Peripherally administered [Nle4,D-Phe7]-α -melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice

Journal of Molecular Endocrinology

Volumn 33, Issue 3, 2004, Pages 693-703

  Hoggard, N ^a   Rayner, D V ^a   Johnston, S L ^a   Speakman, J R ^a,b  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN DERIVATIVE; ALPHA INTERMEDIN[N 4 LEUCINE 7 DEXTRO PHENYLALANINE]; LEPTIN; M 8764; OXYGEN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; AGOUTI-RELATED PROTEIN; ALPHA INTERMEDIN; CARBON DIOXIDE; DRUG DERIVATIVE; MSH, 4 NLE 7 PHE ALPHA; MSH, 4-NLE-7-PHE-ALPHA-; PROTEIN; SIGNAL PEPTIDE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CALORIC RESTRICTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DIET RESTRICTION; DRUG PENETRATION; ENERGY EXPENDITURE; ENERGY METABOLISM; HORMONE DEFICIENCY; HORMONE RELEASE; HORMONE SYNTHESIS; IN VITRO STUDY; LEAN BODY WEIGHT; LUNG GAS EXCHANGE; METABOLIC RATE; METABOLITE; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; REST; STATISTICAL SIGNIFICANCE; WILD TYPE; ANIMAL; BASAL METABOLIC RATE; BODY WEIGHT; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; MALE; METABOLISM; MOUSE MUTANT; OXYGEN CONSUMPTION; SECRETION;

ALPHA-MSH; ANIMALS; BASAL METABOLISM; CARBON DIOXIDE; CELLS, CULTURED; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; OXYGEN; OXYGEN CONSUMPTION; PROTEINS; RATS; THINNESS;

EID: 11244325044     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01632     Document Type: Article

References (38)

1. Ahima RS & Osei SY 2004 Leptin signaling. Physiology and Behavior 81 223-241.
2. Ahima RS, Saper CB, Flier JS & Elmquist JK 2000 Leptin regulation of neuroendocrine systems. Frontiers in Neuroendocrinology 21 263-307.
3. Asakawa A, Inui A, Goto K, Yuzuriha H, Takimoto Y, Inui T, Katsuura G, Fujino NM, Meguid MM & Kasuga M 2002 Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. International Journal of Molecular Medicine 10 523-525.
4. Ballor DL 1991 Effect of dietary restriction and/or exercise on 23-h metabolic rate and body composition in female rats. Journal of Applied Physiology 71 801-806.
5. Barsh G 1999 From Agouti to POMC - 100 years of fat blonde mice. Nature Medicine 5 984-985.
6. Bluther S, Ziotopoulou M, Bullen JW Jr, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E & Mantzoros CS 2004 Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes 53 82-90.
7. Boston BA & Cone RD 1996 Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 137 2043-2050.
8. Chagnon YC, Chen WJ, Perusse L, Chagnon M, Nadeau A, Wilkison WO & Bouchard C 1997 Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Molecular Medicine 3 663-673.
9. Charbonneau C, Bai F, Richards BS & Argyropoulos G 2004 Central and peripheral interactions between the agouti-related protein and leptin. Biochemical and Biophysical Research Communications 319 518-524.
10. Crabtree JT, Duncan JS & Trayhurn P 2000 A highly sensitive chemiluminescence ELISA for the measurement of leptin. International Journal of Obesity 24 136.
11. Fan W, Boston BA, Kesterson RA, Hruby VJ & Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 165-168.
12. Forbes S, Bui S, Robinson BR, Hochgeschwender U & Brennan MB 2001 Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway. PNAS 98 4233-4237.
13. Gibbs HD, Broom J, Brown J, Laws RA, Reckless JPD Noble PA, Kumar S, McCombie EL, lean MEJ, Lyons FG et al. 2004 Current approaches to obesity management in UK Primary Care: the Counterweight Programme. Journal of Human Nutrition and Dietetics 17 183-190.
14. Hamilton BS & Doods HN 2002 Chronic application of MTII in a rat model of obesity results in sustained weight loss. Obesity Research 10 182-187.
15. Hardie LJ, Rayner DV, Holmes S & Trayhurn P 1996 Circulating leptin levels are modulated by fasting, cold-exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochemical and Biophysical Research Communications 223 660-665.
16. Hayes J, Speakman J & Racey P 1992 Sampling bias in respirometry. Physiological Zoology 65 604-619.
17. Haynes WG, Morgan DA, Djalali A, Sivitz WI & Mark AL 1999 Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33 542-547.
18. Hoggard N, Hunter L, Duncan JS & Rayner DV 2004a Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system. Journal of Molecular Endocrinology 32 145-153.
19. Hoggard N, Johnstone AM, Fabe P, Gibney ER, Elia M, Lobley G, Ray V, Hurgam G, Hunter L, Bashir S et al. 2004b Plasma concentrations of alpha-MSH, AgRP and leptin in lean and obese men and their relationship to differing states of energy balance perturbation. Clinical Endocrinology 61 31-39.
20. Hwa JJ, Ghibaudi L, Gao J & Parker EM 2001 Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 281 R444-R451.
21. Jonsson L, Skarphedinsson JO, Skuladottir GV, Atlason PT, Eiriksdottir VH, Franzson L & Schioth HB 2001 Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703-3708.
22. Kask A, Pahkla R, Irs A, Rago L, Wikberg JES & Schioth HB 1999 Long-term administration of MC4 receptor antagonist HS014 causes hyperphagia and obesity in rats. Neuroreport 10 707-711.
23. Kastin AJ, Redding TW, Hall R, Besser GM & Schally AV 1975 Lipid mobilizing hormones of the hypothalamus and pituitary. Pharmacology, Biochemistry, and Behaviour 3 121-126.
24. Kastin AJ, Akerstrom V & Hackler L 2000 Agouti-related protein(83-132) aggregates and crosses the blood brain barrier slowly. Metabolism 49 1444-1448.
25. Li JY, Finniss S, Yang YK, Zeng Q, Qu SY, Barsh G, Dickinson C & Gantz I 2000 Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Endocrinology 141 1942-1950.
26. MacNeil DJ, Howard AD, Guan X, Fong TM, Nargund RP, Bednarek MA, Goulet MT, Weinberg DH, Strack AM, Marsh DJ et al. 2002 The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. European Journal of Pharmacology 440 141-157.
27. Mitchell SE, Rees WD, Hardie LJ, Hoggard N, Tadayyon M, Arch JRS & Trayhurn P 1997 ob gene expression and secretion of leptin following differentiation of rat preadipocytes to adipocytes in primary culture. Biochemical and Biophysical Research Communications 230 360-364.
28. Penny RJ & Thody AJ 1978 An improved radioimmunoassay for alpha-melanocyte-stimulating hormone (alpha-MSH) in the rat: serum and pituitary alpha-MSH levels after drugs which modify catecholaminergic neurotransmission. Neuroendocrinology 25 193-203.
29. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS & Mantzoros CS 2002 Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 51 1337-1345.
30. Raposinho PD, Castillo E, d'Alleves V, Broqua P, Pralong FP & Aubert ML 2000 Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes. Endocrinology 141 4419-4427.
31. Rossi M, Kim MS, Morgan DG, Small CJ, Edwards CM, Sunter D, Abusnana S, Goldstone AP, Russell SH, Stenley SA et al. 1998 A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139 4428-4431.
32. Shen CP, Wu KK, Shearman LP, Camacho R, Tota MR, Fong TM & Van der Ploeg LH 2002 Plasma agouti-related protein level: a possible correlation with fasted and fed states in humans and rats. Journal of Neuroendocrinology 14 607-610.
33. Small CJ, Liu YL, Stanley SA, Connoley IP, Kennedy A, Stock MJ & Bloom SR 2003 Chronic CNS administration of Agouti-related protein (AgRP) reduces energy expenditure. International Journal of Obesiy and Related Metabolic Disorders 27 530-533.
34. Trayhurn P, Duncan JS & Rayner DV 1995 Acute cold-induced suppression of ob (Obese) gene-expression in white adipose-tissue of mice - mediation by the sympathetic system. Biochemical Journal 311 729-733.
35. Tschop M 2004 Plenary presentation on 'Ghrelin'. Experimental Biology 2004 meeting, Washington DC, USA.
36. Weinsier RL, Hunter GR, Schutz Y, Zuckerman PA & Darnell BE 2002 Physical activity in free-living, overweight white and black women: divergent responses by race to diet-induced weight loss. American Journal of Clinical Nutrition 76 736-742.
37. Zhang YY, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homolog. Nature 372 425-432.
38. Zimanyi IA & Pelleymounter MA 2003 The role of melanocortin peptides and receptors in regulation of energy balance. Current Pharmaceutical Design 9 627-641.