A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo

Endocrinology

Volumn 139, Issue 10, 1998, Pages 4428-4431

  Rossi, M ^a   Kim, M S ^a   Morgan, D G A ^a   Small, C J ^a   Edwards, C M B ^a   Sunter, D ^a   Abusnana, S ^a   Goldstone, A P ^a   Russell, S H ^a   Stanley, S A ^a   Smith, D M ^a   Yagaloff, K ^b   Ghatei, M A ^a   Bloom, S R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; AGOUTI RELATED PROTEIN[83-132]; ALPHA INTERMEDIN; HORMONE RECEPTOR BLOCKING AGENT; MELANOCORTIN RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; HYPERPHAGIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 15144357684     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.10.6332     Document Type: Article

References (24)

1. Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik RP, Wilkison WO, et al 1994 Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371:799-802
2. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD 1994 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol.Endocrinol. 8:1298-1308
3. Tsujii S, Bray GA 1989 Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res.Bull. 23:165-169
4. Huszar D, Lynch CA, Fairchild HV, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
5. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168
6. Shutter JR, Graham M, Kinsey AC, Scully S , Luthy R, Stark KL 1997 Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11:593-602
7. Ollmann MM, Wilson BD, Yang YK, Kerns JA , Chen Y, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
8. Fong TM, Mao C, MacNeil T, Kalyani R, SmithT, Weinberg D, Tota MR, Van-der, Ploeg LH 1997 ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. BBRC 237:629-631
9. Graham M, Shutter JR, Sarmiento U, Sarosi I, Stark KL 1997 Overexpression of Agrt leads to obesity in transgenic mice. Nat.Genet. 17:273-274
10. Quillan JM, Sadee W, Wei ET, Jimenez CC, Ji L, Chang JK 1998 Chemical synthesis of an active agouti related protein fragment, JKC-358: a potent inhibitor of the melanocortin receptor. FEBS Lett in press
11. Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR 1997 Melanin concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138:351-355
12. Smith AI, Funder JW 1988 Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr.Rev. 9:159-179
13. Emeson RB, Eipper BA 1986 Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus. J.Neurosci. 6:837-849
14. Mezty E, Kiss JZ, Mueller GP, Eskay R, O'Donohue TL, Palkovits M 1985 Distribution of the pro-opiomelanocortin derived peptides, adrenocorticotrope hormone, alpha-melanocyte-stimulatirig hormone and beta-endorphin (ACTH, alpha-MSH, beta-END) in the rat hypothalamus. Brain Res. 328:341-347
15. Willard DH, Bodnar W, Harris C, Kiefer L, Nichols JS, Blanchard S, Hoffman C, Moyer M, Burkhart W, Weiel J, Wilkison WO, Rocque W 1995 Agouti structure and function: characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist. Biochemistry 34:12341-12346
16. Kiefer LL, Veal JM, Mountjoy KG, Wilkison WO 1998 Melanocortin receptor binding determinants in the agouti protein Biochemistry 37:991-997
17. Stanley BG, Leibowitz SF 1984 Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35:2635-2642
18. Kyrkouli SE, Stanley BG, Leibowitz SF 1986 Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur.J.Pharmacol. 122:159-160
19. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
20. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P 1996 Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J.Neuroendocrinol. 8:733-735
21. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D, Woods SC, Seeley RJ, Weigle DS 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535
22. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y 1997 Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc.Natl.Acad.Sci.U.S.A. 94:10455-10460
23. Goldstone AP, Mercer JG, Gunn I, Moar KM , Edwards CM, Rossi M, Howard JK, Rasheed S, Turton MD, Small C, Heath MM, O'Shea D, Steere J, Meeran K, Ghatei MA, Haggard N, Bloom SR 1997 Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents. FEBS Lett. 415:134-138
24. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van DG, Baskin DG, Schwartz MW 1997 Melanocortin receptors in leptin effects. Nature 390:349