Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals

Diabetes

Volumn 50, Issue 2, 2001, Pages 248-254

  Small, Caroline J ^a   Kim, Min S ^a   Stanley, Sarah A ^a   Mitchell, John R D ^a   Murphy, Kevin ^a   Morgan, David G A ^a   Ghatei, Mohammad A ^a   Bloom, Stephen R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; LEPTIN; MELANOCORTIN RECEPTOR; THYROTROPIN; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY EXPENDITURE; ENERGY METABOLISM; EPIDIDYMIS FAT; FOOD INTAKE; HYPOPHYSIS FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROTROPIN BLOOD LEVEL; WEIGHT GAIN;

EID: 0035142129     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.2.248     Document Type: Article

References (61)

1. From Agouti to Pomc: 100 years of fat blonde mice
2. The central melanocortin system and its role in energy homeostasis
3. The role of melanocortin signalling in the control of body weight: Evidence from human and murine genetic models
4. Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or proopiomelanocortin concentrations in dietary-obese and food-restricted rats
5. Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: Further evidence that activation of MC4-R is a physiological inhibitor of feeding
6. Obesity in the mouse model of proopiomelanocortin deficiency responds to peripheral melanocortin
7. Proopiomelanocortin products and human early-onset obesity
8. A frameshift mutation in MC4R associated with dominantly inherited human obesity
9. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
10. A frameshift mutation in human MC4R is associated with a dominant form of obesity
11. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
12. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
13. Integration of NPY, AGRP and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
14. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
15. Evidence for involvement of the melanocortin MC4 receptor in the effects of leptin on food intake and body weight
16. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
17. Long term orexigedic effect of a novel melanocortin 4 receptor selective antagonist
18. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
19. Physiological and anatomical circuitry between agouti-related protein and leptin signaling
20. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
21. Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
22. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
23. Co-expression of AGRP and NPY in fasting-activated hypothalamic neurons
24. The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
25. Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain
26. Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues
27. Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus
28. Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behaviour
29. Effect of corticotropin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue
30. Neuropeptide Y in hypothalamic paraventricular nucleus: A center coordinating energy metabolism
31. Agouti related peptide (AGRP) stimulates the hypothalamo pituitary gonadal axis in vivo and in vitro in males
32. Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats
33. Neuropeptide Y stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamus in vitro: Modulation by ovarian hormones
34. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats
35. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
36. Alpha-melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
37. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effects of leptin
38. A synthetic human agouti-related protein-(83-132)-NH2 fragment is a potent inhibitor of melanocortin receptor function
39. Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release
40. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor
41. Galanin is a paracrine inhibitor of gonadotroph function in the female rat
42. Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet
43. Determination of serum proteins by means of the Biuret reaction
44. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
45. "Western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
46. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity
47. Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
48. Differential responses of yellow Avy/A and agouti A/a (BALB/c X VY) F1 hybrid mice to the same diets: Glucose tolerance, weight gain, and adipocyte cellularity
49. Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction
50. Testosterone, body composition and aging
51. Characterization of the hypothalamo-pituitary-IGF-I axis in rats made obese by overfeeding
52. Evidence for an interaction between alpha-MSH and opioids in the regulation of gonadotropin secretion in man
53. Genetic regulation of plasma corticosterone concentration and its response to castration and allogeneic tumour growth in the mouse
54. Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide Y infusion in normal rats
55. Neuropeptide Y in relation to carbohydrate intake, corticosterone and dietary obesity
56. Plasma corticosterone concentrations in diabetic (db) mice
57. The pituitary-adrenal system of the genetically obese (ob/ob) mouse
58. The role of central melanocortin receptors in the activation of the hypothalamus-pituitary-adrenal-axis and the induction of excessive grooming
59. Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1 beta and alpha MSH: Studies in rats with different susceptibility to inflammatory disease
60. Role of leptin in the neuroendocrine response to fasting