Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3285-3299

  Xu, Ruo ^a   Li, Shengjian ^a   Paruchova, Jaroslava ^a   McBriar, Mark D ^a   Guzik, Henry ^a   Palani, Anandan ^a   Clader, John W ^a   Cox, Kathleen ^a   Greenlee, William J ^a   Hawes, Brian E ^a   Kowalski, Timothy J ^a   O'Neill, Kim ^a   Spar, Brian D ^a   Weig, Blair ^a   Weston, Daniel J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bicyclo 4.1.0 heptane; Biphenyl amine replacement; Melanin concentrating hormone 1 receptor antagonist

Indexed keywords

HEPTANE DERIVATIVE; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; N [1 (3 CYANOPHENYL) 4 PIPERIDINYL] N' [4 FLUORO 3 (TRIFLUOROMETHYL)PENYL] N (1 PYRROLIDINYL)ETHYL]UREA; N [3 4 [[[(3 CHLORO 4 FLUOROPHENYL)AMINO]CARBONYL][2 (1 PYRROLIDINYL)ETHYL]AMINO]BICYCLO[4.1.0]HEPT 1 YL]PHENYL]ACETAMIDE; N [5 (3 CYANOPHENYL) 2 PYRIMIDINYL] N' [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL] N [2 (1 PYRROLIDINYL)ETHYL]UREA; N [5 (3 CYANOPHENYL)PYRAZIN 2 YL] N' [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL] N [2 (1 PYRROLIDINYL)ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [2 (3 FLUORO 1 PYRROLIDINYL)ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [2 (3,3 DIFLUORO 1 PYRROLIDINYL)ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [2 (4,4 DIFLUORO 1 PIPERIDINYL)ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [3 (1 PYRROLIDINYL)PROPYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [3 (3 FLUORO 1 PYRROLIDINYL)PROPYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [3 (4 METHYL 1 PIPERAZINYL)PROPYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [3 [3 HYDROXY 1 PYRROLIDINYL]PROPYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3,4 DICHLOROPHENYL) N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3,5 DICHLOROPHENYL) N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N [6 (3 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (4 FLUORO 3 TRIFLUOROMETHYLPHENYL) N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N [6 (3 CYANOPHENYLBICYCLO[4.1.0]HEPT 3 YL] N' (4 FLUORO 3 TRIFLUOROMETHYLPHENYL) N [2 (1 PYRROLIDINYL)ETHYL]UREA; N [6 (3 FLUOROPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N [6 (4 CYANOPHENYL)BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N [6 [3 (THIOMETHOXY)PHENYL]BICYCLO[4.1.0]HEPT 3 YL] N' (3 CHLORO 4 FLUOROPHENYL) N [3 (1 PYRROLIDINYL)PROPYL]UREA; N' (4 FLUORO 3 TRIFLUOROMETHYL PHENYL) N [4 (3 CYANOPHENYL) 3 CYCLOHEXEN 1 YL] N [2 (1 PYRROLIDINYL)ETHYL]UREA; N' (4 FLUORO 3 TRIFLUOROMETHYLPHENYL) N [4 (3 CYANOPHENYL) 4 METHYLCYCLOHEXYL] N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; N' (4 FLUORO 3 TRIFLUOROMETHYLPHENYL) N [4 (3 CYANOPHENYL)CYCLOHEXYL] N [2 [3 HYDROXY 1 PYRROLIDINYL]ETHYL]UREA; PHENYL GROUP; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG BINDING; MOUSE; MUTAGENESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMINOBIPHENYL COMPOUNDS; ANIMALS; BICYCLO COMPOUNDS; CELL LINE; CRICETINAE; DRUG EVALUATION, PRECLINICAL; HEPTANES; MICE; MOLECULAR STRUCTURE; MUTAGENS; RATS; RECEPTORS, PITUITARY HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33645868001     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.046     Document Type: Article

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