Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity

Nature

Volumn 390, Issue 6656, 1997, Pages 165-169

  Ohki Hamazaki, Hiroko ^a,b   Watase, Kei ^a   Yamamoto, Kazutoshi ^c   Ogura, Hiroo ^d   Yamano, Mariko ^e   Yamada, Kazuyuki ^a   Maeno, Hiroshi ^a   Imaki, Junko ^f   Kikuyama, Sakae ^c   Wada, Etsuko ^a   Wada, Keiji ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d EISAI CO LTD   (Japan)

^e Osaka Prefecture University   (Japan)

^f NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN RECEPTOR; GASTRIN RELEASING PEPTIDE; GLUCAGON; GLUCOSE; GROWTH HORMONE; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; MESSENGER RNA; NEUROMEDIN B; OXYGEN; PEPTIDE; RECEPTOR SUBTYPE; THYROID HORMONE;

ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; LOCOMOTION; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ADIPOSE TISSUE, BROWN; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; ENERGY METABOLISM; FEMALE; GENE DELETION; GENE TARGETING; GLUCOSE; GLUCOSE TOLERANCE TEST; HEART RATE; HORMONES; LEPTIN; MALE; METABOLIC DISEASES; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; OBESITY; PROTEINS; RECEPTORS, BOMBESIN;

ANIMALIA; BOVINE RESPIRATORY SYNCYTIAL VIRUS; MAMMALIA;

EID: 0030662465     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36568     Document Type: Article

References (19)

1. Lebacq-Verheyden, A.-M., Trepel, J., Sausville, E. A. & Battey, J. in Handbook of Experimental Pharmacology, Vol. 95/II. Peptide Growth Factors and their Receptors II (eds Sporn, M. B. & Roberts, A. B.) 71-124 (Springer, Berlin, Heidelberg, 1990).
2. Spindel, E. R., Giladi, E., Brehm, P., Goodman, R. H. & Segerson, T. P. Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol. Endocrinol. 4, 1956-1963 (1990).
3. Battey, J. F. et al. Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Proc. Natl Acad. Sci. USA 88, 395-399 (1991).
4. Corjay, M. H. et al. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. J. Biol. Chem. 266, 18771-18779(1991).
5. Wada, E. et al. cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Neuron 6, 421-430 (1991).
6. Fathi, Z. et al. A novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J. Biol. Chem. 268, 5979-5984 (1993).
7. Gorbulev, V., Akhundova, A., Buchner, H. & Fahrenholz, F. Molecular cloning of a new bombesin receptor subtype expressed in uterus during pregnancy. Eur. J. Biochem. 208, 405-410 (1992).
8. Ohki-Hamazaki, H., Wada, E., Matsui, K. & Wada, K. Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res. 762, 165-172 (1997).
9. Bray, G. A. & York, D. A. Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis. Physiol. Rev. 59, 719-809 (1979).
10. Frederich, R. C. et al. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nature Med. 1, 1311-1314 (1995).
11. Maffei, M. et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1, 1155-1161 (1995).
12. Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J. & Porte, D. Jr Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nature Med. 2, 589-593 (1996).
13. Wu, J. M., Nitecki, D. E., Biancalana, S. & Feldman, R. I. Discovery of high affinity bombesin receptor subtype 3 agonists. Mol. Pharmacol. 50, 1355-1363 (1996).
14. Boer, P. H. et al. Polymorphisms in the coding and noncoding region of murine Pgk-1 alleles. Biochem. Gen. 28, 299-308 (1990).
15. Yanofsky, R. L., Fine, M. & Pellow, J. W. A mutant neomycin phosphotransferase II gene reduces the resistance of transformants to antibiotic selection pressure. Proc. Natl Acad. Sci. USA 87, 3435-3439 (1990).
16. Nabeshima, Y. et al. Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature 364, 532-535 (1993).
17. Hooper, M., Hardy, K., Handyside, A., Hunter, S. & Monk, M. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 326, 292-295 (1987).
18. Yamamoto, K. & Kikuyama, S. Radioimmunoassay of prolactin in plasma of bullfrog tadpoles. Endocrinol. Jpn 29, 159-167 (1982).
19. Bouillaud, F., Weissenbach, J. & Ricquier, D. Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein. J. Biol. Chem. 261, 1487-1490 (1986).