Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 3, 1997, Pages 919-922

  Mynatt, R L ^a   Miltenberger, R J ^a   Klebig, M L ^a,e   Zemel, M B ^b   Wilkinson, J E ^c   Wilkison, W O ^d   Woychik, R P ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

^c Elvis Presley Memorial Trauma Center Memphis   (United States)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

Author keywords

diabetes; transgenic mice

Indexed keywords

GENE PRODUCT; INSULIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENETIC PREDISPOSITION; INSULIN TREATMENT; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; TISSUE SPECIFICITY; TRANSGENIC MOUSE; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMALS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; OBESITY; PROTEINS; RNA, MESSENGER; WEIGHT GAIN;

EID: 0031037570     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.3.919     Document Type: Article

References (33)

1. Bultman, S. J., Michaud, E. J. & Woychik, R. P. (1992) Cell 71, 1195-1204.
2. Miller, M. W., Duhl, D. M. J., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M. & Barsh, G. S. (1993) Genes Dev. 7, 454-467.
3. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J. M. (1994) Nature (London) 372, 425-432.
4. Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I. & Morgenstern, J. P. (1996) Cell 84, 491-495.
5. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. B., Woolf, E. A., Monroe, C. A. & Tepper, R. I. (1995) Cell 83, 1263-1271.
6. Naggert, J. K., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouille, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J. & Leiter, E. H. (1995) Nat. Genet. 10, 135-142.
7. Noben-Trauth, K., Naggert, J. K., North, M. A. & Nishina, P. M. (1996) Nature (London) 380, 534-538.
8. Kleyn, P. W., Fan, W., Kovats, S. G., Lee, J. J., Pulido, J. C. et al. (1996) Cell 85, 281-290.
9. Silvers, W. K. (1979) The Coat Colors of Mice: A Model for Mammalian Gene Action and Interaction (Springer, New York).
10. Klehig, M. L., Wilkinson, J. E. & Woychik, R. P. (1996) in Molecular Analysis of the Mouse Agouti Gene and the Role of Dominant Agouti-Locus Mutations in Obesity and Insulin Resistance, eds. Bray, G. A. & Ryan, D. H. (Louisiana State Univ. Press, Baton Rouge), Vol. 5, pp. 120-160.
11. Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S. & Wolff, G. L. (1994) FASEB J. 8, 479-488.
12. Bultman, S. J., Klebig, M. L., Michaud, E. J., Sweet, H. O., Davisson, M. T. & Woychik, R. P. (1994) Genes Dev. 8, 481-490.
13. Michaud, E. J., Bultman, S. J., Stubbs, L. J. & Woychik, R. P. (1993) Genes Dev. 7, 1203-1213.
14. Michaud, E. J., van Vugt, M. J., Bultman, S. J., Sweet, H.O., Davisson, M. T. & Woychik, R. P. (1994) Genes Dev. 8, 1463-1472.
15. Vrieling, H., Duhl, D. M. J., Miller, S. E., Miller, K. A. & Barsh, G. S. (1994) Proc. Natl. Acad. Sci. USA 91, 5667-5671.
16. Lu, D., Willard, D., Patel, I. R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O. & Cone, R. D. (1994) Nature (London) 371, 799-802.
17. Blanchard, S. G., Harris, C. O., Ittoop, O. R., Nichols, J. S., Parks, D. J., Truesdale, A. T. & Wilkison, W. O. (1995) Biochemistry 34, 10406-10411.
18. Klebig, M. L., Wilkinson, J. E., Geisler, J. G. & Woychik, R. P. (1995) Proc. Natl. Acad. Sci. USA 92, 4728-4732.
19. Wolff, G. L. (1963) Genetics 48, 1041-1058.
20. Kwon, H. Y., Bultman, S. J., Loffler, C., Chen, W. J., Furdon, P. J., Powell, J. G., Usala, A. L., Wilkison, W., Hansmann, I. & Woychik, R. P. (1994) Proc. Natl. Acad. Sci. USA 91, 9760-9764.
21. Yen, T. T., Allan, J. A., Yu, P. L., Acton, M. A. & Pearson, D. V. (1976) Biochim. Biophys. Acta 441, 213-220.
22. Jones, B. H., Kim, J.-H., Zemel, M. B., Woychik, R. P., Michaud, E. J., Wilkison, W. O. & Moustaid, N. (1996) Am. J. Physiol. 270, E192-E196.
23. Graves, R. A., Tontonoz, P., Ross, S. R. & Spiegelman, B. M. (1991) Genes Dev. 5, 428-437.
24. Ross, S. R., Graves, R. A., Greenstein, A., Platt, K. A., Shyu, H.-L., Mellovitz, B. & Spiegelman, B. M. (1990) Proc. Natl. Acad. Sci. USA 87, 9590-9594.
25. Hogan, B., Costantini, F. & Lacy, E. (1986) Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
26. Overbeek, P. A., Aguilar-Cordova, E., Hanteen, G., Schaffner, D. L., Patel, P., Lebovitz, R. M. & Lieberman, M. L. (1991) Transgenic Res. 1, 31-37.
27. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
28. Boston, B. A. & Cone, R. D. (1996) Endocrinology 137, 2043-2050.
29. White, J. E. & Engel, F. L. (1958) J. Clin. Invest. 37, 1556-1563.
30. Oelofsen, W. & Ramachandrand, J. (1983) Arch. Biochem. Biophys. 225, 414-421.
31. Warbritton, A., Gill, A. M., Yen, T. T., Bucci, T. & Wolff, G. L. (1994) Proc. Soc. Exp. Biol. Med. 206, 145-151.
32. Zemel, M. B., Kim, J. H., Woychik, R. P., Michaud, E. J., Kadwell, S. H., Patel, I. R. & Wilkison, W. O. (1995) Proc. Natl. Acad. Sci. USA 92, 4733-4737.
33. Newgard, C. B. & McGarry, J. D. (1995) Annu. Rev. Biochem. 64, 689-719.