Neuropeptide Y-Induced Feeding and Its Control

Vitamins and Hormones

Volumn 54, Issue C, 1998, Pages 51-66

  Heinrichs, Stephen C ^a   Menzaghi, Frédérique ^b   Koob, George F ^b  

^a NEUROCRINE BIOSCIENCES INC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE Y;

ANIMAL; APPETITE; DRUG EFFECT; EATING DISORDER; ENERGY METABOLISM; FEEDING BEHAVIOR; GENETICS; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; APPETITE; EATING DISORDERS; ENERGY METABOLISM; FEEDING BEHAVIOR; HUMANS; NEUROPEPTIDE Y;

EID: 0031613135     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(08)60921-8     Document Type: Article

References (82)

1. Adrian T.E., Allen J.M., Bloom S.R., et al. Neuropeptide Y distribution in human brain. Nature 306 (1983) 584
2. American Psychological Association APA. Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (1994), APA, Washington, DC
3. Balasubramaniam A., Sheriff S., Johnson M.E., Prabhakaran M., Huang Y., Fischer J.E., and Chance W.T. [D-TRP32]neuropeptide Y: A competitive antagonist of NPY in rat hypothalamus. J. Med. Chem. 37 (1994) 811-815
4. Beck B., Jhanwar-Uniyal M., Burlet A., Chapleur-Chateau M., Leibowitz S.F., and Burlet C. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528 (1990) 245-249
5. Beck B., Burlet A., Nicolas J.-P., and Burlet C. Unexpected regulation of hypothalamic neuropeptide Y by food deprivation and refeeding in the Zucker rat. Life Sci. 50 (1992) 923-930
6. Billington C.J., Briggs J.E., Grace M., and Levine A.S. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol. 260 (1991) R321-R327
7. Brady L.S., Smith M.A., Gold P.W., and Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52 (1990) 441-447
8. Brief D.J., Sipols A.J., and Woods S.C. Intraventricular neuropeptide Y injections stimulate food intake in lean but not obese Zucker rats. Physiol. Behav. 51 (1992) 1105-1110
9. Brown C.M., and Coscina D.V. Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding. Pharmacol. Biochem. Behav. 51 4 (1995) 641-646
10. Curzon G. Serotonin and appetite. Ann. N.Y. Acad. Sci. 600 (1990) 521-530
11. Dryden S., McCarthy H.D., Malabu U.H., Ware M., and Williams G. Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: Evidence that NPY may mediate serotonin's effects on food intake. Peptides 14 (1993) 791-796
12. Dryden S., Wang Q., Frankish H.M., Pickavance L., and Williams G. The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat. Brain Res. 699 (1995) 12-18
13. Dube M.G., Sahu A., Kalra P.S., and Kalra S.P. Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats: An in vitro study. Endocrinology 131 (1992) 684-688
14. Erickson J.C., Clegg K.E., and Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381 (1996) 415-418
15. Everitt B.J., Hokfelt T., Terenius L., Tatemoto K., Mutt V., and Goldstein M. Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with cate-cholamines in the central nervous system of the rat. Neuroscience 11 (1984) 443-462
16. Flood J.F., and Morley J.E. Increased food intake by neuropeptide Y is due to an increased motivation to eat. Peptides 12 (1991) 1329-1332
17. Frankish H.M., McCarthy H.D., Dryden S., Kilpatrick A., and Williams G. Neuropeptide Y receptor numbers are reduced in the hypothalamus of streptozotocin-diabetic and food-deprived rats: Further evidence of increased activity of hypothalamic NPY-containing pathways. Peptides 14 (1993) 941-948
18. Gehlert D.R. Subtypes of receptors for neuropeptide Y: Implications for the targeting of therapeutics. Life Sci. 55 8 (1994) 551-562
19. Gerald C., et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382 (1996) 168-171
20. Grundemar L., and Hakanson R. Neuropeptide Y effector systems: Perspectives for drug development. Trends Pharmacol. Sci. 15 (1994) 153-159
21. Haas D.A., and George S.R. Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: Lack of effect in other rat brain regions. Life Sci. 41 (1987) 2725-2731
22. Hanson E.S., and Dallman M.F. Neuropeptide Y (NPY) may integrate responses of hypothalamic feeding systems and the hypothalamo-pituitary-adrenal axis. J. Neuroendocrinol. 7 (1995) 273-279
23. Härfstrand A. Brain neuropeptide Y mechanisms. Basic aspects and involvement in cardiovascular and neuroendocrine regulation. Acta Physiol. Scand. 131 (1987) 35-37 Suppl. 5
24. Heilig M. Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amygdala and paradoxically increases feeding. Regul. Peptides 59 (1995) 201-205
25. Heilig M., and Widerlov E. Neurobiology and clinical aspects of neuropeptide Y. Crit. Rev. Neurobiol. 9 2,3 (1995) 115-136
26. Heilig M., McLeod S., Brot M., Heinrichs S.C., Menzaghi F., and Koob G.F. Anxiolytic-like action of neuropeptide Y: Mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8 4 (1993) 357-363
27. Heinrichs S.C., Cole B.J., Merlo Pich E., Menzaghi F., Koob G.F., and Hauger R.L. Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor. Peptides 13 (1992) 879-884
28. Heinrichs S.C., Merlo Pich E., Miczek K.A., Britton K.T., and Koob G.F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res. 581 (1992) 190-197
29. Heinrichs S.C., Menzaghi F., Merlo Pich E., Hanger R.L., and Koob G.F. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res. 611 1 (1993) 18-24
30. Hulsey M.G., Pless C.M., and Martin R.J. ICV administration of anti-corticotropin-releasing factor antisense oligonucleotide: Effects on feeding behavior and body weight. Regul. Peptides 59 (1995) 241-246
31. Imaki T., Nahan J.L., Rivier C., Sawchenko P.E., and Vale W. Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress. J. Neurosci. 11 (1991) 585-599
32. Jeanrenaud B. Central nervous system and peripheral abnormalities: Clues to the understanding of obesity and NIDDM. Diabetologia 37 (1994) S169-S178 Suppl. 2)
33. Jhanwar-Uniyal M., Beck B., Burlet C., and Leibowitz S.F. Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites. Brain Res. 536 (1990) 331-334
34. Kalra S.P., and Kalra P.S. Neuropeptide Y: A novel peptidergic signal for the control of feeding behavior. Curr. Topics Neuroendocrinol. 10 (1990) 191-221
35. Kalra S.P., Clark J.T., Sahu A., Dube M.G., and Kalra P.S. Control of feeding and sexual behaviors by neuropeptide Y: Physiological implications. Synapse 2 (1988) 254-257
36. Kalra S.P., Dube M.G., and Kalra P.S. Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: Effects of adrenalectomy and cholecystokinin. Peptides 9 (1988) 723-728
37. Kalra S.P., Dube M.G., Sahu A., Phelps C.P., and Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Nat. Acad. Sci. USA 88 (1991) 10931-10935
38. Kaye W.H., Berrettini W., Gwirtsman H., and George D.T. Altered cerebrospinal fluid neuropeptide Y and peptide YY immunoreactivity in anorexia and bulimia nervosa. Arch. Gen. Psychiatr. 47 (1990) 548-556
39. Krahn D.D., Gosnell B.A., Levine A.S., and Morley J.E. Behavioral effects of corticotropin-releasing factor: Localization and characterization of central effects. Brain Res. 443 (1988) 63-69
40. Kyrkouli S.E., Stanley B.G., Hutchinson R., Seirafi R.D., and Leibowitz S.F. Peptide-amine interactions in the hypothalamic paraventricular nucleus: Analysis of galanin and neuropeptide Y in relation to feeding. Brain Res. 521 (1990) 185-191
41. Lambert P.D., Wilding J.P.H., Al-Dokhayel A.A.M., Bohuon C., Comoy E., Gilbey S.G., and Bloom S.R. Neuropeptide Y: A central regulator of energy homeostasis. Regul. Peptides 49 (1993) 93-107
42. Leibowitz S.F. Brain monoamines and peptides: Role in the control of eating behavior. Fed. Proc. 45 (1986) 1396-1403
43. Li B.-H., Xu B., Rowland N.E., and Kalra S.P. c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption. Brain Res. 665 (1994) 277-284
44. Liposits Z., Sievers L., and Paull W.K. Neuropeptide-Y and ACTH-immunore-active innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. Histochemistry 88 (1988) 227-234
45. Lopez-Valpuesta F.J., Nyce J.W., Griffin-Biggs T.A., Ice J.C., and Myers R.D. Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats. Proc. R. Soc. London 263 (1996) 881-886
46. Lundberg J.M., Modin A., and Malmstrom R.E. Recent developments with neuropeptide Y receptor antagonists. Trends Pharmacol. Sci. 17 9 (1996) 301-304
47. Menzaghi F., Heinrichs S.C., Merlo Pich E., Tilders F.-J.H., and Koob G.F. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain Res. 618 (1993) 76-82
48. Merlo Pich E., Messori B., Zoli M., Ferraguti F., Marrama P., Biagini G., Fuxe K., and Agnati L. Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats. Brain Res. 575 (1992) 265-271
49. Morley J.E. Neuropeptide regulation of appetite and weight. Endocrinol. Rev. 8 (1987) 256-287
50. Morley J.E., Levine A.S., Gosnell B.A., Kneip J., and Grace M. Effect of neuropeptide Y on ingestive behaviors in the rat. Am. J. Physiol. 252 (1987) R599-R609
51. Myers R.D., Wooten M.H., Ames C.D., and Nyce J.W. Anorexic action of a new potential neuropeptide Y antagonist [D-Tyr27-36, D-Thr32]-NPY (27-36) infused into the hypothalamus of the rat. Brain Res. Bull. 37 3 (1995) 237-245
52. Paez X., and Myers R.D. Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide Y in the hypothalamus. Peptides 12 (1991) 609-616
53. Pesonen U., Huupponen R., Rouru J., and Koulu M. Hypothalamic neuropeptide expression after food restriction in Zucker rats: Evidence of persistent neuropeptide Y gene activation. Mol. Brain Res. 16 (1992) 255-260
54. Richard D. Exercise and the neurobiological control of food intake and energy expenditure. Int. J. Obesity 19 (1995) S73-S79 Suppl. 4
55. Rogers P., McKibbin P.E., and Williams G. Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: Possible implications for the anorectic effect of fenfluramine. Peptides 12 (1991) 251-255
56. Sahu A., Kalra P.S., and Kalra S.P. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9 (1988) 83-86
57. Sahu A., Sninsky C.A., Phelps C.P., Dube M.G., Kalra P.S., and Kalra S.P. Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats. Endocrinology 131 6 (1992) 2979-2985
58. Sanacora G., Kershaw M., Finkelstein J.A., and White J.D. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127 (1990) 730-737
59. Sawchenko P.E., and Swanson L.W. Organization of CRF immunoreactive cells and fibers in the rat brain: Immunohistochemical studies. In: De Souza E.B., and Nemeroff C.B. (Eds). Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide (1990), CRC Press, Boca Raton, FL 29-52
60. Schwartz M.W., Marks J.L., Sipols A.J., Baskin D.G., Woods S.C., Kahn S.E., and Porte Jr. D. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128 (1991) 2645-2647
61. Schwartz M.W., Figlewicz D.P., Baskin D.G., Woods S.C., and Porte Jr. D. Insulin in the brain: A hormonal regulator of energy balance. Endocrine Rev. 13 2 (1992) 387-414
62. Schwartz M.W., Sipols A.J., Grubin C.E., and Baskin D.G. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Res. Bull. 31 (1993) 361-367
63. Shibasaki T., Oda T., Imaki T., Ling N., and Demura H. Injection of anti-neuropeptide Y γ-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats. Brain Res. 601 (1993) 313-316
64. Shimizu H., and Bray G.A. Effects of neuropeptide Y on norepinephrine and serotonin metabolism in rat hypothalamus in vivo. Brain Res. Bull. 22 (1989) 945-950
65. Stanley B.G., and Leibowitz S.F. Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior. Proc. Nat. Acad. Sci. USA 82 (1985) 3940-3943
66. Stanley B.G., and Thomas W.J. Feeding responses to perifornical hypothalamic injection of neuropeptide Y in relation to circadian rhythms of eating behavior. Peptides 14 (1993) 475-481
67. Stanley B.G., Daniel D.R., Chin A.S., and Leibowitz S.F. Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6 (1985) 1205-1211
68. Stanley B.G., Lanthier D., Chin A.S., and Leibowitz S.F. Suppression of neuropeptide Y-elicited eating by adrenalectomy or hypophysectomy: Reversal with corticosterone. Brain Res. 501 (1989) 32-36
69. Stricker-Krongrad A., Barbanel G., Beck B., Burlet A., Nicolas J.P., and Burlet C. K+-stimulated neuropeptide Y release into the paraventricular nucleus and relation to feeding behavior in free-moving rats. Neuropeptides 24 (1993) 307-312
70. Terenghi G., Polak J.M., Hamid Q., et al. Localization of neuropeptide Y mRNA in neurons of human cerebral cortex by means of in situ hybridization with a complementary RNA probe. Proc. Nat. Acad. Sci. USA 84 (1987) 7315-7318
71. Tsagarakis S., Rees L.H., Besser G.M., and Grossman A. Neuropeptide-Y stimulates CRF-41 release from rat hypothalami in vitro. Brain Res. 502 (1989) 167-170
72. Vettor R., Zarjevski N., Cusin I., Rohner-Jeanrenaud F., and Jeanrenaud B. Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia 37 (1994) 1202-1208
73. Wahlestedt C., Skagerberg G., Ekman R., Heilig M., Sundler F., and Hakanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res. 417 (1987) 33-38
74. Wahlestedt C. Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol. Sci. 15 (1994) 42-46
75. Wahlestedt C., and Reis D.J. Neuropeptide Y-related peptides and their receptors-Are the receptors potential therapeutic drug targets. Annu. Rev. Pharmacol. Toxicol. 32 (1993) 309-352
76. Wahlestedt C., Merlo Pich E., Koob G.F., Yee F., and Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science 259 (1993) 528-531
77. Ware M., Garton M.J., Malabu U.H., Dickie A., Davidson-Lamb R., Walmsley D., and Williams G. Neuropeptide Y concentrations in cerebro-spinal fluid are unchanged in obesity. Clin. Sci. 84 (1993) 44P
78. White J.D. Neuropeptide Y: A central regulator of energy homeostasis. Regul. Peptides 49 (1993) 93-107
79. White J.D., Olchovsky D., Kershaw M., and Berelowitz M. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology 126 (1990) 765-772
80. Williams G., Gill J.S., Lee Y.C., Cardoso H.M., Okpere B.E., and Bloom S.R. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats. Diabetes 38 (1989) 321-327
81. Wurtman J.J., and Wurtman R.J. Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats. Life Sci. 24 (1979) 895-904
82. Zarjevski N., Cusin I., Vettor R., Rohner-Jeanrenaud F., and Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133 (1993) 1753-1758