. Chem. - Central Nervous System Agents 3 3 (2003) 229-241
250. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., and Yanagisawa M. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
251. Sakurai T., Moriguchi T., Furuya K., Kajiwara N., Nakamura T., Yanagisawa M., and Goto K. Structure and function of human prepro-orexin gene. J. Biol. Chem. 274 (1999) 17771-17776
252. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., and Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature 377 (1995) 527-529
253. Samanin R., and Garattini S. Pharmacology of ingestive behavior. Thérapie 51 (1996) 107-115
254. Sarson D.L., Scopinaro N., and Bloom S.R. Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity. Int. J. Obes. 5 (1981) 471-480
255. Satoh N., Ogawa Y., Katsura G., Tsuji T., Masuzaki H., Hiraoka J., Okazaki T., Tamaki M., Hayase M., Yoshimasa Y., Nishi S., Hasoda K., and Nakao K. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: Evidence for the loss of its satiety effect in the VMH-lesioned rats. Endocrinology 138 (1997) 947-954
256. Sawchenko P.E., Swanson L.W., Grzanna R., Howe P.R., Bloom S.R., and Polak J.M. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. Comp. J. Neurol. 241 (1985) 138-153
257. Schick R.R., Schusdziarra V., Yaksh T.L., and Go V.L.W. Brain regions where cholecystokinin exerts its effect on satiety. Ann. NY Acad. Sci. 713 (1994) 242-254
258. Schmidt P.T., Naslund E., Gryback P., Jocobsson H., Hartmann B., Holst J.J., and Hellstrom P.M. Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. Regul. Pept. 116 1-3 (2003) 21-25
259. Schwartz M.W., Figlewicz D.P., Baskin D.G., Woods S.C., and Porte D.J. Insulin in the brain: A hormonal regulator of energy balance. Endocr. Rev. 13 (1992) 387-414
260. Schwartz M.W., Sipols A.J., Marks J.L., Sanacora G., White J.D., Scheurink A., Kahn S.E., Baskin D.G., Woods S.C., Figlewicz D.P., et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130 (1992) 3608-3616
261. Schwartz M.W., Dallman M.F., and Woods S.C. Hypothalamic response to starvation: implications for the study of wasting disorders. Am. J. Physiol. 269 (1995) R949-R957
262. Sinha M.K., and Caro J.F. Clinical aspects of leptin. Vitam. Horm. 54 (1998) 1-30
263. Sinha M., Sturis J., Ohannesian J., Magosin S., Stephens T., Heiman M.L., Polonsky K.S., and Caro J.F. Ultradian oscillations of leptin secretion in humans. Biochem. Biophys. Res. Commun. 228 3 (1996) 733-738
264. Sipols A.J., Baskin D.G., and Schwartz M.W. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44 (1995) 147-151
265. Slusher B.S., Zacco A.E., Maslanski J.A., Norris T.E., McLane M.W., Moore W.C., Rogers N.E., and Ignarro L.J. The cloned neurotensin receptor mediates cyclic GMP formation when coexpressed with nitric oxide synthase cDNA. Mol. Pharmacol. 46 (1994) 115-121
266. 2 receptors in corticotropin-releasing factor- and urocortin-induced anorexia. Neuroreport 9 7 (1998) 1601-1606
267. Small C.J., and Bloom S.R. Gut hormones as peripheral anti-obesity agents. Curr. Drug Targets CNS. Neurol. Disord. 3 5 (2004) 379-388
268. Small C.J., Kim M.S., Stanley S.A., Mitchell J.R., Murphy K., Morgan D.G., Ghatei M.A., and Bloom S.R. Effects of chronic central nervous system administration of Agouti-related protein in pair-fed animals. Diabetes 50 (2001) 248-254
269. Smart D., Jerman J.C., Brough J.C., Rushton S.L., Murdock P.R., Jewitt F., Elshourbagy N.A., Ellis C.E., Middlemiss D.N., and Brown F. Characterisation of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell line using FLIPR. Br. J. Pharmacol. 128 (1999) 1-3
270. Smart D., Jerman J.C., Brough J.C., Neville W.A., Jewitt F., and Porter R.A. The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors. Br. J. Pharmacol. 129 (2000) 1289-1291
271. Smith E.M., and Blalock J.E. Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon. Proc. Natl. Acad. Sci. USA 78 (1981) 7530-7534
272. Smith B.K., York D.A., and Bray G.A. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides 15 7 (1994) 1267-1272
273. Spina M., Merlo-Pich E., Chan R.K., Basso A.M., Rivier J., Vale W., and Koob G.F. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 273 (1996) 1561-1564
274. Spindel E. Mammalian bombesin-like peptides. Trends Neurosci. 9 (1986) 130-133
275. Stanley B.G., Hoebel B.G., and Leibowitz S.F. Neurotensin: Effects of hypothalamic and intravenous injections on eating and drinking in rats. Peptides 4 (1983) 493-500
276. Stanley B.G., Kyrkouli S.E., Lampert S., and Leibowitz S.F. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7 (1986) 1189-1192
277. Stanley S.A., Small C.J., Murphy K.G., Rayes E., Abbott C.R., Seal L.J., Morgan D.G., Sunter D., Dakin C.L., Kim M.S., Hunter R., Kuhar M., Ghatei M.A., and Bloom S.R. Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain Res. 893 1-2 (2001) 186-194
278. Strobel A., Issad T., Camoin L., Ozata M., and Strosberg A.D. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 18 (1998) 213-215
279. Taché Y., and Brown M. On the role of bombesin in homeostasis. Trends Neurosci. 5 (1982) 431-433
280. Tanaka K., Masu M., and Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron 4 (1990) 847-854
281. Tanaka M., Naruo T., Muranaga T., Yasuhara D., Shiya T., Nakazato M., Matsukura S., and Nozoe S. Increased fasting plasma ghrelin levels in patients with bulimia nervosa. Eur. J. Endocrinol. 146 (2002) 1-3
282. Tanaka M., Naruo T., Nagai N., Kuroki N., Shiiya T., Nakazato M., Matsukura S., and Nozoe S. Habitual binge/purge behaviour influences circulating ghrelin levels in eating disorders. J. Psychiatr. Res. 37 1 (2003) 17-22
283. Tang-Christensen M., Vrang N., and Larsen P.J. Glucagon-like peptide containing pathways in the regulation of feeding behaviour. Int. J. Obes. Relat. Metab. Disord. 25 Suppl. 5 (2001) S42-S47
284. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272 (1997) 6093-6096
285. Tempel D.L., and Leibowitz S.F. Adrenal steroid receptors: interactions with brain neuropeptide systems in relation to nutrient intake and metabolism. J. Neuroendocrinol. 6 (1994) 479-501
286. Ter Horst G.J., de Boer P., Luiten P.G., and van Willigen J.D. Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat. Neuroscience 31 (1989) 785-797
287. The National Heart, Lung, and Blood Institute and National Institute of Diabetes and Digestive and Kidney Diseases. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. 1998. Available from: http://www.nhlbi.nih.gov/guidelines/obesity/ob_home.htm.
288. Tolle V., Kadem M., Bluet Pajot M., Frere D., Foulon C., Bossu C., Dardennes R., Mounier C., Zizzari P., Lang F., Eppelbaum J., and Estour B. Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J. Clin. Endocrinol. Metab. 88 (2003) 109-116
289. Trayhurn P., Hoggard N., Mercer J.G., and Rayner D.V. Leptin: fundamental aspects. Int. J. Obes. Relat. Metab. Disord. 23 1 (1999) 22-28
290. Trayhurn P., Hoggard N., and Rayner D.V. White adipose tissue as a secretory and endocrine organ: Leptin and other secreted proteins. In: Klaus S. (Ed). Adipose Tissue (2001), Landes Bioscience, Austin, TX
291. Tritos N.A., Elmquist J.K., Mastaitis J.W., Flier J.S., and Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Endocrinology 139 (1998) 4634-4641
292. Tritos N.A., Vincent D., Gillette J., Ludwig D.S., Flier E.S., and Maratos-Flier E. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes 47 (1998) 1687-1692
293. Trudeau L.E. Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes: evidence for the involvement of multiple receptors. Neuroscience 97 (2000) 293-302
294. Tschop M., Smiley D., and Helman M. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
295. Tschop M., Flora D.B., Mayor J.P., and Heiman M.L. Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats. Obes. Res. 10 (2002) 991-999
296. Turnbull A.V., and Rivier C. Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides. Proc. Soc. Exp. Biol. Med. 215 (1997) 1-10
297. Turton M.D., O'Shea D., Gunn I., Beak S.A., Edwards C.M., Meeran K., Choi S.J., Taylor G.M., Heath M.M., Lambert P.D., Wilding J.P., Smith D.M., Ghatei M.A., Herbert J., and Bloom S.R. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 (1996) 69-72
298. Vale W., Speiss J., Rivier C., and Rivier J. Characterization of a 41-amino acid residue ovine hypothalamic peptide that stimulates secretion of corticotropin and -endorphin. Science 213 (1981) 1394-1397
299. van den Pol A.N., Gao X.-B., Obrietan K., Kilduff T.S., and Belousov A.B. Presynaptic and postsynaptic actions and modulation of neuroendocrine by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 18 19 (1998) 7962-7971
300. van der Kooy D., Koda L.Y., McGinty J.F., Gerfen C.R., and Bloom F.E. The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. Comp. J. Neurol. 224 (1984) 1-24
301. Vanhoutte P.M., Saxena P.R., Paoletti R., Brunello N., Jackson N., and Jackson A.S. Serotonin: From Cell Biology to Pharmacology and Therapeutics (1993), Kluwer Academic, Dordrecht, The Netherlands
302. Vaughan J., Donaldson C., Bittencourt J., Perrin M.H., Lewis K., Sutton S., Chan R., Turnbull A.V., Lovejoy D., Rivier C., Rivier J., Sawchenko P.E., and Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin and to corticotropin-releasing factor. Nature 378 (1995) 287-292
303. Vickers S.P., and Kennett G.A. Cannabinoids and the regulation of ingestive behavior. Curr. Drug Targets 6 2 (2005) 215-223
304. Vita N., Laurent P., Lefort S., Chalon P., Dumont X., Kaghad M., Gully D., Le Fur G., Ferrara P., and Caput D. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett. 317 (1993) 139-142
305. Vita N., Oury-Donat F., Chalon P., Guillemot M., Kaghad M., Bachy A., Thurneyssen O., Garcia S., Poinot-Chazel C., Casellas P., et al. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Eur. J. Pharmacol. 360 (1998) 265-272
306. Vrang N., Phifer C.B., Corkern M.M., and Berthoud H.R. Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003) R 470-R 478
307. Wada E., Way J., Shapira H., Kusano K., Lebacq-Verheyden A.M., Coy D., Jensen R., and Battey J. cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Neuron 6 (1991) 421-430
308. Wada E., Wray S., Key S., and Battey J. Comparison of gene expression for two distinct bombesin receptor subtypes in postnatal rat central nervous system. Mol. Cell. Neurosci. 3 (1992) 446-460
309. Wada E., Watase K., Yamada K., Ogura H., Yamano M., Inomata Y., Eguchi J., Yamamoto K., Sunday M.E., Maeno H., et al. Generation and characterization of mice lacking gastrin-releasing peptide receptor. Biochem. Biophys. Res. Commun. 239 (1997) 28-33
310. Wahlestedt C., and Reis D.J. Neuropeptide Y-related peptides & their receptors: Are the receptors potential therapeutic drug targets?. Ann. Rev. Pharmacol. Toxicol. 32 (1993) 309-352
311. Wenger T., and Moldrich G. The role of endocannabinoids in the hypothalamic regulation of visceral function. Prostaglandins Leukot. Essent. Fatty Acids 66 2-3 (2002) 301-307
312. Westermark P., Wernstedt C., Wilander E., and Sletten K. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem. Biophys. Res. Commun. 140 (1986) 827-831
313. Whitehouse F., Ratner R., Rosenstock J., Schonfeld S., and Kolterman O.G. Pramlintide showed positive effects on body weight in type 1 and type 2 diabetes. Diabetes 47 (1998) S1
314. Whitehouse F., Kruger D.F., Fineman M., Shen L., Ruggles J.A., Maggs D.G., Weyer C., and Kolterman O.G. A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes. Diabetes Care 25 (2002) 724-730
315. Widdowson P.S., Upton R., Henderson L., Buckingham R., Wilson S., and Williams G. Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res. 774 (1997) 1-10
316. Wilding J.P. Neuropeptides and appetite control. Diabet. Med. 19 8 (2002) 619-627
317. Wilding J.P., Gilbey S.G., Bailey C.J., Batt R.A., Williams G., Ghatei M.A., and Bloom S.R. Increased neuropeptide-Y mRNA and decreased neurotensin mRNA in the hypothalamus of the ob/ob mouse. Endocrinology 132 (1993) 1939-1944
318. Williams G., Gill J.S., Lee Y.C., Cardoso H.M., Okpere B.E., and Bloom S.R. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats. Diabetes 38 (1989) 321-327
319. Williams G., Joanne A., Harrold, and Cutler D.J. The hypothalamus and the regulation of energy homeostasis: Lifting the lid on the black box. Proc. Nutr. Soc. 59 (2000) 385-396
320. Williams G., Bing C., Cai X.J., Harrold J.A., King P.J., and Liu X.H. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol. Behav. 74 4-5 (2001) 683-701
321. Willie J.T., Chemelli R.M., Sinton C.M., and Yanagisawa M. To eat or to sleep ? Orexin in the regulation of feeding and wakefulness. Ann. Rev. Neurosci. 24 (2001) 429-458
322. Wilson B.D., Ollmann M.M., and Barsh G.S. The role of agouti-related protein (Agrp) in regulation of body weight. Mol. Med. Today 5 (1999) 250-256
323. Woods S.C., Decke E., and Vasselli J.R. Metabolic hormones and regulation of body weight. Psychol. Rev. 81 (1974) 26-43
324. Woods S.C., Seeley R.J., Baskin D.G., and Schwartz M.W. Insulin and the blood-brain barrier. Curr. Pharmaceut. Design 9 (2003) 795-800
325. World Health Organization. Obesity: preventing and managing the global epidemic. Report of the World Health Organization on Obesity. Geneva, Switzerland; 1998. Available from: http://www.who.int/nut/documents/obesity_executive_summary.pdf.
326. Xu R., Li S., Paruchova J., McBriar M.D., Guzik H., Palani A., Clader J.W., Cox K., Greenlee W.J., Hawes B.E., Kowalski T.J., O'Neill K., Spar B.D., Weig B., and Weston D.J. Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists. Bioorg. Med. Chem. 14 10 (2006) 3285-3299
327. Yamada M., Watson M.A., and Richelson E. Neurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor. Eur. J. Pharmacol. 244 (1993) 99-101
328. Yang Y.-K., Thompson D.A., Dickinson C.J., Wilken J., Barsh G.S., Kent S.B.H., and Gantz I. Characterization of agouti-related protein binding to melanocortin receptors. Mol. Endocrinol. 13 (1999) 148-155
329. York D.A., and Hansen B. Animal models of obesity. In: Bray G.A., Bouchard C., and James W.P.T. (Eds). Handbook of Obesity (1998), Dekker, New York 191-221
330. Yoshihara T., Honma S., and Honma K. Effects of restricted daily feeding on neuropeptide Y release in the rat paraventricular nucleus. Am. J. Physiol. Endocrinol. Metab. 270 (1996) E589-E595
331. Zhang Y.Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homolog. Nature 372 (1994) 425-432
332. Zheng H., Patterson L.M., and Berthoud H.R. CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intake. Brain Res. 957 2 (2002) 298-310
333. Zhenjun T., Ronald F., Jiang C., and Zhang X. Galanin inhibits gut-related vagal neurons in rats. J. Neurophysiol. 91 (2004) 2330-2343
334. Zhou A., Bloomquist B.T., and Mains R.E. The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. J. Biol. Chem. 268 (1993) 1763-1769
335. Zoli M., Torri C., Ferrari R., Jansson A., Zini I., Fuxe K., and Agnati L.F. The emergence of the volume transmission concept. Brain Res. Rev. 26 (1998) 136-147
336. Zsürger N., Mazella J., and Vincent J.P. Solubilization and purification of a high affinity neurotensin receptor from newborn human brain. Brain Res. 639 (1994) 245-252